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  <xs:element id="notv_LineOfCreditFacilityFeeConsiderationPayablePercentageOfRevolvingCommitmentsHeldByConsentingRevolvingLenderPaidInCashUponCertainPrepayments" abstract="false" name="LineOfCreditFacilityFeeConsiderationPayablePercentageOfRevolvingCommitmentsHeldByConsentingRevolvingLenderPaidInCashUponCertainPrepayments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="notv_DebtInstrumentCovenantChargesAddBackAllowance" abstract="false" name="DebtInstrumentCovenantChargesAddBackAllowance" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_ProceedsFromDelayedDrawTermLoan" abstract="false" name="ProceedsFromDelayedDrawTermLoan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_BusinessCombinationPeriodForPaymentOfConsideration" abstract="false" name="BusinessCombinationPeriodForPaymentOfConsideration" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_DebtInstrumentSettlementTerm" abstract="false" name="DebtInstrumentSettlementTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_DebtInstrumentAdditionalPrincipalAmountIssued" abstract="false" name="DebtInstrumentAdditionalPrincipalAmountIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_UnamortizedDebtIssuanceCostsForConvertibleSeniorNotes" abstract="false" name="UnamortizedDebtIssuanceCostsForConvertibleSeniorNotes" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_CouponInterestExpenseDebt" abstract="false" name="CouponInterestExpenseDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_AccretionExpenseDebt" abstract="false" name="AccretionExpenseDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_DebtInstrumentConvertibleScheduledTradingDays" abstract="false" name="DebtInstrumentConvertibleScheduledTradingDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="notv_DebtInstrumentDebtDefaultCurePeriod" abstract="false" name="DebtInstrumentDebtDefaultCurePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_DebtInstrumentDebtDefaultCureOrWaiverPeriodAfterNotice" abstract="false" name="DebtInstrumentDebtDefaultCureOrWaiverPeriodAfterNotice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_DebtInstrumentDebtDefaultPeriodForDischargeOrStay" abstract="false" name="DebtInstrumentDebtDefaultPeriodForDischargeOrStay" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_DebtInstrumentDebtDefaultNoticeForMinimumPercentageOfNoteholders" abstract="false" name="DebtInstrumentDebtDefaultNoticeForMinimumPercentageOfNoteholders" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="notv_DebtInstrumentDebtDefaultRightToReceiveSpecialInterestMaximumTerm" abstract="false" name="DebtInstrumentDebtDefaultRightToReceiveSpecialInterestMaximumTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_DebtInstrumentDebtDefaultRightToReceiveSpecialInterestMaximumRate" abstract="false" name="DebtInstrumentDebtDefaultRightToReceiveSpecialInterestMaximumRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="notv_DebtInstrumentCovenantDefaultAmount" abstract="false" name="DebtInstrumentCovenantDefaultAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_DebtInstrumentWaiverPeriodAfterAcquisitionClosing" abstract="false" name="DebtInstrumentWaiverPeriodAfterAcquisitionClosing" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_DebtInstrumentCovenantChargesOrExpensesAddbackLimit" abstract="false" name="DebtInstrumentCovenantChargesOrExpensesAddbackLimit" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_TradeReceivablesAndContractAssetsNetAbstract" abstract="true" name="TradeReceivablesAndContractAssetsNetAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_ContractWithCustomerAssetsAndReceivablesBeforeAllowanceForCreditLossCurrent" abstract="false" name="ContractWithCustomerAssetsAndReceivablesBeforeAllowanceForCreditLossCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_ResearchModelInventoryGross" abstract="false" name="ResearchModelInventoryGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_SecuritiesClassActionLawsuitMember" abstract="true" name="SecuritiesClassActionLawsuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_A2025CybersecurityIncidentMember" abstract="true" name="A2025CybersecurityIncidentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_PrepaidResearchModels" abstract="false" name="PrepaidResearchModels" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_AdvanceToSuppliersNoncurrent" abstract="false" name="AdvanceToSuppliersNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_OtherMiscellaneousAssetsNoncurrent" abstract="false" name="OtherMiscellaneousAssetsNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_USDOJAgreementMember" abstract="true" name="USDOJAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_AccruedTaxes" abstract="false" name="AccruedTaxes" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_AccruedExpensesAndOtherLiabilitiesCurrent" abstract="false" name="AccruedExpensesAndOtherLiabilitiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_FeesInvoicedInAdvanceAbstract" abstract="true" name="FeesInvoicedInAdvanceAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_LongTermClientDeposits" abstract="false" name="LongTermClientDeposits" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_LossContingencyAccrualInterestRate" abstract="false" name="LossContingencyAccrualInterestRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="notv_GainContingencySettlementGainLoss" abstract="false" name="GainContingencySettlementGainLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_NumberOfFacilitiesCompanyServesAsLessorToLessee" abstract="false" name="NumberOfFacilitiesCompanyServesAsLessorToLessee" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="notv_OperatingLeaseAssetsAndLiabilitiesLesseeAbstract" abstract="true" name="OperatingLeaseAssetsAndLiabilitiesLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_FinanceLeaseCostAbstract" abstract="true" name="FinanceLeaseCostAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_CashFlowsLesseeAbstract" abstract="true" name="CashFlowsLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" abstract="true" name="RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_WeightedAverageRemainingLeaseTermAbstract" abstract="true" name="WeightedAverageRemainingLeaseTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_LeasesWeightedAverageDiscountRateAbstract" abstract="true" name="LeasesWeightedAverageDiscountRateAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="notv_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour" abstract="false" name="LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_FinanceLeaseLiabilityPaymentsDueAfterYearFour" abstract="false" name="FinanceLeaseLiabilityPaymentsDueAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_InotivInc.2024EquityIncentivePlanThe2024PlanMember" abstract="true" name="InotivInc.2024EquityIncentivePlanThe2024PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_CommonAndPreferredStockSharesAuthorized" abstract="false" name="CommonAndPreferredStockSharesAuthorized" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="notv_SaleOfStockOverAllotmentOptionPeriod" abstract="false" name="SaleOfStockOverAllotmentOptionPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_EnvigoRMSLLCEnvigoRMSClassActionLawsuitMember" abstract="true" name="EnvigoRMSLLCEnvigoRMSClassActionLawsuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_USDOJAgreementFinesMember" abstract="true" name="USDOJAgreementFinesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_USDOJAgreementFacilityImprovementsMember" abstract="true" name="USDOJAgreementFacilityImprovementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_LossContingencyPaymentTimingAxis" abstract="true" name="LossContingencyPaymentTimingAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="notv_LossContingencyPaymentTimingDomain" abstract="true" name="LossContingencyPaymentTimingDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_LossContingencyPaymentPeriodThreeMember" abstract="true" name="LossContingencyPaymentPeriodThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_LossContingencyPaymentPeriodTwoMember" abstract="true" name="LossContingencyPaymentPeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_LossContingencyPaymentPeriodOneMember" abstract="true" name="LossContingencyPaymentPeriodOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_LossContingencyPaymentPeriodFourMember" abstract="true" name="LossContingencyPaymentPeriodFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_VirginiaAnimalFightingTaskforceAndHumaneSocietyUnitedStatesMember" abstract="true" name="VirginiaAnimalFightingTaskforceAndHumaneSocietyUnitedStatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_NationalFishAndWildlifeFoundationMember" abstract="true" name="NationalFishAndWildlifeFoundationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_CertainInsurersMember" abstract="true" name="CertainInsurersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="notv_LossContingencyNumberOfQuarterlyInstallments" abstract="false" name="LossContingencyNumberOfQuarterlyInstallments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="notv_LossContingencyLiensCapacityOfAdditionalDebtToBeSecured" abstract="false" name="LossContingencyLiensCapacityOfAdditionalDebtToBeSecured" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="notv_LossContingencyProbationPeriod" abstract="false" name="LossContingencyProbationPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_LossContingencyMonitorshipExpirationPeriodPeriodAfterCompletionOfSelectionProcess" abstract="false" name="LossContingencyMonitorshipExpirationPeriodPeriodAfterCompletionOfSelectionProcess" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_LossContingencyMonitorshipExpirationPeriodPeriodAfterCompletionOfProbation" abstract="false" name="LossContingencyMonitorshipExpirationPeriodPeriodAfterCompletionOfProbation" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="notv_LineOfCreditFacilityClosingFeePercentage" abstract="false" name="LineOfCreditFacilityClosingFeePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="notv_LineOfCreditPercentageOfExistingLendersThatMustApproveAmendment" abstract="false" name="LineOfCreditPercentageOfExistingLendersThatMustApproveAmendment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="notv_LineOfCreditExistingLendersConsentFeePercent" abstract="false" name="LineOfCreditExistingLendersConsentFeePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="notv_NumberOfBoardMembers" abstract="false" name="NumberOfBoardMembers" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
