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<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">1.</td> <td style="text-align: justify">The Company </td></tr> </table> Background Xenetic Biosciences, Inc. (“Xenetic” or the “Company”), incorporated in the state of Nevada and based in Framingham, Massachusetts, is a biopharmaceutical company focused on advancing innovative immune-oncology technologies addressing difficult to treat cancers. The Company’s proprietary Deoxyribonuclease (“DNase”) technology is designed to improve outcomes of existing treatments, including immunotherapies, by targeting neutrophil extracellular traps (“NETs”), which are involved in cancer progression. Xenetic is currently focused on advancing its systemic DNase program into the clinic as an adjunctive therapy for pancreatic carcinoma and locally advanced or metastatic solid tumors. As used in this Quarterly Report on Form 10-Q (“Quarterly Report”), unless otherwise indicated, all references herein to “Xenetic,” the “Company,” “we” or “us” refer to Xenetic Biosciences, Inc. and its wholly-owned subsidiaries. The Company, directly or indirectly, through its wholly-owned subsidiaries, Hesperix S.A. (“Hesperix”) and Xenetic Biosciences (U.K.) Limited (“Xenetic UK”), and the wholly-owned subsidiaries of Xenetic UK, Lipoxen Technologies Limited (“Lipoxen”), Xenetic Bioscience, Incorporated and SymbioTec, GmbH (“SymbioTec”), own various United States (“U.S.”) federal trademark registrations and applications along with unregistered trademarks and service marks, including but not limited to XCART™, OncoHist™, PolyXen™, ErepoXen™, and ImuXen™, which may be used throughout this Quarterly Report. All other company and product names may be trademarks of the respective companies with which they are associated. Going Concern and Management’s Plan Management evaluates whether there are conditions or events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that the financial statements are issued. The Company has incurred substantial losses since its inception and expects to continue to incur operating losses in the near-term. The Company believes that its existing resources will be adequate to fund the Company’s operations for a period of at least twelve months from the date of the issuance of these financial statements. In addition, the Company raised $4.0 million in an underwritten offering of common stock in October 2025. However, the Company anticipates it will need additional capital in the long-term to pursue its business initiatives. While the Company believes it will continue to have access to capital resources through possible public or private equity offerings, debt financings, corporate collaborations, related party funding, or other means to continue as a going concern, the terms, timing and extent of any future financing will depend upon several factors, including the achievement of progress in its product development programs, its ability to identify and enter into licensing or other strategic arrangements, its continued listing on the Nasdaq Stock Market (“Nasdaq”), and factors related to financial, economic, geo-political, industry and market conditions, many of which are beyond its control. The capital markets for the biotech industry can be highly volatile, which make the terms, timing and extent of any future financing uncertain. Recent Developments The Company and its board of directors (the “Board”) have initiated a formal strategic review process with the assistance of outside financial and legal advisors. The Company is considering a wide range of alternatives to maximize shareholder value, including, but not limited to, the sale of all or part of the Company or its assets or a business combination, including a “reverse merger”, share exchange or similarly structured transaction. An independent committee of the Board has engaged in discussions with third parties regarding potential transactions. Any such completed transaction could have a significant impact on the Company’s stockholders, including if the transaction would result in the current investors of the counterparty holding a substantial majority of the Company’s outstanding common stock following consummation of the potential transaction. Given the current stage of such discussions, at this time there is no way to quantify the potential impact of a transaction, if any. There is no deadline or definitive timetable set for the completion of the strategic alternatives process, and there can be no assurance any proposal will be made or accepted, any agreement will be executed, or any transaction will be consummated in connection with this review. In addition, if the Company does enter into definitive agreements with respect to a potential transaction, the Company expects that consummation of the potential transaction would be subject to a number of conditions, including approval by the Company’s stockholders and Nasdaq, and other customary conditions, which would be out of the Company’s control and may never be satisfied. The Company remains committed to advancing its DNase technology and does not intend to make further announcements regarding the review process unless and until the Board approves a specific transaction or otherwise determines that further disclosure is appropriate.

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px; text-align: justify">2.</td> <td style="text-align: justify">Risks and Uncertainties </td></tr> </table> Impact of Global Events and Conflicts on Operations The short and long-term implications of geopolitical events and global conflicts, including those in Ukraine and the Middle East are difficult to predict at this time. The imposition of current and future sanctions and counter sanctions may have an adverse effect on the economic markets generally and could impact our business, financial condition, and results of operations.

