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Statement - Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 008 - Statement - Consolidated Statements of Operations and Comprehensive Income (Loss) link:calculationLink link:definitionLink link:presentationLink 009 - Statement - Consolidated Statements of Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 010 - Statement - Consolidated Statements of Stockholders' Equity (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 011 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 1 - Organization and Nature of Business 1 link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 2 - Summary of Significant Accounting Policies 1 link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 3 - Fair Value of Financial Instruments 1 link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 4 - Balance Sheet Components 1 link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 5 - Revenue 1 link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties 1 link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 7 - Leases 1 link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 8 - Commitments and Contingencies 1 link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note 9 - Stockholders' Equity 1 link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 10 - Equity Incentive Plans 1 link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note 11 - Net Income (Loss) Per Share Attributable to Common Stockholders 1 link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note 12 - Segment Reporting 1 link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note 13 - Subsequent Events 1 link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note 1 - Organization and Nature of Business link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note 2 - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note 3 - Fair Value of Financial Instruments link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note 4 - Balance Sheet Components link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note 5 - Revenue link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note 7 - Leases link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note 8 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note 9 - Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note 10 - Equity Incentive Plans link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note 11 - Benefit Plan link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note 12 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note 13 - Net Income (Loss) Per Share Attributable to Common Stockholders link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note 14 - Segment Reporting link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note 15 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note 3 - Fair Value of Financial Instruments 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note 4 - Balance Sheet Components 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 044 - Disclosure - Note 7 - Leases 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 045 - Disclosure - Note 9 - Stockholders' Equity 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 046 - Disclosure - Note 10 - Equity Incentive Plans 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 047 - Disclosure - Note 11 - Net Income (Loss) Per Share Attributable to Common Stockholders 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 048 - Disclosure - Note 12 - Segment Reporting 1 (Tables) link:calculationLink link:definitionLink link:presentationLink 049 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 050 - Disclosure - Note 3 - Fair Value of Financial Instruments (Tables) link:calculationLink link:definitionLink link:presentationLink 051 - Disclosure - Note 4 - Balance Sheet Components (Tables) link:calculationLink link:definitionLink link:presentationLink 052 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties (Tables) link:calculationLink link:definitionLink link:presentationLink 053 - Disclosure - Note 7 - Leases (Tables) link:calculationLink link:definitionLink link:presentationLink 054 - Disclosure - Note 9 - Stockholders' Equity (Tables) link:calculationLink link:definitionLink link:presentationLink 055 - Disclosure - Note 10 - Equity Incentive Plans (Tables) link:calculationLink link:definitionLink link:presentationLink 056 - Disclosure - Note 12 - Income Taxes (Tables) link:calculationLink link:definitionLink link:presentationLink 057 - Disclosure - Note 13 - Net Income (Loss) Per Share Attributable to Common Stockholders (Tables) link:calculationLink link:definitionLink link:presentationLink 058 - Disclosure - Note 14 - Segment Reporting (Tables) link:calculationLink