v3.26.1
Segment Information - Schedule of Reportable Segment Net Revenues and Loss (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2026
Mar. 31, 2025
Revenues:    
Revenue, Product and Service [Extensible Enumeration] us-gaap:LicenseMember us-gaap:LicenseMember
Total revenues $ 258 $ 5,874
Less:    
Research and development 2,909 13,606
General and administrative 4,887 6,824
Other segment items [1] 1 174
Interest income (336) (864)
Consolidated loss (7,203) (13,866)
Grant Revenue    
Revenues:    
Total revenues 0 763
Collaboration revenue - related party    
Revenues:    
Total revenues $ 258 $ 5,099
Collaboration revenue    
Revenues:    
Revenue, Product and Service [Extensible Enumeration] us-gaap:LicenseMember us-gaap:LicenseMember
Total revenues $ 0 $ 12
Tebipenem HBr    
Less:    
Research and development 412 8,669
SPR720    
Less:    
Research and development 0 449
SPR206    
Less:    
Research and development 0 49
Research and development personnel related (including share-based compensation)    
Less:    
Research and development 1,669 3,337
Facility related and other    
Less:    
Research and development 828 1,102
General and administrative 916 443
General and administrative personnel related (including share-based compensation)    
Less:    
General and administrative 2,290 4,118
Professional and consultant fees    
Less:    
General and administrative $ 1,681 $ 2,263
[1] Other segment items include restructuring charges, impairment of long-term asset and other income, net.