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">3.</td> <td style="text-align: justify">Summary of Significant Accounting Policies </td></tr> </table> Preparation of Interim Financial Statements The accompanying condensed consolidated interim financial statements were prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”) and, in the opinion of management, include all normal and recurring adjustments necessary to present fairly the results of the interim periods shown. Certain information and footnote disclosures normally included in financial statements prepared in accordance with U.S. generally accepted accounting principles have been condensed or omitted pursuant to such SEC rules and regulations. Management believes that the disclosures made are adequate to make the information presented not misleading. The results for the interim periods are not necessarily indicative of results for the full year. The condensed consolidated financial statements contained herein should be read in conjunction with the consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025 filed with the SEC on March 12, 2026, and amended on April 24, 2026. Principles of Consolidation The condensed consolidated financial statements of the Company include the accounts of Hesperix, Xenetic UK and Xenetic UK’s wholly-owned subsidiaries: Lipoxen, Xenetic Bioscience, Incorporated, and SymbioTec. Certain of the Company’s subsidiaries require guarantees of support from Xenetic. While all intercompany balances and transactions have been eliminated in consolidation, the Company has $0.2 million of cash collateralizing these guarantees. Segment Information The Company is required to disclose significant segment expenses that are regularly provided to the chief operating decision maker (“CODM”), a description of other segment items by reportable segment, and any additional measures of a segment's profit or loss used by the CODM when deciding how to allocate resources. The Company is principally engaged in pre-clinical research and development activities to advance its DNase technology. Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the CODM, who is the Company’s Chief Executive Officer, in making decisions on how to allocate resources and assess performance. The Company views its operations and manages its business as a single operating segment. The Company’s measure of segment profit or loss is net loss. The CODM manages and allocates to the operations of the Company on a total company basis. Managing and allocating resources on a consolidated basis enables the CODM to assess the overall level of resources available and how best to deploy these resources across functions, therapeutic areas and research and development projects that are in line with the Company’s long-term company-wide strategic goals. Consistent with this decision-making process, the CODM uses consolidated financial information for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. The following table is representative of the significant expense categories regularly provided to the CODM when managing the Company’s single reporting segment. A reconciliation to the condensed consolidated net loss for the three months ended March 31, 2026 and 2025 is as follows: <table cellpadding="0" cellspacing="0" id="xdx_881_eus-gaap--ScheduleOfSegmentReportingInformationBySegmentTextBlock_zbEiXRur6UY" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Summary of Significant Accounting Policies (Details - Segment information)"> <tr style="vertical-align: bottom"> <td>Net loss by segment</td><td> </td> <td colspan="2" id="xdx_497_20260101__20260331_zihZfJPNSpK2" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" id="xdx_498_20250101__20250331_zMlsYUVTvAhf" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Three Months Ended March 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2026</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_40F_eus-gaap--Revenues_zbS2CV6A4MOk" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 66%">Revenue</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 13%; text-align: right">806,923</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 13%; text-align: right">593,261</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_40D_eus-gaap--OperatingCostsAndExpenses_hsrt--ProductOrServiceAxis__custom--ProgramExpensesMember_z8Weg2C8w117" style="vertical-align: bottom; background-color: White"> <td>Program expenses(1)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">658,229</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">875,798</td><td style="text-align: left"> </td></tr> <tr id="xdx_407_eus-gaap--OperatingCostsAndExpenses_hsrt--ProductOrServiceAxis__custom--NonProgramExpensesMember_zYXgPeUriW5h" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td>Non-program expenses(2)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">511,055</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">422,515</td><td style="text-align: left"> </td></tr> <tr id="xdx_409_eus-gaap--SalariesAndWages_zMs01KD8Vcx3" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Salaries and wages</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">128,444</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">218,106</td><td style="text-align: left"> </td></tr> <tr id="xdx_405_ecustom--OtherSegmentItems_zXEM2V64Ee06" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Other segment items(3)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(34,423</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(20,017</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_407_eus-gaap--NetIncomeLoss_zBth0NJ4cIM2" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Net loss</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">(456,382</td><td style="padding-bottom: 2.5pt; text-align: left">)</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">(903,141</td><td style="padding-bottom: 2.5pt; text-align: left">)</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 24px"> </td> <td style="width: 24px">(1)</td> <td style="text-align: justify">Includes external research and development.</td></tr> <tr style="vertical-align: top"> <td style="width: 24px"> </td> <td style="width: 24px">(2)</td> <td style="text-align: justify">Includes information technology, legal, intellectual property and other general and administrative expenses.</td></tr> <tr style="vertical-align: top"> <td style="width: 24px"> </td> <td style="width: 24px">(3)</td> <td style="text-align: justify">Includes stock-based compensation expense, interest income and other expense (income).</td></tr> </table> Basic and Diluted Net Loss per Share The Company computes basic net loss per share by dividing net loss applicable to common stockholders by the weighted-average number of shares of the Company’s common stock outstanding during the period. The Company computes diluted net loss per share after giving consideration to the dilutive effect of stock options that are outstanding during the period, except where such non-participating securities would be anti-dilutive. For the three months ended March 31, 2026 and 2025, basic and diluted net loss per share are the same for each respective period due to the Company’s net loss position. Potentially dilutive, non-participating securities have not been included in the calculations of diluted net loss per share, as their inclusion would be anti-dilutive.