link:definitionLink link:presentationLink 059 - Disclosure - Note 1 - Organization and Nature of Business 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 060 - Disclosure - Note 2 - Summary of Significant Accounting Policies 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 061 - Disclosure - Note 3 - Fair Value of Financial Instruments 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 062 - Disclosure - Note 3 - Fair Value of Financial Instruments - Financial Assets Measured on a Recurring Basis 1 (Details) link:calculationLink link:definitionLink link:presentationLink 063 - Disclosure - Note 4 - Balance Sheet Components 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 064 - Disclosure - Note 4 - Balance Sheet Components - Cash and Cash Equivalents and Investments 1 (Details) link:calculationLink link:definitionLink link:presentationLink 065 - Disclosure - Note 4 - Balance Sheet Components - Prepaid Expenses and Other Current Assets 1 (Details) link:calculationLink link:definitionLink link:presentationLink 066 - Disclosure - Note 4 - Balance Sheet Components - Property and Equipment, Net 1 (Details) link:calculationLink link:definitionLink link:presentationLink 067 - Disclosure - Note 4 - Balance Sheet Components - Intangible Assets 1 (Details) link:calculationLink link:definitionLink link:presentationLink 068 - Disclosure - Note 4 - Balance Sheet Components - Estimated Future Amortization Expense 1 (Details) link:calculationLink link:definitionLink link:presentationLink 069 - Disclosure - Note 4 - Balance Sheet Components - Deferred Revenue, by Arrangement, Disclosure 1 (Details) link:calculationLink link:definitionLink link:presentationLink 070 - Disclosure - Note 4 - Balance Sheet Components - Accrued Liabilities 1 (Details) link:calculationLink link:definitionLink link:presentationLink 071 - Disclosure - Note 5 - Revenue 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 072 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 073 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties - Deferred Revenue Activity 1 (Details) link:calculationLink link:definitionLink link:presentationLink 074 - Disclosure - Note 7 - Leases 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 075 - Disclosure - Note 7 - Leases - Lease Liabilities Payment Obligations 1 (Details) link:calculationLink link:definitionLink link:presentationLink 076 - Disclosure - Note 7 - Leases - Operating Lease Expenses 1 (Details) link:calculationLink link:definitionLink link:presentationLink 077 - Disclosure - Note 8 - Commitments and Contingencies 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 078 - Disclosure - Note 9 - Stockholders' Equity 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 079 - Disclosure - Note 9 - Stockholders' Equity - Shares of Common Stock Reserved for Issuance 1 (Details) link:calculationLink link:definitionLink link:presentationLink 080 - Disclosure - Note 9 - Stockholders' Equity - Summary of Warrants Outstanding 1 (Details) link:calculationLink link:definitionLink link:presentationLink 081 - Disclosure - Note 10 - Equity Incentive Plans 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 082 - Disclosure - Note 10 - Equity Incentive Plans - Summary of Stock Option Transactions 1 (Details) link:calculationLink link:definitionLink link:presentationLink 083 - Disclosure - Note 10 - Equity Incentive Plans - Assumptions of Options 1 (Details) link:calculationLink link:definitionLink link:presentationLink 084 - Disclosure - Note 10 - Equity Incentive Plans - Total Stock-based Compensation Recognized for Options 1 (Details) link:calculationLink link:definitionLink link:presentationLink 085 - Disclosure - Note 11 - Net Income (Loss) Per Share Attributable to Common Stockholders 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 086 - Disclosure - Note 11 - Net Income (Loss) Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net (Loss) Income Per Share 1 (Details) link:calculationLink link:definitionLink link:presentationLink 087 - Disclosure - Note 11 - Net Income (Loss) Per Share Attributable to Common Stockholders - Summary of Antidilutive Securities 1 (Details) link:calculationLink link:definitionLink link:presentationLink 088 - Disclosure - Note 12 - Segment Reporting 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 089 - Disclosure - Note 12 - Segment Reporting - Schedule of Segment Reporting Information, by Segment 1 (Details) link:calculationLink link:definitionLink link:presentationLink 090 - Disclosure - Note 13 - Subsequent Events 1 (Details Textual) link:calculationLink link:definitionLink link:presentationLink 091 - Disclosure - Note 1 - Organization and Nature of Business (Details Textual) link:calculationLink link:definitionLink link:presentationLink 