The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABORATORIES COM 002824100 696,000 6,779 SH SOLE 6,779 0 0
ABBVIE INC COM 00287Y109 1,332,344 6,126 SH SOLE 6,126 0 0
ABIVAX SA SPONSORED ADS 00370M103 2,137,697 19,198 SH SOLE 19,198 0 0
ABIVAX SA SPONSORED ADS 00370M103 325,320 253 SH Call SOLE 253 0 0
ABIVAX SA SPONSORED ADS 00370M103 288,425 253 SH Put SOLE 253 0 0
ABIVAX SA SPONSORED ADS 00370M103 405,314 3,640 SH SOLE 3,640 0 0
ADAGENE INC ADS 005329107 137,694 35,126 SH SOLE 35,126 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 92,843 6,689 SH SOLE 6,689 0 0
ADLAI NORTYE LTD SPONSORED ADS 00704R109 233,425 33,732 SH SOLE 33,732 0 0
AKAMAI TECHNOLOGIES INC COM 00971T101 841,161 7,324 SH SOLE 7,324 0 0
ALKERMES PLC SHS G01767105 447,021 12,642 SH SOLE 12,642 0 0
ALKERMES PLC SHS G01767105 456,887 12,921 SH SOLE 12,921 0 0
ALLY FINL INC COM 02005N100 17,390 94 SH Put SOLE 94 0 0
ALPHABET INC CAP STK CL C 02079K107 2,774,510 9,672 SH SOLE 9,672 0 0
ALUMIS INC COM 022307102 179,185 253 SH Call SOLE 253 0 0
ALUMIS INC COM 022307102 6,069 79 SH Put SOLE 79 0 0
AMCOR PLC COM NEW G0250X149 1,174,175 29,539 SH SOLE 29,539 0 0
AMERANT BANCORP INC CL A 023576101 460,063 20,874 SH SOLE 20,874 0 0
AMERIS BANCORP COM 03076K108 1,094,824 14,038 SH SOLE 14,038 0 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 221,353 17,808 SH SOLE 17,808 0 0
AN2 THERAPEUTICS INC COM 037326105 130,490 38,155 SH SOLE 38,155 0 0
ANAVEX LIFE SCIENCES CORP COM NEW 032797300 6 322 SH Call SOLE 322 0 0
ANAVEX LIFE SCIENCES CORP COM NEW 032797300 406 828 SH Call SOLE 828 0 0
ANNEXON INC COM 03589W102 186,283 33,625 SH SOLE 33,625 0 0
ANNEXON INC COM 03589W102 12,467 69 SH Call SOLE 69 0 0
ANNEXON INC COM 03589W102 159,567 536 SH Call SOLE 536 0 0
ANNEXON INC COM 03589W102 73,260 292 SH Call SOLE 292 0 0
ANTERIS TECHNOLOGIES GLOBAL COM 03675P102 241,802 43,568 SH SOLE 43,568 0 0
ANTERIS TECHNOLOGIES GLOBAL COM 03675P102 235,015 42,345 SH SOLE 42,345 0 0
ANTERO RESOURCES CORP COM 03674X106 358,307 8,101 SH SOLE 8,101 0 0
APOGEE THERAPEUTICS INC COM 03770N101 1,934,022 566 SH Call SOLE 566 0 0
APOLLO GLOBAL MGMT INC COM 03769M106 67,725 258 SH Call SOLE 258 0 0
APOLLO GLOBAL MGMT INC COM 03769M106 7,371 46 SH Call SOLE 46 0 0
APPLE INC COM 037833100 23 1 SH Put SOLE 1 0 0
APPLOVIN CORP COM CL A 03831W108 2,020 1 SH Put SOLE 1 0 0
ARBOR REALTY TRUST INC COM 038923108 154 335 SH Call SOLE 335 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,300,385 60,203 SH SOLE 60,203 0 0
ARGENX SE SPONSORED ADR 04016X101 184,753 253 SH SOLE 253 0 0
ARK ETF TR INNOVATION ETF 00214Q104 2,610 49 SH Put SOLE 49 0 0
ARRIVENT BIOPHARMA INC COM 04272N102 187,052 8,108 SH SOLE 8,108 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 166,845 2,661 SH SOLE 2,661 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 27,075 237 SH Call SOLE 237 0 0
ASTERA LABS INC COM 04626A103 3,673,354 33,516 SH SOLE 33,516 0 0
ASTRAZENECA PLC ORD G0593M107 243,764 1,236 SH SOLE 1,236 0 0
ATRIUM THERAPEUTICS INC COM 04965N104 3,784 283 SH SOLE 283 0 0
ATYR PHARMA INC COM NEW 002120202 122 28 SH Call SOLE 28 0 0
ATYR PHARMA INC COM NEW 002120202 4,993 27 SH Put SOLE 27 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306 118,216 7,918 SH SOLE 7,918 0 0
AXOS FINANCIAL INC COM 05465C100 1,984,809 23,326 SH SOLE 23,326 0 0
AXT INC COM 00246W103 13,308,420 233,563 SH SOLE 233,563 0 0