Preparation of Interim Financial Statements The accompanying condensed consolidated interim financial statements were prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”) and, in the opinion of management, include all normal and recurring adjustments necessary to present fairly the results of the interim periods shown. Certain information and footnote disclosures normally included in financial statements prepared in accordance with U.S. generally accepted accounting principles have been condensed or omitted pursuant to such SEC rules and regulations. Management believes that the disclosures made are adequate to make the information presented not misleading. The results for the interim periods are not necessarily indicative of results for the full year. The condensed consolidated financial statements contained herein should be read in conjunction with the consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025 filed with the SEC on March 12, 2026, and amended on April 24, 2026.

Principles of Consolidation The condensed consolidated financial statements of the Company include the accounts of Hesperix, Xenetic UK and Xenetic UK’s wholly-owned subsidiaries: Lipoxen, Xenetic Bioscience, Incorporated, and SymbioTec. Certain of the Company’s subsidiaries require guarantees of support from Xenetic. While all intercompany balances and transactions have been eliminated in consolidation, the Company has $0.2 million of cash collateralizing these guarantees.

200000

Segment Information The Company is required to disclose significant segment expenses that are regularly provided to the chief operating decision maker (“CODM”), a description of other segment items by reportable segment, and any additional measures of a segment's profit or loss used by the CODM when deciding how to allocate resources. The Company is principally engaged in pre-clinical research and development activities to advance its DNase technology. Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the CODM, who is the Company’s Chief Executive Officer, in making decisions on how to allocate resources and assess performance. The Company views its operations and manages its business as a single operating segment. The Company’s measure of segment profit or loss is net loss. The CODM manages and allocates to the operations of the Company on a total company basis. Managing and allocating resources on a consolidated basis enables the CODM to assess the overall level of resources available and how best to deploy these resources across functions, therapeutic areas and research and development projects that are in line with the Company’s long-term company-wide strategic goals. Consistent with this decision-making process, the CODM uses consolidated financial information for purposes of evaluating performance, forecasting future period financial results, allocating resources and setting incentive targets. The following table is representative of the significant expense categories regularly provided to the CODM when managing the Company’s single reporting segment. A reconciliation to the condensed consolidated net loss for the three months ended March 31, 2026 and 2025 is as follows: <table cellpadding="0" cellspacing="0" id="xdx_881_eus-gaap--ScheduleOfSegmentReportingInformationBySegmentTextBlock_zbEiXRur6UY" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Summary of Significant Accounting Policies (Details - Segment information)"> <tr style="vertical-align: bottom"> <td>Net loss by segment</td><td> </td> <td colspan="2" id="xdx_497_20260101__20260331_zihZfJPNSpK2" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" id="xdx_498_20250101__20250331_zMlsYUVTvAhf" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Three Months Ended March 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2026</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_40F_eus-gaap--Revenues_zbS2CV6A4MOk" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 66%">Revenue</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 13%; text-align: right">806,923</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 13%; text-align: right">593,261</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_40D_eus-gaap--OperatingCostsAndExpenses_hsrt--ProductOrServiceAxis__custom--ProgramExpensesMember_z8Weg2C8w117" style="vertical-align: bottom; background-color: White"> <td>Program expenses(1)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">658,229</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">875,798</td><td style="text-align: left"> </td></tr> <tr id="xdx_407_eus-gaap--OperatingCostsAndExpenses_hsrt--ProductOrServiceAxis__custom--NonProgramExpensesMember_zYXgPeUriW5h" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td>Non-program expenses(2)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">511,055</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">422,515</td><td style="text-align: left"> </td></tr> <tr id="xdx_409_eus-gaap--SalariesAndWages_zMs01KD8Vcx3" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Salaries and wages</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">128,444</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">218,106</td><td style="text-align: left"> </td></tr> <tr id="xdx_405_ecustom--OtherSegmentItems_zXEM2V64Ee06" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Other segment items(3)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(34,423</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(20,017</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_407_eus-gaap--NetIncomeLoss_zBth0NJ4cIM2" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Net loss</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">(456,382</td><td style="padding-bottom: 2.5pt; text-align: left">)</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">(903,141</td><td style="padding-bottom: 2.5pt; text-align: left">)</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 24px"> </td> <td style="width: 24px">(1)</td> <td style="text-align: justify">Includes external research and development.</td></tr> <tr style="vertical-align: top"> <td style="width: 24px"> </td> <td style="width: 24px">(2)</td> <td style="text-align: justify">Includes information technology, legal, intellectual property and other general and administrative expenses.</td></tr> <tr style="vertical-align: top"> <td style="width: 24px"> </td> <td style="width: 24px">(3)</td> <td style="text-align: justify">Includes stock-based compensation expense, interest income and other expense (income).</td></tr> </table>

