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          <link:definition>999061 - Disclosure - SCHEDULE OF MATURITIES OF OPERATING LEASE LIABILITIES (Details)</link:definition>
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        <link:roleType roleURI="http://abeonatherapeutics.com/role/LeasesDetailsNarrative" id="LeasesDetailsNarrative">
          <link:definition>999062 - Disclosure - LEASES (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://abeonatherapeutics.com/role/ScheduleOfDebtAndNetOfDebtIssuanceCostsDetails" id="ScheduleOfDebtAndNetOfDebtIssuanceCostsDetails">
          <link:definition>999063 - Disclosure - SCHEDULE OF DEBT AND NET OF DEBT ISSUANCE COSTS (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999064 - Disclosure - SCHEDULE OF FUTURE PAYMENT OBLIGATIONS (Details)</link:definition>
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          <link:definition>999065 - Disclosure - DEBT (Details Narrative)</link:definition>
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          <link:definition>999066 - Disclosure - EQUITY (Details Narrative)</link:definition>
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          <link:definition>999067 - Disclosure - SCHEDULE OF STOCK BASED COMPENSATION (Details)</link:definition>
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          <link:definition>999068 - Disclosure - SCHEDULE OF STOCK OPTION ACTIVITY (Details)</link:definition>
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          <link:definition>999069 - Disclosure - SCHEDULE OF RESTRICTED STOCK AWARD ACTIVITY (Details)</link:definition>
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          <link:definition>999070 - Disclosure - STOCK-BASED COMPENSATION (Details Narrative)</link:definition>
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          <link:definition>999071 - Disclosure - LICENSE/SUPPLIER AGREEMENTS (Details Narrative)</link:definition>
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          <link:definition>999072 - Disclosure - SCHEDULE OF SIGNIFICANT EXPENSE CATEGORIES (Details)</link:definition>
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    <element id="ABEO_OtherGeneralAndAdministrativeExpenses" name="OtherGeneralAndAdministrativeExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ABEO_OtherSegments" name="OtherSegments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ABEO_ScheduleOfRevenueFromProductSalesTableTextBlock" name="ScheduleOfRevenueFromProductSalesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="ABEO_LicenseAgreementMember" name="LicenseAgreementMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
    <element id="ABEO_PrecommercialPreparationCosts" name="PrecommercialPreparationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="ABEO_AllocatedShareBasedCompensationExpenseGeneralAndAdministrative" name="AllocatedShareBasedCompensationExpenseGeneralAndAdministrative" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
