Note 12 - Income Taxes (Tables)
|
12 Months Ended |
Dec. 31, 2025 |
| Notes Tables |
|
| Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] |
| | | Year Ended December 31, | |
| | | 2025 | | | 2024 | |
| | | | | | | | | |
| United States | | $ | 14,703 | | | $ | (67,489 | ) |
| Foreign | | | 2,100 | | | | 801 | |
| | | | | | | | | |
| Total worldwide pretax earnings | | $ | 16,803 | | | $ | (66,688 | ) |
|
| Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] |
| | | Year Ended December 31, | |
| | | 2025 | | | 2024 | |
| | | | | | | | | |
| Current: | | | | | | | | |
| Federal | | $ | — | | | $ | — | |
| State | | | 3 | | | | 3 | |
| Foreign | | | 473 | | | | 257 | |
| | | | | | | | | |
| Total Current | | | 476 | | | | 260 | |
| | | | | | | | | |
| Deferred: | | | | | | | | |
| Federal | | | — | | | | — | |
| State | | | — | | | | — | |
| Foreign | | | — | | | | — | |
| | | | | | | | | |
| Total Deferred | | | — | | | | — | |
| | | | | | | | | |
| Provision for income taxes | | $ | 476 | | | $ | 260 | |
|
| Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
| | | December 31, 2025 | | | December 31, 2024 | |
| Deferred tax assets: | | | | | | | | |
| Net operating loss carry-forwards | | $ | 54,574 | | | $ | 48,154 | |
| Research and development tax credits | | | 20,387 | | | | 12,949 | |
| Capitalized research and development | | | 18,283 | | | | 27,892 | |
| Sale of future royalties | | | 1,608 | | | | 1,179 | |
| Lease liability | | | 2,068 | | | | 3,682 | |
| Accruals, reserves and other | | | 1,203 | | | | 1,790 | |
| Stock based compensation | | | 6,757 | | | | 4,886 | |
| Total deferred tax assets | | | 104,880 | | | | 100,532 | |
| Valuation allowance | | | (100,494 | ) | | | (94,119 | ) |
| Deferred tax assets net of valuation allowance | | | 4,386 | | | | 6,413 | |
| Deferred tax liabilities: | | | | | | | | |
| Intangible assets | | | (1,755 | ) | | | (1,999 | ) |
| Right-of-use assets | | | (2,631 | ) | | | (4,309 | ) |
| Depreciation on property and equipment | | | — | | | | (105 | ) |
| Total deferred tax liabilities | | | (4,386 | ) | | | (6,413 | ) |
| | | | | | | | | |
| Net deferred tax assets | | $ | — | | | $ | — | |
|
| Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
| | | Year Ended December 31, | | | Year Ended December 31, | |
| | | 2025 | | | 2024 | |
| | | $ | | | % | | | % | |
| | | | | | | | | | | | | |
| U.S. federal taxes at statutory rate | | $ | 3,528 | | | | 21.0 | % | | | 21.0% | |
| State taxes (net of federal benefit) | | | 3 | | | | — | | | | 0.1 | |
| Foreign | | | 473 | | | | 2.8 | | | | — | |
| Foreign rate differential | | | — | | | | — | | | | (0.7) | |
| Other nondeductible items | | | (76 | ) | | | (0.5 | ) | | | (0.1) | |
| Tax credits | | | (11,442 | ) | | | (68.1 | ) | | | 4.2 | |
| Change in valuation allowance | | | 2,960 | | | | 17.6 | | | | (17.4) | |
| Changes in unrecognized tax benefits | | | 4,577 | | | | 27.2 | | | | — | |
| Prior year true-up | | | — | | | | — | | | | (5.5) | |
| Stock-based compensation | | | 453 | | | | 2.7 | | | | (2.0) | |
| | | | | | | | | | | | | |
| Provision for income taxes | | $ | 476 | | | | 2.8 | % | | | (0.4)% | |
|
| Schedule of Income Taxes Paid [Table Text Block] |
| | | Year Ended December 31, | |
| | | 2025 | |
| | | | | |
| Federal | | $ | — | |
| State and Local | | | | |
| California Extension | | | 1,600 | |
| Massachusetts Extension | | | 1,000 | |
| New York Refund | | | (75 | ) |
| Total State and Local | | | 2,525 | |
| | | | | |
| Foreign | | | | |
| Withholding Tax on Daiichi Royalty | | | 96,464 | |
| Total Foreign | | | 96,464 | |
| | | | | |
| Total Taxes Paid | | $ | 98,989 | |
|
| Schedule of Income Tax by State [Table Text Block] |
| | | Year Ended December 31, | |
| | | 2025 | |
| | | | | | | | | |
| California | | $ | 1,600 | | | | 63.4 | % |
| | | | | | | | | |
| Total | | $ | 1,600 | | | | 63.4 | % |
|
| Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
| | | Year Ended December 31, | |
| | | 2025 | | | 2024 | |
| | | | | | | | | |
| Beginning Balance | | $ | 8,537 | | | $ | 6,566 | |
| Additions based on tax positions related to the current year | | | 5,061 | | | | 1,977 | |
| Decreases related to prior years’ tax positions | | | — | | | | (6 | ) |
| | | | | | | | | |
| Ending Balance | | $ | 13,598 | | | $ | 8,537 | |
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