<table cellpadding="0" cellspacing="0" id="xdx_881_eus-gaap--ScheduleOfSegmentReportingInformationBySegmentTextBlock_zbEiXRur6UY" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Summary of Significant Accounting Policies (Details - Segment information)"> <tr style="vertical-align: bottom"> <td>Net loss by segment</td><td> </td> <td colspan="2" id="xdx_497_20260101__20260331_zihZfJPNSpK2" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" id="xdx_498_20250101__20250331_zMlsYUVTvAhf" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Three Months Ended March 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2026</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_40F_eus-gaap--Revenues_zbS2CV6A4MOk" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 66%">Revenue</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 13%; text-align: right">806,923</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 13%; text-align: right">593,261</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_40D_eus-gaap--OperatingCostsAndExpenses_hsrt--ProductOrServiceAxis__custom--ProgramExpensesMember_z8Weg2C8w117" style="vertical-align: bottom; background-color: White"> <td>Program expenses(1)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">658,229</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">875,798</td><td style="text-align: left"> </td></tr> <tr id="xdx_407_eus-gaap--OperatingCostsAndExpenses_hsrt--ProductOrServiceAxis__custom--NonProgramExpensesMember_zYXgPeUriW5h" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td>Non-program expenses(2)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">511,055</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">422,515</td><td style="text-align: left"> </td></tr> <tr id="xdx_409_eus-gaap--SalariesAndWages_zMs01KD8Vcx3" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Salaries and wages</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">128,444</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">218,106</td><td style="text-align: left"> </td></tr> <tr id="xdx_405_ecustom--OtherSegmentItems_zXEM2V64Ee06" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Other segment items(3)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(34,423</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(20,017</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_407_eus-gaap--NetIncomeLoss_zBth0NJ4cIM2" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Net loss</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">(456,382</td><td style="padding-bottom: 2.5pt; text-align: left">)</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">(903,141</td><td style="padding-bottom: 2.5pt; text-align: left">)</td></tr> </table>

806923

593261

658229

875798

511055

422515

128444

218106

-34423 -20017

-456382

-903141

Basic and Diluted Net Loss per Share The Company computes basic net loss per share by dividing net loss applicable to common stockholders by the weighted-average number of shares of the Company’s common stock outstanding during the period. The Company computes diluted net loss per share after giving consideration to the dilutive effect of stock options that are outstanding during the period, except where such non-participating securities would be anti-dilutive. For the three months ended March 31, 2026 and 2025, basic and diluted net loss per share are the same for each respective period due to the Company’s net loss position. Potentially dilutive, non-participating securities have not been included in the calculations of diluted net loss per share, as their inclusion would be anti-dilutive.