AYTU BIOPHARMA INC COM 054754858 253,609 92,897 SH SOLE 92,897 0 0
BEACON FINANCIAL CORP. COM 084680107 280,620 9,354 SH SOLE 9,354 0 0
BENITEC BIOPHARMA INC COM NEW 08205P209 194,970 18,307 SH SOLE 18,307 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 558,828 120,437 SH SOLE 120,437 0 0
BIOAGE LABS INC COM 09077V100 265,271 15,167 SH SOLE 15,167 0 0
BIOGEN INC COM 09062X103 348,877 1,903 SH SOLE 1,903 0 0
BIOHAVEN LTD COM G1110E107 132,490 806 SH Call SOLE 806 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 2,116,793 37,472 SH SOLE 37,472 0 0
BITDEER TECHNOLOGIES GROUP CL A ORD SHS G11448100 803,282 92,865 SH SOLE 92,865 0 0
BLOOM ENERGY CORP COM CL A 093712107 33,195 245 SH SOLE 245 0 0
BRIDGEBIO PHARMA INC COM 10806X102 1,599,115 21,534 SH SOLE 21,534 0 0
BRIDGEBIO PHARMA INC COM 10806X102 169,016 2,276 SH SOLE 2,276 0 0
BRIDGEBIO PHARMA INC NOTE 1.750% 3/0 10806XAJ1 101,757 60,000 PRN SOLE 60,000 0 0
BRIGHT MINDS BIOSCIENCES INC COM NEW 10919W405 168,561 2,310 SH SOLE 2,310 0 0
CANADIAN SOLAR INC COM 136635109 692,500 50,000 SH SOLE 50,000 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 998,962 831 SH Call SOLE 831 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 605,963 19,933 SH SOLE 19,933 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 157,064 1,045 SH Put SOLE 1,045 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 7,977 266 SH Put SOLE 266 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 23,363 267 SH Put SOLE 267 0 0
CARNIVAL CORP COMMON STOCK 143658300 378 54 SH Put SOLE 54 0 0
CARVANA CO CL A 146869102 943,140 3,000 SH SOLE 3,000 0 0
CELCUITY INC COM 15102K100 19,350 45 SH Call SOLE 45 0 0
CELCUITY INC COM 15102K100 153,404 1,344 SH SOLE 1,344 0 0
CELCUITY INC COM 15102K100 399,376 3,499 SH SOLE 3,499 0 0
CENCORA INC COM 03073E105 381,994 1,216 SH SOLE 1,216 0 0
CERTARA INC COM 15687V109 163,151 28,623 SH SOLE 28,623 0 0
CG ONCOLOGY INC COM 156944100 787,728 11,639 SH SOLE 11,639 0 0
CHARLES RIV LABS INTL INC COM 159864107 455,918 2,643 SH SOLE 2,643 0 0
CHEVRON CORPORATION COM 166764100 211 1 SH SOLE 1 0 0
CIENA CORP COM NEW 171779309 4,595,867 11,838 SH SOLE 11,838 0 0
CITIGROUP INC COM NEW 172967424 934,385 8,239 SH SOLE 8,239 0 0
CLIMB BIO INC COM 28658R106 495,426 72,325 SH SOLE 72,325 0 0
CMB.TECH NV SHS B38564108 999,186 80,385 SH SOLE 80,385 0 0
CMB.TECH NV SHS B38564108 387,223 30,725 SH SOLE 30,725 0 0
COASTAL FINL CORP WA COM NEW 19046P209 1,877,615 24,673 SH SOLE 24,673 0 0
COGENT BIOSCIENCES INC COM 19240Q201 3,141,400 81,616 SH SOLE 81,616 0 0
COGENT BIOSCIENCES INC COM 19240Q201 419,541 10,900 SH SOLE 10,900 0 0
COHERENT CORP COM 19247G107 97,904 411 SH SOLE 411 0 0
COHERENT CORP COM 19247G107 3,174,625 13,327 SH SOLE 13,327 0 0
COINBASE GLOBAL INC COM CL A 19260Q107 96,625 47 SH Put SOLE 47 0 0
COLUMBIA BKG SYS INC COM 197236102 1,154,693 42,096 SH SOLE 42,096 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 44,572 8,060 SH SOLE 8,060 0 0
COMPASS THERAPEUTICS INC COM 20454B104 381,901 72,193 SH SOLE 72,193 0 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101 132,957 50,747 SH SOLE 50,747 0 0
CONNECTONE BANCORP INC COM 20786W107 313,075 11,695 SH SOLE 11,695 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 85,556 292 SH Call SOLE 292 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 1,044,412 111,226 SH SOLE 111,226 0 0
