<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019ce305-8810-732a-a011-c1da7f22f708,g:2bcbb4c1-4194-4006-a367-3bfddc661054-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.eltx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="eltx-20260331.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019ce305-88c7-7dc1-bf1e-f5b449eabfcb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019ce305-88c7-7453-a9e9-fb0de0343979" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ce305-88c7-7dc1-bf1e-f5b449eabfcb" xlink:to="loc_us-gaap_LiabilitiesCurrent_019ce305-88c7-7453-a9e9-fb0de0343979" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_WarrantLiability_019ce305-88c7-7aea-a057-df93edd39991" xlink:href="eltx-20260331.xsd#eltx_WarrantLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ce305-88c7-7dc1-bf1e-f5b449eabfcb" xlink:to="loc_eltx_WarrantLiability_019ce305-88c7-7aea-a057-df93edd39991" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ce305-88c7-7b69-8b36-194986ea56a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ce305-88c7-7dc1-bf1e-f5b449eabfcb" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ce305-88c7-7b69-8b36-194986ea56a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019ce305-88c7-7446-bf63-6ea90616978d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019ce305-88c7-7dc1-bf1e-f5b449eabfcb" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019ce305-88c7-7446-bf63-6ea90616978d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019ce305-88c7-7fd6-a9a1-9d47268e40ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019ce305-88c7-7c0e-88c9-0b914bf63c0d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ce305-88c7-7fd6-a9a1-9d47268e40ec" xlink:to="loc_us-gaap_AccountsPayableCurrent_019ce305-88c7-7c0e-88c9-0b914bf63c0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-88c7-7f0f-b117-cf4d88969ef4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ce305-88c7-7fd6-a9a1-9d47268e40ec" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-88c7-7f0f-b117-cf4d88969ef4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ce305-88c7-71c5-bfef-640b67aa9914" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019ce305-88c7-7fd6-a9a1-9d47268e40ec" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ce305-88c7-71c5-bfef-640b67aa9914" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019ce305-88c7-7cb5-b857-2257634e91bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019ce305-88c7-7977-b10a-766e7070c7b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ce305-88c7-7cb5-b857-2257634e91bb" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019ce305-88c7-7977-b10a-766e7070c7b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019ce305-88c7-7d8b-911c-1339d77047bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ce305-88c7-7cb5-b857-2257634e91bb" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019ce305-88c7-7d8b-911c-1339d77047bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019ce305-88c7-732c-a973-d6739ace01fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ce305-88c7-7cb5-b857-2257634e91bb" xlink:to="loc_us-gaap_AssetsCurrent_019ce305-88c7-732c-a973-d6739ace01fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_019ce305-88c7-7e06-9056-c5cf28086d52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ce305-88c7-7cb5-b857-2257634e91bb" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_019ce305-88c7-7e06-9056-c5cf28086d52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseOtherNoncurrent_019ce305-88c7-77f6-8f05-51b864286210" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseOtherNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019ce305-88c7-7cb5-b857-2257634e91bb" xlink:to="loc_us-gaap_PrepaidExpenseOtherNoncurrent_019ce305-88c7-77f6-8f05-51b864286210" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019ce305-88c7-7947-9814-fed221e92021" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_019ce305-88c7-7f58-ac04-fbb02ec87086" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ce305-88c7-7947-9814-fed221e92021" xlink:to="loc_us-gaap_TreasuryStockCommonValue_019ce305-88c7-7f58-ac04-fbb02ec87086" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019ce305-88c7-7e8c-bbad-471b18d57e92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ce305-88c7-7947-9814-fed221e92021" xlink:to="loc_us-gaap_CommonStockValue_019ce305-88c7-7e8c-bbad-471b18d57e92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019ce305-88c7-7426-a570-063409e3a61b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ce305-88c7-7947-9814-fed221e92021" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019ce305-88c7-7426-a570-063409e3a61b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ce305-88c7-7944-8bdf-adb341aa2371" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ce305-88c7-7947-9814-fed221e92021" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019ce305-88c7-7944-8bdf-adb341aa2371" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019ce305-88c7-7ee4-8e62-4de8720191fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019ce305-88c7-7947-9814-fed221e92021" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019ce305-88c7-7ee4-8e62-4de8720191fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019ce305-88c7-7379-82c3-67b56864c1dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ce305-88c7-7e30-9cd2-2f2a8ba25464" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ce305-88c7-7379-82c3-67b56864c1dc" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ce305-88c7-7e30-9cd2-2f2a8ba25464" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ce305-88c7-70a5-bb39-8fff36a6c50b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019ce305-88c7-7379-82c3-67b56864c1dc" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ce305-88c7-70a5-bb39-8fff36a6c50b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ce305-88c7-7c45-a777-fcd1681cdb84" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019ce305-88c7-774c-96ba-fbc7b4eeaa24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ce305-88c7-7c45-a777-fcd1681cdb84" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019ce305-88c7-774c-96ba-fbc7b4eeaa24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019ce305-88c7-798f-9086-3a42dfad88c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ce305-88c7-7c45-a777-fcd1681cdb84" xlink:to="loc_us-gaap_StockholdersEquity_019ce305-88c7-798f-9086-3a42dfad88c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019ce305-88c7-71e6-b723-227580d8b583" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019ce305-88c7-7c45-a777-fcd1681cdb84" xlink:to="loc_us-gaap_Liabilities_019ce305-88c7-71e6-b723-227580d8b583" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="eltx-20260331.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019ce305-88c7-718c-8089-43a902770b72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019ce305-88c7-7a6b-8d2a-359a244ce4c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019ce305-88c7-718c-8089-43a902770b72" xlink:to="loc_us-gaap_CostsAndExpenses_019ce305-88c7-7a6b-8d2a-359a244ce4c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ce305-88c7-77fd-aec3-0211273c09c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019ce305-88c7-7506-b587-8844b2381e9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ce305-88c7-77fd-aec3-0211273c09c8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019ce305-88c7-7506-b587-8844b2381e9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ce305-88c7-7a4a-bafc-4e86a6547cab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019ce305-88c7-77fd-aec3-0211273c09c8" xlink:to="loc_us-gaap_NetIncomeLoss_019ce305-88c7-7a4a-bafc-4e86a6547cab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019ce305-88c7-7bf4-b3dc-4a2dd21bcc71" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019ce305-88c7-745e-987a-67b999048d69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ce305-88c7-7bf4-b3dc-4a2dd21bcc71" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019ce305-88c7-745e-987a-67b999048d69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019ce305-88c7-7846-9928-4c6408a56528" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ce305-88c7-7bf4-b3dc-4a2dd21bcc71" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019ce305-88c7-7846-9928-4c6408a56528" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019ce305-88c7-77ea-b3d1-df92be955057" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ce305-88c7-7bf4-b3dc-4a2dd21bcc71" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019ce305-88c7-77ea-b3d1-df92be955057" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019ce305-88c7-7dbc-b71f-aaae9cdd0d97" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019ce305-88c7-7bf4-b3dc-4a2dd21bcc71" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019ce305-88c7-7dbc-b71f-aaae9cdd0d97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ce305-88c7-7e32-8288-d0c2df6c7636" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019ce305-88c7-7493-aaa4-00ca41207685" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ce305-88c7-7e32-8288-d0c2df6c7636" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019ce305-88c7-7493-aaa4-00ca41207685" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019ce305-88c7-731e-8c08-55f6a8999eff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019ce305-88c7-7e32-8288-d0c2df6c7636" xlink:to="loc_us-gaap_OperatingIncomeLoss_019ce305-88c7-731e-8c08-55f6a8999eff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019ce305-88c7-78e8-acde-ad7d0d1b69c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019ce305-88c7-760f-9205-b8464df9db5b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019ce305-88c7-78e8-acde-ad7d0d1b69c7" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019ce305-88c7-760f-9205-b8464df9db5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019ce305-88c7-7e52-8640-1173c28d157f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019ce305-88c7-78e8-acde-ad7d0d1b69c7" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019ce305-88c7-7e52-8640-1173c28d157f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="eltx-20260331.