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">4.</td> <td style="text-align: justify">Significant Strategic Collaborations</td></tr> </table> Takeda Pharmaceutical Co. Ltd. (together with its wholly-owned subsidiaries, “Takeda”) In October 2017, the Company granted to Takeda the right to grant a non-exclusive sublicense to certain patents related to the Company’s PolyXen technology that were previously exclusively licensed to Takeda in connection with products related to the treatment of blood and bleeding disorders. Royalty payments of approximately $0.8 million and $0.6 million were recorded as revenue during the three months ended March 31, 2026 and 2025, respectively, and are based on single digit royalties on net sales of certain covered products. The Company’s policy is to recognize royalty payments as revenue when they are reliably measurable, which is upon receipt of reports from Takeda. The Company receives these reports in the quarter subsequent to the actual sublicensee sales. At the time the revenue was received, there were no remaining performance obligations and all other revenue recognition criteria were met. Catalent Pharma Solutions LLC (“Catalent”) On June 30, 2022, the Company entered into a Statement of Work (the “SOW”) with Catalent to outline the general scope of work, timeline, and pricing pursuant to which Catalent will provide certain services to the Company to perform current Good Manufacturing Practices manufacturing of the Company’s recombinant protein, human DNase I. The parties agreed to enter into a Master Services Agreement that will contain terms and conditions to govern the project contemplated by the SOW and that will supersede the addendum to the SOW containing Catalent’s standard terms and conditions. The Company has paid Catalent approximately $3.0 million through March 31, 2026, of which $28,000 and $53,000 has been recognized as an advance payment and is included in prepaid expenses and other current assets as of March 31, 2026 and December 31, 2025, respectively, and approximately $0.1 million has been recognized as a liability and is included in accrued expenses and other current liabilities as of both March 31, 2026 and December 31, 2025. In addition, approximately $0.3 million has been recognized as long-term within other assets as of both March 31, 2026 and December 31, 2025. Scripps Research Institute (“Scripps Research”) On March 17, 2023, the Company and Scripps Research entered into a Research Funding and Option Agreement (the “Agreement”), pursuant to which the Company has agreed to provide Scripps Research an aggregate of up to $0.9 million to fund research relating to advancing the pre-clinical development of the Company’s DNase technology. Under the Agreement, the Company has the option to acquire a worldwide exclusive license to Scripps Research’s rights in the Technology or Patent Rights (as defined in the Agreement), as well as a non-exclusive, royalty-free, non-transferrable license to make and use TSRI Technology (as defined in the Agreement) solely for the Company’s internal research purposes during the performance of the research program contemplated by the Agreement. During the second quarter of 2024, the Company amended the Agreement to extend the term to October 31, 2024 with no additional funding required. On November 1, 2024, the Company and Scripps Research entered into a Second Amendment to the Agreement (the “Second Amendment”) extending the term of the Agreement for an additional twelve (12) month period and to provide Scripps Research additional funding in an aggregate amount of up to approximately $<span id="xdx_908_eus-gaap--IncreaseDecreaseInContractWithCustomerLiability_c20241101__20241102__srt--CounterpartyNameAxis__custom--ScrippsResearchMember_zEpwV37x2Ie6" title="Increase in contractual liabilitiy">400,000 to fund continuing research. The research funding was payable by the Company to Scripps Research on a monthly basis in accordance with a negotiated budget, which provided for an initial payment of approximately $65,000 on the date of the Second Amendment and subsequent monthly payments of approximately $65,000 over a 5-month period. All other terms of the Agreement remain unchanged. Effective May 1, 2025, the Company and Scripps Research entered into a Third Amendment to the Agreement (the “Third Amendment”), pursuant to which the Company expanded the services to be performed under the Agreement and provided Scripps Research additional funding in an aggregate amount of up to approximately $<span id="xdx_901_eus-gaap--IncreaseDecreaseInContractWithCustomerLiability_dm_c20250501__20250502__srt--CounterpartyNameAxis__custom--ScrippsResearchMember_zyQPidilLLhj" title="Increase in contractual liabilitiy">0.4 million to fund continuing research. The research funding was payable by the Company to Scripps Research on a monthly basis in accordance with a negotiated budget, which provided for an initial payment of approximately $70,000 on the date of the Third Amendment and subsequent monthly payments of approximately $70,000 over a 5-month period. All other terms of the Agreement remained unchanged. Effective November 1, 2025, the Company and Scripps Research entered into a Fourth Amendment to the Agreement (the “Fourth Amendment”), pursuant to which the Company extended and expanded the services to be performed under the Agreement and provided Scripps Research with additional funding in an aggregate amount of up to approximately $<span id="xdx_90A_eus-gaap--IncreaseDecreaseInContractWithCustomerLiability_dm_c20251101__20251102__srt--CounterpartyNameAxis__custom--ScrippsResearchMember_zMiXyxaj9xv1" title="Increase in contractual liabilitiy">0.3 million. The research funding was payable by the Company to Scripps Research on a monthly basis in accordance with a negotiated budget, which provided for an initial payment of approximately $85,000 on the effective date of the Fourth Amendment and subsequent monthly payments of approximately $85,000 over a 3-month period. All other terms of the Agreement remained unchanged. Effective March 1, 2026, the Company and Scripps Research entered into a Fifth Amendment to the Agreement (the “Fifth Amendment”), pursuant to which the Company extended and expanded the services to be performed under the Agreement and agreed to provide Scripps Research additional funding in an aggregate amount of up to approximately $<span id="xdx_90F_eus-gaap--IncreaseDecreaseInContractWithCustomerLiability_dm_c20260301__20260302__srt--CounterpartyNameAxis__custom--ScrippsResearchMember_zbsp5qm3kiAc" title="Increase in contractual liabilitiy">0.5 million. The research funding is payable by the Company to Scripps Research on a monthly basis in accordance with a negotiated budget, which provides for an initial payment of approximately $80,000 on the effective date of the Fifth Amendment and subsequent monthly payments of approximately $80,000 over a 5-month period. All other terms of the Agreement remain unchanged. The Company paid Scripps Research approximately $2.0 million under the Agreement through March 31, 2026, of which approximately $<span id="xdx_903_eus-gaap--AccountsPayableAndOtherAccruedLiabilitiesCurrent_iI_dm_c20260331__srt--CounterpartyNameAxis__custom--ScrippsResearchMember_zUjwnzzrHK35" title="Accrued expenses and other liabilities">0.1 million was included in accounts payable as of March 31, 2026 and $<span id="xdx_90D_eus-gaap--AccountsPayableAndOtherAccruedLiabilitiesCurrent_iI_dm_c20251231__srt--CounterpartyNameAxis__custom--ScrippsResearchMember_zLBkRCWCF4d8" title="Accrued expenses and other liabilities">0.2 million was included in accrued expenses and other current liabilities as of December 31, 2025. University of Virginia (“UVA”) On December 21, 2023, the Company entered into a Research Funding and Material Transfer Agreement with UVA (the “UVA Agreement”) to advance the development of our systemic DNase program. Under the terms of the UVA Agreement, in addition to advancing our existing intellectual property, the Company has an option to acquire an exclusive license to any new intellectual property arising from the DNase research program. Allan Tsung, MD, a member of the Company’s Scientific Advisory Board and Chair of the Department of Surgery at the UVA School of Medicine, will oversee the research conducted under the UVA Agreement. In November 2024, the Company and UVA entered into an amendment to extend the UVA Agreement through December 2025. UVA produced preclinical and translational data under the UVA Agreement and has investigated combinations of DNase I with immunotherapies in models of primary and metastatic colorectal cancer. The Company is currently in discussions with UVA concerning potential expansion of the scope of work under the UVA Agreement. The Company paid UVA approximately $0.6 million under the UVA Agreement through March 31, 2026, of which approximately $77,000 was recorded within accounts payable as of March 31, 2026 and approximately $31,000 was recorded within accrued expenses and other current liabilities as of December 31, 2025. Other Agreements The Company has also entered into various research, development, license and supply agreements with Serum Institute of India (“Serum Institute”), PJSC Pharmsynthez (“Pharmsynthez”) and SynBio LLC (“SynBio”), a wholly owned subsidiary of Pharmsynthez. The Company and its collaborative partners continue to engage in research and development activities with no resultant commercial products through March 31, 2026. No amounts were recognized as revenue related to the Serum Institute, Pharmsynthez or SynBio agreements during the three months ended March 31, 2026 and 2025, respectively.