092 - Disclosure - Note 2 - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 093 - Disclosure - Note 2 - Summary of Significant Accounting Policies - Estimated Useful Lives (Details) link:calculationLink link:definitionLink link:presentationLink 094 - Disclosure - Note 3 - Fair Value of Financial Instruments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 095 - Disclosure - Note 3 - Fair Value of Financial Instruments - Financial Assets Measured on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 096 - Disclosure - Note 4 - Balance Sheet Components (Details Textual) link:calculationLink link:definitionLink link:presentationLink 097 - Disclosure - Note 4 - Balance Sheet Components - Cash and Cash Equivalents and Investments (Details) link:calculationLink link:definitionLink link:presentationLink 098 - Disclosure - Note 4 - Balance Sheet Components - 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Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties (Details Textual) link:calculationLink link:definitionLink link:presentationLink 106 - Disclosure - Note 6 - Liabilities Related to Sale of Future Royalties - Deferred Revenue Activity (Details) link:calculationLink link:definitionLink link:presentationLink 107 - Disclosure - Note 7 - Leases (Details Textual) link:calculationLink link:definitionLink link:presentationLink 108 - Disclosure - Note 7 - Leases - Lease Liabilities Payment Obligations (Details) link:calculationLink link:definitionLink link:presentationLink 109 - Disclosure - Note 7 - Leases - Operating Lease Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 110 - Disclosure - Note 8 - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 111 - Disclosure - Note 9 - Stockholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 112 - Disclosure - Note 9 - Stockholders' Equity - Shares of Common Stock Reserved for Issuance (Details) link:calculationLink link:definitionLink link:presentationLink 113 - Disclosure - Note 9 - Stockholders' Equity - Summary of Warrants Outstanding (Details) link:calculationLink link:definitionLink link:presentationLink 114 - Disclosure - Note 10 - Equity Incentive Plans (Details Textual) link:calculationLink link:definitionLink link:presentationLink 115 - Disclosure - Note 10 - Equity Incentive Plans - Summary of Stock Option Transactions (Details) link:calculationLink link:definitionLink link:presentationLink 116 - Disclosure - Note 10 - Equity Incentive Plans - Assumptions of Options (Details) link:calculationLink link:definitionLink link:presentationLink 117 - Disclosure - Note 10 - Equity Incentive Plans - Total Stock-based Compensation Recognized for Options (Details) link:calculationLink link:definitionLink link:presentationLink 118 - Disclosure - Note 11 - Benefit Plan (Details Textual) link:calculationLink link:definitionLink link:presentationLink 119 - Disclosure - Note 12 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 120 - Disclosure - Note 12 - Income Taxes - Schedule of Income Before Income Tax (Details) link:calculationLink link:definitionLink link:presentationLink 121 - Disclosure - Note 12 - Income Taxes - Components of Income Tax Expense (Details) link:calculationLink link:definitionLink link:presentationLink 122 - Disclosure - Note 12 - Income Taxes - Components of Deferred Tax Assets (Details) link:calculationLink link:definitionLink link:presentationLink 123 - Disclosure - Note 12 - Income Taxes - Reconciliation of Effective Tax Rate (Details) link:calculationLink link:definitionLink link:presentationLink 124 - Disclosure - Note 12 - Income Taxes - Income Taxes Paid (Details) link:calculationLink link:definitionLink link:presentationLink 125 - Disclosure - Note 12 - Income Taxes - Schedule of State and Local Income Tax (Details) link:calculationLink link:definitionLink link:presentationLink 126 - Disclosure - Note 12 - Income Taxes - Unrecognized Tax Benefits (Details) link:calculationLink link:definitionLink link:presentationLink 127 - Disclosure - Note 13 - Net Loss Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net (Loss) Income Per Share (Details) link:calculationLink link:definitionLink link:presentationLink 128 - Disclosure - Note 13 - Net Loss Per Share Attributable to Common Stockholders - Summary of Antidilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 129 - Disclosure - Note 14 - Segment Reporting (Details Textual) link:calculationLink link:definitionLink link:presentationLink 130 - Disclosure - Note 14 - Segment Reporting - Schedule of Segment Reporting Information, by Segment (Details) link:calculationLink link:definitionLink link:presentationLink 131 - Disclosure - Note 15 - Subsequent Events (Details Textual) link:calculationLink link:definitionLink link:presentationLink