v3.26.1
Segments - Schedule of Significant Expense Categories Reviewed by CODM (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2026
Mar. 31, 2025
Segment Reporting Information [Line Items]    
Revenue $ 4,580 $ 0
Operating expenses:    
Research and development 13,601 28,816
General and administrative 5,156 5,790
Total operating expenses 18,757 34,606
Loss from operations (14,177) (34,606)
Other income, net 3,792 2,521
Net loss (10,385) (32,085)
JAK2 V617F    
Operating expenses:    
Research and development 1,412 1,175
KAT6A    
Operating expenses:    
Research and development 791 506
Discovery Programs    
Operating expenses:    
Research and development 54 787
Other    
Operating expenses:    
Research and development 838 9,901
General Costs, Including Personnel Related    
Operating expenses:    
Research and development $ 10,506 $ 16,447