3000000.0

28000

53000

100000

300000

900000

400000

300000

500000

2000000.0

100000

200000

600000

77000

31000

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">5.</td> <td style="text-align: justify">Fair Value Measurements </td></tr> </table> Accounting Standards Codification Topic 820, Fair Value Measurement, defines fair value as the price that would be received to sell an asset or be paid to transfer a liability in an orderly transaction between market participants at the measurement date. The Company applies the following fair value hierarchy, which prioritizes the inputs used to measure fair value into three levels and bases the categorization within the hierarchy upon the lowest level of input that is available and significant to the fair value measurement. Level 1 inputs are unadjusted quoted prices in active markets for identical assets or liabilities that the reporting entity has the ability to access at the measurement date. Level 2 utilizes quoted market prices in markets that are not active, broker or dealer quotations, or alternative pricing sources with reasonable levels of price transparency. Level 3 inputs are unobservable inputs for the asset or liability in which there is little, if any, market activity for the asset or liability at the measurement date. As of March 31, 2026 and December 31, 2025, the carrying amounts of the Company’s financial instruments approximate fair value due to their short maturities. There were no financial instruments classified as Level 3 in the fair value hierarchy during the three months ended March 31, 2026 and 2025.

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">6.</td> <td style="text-align: justify">Stockholders’ Equity </td></tr> </table> Warrants The Company has warrants to purchase approximately 800 shares of the Company’s common stock outstanding as of both March 31, 2026 and December 31, 2025. These warrants have an exercise price of $29.09 per share of common stock and expire on July 3, 2026. <span id="xdx_900_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_dn_c20250101__20250331_zFnkRgttCuXj" title="Warrants forfeited during period"><span id="xdx_90E_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_dn_c20260101__20260331_zRd8Cncw9Vt" title="Warrants forfeited during period">None of these warrants were exercised or forfeited during the three months ended March 31, 2026 and 2025.