CORCEPT THERAPEUTICS INC COM 218352102 3,939 132 SH Call SOLE 132 0 0
CORCEPT THERAPEUTICS INC COM 218352102 79,939 269 SH Call SOLE 269 0 0
CORCEPT THERAPEUTICS INC COM 218352102 101,904 2,528 SH SOLE 2,528 0 0
COREWEAVE INC COM CL A 21873S108 224,043 2,892 SH SOLE 2,892 0 0
COREWEAVE INC COM CL A 21873S108 354 12 SH Put SOLE 12 0 0
COREWEAVE INC COM CL A 21873S108 897 13 SH Put SOLE 13 0 0
CORMEDIX INC COM 21900C308 149,634 427 SH Put SOLE 427 0 0
CORNING INC COM 219350105 6,744 7 SH Call SOLE 7 0 0
CORNING INC COM 219350105 8,034,195 59,088 SH SOLE 59,088 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 11 270 SH Call SOLE 270 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 907,806 62,051 SH SOLE 62,051 0 0
CRH PLC ORD G25508105 1,181,864 11,243 SH SOLE 11,243 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,724 270 SH Call SOLE 270 0 0
CUE BIOPHARMA INC COM 22978P106 7,672 33,369 SH SOLE 33,369 0 0
CVB FINL CORP COM 126600105 1,648,635 85,025 SH SOLE 85,025 0 0
CYTOKINETICS INC COM NEW 23282W605 111,505 126 SH Call SOLE 126 0 0
CYTOKINETICS INC COM NEW 23282W605 84,755 506 SH Put SOLE 506 0 0
CYTOKINETICS INC COM NEW 23282W605 85,539 105 SH Call SOLE 105 0 0
CYTOMX THERAPEUTICS INC. COM 23284F105 14,018 801 SH Call SOLE 801 0 0
DAMORA THERAPEUTICS INC COM NEW 36322Q206 138,254 5,338 SH SOLE 5,338 0 0
DARLING INGREDIENTS INC COM 237266101 583,053 9,658 SH SOLE 9,658 0 0
DBV TECHNOLOGIES S A SPONSORED ADS 23306J309 237,979 11,392 SH SOLE 11,392 0 0
DEFINIUM THERAPEUTICS INC COM SHS 24477V105 299,773 15,861 SH SOLE 15,861 0 0
DELL TECHNOLOGIES INC CL C 24703L202 12,449 15 SH Call SOLE 15 0 0
DEXCOM INC COM 252131107 301,503 4,801 SH SOLE 4,801 0 0
DHT HOLDINGS INC SHS NEW Y2065G121 153,212 8,386 SH SOLE 8,386 0 0
DIANTHUS THERAPEUTICS INC COM 252828108 212,150 2,528 SH SOLE 2,528 0 0
DIANTHUS THERAPEUTICS INC COM 252828108 412,383 4,914 SH SOLE 4,914 0 0
DIGITALOCEAN HLDGS INC COM 25402D102 10,014 15 SH Call SOLE 15 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 591,008 539 SH Call SOLE 539 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 316,670 10,053 SH SOLE 10,053 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 553,753 6,915 SH SOLE 6,915 0 0
ELDORADO GOLD CORP NEW COM 284902509 1,793,605 52,246 SH SOLE 52,246 0 0
ELI LILLY & CO COM 532457108 1,395,291 1,517 SH SOLE 1,517 0 0
ELI LILLY & CO COM 532457108 357,791 389 SH SOLE 389 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 208,711 16,525 SH SOLE 16,525 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102 2,430 62 SH SOLE 62 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102 256,525 6,544 SH SOLE 6,544 0 0
ENOVA INTL INC COM 29357K103 1,322,169 9,734 SH SOLE 9,734 0 0
ENTERA BIO LTD SHS M40527109 6,528 5,881 SH SOLE 5,881 0 0
EQUILLIUM INC COM 29446K106 220,234 110,117 SH SOLE 110,117 0 0
EQUINOX GOLD CORP COM 29446Y502 1,731,831 119,767 SH SOLE 119,767 0 0
ERASCA INC COM 29479A108 457,409 28,270 SH SOLE 28,270 0 0
EUPRAXIA PHARMACEUTICALS INC COM 29842P105 73,211 10,112 SH SOLE 10,112 0 0
EUPRAXIA PHARMACEUTICALS INC COM 29842P105 201,373 27,814 SH SOLE 27,814 0 0
EVOLUS INC COM 30052C107 10 318 SH Call SOLE 318 0 0
EXPAND ENERGY CORPORATION COM 165167735 1,457,432 13,077 SH SOLE 13,077 0 0
EYEPOINT INC COM NEW 30233G209 153,959 269 SH Call SOLE 269 0 0
EYEPOINT INC COM NEW 30233G209 581,107 45,082 SH SOLE 45,082 0 0