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ce305-8980-770a-af8c-0a994ef147f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-8980-7fd3-95d7-b29ccfb852cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ce305-8980-770a-af8c-0a994ef147f4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-8980-7fd3-95d7-b29ccfb852cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-8980-78b0-9860-c18147ffe39b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ce305-8980-770a-af8c-0a994ef147f4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-8980-78b0-9860-c18147ffe39b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ce305-8980-7816-bd8c-a710b68d457b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019ce305-8980-770a-af8c-0a994ef147f4" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ce305-8980-7816-bd8c-a710b68d457b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ce305-8980-7adb-b405-452a7febeb0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ce305-8980-72a6-ae53-cc294b33bcbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ce305-8980-7adb-b405-452a7febeb0f" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019ce305-8980-72a6-ae53-cc294b33bcbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalents_019ce305-8980-7f94-8942-673e50584594" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019ce305-8980-7adb-b405-452a7febeb0f" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalents_019ce305-8980-7f94-8942-673e50584594" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019ce305-88c7-7f17-aef3-603db5dede69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_NetIncomeLoss_019ce305-88c7-7f17-aef3-603db5dede69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019ce305-88c7-7096-8a43-94d9cec2d96e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019ce305-88c7-7096-8a43-94d9cec2d96e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_InterestExpenseNoncash_019ce305-88c7-7ad7-8c48-249636e6fb3f" xlink:href="eltx-20260331.xsd#eltx_InterestExpenseNoncash"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_eltx_InterestExpenseNoncash_019ce305-88c7-7ad7-8c48-249636e6fb3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_019ce305-88c7-78f2-8f8f-94d69ebbb9db" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_019ce305-88c7-78f2-8f8f-94d69ebbb9db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019ce305-88c7-70ba-a859-454fff3a98a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019ce305-88c7-70ba-a859-454fff3a98a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019ce305-88c7-7401-89cd-bd9775bfd7b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_ShareBasedCompensation_019ce305-88c7-7401-89cd-bd9775bfd7b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019ce305-88c7-7687-8f3e-68736569f78a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019ce305-88c7-7687-8f3e-68736569f78a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019ce305-88c7-7675-b94b-b587e87b7573" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019ce305-88c7-7675-b94b-b587e87b7573" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019ce305-88c7-76cc-9ee5-3eae97f04c04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019ce305-88c7-76cc-9ee5-3eae97f04c04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_IncreaseDecreaseInAccruedExpenses_019ce305-88c7-78b8-a05f-de3e5b39c464" xlink:href="eltx-20260331.xsd#eltx_IncreaseDecreaseInAccruedExpenses"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_eltx_IncreaseDecreaseInAccruedExpenses_019ce305-88c7-78b8-a05f-de3e5b39c464" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019ce305-88c7-76b2-bcfa-ad9cc81d5634" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019ce305-88c7-76b2-bcfa-ad9cc81d5634" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019ce305-88c7-79ef-83ef-ef9410f94c5c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019ce305-88c7-79ef-83ef-ef9410f94c5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019dfd7d-9d72-7591-844f-198de0a54598" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019ce305-88c7-7751-984e-0563011895e4" xlink:to="loc_us-gaap_Depreciation_019dfd7d-9d72-7591-844f-198de0a54598" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-88c7-7b88-8084-2a929db3d997" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_ProceedsFromIssuanceOfCommonStockFromAtTheMarketOfferingsNetOfIssuanceCosts_019ce305-88c7-728f-9731-8bcbbd860148" xlink:href="eltx-20260331.xsd#eltx_ProceedsFromIssuanceOfCommonStockFromAtTheMarketOfferingsNetOfIssuanceCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-88c7-7b88-8084-2a929db3d997" xlink:to="loc_eltx_ProceedsFromIssuanceOfCommonStockFromAtTheMarketOfferingsNetOfIssuanceCosts_019ce305-88c7-728f-9731-8bcbbd860148" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_PaymentOfOfferingCostsForTheIssuanceOfCommonStockFromAtTheMarketOffering_019ce305-88c7-7c1b-a763-0fe3c144d312" xlink:href="eltx-20260331.xsd#eltx_PaymentOfOfferingCostsForTheIssuanceOfCommonStockFromAtTheMarketOffering"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-88c7-7b88-8084-2a929db3d997" xlink:to="loc_eltx_PaymentOfOfferingCostsForTheIssuanceOfCommonStockFromAtTheMarketOffering_019ce305-88c7-7c1b-a763-0fe3c144d312" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_019ce305-88c7-7741-a11b-19ab05d676fb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromWarrantExercises"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-88c7-7b88-8084-2a929db3d997" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_019ce305-88c7-7741-a11b-19ab05d676fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_019ce305-88c7-7e14-aa00-ef3211826c26" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-88c7-7b88-8084-2a929db3d997" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_019ce305-88c7-7e14-aa00-ef3211826c26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019ce305-88c7-70e8-a7a8-e14e510927cc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019ce305-88c7-7b88-8084-2a929db3d997" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019ce305-88c7-70e8-a7a8-e14e510927cc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="simple" xlink:href="eltx-20260331.xsd#FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_019ce305-8980-758a-8533-8d6ba15ac850" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_WarrantsFairValueDisclosure_019ce305-8980-7998-8f8a-c872259587c6" xlink:href="eltx-20260331.xsd#eltx_WarrantsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_019ce305-8980-758a-8533-8d6ba15ac850" xlink:to="loc_eltx_WarrantsFairValueDisclosure_019ce305-8980-7998-8f8a-c872259587c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019ce305-8980-7a43-b40f-4e59d4b9771b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019ce305-8980-70ed-ab87-0c2afffbbb5b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019ce305-8980-7a43-b40f-4e59d4b9771b" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019ce305-8980-70ed-ab87-0c2afffbbb5b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/BalanceSheetComponentsScheduleofPrepaidandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="eltx-20260331.xsd#BalanceSheetComponentsScheduleofPrepaidandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/BalanceSheetComponentsScheduleofPrepaidandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ce305-8980-74d8-b84f-d5510043f9d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_OtherPrepaidExpensesAndOtherAssetsCurrent_019ce305-8980-75ab-bc4e-42177d98eb60" xlink:href="eltx-20260331.xsd#eltx_OtherPrepaidExpensesAndOtherAssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ce305-8980-74d8-b84f-d5510043f9d4" xlink:to="loc_eltx_OtherPrepaidExpensesAndOtherAssetsCurrent_019ce305-8980-75ab-bc4e-42177d98eb60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_PrepaidResearchAndDevelopmentExpenses_019ce305-8980-7d22-ae9b-69aca280b04b" xlink:href="eltx-20260331.xsd#eltx_PrepaidResearchAndDevelopmentExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ce305-8980-74d8-b84f-d5510043f9d4" xlink:to="loc_eltx_PrepaidResearchAndDevelopmentExpenses_019ce305-8980-7d22-ae9b-69aca280b04b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_AdvancedProfessionalFees_019ce305-8980-7191-a21d-859c7f254b3e" xlink:href="eltx-20260331.xsd#eltx_AdvancedProfessionalFees"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ce305-8980-74d8-b84f-d5510043f9d4" xlink:to="loc_eltx_AdvancedProfessionalFees_019ce305-8980-7191-a21d-859c7f254b3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_019ce305-8980-78db-9e20-3c88809ad7e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019ce305-8980-74d8-b84f-d5510043f9d4" xlink:to="loc_us-gaap_PrepaidInsurance_019ce305-8980-78db-9e20-3c88809ad7e6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/BalanceSheetComponentsScheduleofPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="eltx-20260331.xsd#BalanceSheetComponentsScheduleofPropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/BalanceSheetComponentsScheduleofPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019ce305-8980-70c4-b621-c81f922bae7d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019ce305-8980-7ba3-8d46-ae6de1210599" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019ce305-8980-70c4-b621-c81f922bae7d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019ce305-8980-7ba3-8d46-ae6de1210599" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019ce305-8980-7e69-966c-2e4847f3a382" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019ce305-8980-70c4-b621-c81f922bae7d" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