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          <link:definition>999043 - Disclosure - BUSINESS (Details Narrative)</link:definition>
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          <link:definition>999044 - Disclosure - SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)</link:definition>
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          <link:definition>999045 - Disclosure - Information about significant segment expenses regularly provided to the CODM is as follows (in thousands): (Details)</link:definition>
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          <link:definition>999050 - Disclosure - The following table provides the gross carrying amount and accumulated amortization for each major class of intangible asset: (Details)</link:definition>
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          <link:definition>999054 - Disclosure - STOCKHOLDERS&#8217; EQUITY (Details Narrative)</link:definition>
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          <link:definition>999055 - Disclosure - The Company&#8217;s net product revenues are summarized below: (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
        </link:roleType>
        <link:roleType roleURI="http://tonixpharma.com/role/CompanyRepurchasedFollowingCapitalStockDetails" id="CompanyRepurchasedFollowingCapitalStockDetails">
          <link:definition>999059 - Disclosure - The Company repurchased the following capital stock: (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/SummaryOfStockOptionActivityAndRelatedInformationForPlansForThreeMonthsEndedMarch312026IsAsFollowsDetails" id="SummaryOfStockOptionActivityAndRelatedInformationForPlansForThreeMonthsEndedMarch312026IsAsFollowsDetails">
          <link:definition>999060 - Disclosure - A summary of the stock option activity and related information for the Plans for the three months ended March 31, 2026, is as follows: (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/AssumptionsUsedInValuationOfStockOptionsGrantedDuringThreeMonthsEndedMarch312026And2025WereAsFollowsDetails" id="AssumptionsUsedInValuationOfStockOptionsGrantedDuringThreeMonthsEndedMarch312026And2025WereAsFollowsDetails">
          <link:definition>999061 - Disclosure - The assumptions used in the valuation of stock options granted during the three months ended March 31, 2026, and 2025 were as follows: (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/Stock-basedCompensationDetailsNarrative" id="Stock-basedCompensationDetailsNarrative">
          <link:definition>999062 - Disclosure - STOCK-BASED COMPENSATION (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/Stock-basedCompensationDetailsNarrativeDefOnly" id="Stock-basedCompensationDetailsNarrativeDefOnly">
          <link:definition>999062 - Disclosure - STOCK-BASED COMPENSATION (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/FollowingTableSummarizesInformationWithRespectToOutstandingWarrantsToPurchaseCommonStockOfCompanyAtMarch312026Details" id="FollowingTableSummarizesInformationWithRespectToOutstandingWarrantsToPurchaseCommonStockOfCompanyAtMarch312026Details">
          <link:definition>999063 - Disclosure - The following table summarizes information with respect to outstanding warrants to purchase common stock of the Company at March 31, 2026: (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
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          <link:definition>999064 - Disclosure - WARRANTS TO PURCHASE COMMON STOCK (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/AtMarch312026FutureMinimumLeasePaymentsForOperatingLeasesWithNon-cancelableTermsOfMoreThanOneYearWereAsFollowsInThousandsDetails" id="AtMarch312026FutureMinimumLeasePaymentsForOperatingLeasesWithNon-cancelableTermsOfMoreThanOneYearWereAsFollowsInThousandsDetails">
          <link:definition>999065 - Disclosure - At March 31, 2026, future minimum lease payments for operating leases with non-cancelable terms of more than one year were as follows (in thousands): (Details)</link:definition>
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        <link:roleType roleURI="http://tonixpharma.com/role/OtherInformationRelatedToLeasesIsAsFollowsDetails" id="OtherInformationRelatedToLeasesIsAsFollowsDetails">
          <link:definition>999066 - Disclosure - Other information related to leases is as follows: (Details)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/CommitmentsDetailsNarrative" id="CommitmentsDetailsNarrative">
          <link:definition>999068 - Disclosure - COMMITMENTS (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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        <link:roleType roleURI="http://tonixpharma.com/role/SubsequentEventsDetailsNarrative" id="SubsequentEventsDetailsNarrative">
          <link:definition>999069 - Disclosure - SUBSEQUENT EVENTS (Details Narrative)</link:definition>
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          <link:usedOn>link:calculationLink</link:usedOn>
          <link:usedOn>link:definitionLink</link:usedOn>
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    <element id="tnxp_GrantAmountAwarded" name="GrantAmountAwarded" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_IncreaseDecreaseInResearchAndDevelopmentExpense" name="IncreaseDecreaseInResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_InventoryCurrentAndNoncurrent" name="InventoryCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_PrepaidPrescriptionDrugUserFeeActFees" name="PrepaidPrescriptionDrugUserFeeActFees" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_CompensationAndCompensationRelatedAccruedLiabilitiesCurrent" name="CompensationAndCompensationRelatedAccruedLiabilitiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_ProfessionalFeesAndOtherAccruedLiabilitiesCurrent" name="ProfessionalFeesAndOtherAccruedLiabilitiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_DebtInstrumentIssueDiscountPercentage" name="DebtInstrumentIssueDiscountPercentage" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_MinimumBidRequirementPerShare" name="MinimumBidRequirementPerShare" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_PeriodOfBusinessDaysOfComplianceWithMinimumBidRequirement" name="PeriodOfBusinessDaysOfComplianceWithMinimumBidRequirement" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_RevenueRecognizedForValuationAllowancesAndReservesAdjustments" name="RevenueRecognizedForValuationAllowancesAndReservesAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_BusinessCombinationEarnOutPaymentPercentage" name="BusinessCombinationEarnOutPaymentPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_BusinessCombinationEarnOutNetSales" name="BusinessCombinationEarnOutNetSales" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_BusinessCombinationReductionOfEarnOutPaymentPercentageUponEntryOfGenericProduct" name="BusinessCombinationReductionOfEarnOutPaymentPercentageUponEntryOfGenericProduct" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_BusinessCombinationAdditionalRoyaltyPercentage" name="BusinessCombinationAdditionalRoyaltyPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_BusinessCombinationAdditionalRoyaltyPercentageForUSPatent" name="BusinessCombinationAdditionalRoyaltyPercentageForUSPatent" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_BusinessCombinationAdditionalRoyaltyPaymentPeriod" name="BusinessCombinationAdditionalRoyaltyPaymentPeriod" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_AnnualWorldwideNetSalesForMilestone" name="AnnualWorldwideNetSalesForMilestone" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_CommonStockPurchase" name="CommonStockPurchase" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_OfferingPricePerAgreement" name="OfferingPricePerAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_SalesAgentCommissionPercentage" name="SalesAgentCommissionPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAdditionalSharesAuthorized" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfAdditionalSharesAuthorized" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_ClassOfWarrantsOrRightExpirationDate" name="ClassOfWarrantsOrRightExpirationDate" nillable="true" xbrli:periodType="duration" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsBecameExercisable" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsBecameExercisable" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsBecameExercisableUponFDAAcceptanceOfNDAFiling" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsBecameExercisableUponFDAAcceptanceOfNDAFiling" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_ExercisePriceOfWarrantsExpired" name="ExercisePriceOfWarrantsExpired" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_DevelopmentMilestoneFeesPayable" name="DevelopmentMilestoneFeesPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_CommercialAchievementMilestoneFeesPayable" name="CommercialAchievementMilestoneFeesPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="tnxp_DefinedContributionPlanEmployerContributionAmount" name="DefinedContributionPlanEmployerContributionAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