EYEPOINT INC COM NEW 30233G209 179,339 13,913 SH SOLE 13,913 0 0
FIGURE TECHNOLOGY SOLUTIO COM CL A 349381103 651,467 19,189 SH SOLE 19,189 0 0
FIRST SOLAR INC COM 336433107 586,607 3,176 SH SOLE 3,176 0 0
FIRST WESTN FINL INC COM 33751L105 848,502 34,520 SH SOLE 34,520 0 0
FLUTTER ENTMT PLC SHS G3643J108 1,201,277 11,783 SH SOLE 11,783 0 0
FOGHORN THERAPEUTICS INC COM 344174107 97,082 20,310 SH SOLE 20,310 0 0
FOGHORN THERAPEUTICS INC COM 344174107 125,877 26,334 SH SOLE 26,334 0 0
FORTE BIOSCIENCES INC COM NEW 34962G208 174,670 6,744 SH SOLE 6,744 0 0
FRONTLINE PLC COM M46528101 279,200 8,000 SH SOLE 8,000 0 0
FRONTLINE PLC COM M46528101 200,340 6,000 SH SOLE 6,000 0 0
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108 255,731 30,811 SH SOLE 30,811 0 0
GALAXY DIGITAL INC. CL A 36317J209 9,817 73 SH Put SOLE 73 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107 159,230 2,237 SH SOLE 2,237 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 95,524 6,794 SH SOLE 6,794 0 0
GUARDANT HEALTH INC COM 40131M109 377,424 4,086 SH SOLE 4,086 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 659,579 23,548 SH SOLE 23,548 0 0
HUMANA INC COM 444859102 289,041 1,667 SH SOLE 1,667 0 0
HUYA INC ADS REP SHS A 44852D108 73,501 22,273 SH SOLE 22,273 0 0
ICON PLC SHS G4705A100 377,683 3,413 SH SOLE 3,413 0 0
IMMUNITYBIO INC COM 45256X103 98,558 270 SH Put SOLE 270 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 1,476,204 48,962 SH SOLE 48,962 0 0
INCYTE CORP COM 45337C102 1,861,882 19,782 SH SOLE 19,782 0 0
INCYTE CORP COM 45337C102 382,093 266 SH Put SOLE 266 0 0
INDIVIOR PHARMACEUTICALS INC COM 45579U109 549,006 18,012 SH SOLE 18,012 0 0
INOVIO PHARMACEUTICALS INC COM SHS 45773H409 8,550 190 SH Call SOLE 190 0 0
INOVIO PHARMACEUTICALS INC COM SHS 45773H409 247,365 142,164 SH SOLE 142,164 0 0
INTEL CORP COM 458140100 10,957,302 248,296 SH SOLE 248,296 0 0
INTEL CORP COM 458140100 1,151,484 26,093 SH SOLE 26,093 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 632 540 SH Call SOLE 540 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 643,537 9,595 SH SOLE 9,595 0 0
INTERNATIONAL SEAWAYS INC COM Y41053102 451,399 6,364 SH SOLE 6,364 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 450,387 977 SH SOLE 977 0 0
INVENTIVA SA ADS 46124U107 493,795 88,972 SH SOLE 88,972 0 0
INVENTIVA SA ADS 46124U107 217,155 39,127 SH SOLE 39,127 0 0
INVIVYD INC COM 00534A102 72,787 55,990 SH SOLE 55,990 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 30,047 758 SH Call SOLE 758 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 127 7 SH Put SOLE 7 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 15,649 122 SH Put SOLE 122 0 0
ISHARES SILVER TR ISHARES 46428Q109 504 28 SH Put SOLE 28 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 196 23 SH Put SOLE 23 0 0
JADE BIOSCIENCES INC COM NEW 008064206 344 88 SH Put SOLE 88 0 0
JANUX THERAPEUTICS INC COM 47103J105 19,035 80 SH Call SOLE 80 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 2,616,830 13,842 SH SOLE 13,842 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 390,010 2,063 SH SOLE 2,063 0 0
JEFFERSON CAPITAL INC COM 47248R103 341,813 17,775 SH SOLE 17,775 0 0
JOHNSON & JOHNSON COM 478160104 3,322,673 13,593 SH SOLE 13,593 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 181,190 9,001 SH SOLE 9,001 0 0
KANZHUN LIMITED SPONSORED ADS 48553T106 669,500 50,000 SH SOLE 50,000 0 0