019ce305-8980-7e69-966c-2e4847f3a382" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/BalanceSheetComponentsScheduleofAccruedExpensesDetails" xlink:type="simple" xlink:href="eltx-20260331.xsd#BalanceSheetComponentsScheduleofAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/BalanceSheetComponentsScheduleofAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-8980-7286-8e6b-d2f4e9ed541f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_019ce305-8980-7001-80b1-906ae53b5b29" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-8980-7286-8e6b-d2f4e9ed541f" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_019ce305-8980-7001-80b1-906ae53b5b29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019ce305-8980-7c7b-8067-8bec670263e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-8980-7286-8e6b-d2f4e9ed541f" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019ce305-8980-7c7b-8067-8bec670263e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_AccruedClinicalTrialAndResearchAndDevelopmentCostsCurrent_019ce305-8980-777a-b156-41ad766282c3" xlink:href="eltx-20260331.xsd#eltx_AccruedClinicalTrialAndResearchAndDevelopmentCostsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-8980-7286-8e6b-d2f4e9ed541f" xlink:to="loc_eltx_AccruedClinicalTrialAndResearchAndDevelopmentCostsCurrent_019ce305-8980-777a-b156-41ad766282c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_AccruedInterest_019ce305-8980-7167-ac55-87342c59ddb8" xlink:href="eltx-20260331.xsd#eltx_AccruedInterest"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-8980-7286-8e6b-d2f4e9ed541f" xlink:to="loc_eltx_AccruedInterest_019ce305-8980-7167-ac55-87342c59ddb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eltx_AccruedOtherOperatingLiabilitiesCurrent_019d424a-dc72-7c19-83d3-126a99153710" xlink:href="eltx-20260331.xsd#eltx_AccruedOtherOperatingLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019ce305-8980-7286-8e6b-d2f4e9ed541f" xlink:to="loc_eltx_AccruedOtherOperatingLiabilitiesCurrent_019d424a-dc72-7c19-83d3-126a99153710" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="eltx-20260331.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-767d-9d16-497554bf9ff2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019ce305-8981-7d21-b10f-e13c1bf768b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-767d-9d16-497554bf9ff2" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019ce305-8981-7d21-b10f-e13c1bf768b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019ce305-8981-7849-8684-bb8bfc9b6855" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-767d-9d16-497554bf9ff2" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019ce305-8981-7849-8684-bb8bfc9b6855" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019ce305-8981-735c-a418-d6df91c6efe0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-767d-9d16-497554bf9ff2" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019ce305-8981-735c-a418-d6df91c6efe0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019ce305-8981-72e0-b606-3d0a41244acb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-767d-9d16-497554bf9ff2" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019ce305-8981-72e0-b606-3d0a41244acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019ce305-8981-7332-a46a-cf3794525cda" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-767d-9d16-497554bf9ff2" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019ce305-8981-7332-a46a-cf3794525cda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019ce305-8981-7812-ac4c-ca7e6680bcfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ce305-8981-7dcb-8e4e-b4a49b28bb13" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019ce305-8981-7812-ac4c-ca7e6680bcfb" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019ce305-8981-7dcb-8e4e-b4a49b28bb13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ce305-8981-7e46-96b4-3be005cabcfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019ce305-8981-7812-ac4c-ca7e6680bcfb" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019ce305-8981-7e46-96b4-3be005cabcfc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.eltx.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="eltx-20260331.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.eltx.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-7be6-8850-cf75db533a72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019ce305-8981-7c63-9194-1cbeba441a73" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-7be6-8850-cf75db533a72" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019ce305-8981-7c63-9194-1cbeba441a73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019ce305-8981-763c-a946-ec21d98c3345" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019ce305-8981-7be6-8850-cf75db533a72" xlink:to="loc_us-gaap_OperatingLeaseLiability_019ce305-8981-763c-a946-ec21d98c3345" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