800

29.09

2026-07-03

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">7.</td> <td style="text-align: justify">Share-Based Expense </td></tr> </table> Total share-based expense related to stock options was approximately $11,000 and $19,000 during each of the three months ended March 31, 2026 and 2025, respectively. Share-based expense is classified in the condensed consolidated statements of operations as follows: <table cellpadding="0" cellspacing="0" id="xdx_89A_eus-gaap--ScheduleOfShareBasedCompensationActivityTableTextBlock_zcZoaYkj3yD6" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Share-Based Expense (Details)"> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; width: 66%">Allocation of share-based compensation expense</td><td style="width: 2%"> </td> <td style="text-align: left; width: 1%"> </td><td style="text-align: right; width: 13%"> </td><td style="text-align: left; width: 1%"> </td><td style="width: 2%"> </td> <td style="text-align: left; width: 1%"> </td><td style="text-align: right; width: 13%"> </td><td style="text-align: left; width: 1%"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Three Months Ended March 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2026</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Research and development expenses</td><td> </td> <td style="text-align: left">$</td><td id="xdx_981_eus-gaap--ShareBasedCompensation_pp0p0_d0_c20260101__20260331__us-gaap--NatureOfExpenseAxis__custom--ResearchAndDevelopmentMember_zqCMxPU3y2qd" style="text-align: right" title="Share-based compensation">–</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eus-gaap--ShareBasedCompensation_pp0p0_d0_c20250101__20250331__us-gaap--NatureOfExpenseAxis__custom--ResearchAndDevelopmentMember_z7vivdyLLeL2" style="text-align: right" title="Share-based compensation">–</td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 66%; text-align: left; padding-bottom: 1pt">General and administrative expenses</td><td style="width: 2%; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; width: 1%; text-align: left"> </td><td id="xdx_98D_eus-gaap--ShareBasedCompensation_pp0p0_c20260101__20260331__us-gaap--NatureOfExpenseAxis__custom--GeneralAndAdministrativeMember_zuBmcpTo1WW7" style="border-bottom: Black 1pt solid; width: 13%; text-align: right" title="Share-based compensation">11,312</td><td style="width: 1%; padding-bottom: 1pt; text-align: left"> </td><td style="width: 2%; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; width: 1%; text-align: left"> </td><td id="xdx_984_eus-gaap--ShareBasedCompensation_pp0p0_c20250101__20250331__us-gaap--NatureOfExpenseAxis__custom--GeneralAndAdministrativeMember_zKji1ViEflBd" style="border-bottom: Black 1pt solid; width: 13%; text-align: right" title="Share-based compensation">19,251</td><td style="width: 1%; padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-bottom: 2.5pt"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_988_eus-gaap--ShareBasedCompensation_pp0p0_c20260101__20260331_zvkMVqM0nWJd" style="border-bottom: Black 2.5pt double; text-align: right" title="Share-based compensation">11,312</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_988_eus-gaap--ShareBasedCompensation_pp0p0_c20250101__20250331_zTxCRnDeSKyg" style="border-bottom: Black 2.5pt double; text-align: right" title="Share-based compensation">19,251</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> Employee Stock Options No employee stock option awards to purchase shares of common stock were granted or exercised during the three months ended March 31, 2026 and 2025. During the three months ended March 31, 2026 and 2025, options to purchase <span id="xdx_90F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_c20260101__20260331__us-gaap--AwardTypeAxis__custom--EmployeeStockOptionsMember_zFD8MdRcppka" title="Options expired, shares">102 shares of common stock and <span id="xdx_90E_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_c20250101__20250331__us-gaap--AwardTypeAxis__custom--EmployeeStockOptionsMember_z30kXbVGJCd7" title="Options expired, shares">25,836 shares of common stock expired, respectively. The Company recognized a total of approximately $11,000 and $19,000 of share-based expense related to employee stock options during each of the three months ended March 31, 2026 and 2025. Non-Employee Stock Options There were <span id="xdx_904_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iI_do_c20260331__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_zsExZ2XT6lce" title="Options outstanding, shares"><span id="xdx_908_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iI_do_c20251231__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_ziHj1vezvsh2" title="Options outstanding, shares">no non-employee options outstanding as of both March 31, 2026 and December 31, 2025. There were <span id="xdx_90D_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_do_c20260101__20260331__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_zIZddcoo37Dd" title="Options granted"><span id="xdx_902_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_do_c20250101__20250331__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_z1faWMswyB73" title="Options granted">no non-employee stock options granted or exercised during the three months ended March 31, 2026 and 2025. No non-employee stock option grants expired during the three months ended March 31, 2026 and 2025. The Company did not recognize any share-based expense related to non-employee stock options during the three months ended March 31, 2026 and 2025.