KARYOPHARM THERAPEUTICS INC COM NEW 48576U205 94 253 SH Call SOLE 253 0 0
KARYOPHARM THERAPEUTICS INC COM NEW 48576U205 1 88 SH Call SOLE 88 0 0
KARYOPHARM THERAPEUTICS INC COM NEW 48576U205 2,018 269 SH Call SOLE 269 0 0
KKR & CO INC COM 48251W104 50,399 140 SH Call SOLE 140 0 0
KODIAK SCIENCES INC COM 50015M109 1,844 1 SH Call SOLE 1 0 0
KODIAK SCIENCES INC COM 50015M109 1,859,684 48,785 SH SOLE 48,785 0 0
KODIAK SCIENCES INC COM 50015M109 15,813 253 SH Put SOLE 253 0 0
KODIAK SCIENCES INC COM 50015M109 394,688 372 SH Put SOLE 372 0 0
KODIAK SCIENCES INC COM 50015M109 97,244 2,551 SH SOLE 2,551 0 0
LANTHEUS HLDGS INC COM 516544103 200,396 2,642 SH SOLE 2,642 0 0
LARIMAR THERAPEUTICS INC COM 517125100 189,558 42,124 SH SOLE 42,124 0 0
LIPOCINE INC NEW COM NEW 53630X203 101,010 12,642 SH SOLE 12,642 0 0
LIPOCINE INC NEW COM NEW 53630X203 6,392 800 SH SOLE 800 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 32,830 198 SH Call SOLE 198 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 3,850 9 SH Call SOLE 9 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 41,060 118 SH Call SOLE 118 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 38,049 603 SH Call SOLE 603 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 9,986 263 SH Call SOLE 263 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 21,665 134 SH Call SOLE 134 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 6,125 350 SH Call SOLE 350 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 4,181 126 SH Put SOLE 126 0 0
LIVANOVA PLC SHS G5509L101 318,054 5,004 SH SOLE 5,004 0 0
LIVE OAK BANCSHARES INC COM 53803X105 317,307 9,595 SH SOLE 9,595 0 0
LUMENTUM HLDGS INC COM 55024U109 70,276 100 SH SOLE 100 0 0
LUMENTUM HLDGS INC COM 55024U109 14,457,881 20,573 SH SOLE 20,573 0 0
LYELL IMMUNOPHARMA INC COM NEW 55083R203 26,855 10 SH Put SOLE 10 0 0
MACOM TECH SOLUTIONS HLDGS I COM 55405Y100 3,485,167 15,694 SH SOLE 15,694 0 0
MACROGENICS INC COM 556099109 438,494 151,728 SH SOLE 151,728 0 0
MANNKIND CORP COM NEW 56400P706 116,115 47,394 SH SOLE 47,394 0 0
MARVELL TECHNOLOGY INC COM 573874104 12,049 22 SH Call SOLE 22 0 0
MARVELL TECHNOLOGY INC COM 573874104 1,454,252 14,682 SH SOLE 14,682 0 0
MAZE THERAPEUTICS INC COM 578784100 113,191 3,792 SH SOLE 3,792 0 0
MAZE THERAPEUTICS INC COM 578784100 148,534 4,976 SH SOLE 4,976 0 0
MEDTRONIC PLC SHS G5960L103 281,266 3,246 SH SOLE 3,246 0 0
MERCK & CO INC COM 58933Y105 12,524 253 SH Put SOLE 253 0 0
MICRON TECHNOLOGY INC COM 595112103 4,921,653 14,568 SH SOLE 14,568 0 0
MICRON TECHNOLOGY INC COM 595112103 669,599 1,982 SH SOLE 1,982 0 0
MINERALYS THERAPEUTICS INC COM 603170101 181,476 6,699 SH SOLE 6,699 0 0
MINERALYS THERAPEUTICS INC COM 603170101 235,737 8,702 SH SOLE 8,702 0 0
MINISO GROUP HLDG LTD SPONSORED ADS 66981J102 559,273 34,523 SH SOLE 34,523 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 330,720 3,580 SH SOLE 3,580 0 0
MKS INC. COM 55306N104 119,501 520 SH SOLE 520 0 0
MODERNA INC COM 60770K107 3,086 270 SH Put SOLE 270 0 0
MODERNA INC COM 60770K107 4,261 134 SH Put SOLE 134 0 0
MODINE MFG CO COM 607828100 2,748,316 12,682 SH SOLE 12,682 0 0
MONOPAR THERAPEUTICS INC COM NEW 61023L207 22,573 412 SH SOLE 412 0 0
MONOPAR THERAPEUTICS INC COM NEW 61023L207 20,327 371 SH SOLE 371 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 781,375 47,500 SH SOLE 47,500 0 0
