v3.26.1
Segment Information - Summary of Results of Operations Provided to Company's CODM (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2026
Mar. 31, 2025
Revenues [Abstract]    
Total collaboration revenue $ 1,248 $ 4,127
Operating expenses:    
Stock-based compensation expense 2,552 2,928
Total operating expenses 25,835 31,947
Operating loss (24,587) (27,820)
Other income (expense):    
Net loss (23,059) (25,039)
Operating Segments    
Revenues [Abstract]    
Total collaboration revenue 1,248 4,127
Operating expenses:    
Employee-related expenses 7,875 11,664
Facilities and overhead costs 6,391 7,369
Professional services and consulting 2,672 2,545
Research and development supplies and services 6,345 7,441
Stock-based compensation expense 2,552 2,928
Total operating expenses 25,835 31,947
Operating loss (24,587) (27,820)
Other income (expense):    
Interest and other 1,538 2,879
Provision for income taxes (10) (98)
Net loss (23,059) (25,039)
Operating Segments | Ionis    
Revenues [Abstract]    
Total collaboration revenue $ 1,248 3,974
Operating Segments | Affini-T    
Revenues [Abstract]    
Total collaboration revenue   $ 153