<table cellpadding="0" cellspacing="0" id="xdx_89A_eus-gaap--ScheduleOfShareBasedCompensationActivityTableTextBlock_zcZoaYkj3yD6" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Share-Based Expense (Details)"> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; width: 66%">Allocation of share-based compensation expense</td><td style="width: 2%"> </td> <td style="text-align: left; width: 1%"> </td><td style="text-align: right; width: 13%"> </td><td style="text-align: left; width: 1%"> </td><td style="width: 2%"> </td> <td style="text-align: left; width: 1%"> </td><td style="text-align: right; width: 13%"> </td><td style="text-align: left; width: 1%"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Three Months Ended March 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2026</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2025</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Research and development expenses</td><td> </td> <td style="text-align: left">$</td><td id="xdx_981_eus-gaap--ShareBasedCompensation_pp0p0_d0_c20260101__20260331__us-gaap--NatureOfExpenseAxis__custom--ResearchAndDevelopmentMember_zqCMxPU3y2qd" style="text-align: right" title="Share-based compensation">–</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td id="xdx_983_eus-gaap--ShareBasedCompensation_pp0p0_d0_c20250101__20250331__us-gaap--NatureOfExpenseAxis__custom--ResearchAndDevelopmentMember_z7vivdyLLeL2" style="text-align: right" title="Share-based compensation">–</td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 66%; text-align: left; padding-bottom: 1pt">General and administrative expenses</td><td style="width: 2%; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; width: 1%; text-align: left"> </td><td id="xdx_98D_eus-gaap--ShareBasedCompensation_pp0p0_c20260101__20260331__us-gaap--NatureOfExpenseAxis__custom--GeneralAndAdministrativeMember_zuBmcpTo1WW7" style="border-bottom: Black 1pt solid; width: 13%; text-align: right" title="Share-based compensation">11,312</td><td style="width: 1%; padding-bottom: 1pt; text-align: left"> </td><td style="width: 2%; padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; width: 1%; text-align: left"> </td><td id="xdx_984_eus-gaap--ShareBasedCompensation_pp0p0_c20250101__20250331__us-gaap--NatureOfExpenseAxis__custom--GeneralAndAdministrativeMember_zKji1ViEflBd" style="border-bottom: Black 1pt solid; width: 13%; text-align: right" title="Share-based compensation">19,251</td><td style="width: 1%; padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-bottom: 2.5pt"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_988_eus-gaap--ShareBasedCompensation_pp0p0_c20260101__20260331_zvkMVqM0nWJd" style="border-bottom: Black 2.5pt double; text-align: right" title="Share-based compensation">11,312</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_988_eus-gaap--ShareBasedCompensation_pp0p0_c20250101__20250331_zTxCRnDeSKyg" style="border-bottom: Black 2.5pt double; text-align: right" title="Share-based compensation">19,251</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> Employee Stock Options No employee stock option awards to purchase shares of common stock were granted or exercised during the three months ended March 31, 2026 and 2025. During the three months ended March 31, 2026 and 2025, options to purchase <span id="xdx_90F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_c20260101__20260331__us-gaap--AwardTypeAxis__custom--EmployeeStockOptionsMember_zFD8MdRcppka" title="Options expired, shares">102 shares of common stock and <span id="xdx_90E_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_c20250101__20250331__us-gaap--AwardTypeAxis__custom--EmployeeStockOptionsMember_z30kXbVGJCd7" title="Options expired, shares">25,836 shares of common stock expired, respectively. The Company recognized a total of approximately $11,000 and $19,000 of share-based expense related to employee stock options during each of the three months ended March 31, 2026 and 2025. Non-Employee Stock Options There were <span id="xdx_904_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iI_do_c20260331__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_zsExZ2XT6lce" title="Options outstanding, shares"><span id="xdx_908_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iI_do_c20251231__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_ziHj1vezvsh2" title="Options outstanding, shares">no non-employee options outstanding as of both March 31, 2026 and December 31, 2025. There were <span id="xdx_90D_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_do_c20260101__20260331__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_zIZddcoo37Dd" title="Options granted"><span id="xdx_902_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_do_c20250101__20250331__us-gaap--AwardTypeAxis__custom--NonEmployeeStockOptionsMember_z1faWMswyB73" title="Options granted">no non-employee stock options granted or exercised during the three months ended March 31, 2026 and 2025. No non-employee stock option grants expired during the three months ended March 31, 2026 and 2025. The Company did not recognize any share-based expense related to non-employee stock options during the three months ended March 31, 2026 and 2025.

11312

19251

11312

19251

102

25836

11000

19000

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">8.</td> <td style="text-align: justify">Income Taxes </td></tr> </table> During the three months ended March 31, 2026 and 2025, there was no provision for income taxes as the Company incurred losses during both periods. Deferred tax assets and liabilities reflect the net tax effect of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. The Company records a valuation allowance against its deferred tax assets as the Company believes it is more likely than not the deferred tax assets will not be realized. The valuation allowance against deferred tax assets was approximately $39.9 million and $39.8 million as of March 31, 2026 and December 31, 2025, respectively. As of March 31, 2026 and December 31, 2025, the Company did not record any unrecognized tax positions.

39900000

39800000

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">9.</td> <td style="text-align: justify">Related Party Transactions</td></tr> </table> The Company has entered into various research, development, license and supply agreements with PeriNess Ltd. (“PeriNess”), Serum Institute and Pharmsynthez, each a related party whose relationship has not materially changed from that disclosed in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025 filed with the SEC on March 12, 2026, as amended on April 24, 2026. The Company has paid PeriNess approximately $0.3 million to date under this contract through March 31, 2026. As of March 31, 2026 and December 31, 2025, approximately $50,000 was recorded as an advanced payment and included in prepaid expenses and other current assets. In addition, approximately $9,000 and $8,000 was reflected in accounts payable on the March 31, 2026 and 2025 consolidated balance sheet, respectively. No amounts were incurred in connection with agreements with Serum Institute and Pharmsynthez during the three months ended March 31, 2026 and 2025. During the first quarter of 2025, the Company entered into a Consulting Agreement with Dr. Dmitry Genkin, Chairman of our Board, to provide consulting services related to the Company’s DNase-based oncology program. This agreement was effective January 1, 2025 and the Company has paid Dr. Genkin approximately $0.5 million through March 31, 2026, of which approximately $30,000 was reflected within accounts payable as of both March 31, 2026 and December 31, 2025. Dr. Genkin does not receive any fees for his service as a member of the Board.

300000

50000

9000

8000

500000

30000

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 33px">10.</td> <td style="text-align: justify">Subsequent Events </td></tr> </table> The Company performed a review of events subsequent to the balance sheet date through the date the financial statements were issued and determined that there were no such events requiring recognition or disclosure in the financial statements.

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