NEBIUS GROUP N.V. SHS CLASS A N97284108 1,884,904 18,166 SH SOLE 18,166 0 0
NEKTAR THERAPEUTICS COM NEW 640268306 418,749 5,820 SH SOLE 5,820 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581206 224,028 3,956 SH SOLE 3,956 0 0
NEWS CORP NEW CL B 65249B208 960,103 33,676 SH SOLE 33,676 0 0
NEXGEN ENERGY LTD COM 65340P106 2,756,153 237,953 SH SOLE 237,953 0 0
NORTHEAST BK PORTLAND ME COM 66405S100 846,034 7,529 SH SOLE 7,529 0 0
NORTHPOINTE BANCSHARES INC. COM SHS 66661N886 688,243 39,875 SH SOLE 39,875 0 0
NOVO-NORDISK A S ADR 670100205 135,424 3,685 SH SOLE 3,685 0 0
NOVO-NORDISK A S ADR 670100205 338,756 143 SH Put SOLE 143 0 0
NU HLDGS LTD ORD SHS CL A G6683N103 965,147 67,164 SH SOLE 67,164 0 0
NVIDIA CORPORATION COM 67066G104 6,964,838 39,936 SH SOLE 39,936 0 0
OCUGEN INC COM 67577C105 18,336 758 SH Call SOLE 758 0 0
OCUGEN INC COM 67577C105 91,512 50,559 SH SOLE 50,559 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 104 12 SH Call SOLE 12 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 947 165 SH Call SOLE 165 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 4 1 SH Call SOLE 1 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 95 33 SH Call SOLE 33 0 0
OPUS GENETICS INC COM 67577R102 81,531 17,919 SH SOLE 17,919 0 0
PALISADE BIO INC COM 696389402 413,609 236,348 SH SOLE 236,348 0 0
PASITHEA THERAPEUTICS CORP COM NEW 70261F202 215,534 290,555 SH SOLE 290,555 0 0
PASSAGE BIO INC COM NEW 702712209 38,897 4,955 SH SOLE 4,955 0 0
PATHWARD FINANCIAL INC COM 59100U108 834,657 9,354 SH SOLE 9,354 0 0
PBF ENERGY INC CL A 69318G106 322,761 6,418 SH SOLE 6,418 0 0
PDD HOLDINGS INC SPONSORED ADS 722304102 927,488 9,077 SH SOLE 9,077 0 0
PDD HOLDINGS INC SPONSORED ADS 722304102 577,828 5,655 SH SOLE 5,655 0 0
PELTHOS THERAPEUTICS INC COM SHS 171126204 126,207 6,007 SH SOLE 6,007 0 0
PEPGEN INC COM 713317105 67,529 38,152 SH SOLE 38,152 0 0
PERSONALIS INC COM 71535D106 133,318 20,929 SH SOLE 20,929 0 0
PHARVARIS N V COM N69605108 223,288 7,904 SH SOLE 7,904 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 153,796 13,843 SH SOLE 13,843 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 143,575 12,923 SH SOLE 12,923 0 0
POWER SOLUTIONS INTL INC COM NEW 73933G202 261,480 4,295 SH SOLE 4,295 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 364,397 1,131 SH SOLE 1,131 0 0
PRECIGEN INC COM 74017N105 54,095 13,978 SH SOLE 13,978 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 74,629 46,067 SH SOLE 46,067 0 0
PURETECH HEALTH PLC ADS 746237106 26,139 1,759 SH SOLE 1,759 0 0
QCR HLDGS INC COM 74727A104 999,167 11,693 SH SOLE 11,693 0 0
QNITY ELECTRONICS INC COMMON STOCK 74743L100 590,053 5,114 SH SOLE 5,114 0 0
QORVO INC COM 74736K101 2,329,430 30,096 SH SOLE 30,096 0 0
RANGE RES CORP COM 75281A109 542,228 11,734 SH SOLE 11,734 0 0
REGENERON PHARMACEUTICALS COM 75886F107 309,056 400 SH SOLE 400 0 0
RELAY THERAPEUTICS INC COM 75943R102 162,762 16,358 SH SOLE 16,358 0 0
RELMADA THERAPEUTICS INC COM 75955J402 353,380 50,773 SH SOLE 50,773 0 0
REPLIMUNE GROUP INC COM 76029N106 92,117 506 SH Call SOLE 506 0 0
REPLIMUNE GROUP INC COM 76029N106 1,937 14 SH Call SOLE 14 0 0
REPLIMUNE GROUP INC COM 76029N106 101,922 617 SH Put SOLE 617 0 0
REPLIMUNE GROUP INC COM 76029N106 135,546 623 SH Put SOLE 623 0 0
REPLIMUNE GROUP INC COM 76029N106 194,654 25,445 SH SOLE 25,445 0 0
REVOLUTION MEDICINES INC COM 76155X100 35,102 156 SH Put SOLE 156 0 0
