v3.26.1
Note 12 - Income Taxes (Tables)
12 Months Ended
Dec. 31, 2025
Notes Tables  
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
  

Year Ended December 31,

 
  

2025

  

2024

 
         

United States

 $14,703  $(67,489)

Foreign

  2,100   801 
         

Total worldwide pretax earnings

 $16,803  $(66,688)
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
  

Year Ended December 31,

 
  

2025

  

2024

 
         

Current:

        

Federal

 $  $ 

State

  3   3 

Foreign

  473   257 
         

Total Current

  476   260 
         

Deferred:

        

Federal

      

State

      

Foreign

      
         

Total Deferred

      
         

Provision for income taxes

 $476  $260 
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
  

December 31, 2025

  

December 31, 2024

 

Deferred tax assets:

        

Net operating loss carry-forwards

 $54,574  $48,154 

Research and development tax credits

  20,387   12,949 

Capitalized research and development

  18,283   27,892 

Sale of future royalties

  1,608   1,179 

Lease liability

  2,068   3,682 

Accruals, reserves and other

  1,203   1,790 

Stock based compensation

  6,757   4,886 

Total deferred tax assets

  104,880   100,532 

Valuation allowance

  (100,494)  (94,119)

Deferred tax assets net of valuation allowance

  4,386   6,413 

Deferred tax liabilities:

        

Intangible assets

  (1,755)  (1,999)

Right-of-use assets

  (2,631)  (4,309)

Depreciation on property and equipment

     (105)

Total deferred tax liabilities

  (4,386)  (6,413)
         

Net deferred tax assets

 $  $ 
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
  

Year Ended December 31,

  

Year Ended December 31,

 
  

2025

  

2024

 
  

$   

  %    % 
             

U.S. federal taxes at statutory rate

 $3,528   21.0%  21.0% 

State taxes (net of federal benefit)

  3      0.1 

Foreign

  473   2.8    

Foreign rate differential

        (0.7) 

Other nondeductible items

  (76)  (0.5)  (0.1) 

Tax credits

  (11,442)  (68.1)  4.2 

Change in valuation allowance

  2,960   17.6   (17.4) 

Changes in unrecognized tax benefits

  4,577   27.2    

Prior year true-up

        (5.5) 

Stock-based compensation

  453   2.7   (2.0) 
             

Provision for income taxes

 $476   2.8%  (0.4)% 
Schedule of Income Taxes Paid [Table Text Block]
  

Year Ended December 31,

 
  

2025

 
     

Federal

 $ 

State and Local

    

California Extension

  1,600 

Massachusetts Extension

  1,000 

New York Refund

  (75)

Total State and Local

  2,525 
     

Foreign

    

Withholding Tax on Daiichi Royalty

  96,464 

Total Foreign

  96,464 
     

Total Taxes Paid

 $98,989 
Schedule of Income Tax by State [Table Text Block]
  

Year Ended December 31,

 
  

2025

 
         

California

 $1,600   63.4%
         

Total

 $1,600   63.4%
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
  

Year Ended December 31,

 
  

2025

  

2024

 
         

Beginning Balance

 $8,537  $6,566 

Additions based on tax positions related to the current year

  5,061   1,977 

Decreases related to prior years’ tax positions

     (6)
         

Ending Balance

 $13,598  $8,537