REVOLUTION MEDICINES INC COM 76155X100 18,467 35 SH Put SOLE 35 0 0
REVOLUTION MEDICINES INC COM 76155X100 36,947 126 SH Put SOLE 126 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,999,460 20,560 SH SOLE 20,560 0 0
REVOLUTION MEDICINES INC COM 76155X100 533,222 5,483 SH SOLE 5,483 0 0
ROBLOX CORP CL A 771049103 991,440 17,529 SH SOLE 17,529 0 0
ROCKET COS INC COM CL A 77311W101 30,947 326 SH Call SOLE 326 0 0
ROCKET COS INC COM CL A 77311W101 920,735 64,613 SH SOLE 64,613 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 27,677 7,731 SH SOLE 7,731 0 0
ROIVANT SCIENCES LTD SHS G76279101 11,068 860 SH Put SOLE 860 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 248,389 5,178 SH SOLE 5,178 0 0
RUBRIK INC. CL A 781154109 489,700 10,000 SH SOLE 10,000 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202 267,074 69,732 SH SOLE 69,732 0 0
SAILPOINT INC COM 78781J109 1,577,692 119,161 SH SOLE 119,161 0 0
SANDISK CORP COM 80004C200 1,972 2 SH Put SOLE 2 0 0
SANDISK CORP COM 80004C200 119,444 188 SH SOLE 188 0 0
SANDISK CORP COM 80004C200 8,953,211 14,092 SH SOLE 14,092 0 0
SANOFI SA SPONSORED ADR 80105N105 479,198 9,946 SH SOLE 9,946 0 0
SEA LTD SPONSORD ADS 81141R100 248,430 3,000 SH SOLE 3,000 0 0
SEADRILL LTD COM G7997W102 222,997 4,961 SH SOLE 4,961 0 0
SELLAS LIFE SCIENCES GROUP I COM NEW 81642T209 52,734 758 SH Call SOLE 758 0 0
SEMTECH CORP COM 816850101 2,410,886 31,355 SH SOLE 31,355 0 0
SERVISFIRST BANCSHARES INC COM 81768T108 1,208,905 16,599 SH SOLE 16,599 0 0
SHATTUCK LABS INC COM 82024L103 477,292 74,229 SH SOLE 74,229 0 0
SIMILARWEB LTD SHS M84137104 469,800 180,000 SH SOLE 180,000 0 0
SLB LIMITED COM STK 806857108 103,060 2,000 SH SOLE 2,000 0 0
SOLARIS RES INC COM NEW 83419D201 137,523 15,956 SH SOLE 15,956 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204 201,528 27,990 SH SOLE 27,990 0 0
SOUTHSTATE BK CORP COM 84472E102 887,729 9,595 SH SOLE 9,595 0 0
SPROTT INC COM NEW 852066208 959,431 6,714 SH SOLE 6,714 0 0
SPRUCE BIOSCIENCES INC COM NEW 85209E208 165,205 2,528 SH SOLE 2,528 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202 242,263 4,803 SH SOLE 4,803 0 0
STIFEL FINL CORP COM 860630102 886,596 11,994 SH SOLE 11,994 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 22,871 253 SH Put SOLE 253 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 19,713 70 SH Put SOLE 70 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 880,277 18,263 SH SOLE 18,263 0 0
STRYKER CORPORATION COM 863667101 364,735 1,110 SH SOLE 1,110 0 0
SUPER MICRO COMPUTER INC COM NEW 86800U302 4,150 83 SH Put SOLE 83 0 0
SURROZEN INC COM NEW 86889P208 208,076 7,143 SH SOLE 7,143 0 0
SUTRO BIOPHARMA INC COM SHS 869367201 184,608 7,411 SH SOLE 7,411 0 0
TAIWAN SEMICONDUCTOR MANUFAC SPONSORED ADS 874039100 4,219,644 12,486 SH SOLE 12,486 0 0
TALPHERA INC COM NEW 00444T209 29,105 38,968 SH SOLE 38,968 0 0
TANGO THERAPEUTICS INC COM 87583X109 483,587 23,116 SH SOLE 23,116 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 459,903 6,556 SH SOLE 6,556 0 0
TASEKO MINES LTD COM 876511106 1,480,952 229,605 SH SOLE 229,605 0 0
TE CONNECTIVITY PLC ORD SHS G87052109 2,825,950 13,520 SH SOLE 13,520 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 726,793 45,453 SH SOLE 45,453 0 0
TENAX THERAPEUTICS INC COM NEW 88032L605 203,537 12,729 SH SOLE 12,729 0 0
TERADYNE INC COM 880770102 3,306,122 11,152 SH SOLE 11,152 0 0
TERNS PHARMACEUTICALS INC COM 880881107 2,422,642 45,953 SH SOLE 45,953 0 0
TESLA INC COM 88160R101 1,071,755 2,883 SH SOLE 2,883 0 0
TG THERAPEUTICS INC COM 88322Q108 1,763,318 53,080 SH SOLE 53,080 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 247,240 503 SH SOLE 503 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 11,863,852 67,608 SH SOLE 67,608 0 0
TREVI THERAPEUTICS INC COM 89532M101 65,329 5,476 SH SOLE 5,476 0 0
TREVI THERAPEUTICS INC COM 89532M101 267,673 22,437 SH SOLE 22,437 0 0
TRIPADVISOR INC COM 896945201 1,066,000 100,000 SH SOLE 100,000 0 0
TRIUMPH FINANCIAL INC COM 89679E300 846,754 14,193 SH SOLE 14,193 0 0
TYRA BIOSCIENCES INC COM 90240B106 173,039 4,518 SH SOLE 4,518 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 186,120 8,884 SH SOLE 8,884 0 0
UMB FINL CORP COM 902788108 324,722 2,879 SH SOLE 2,879 0 0
UNICYCIVE THERAPEUTICS INC COM NEW 90466Y202 176,522 26,827 SH SOLE 26,827 0 0
UNIQURE NV SHS N90064101 2,408 134 SH Call SOLE 134 0 0
UNIQURE NV SHS N90064101 111,988 506 SH Call SOLE 506 0 0
UNIQURE NV SHS N90064101 79,440 229 SH Put SOLE 229 0 0
UNIQURE NV SHS N90064101 265,752 459 SH Put SOLE 459 0 0
UNIQURE NV SHS N90064101 128,952 7,887 SH SOLE 7,887 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 125,964 39 SH Call SOLE 39 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 15,136 63 SH Call SOLE 63 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 5,619 51 SH Put SOLE 51 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 4,092,748 6,902 SH SOLE 6,902 0 0
UPSTART HLDGS INC COM 91680M107 36,002 188 SH Call SOLE 188 0 0
UPSTREAM BIO INC COM 91678A107 49,455 5,495 SH SOLE 5,495 0 0
UROGEN PHARMA LTD COM M96088105 104,716 5,824 SH SOLE 5,824 0 0
VAXCYTE INC COM 92243G108 323,314 135 SH Call SOLE 135 0 0
VAXCYTE INC COM 92243G108 309,087 5,319 SH SOLE 5,319 0 0
VENTURE GLOBAL INC COM CL A 92333F101 338 27 SH Call SOLE 27 0 0
VERADERMICS INC COMMON STOCK 922967104 580,412 9,191 SH SOLE 9,191 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 41,215 236 SH Call SOLE 236 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 419,301 939 SH SOLE 939 0 0
VIKING THERAPEUTICS INC COM 92686J106 23,480 15 SH Call SOLE 15 0 0
VIKING THERAPEUTICS INC COM 92686J106 318,790 369 SH Call SOLE 369 0 0
VIKING THERAPEUTICS INC COM 92686J106 808,193 561 SH Call SOLE 561 0 0
VIKING THERAPEUTICS INC COM 92686J106 72,766 99 SH Call SOLE 99 0 0
VIKING THERAPEUTICS INC COM 92686J106 202,922 537 SH Call SOLE 537 0 0
VIKING THERAPEUTICS INC COM 92686J106 94,640 91 SH Call SOLE 91 0 0
VIKING THERAPEUTICS INC COM 92686J106 4,329,968 133,066 SH SOLE 133,066 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 68,515 225 SH Call SOLE 225 0 0
VISTAGEN THERAPEUTICS INC COM 92840H400 15,209 26,612 SH SOLE 26,612 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 48,523 379 SH Call SOLE 379 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 413,383 107,094 SH SOLE 107,094 0 0
WELLS FARGO & CO COM 949746101 1,205 33 SH Put SOLE 33 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103 206,834 35,661 SH SOLE 35,661 0 0
YATSEN HLDG LTD SPONSORED ADS 985194208 62,065 20,151 SH SOLE 20,151 0 0
ZAI LAB LTD ADR 98887Q104 232,097 12,339 SH SOLE 12,339 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 275,467 6,657 SH SOLE 6,657 0 0
ZYMEWORKS INC COM 98985Y108 899,812 35,935 SH SOLE 35,935 0 0