S-8 S-8 EX-FILING FEES 0000879407 ARROWHEAD PHARMACEUTICALS, INC. N/A Fees to be Paid Fees to be Paid 0000879407 2026-05-05 2026-05-05 0000879407 1 2026-05-05 2026-05-05 0000879407 2 2026-05-05 2026-05-05 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-8

ARROWHEAD PHARMACEUTICALS, INC.

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

1 Equity Common stock, par value $0.001 per share ("Common Stock") to be issued under the Arrowhead Pharmaceuticals, Inc. Amended and Restated 2021 Incentive Plan (the "2021 Plan") 457(a) 10,500,000 $ 74.38 $ 780,990,000.00 0.0001381 $ 107,854.72
2 Equity Common Stock to be issued under the Arrowhead Pharmaceuticals, Inc. Amended and Restated Inducement Plan (the "Inducement Plan") 457(a) 2,167,050 $ 74.38 $ 161,185,179.00 0.0001381 $ 22,259.67

Total Offering Amounts:

$ 942,175,179.00

$ 130,114.39

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 130,114.39

Offering Note

1

Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this registration statement also covers any additional shares of Common Stock that become issuable by reason of any stock split, stock dividend or similar transaction effected without the receipt of consideration which results in an increase in the number of the registrant's outstanding shares of Common Stock. The "Amount Registered" represents shares of Common Stock issuable under the 2021 Plan. The "Proposed Maximum Offering Price Per Unit" and the "Maximum Aggregate Offering Price" are estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, and are based on the average of the high and low sale prices of the registrant's Common Stock as reported on the Nasdaq Global Select Market on May 1, 2026.

2

Pursuant to Rule 416 under the Securities Act, this registration statement also covers any additional shares of Common Stock that become issuable by reason of any stock split, stock dividend or similar transaction effected without the receipt of consideration which results in an increase in the number of the registrant's outstanding shares of Common Stock. The "Amount Registered" represents shares of Common Stock issuable under the Inducement Plan. The "Proposed Maximum Offering Price Per Unit" and the "Maximum Aggregate Offering Price" are estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(c) and Rule 457(h) under the Securities Act, and are based on the average of the high and low sale prices of the registrant's Common Stock as reported on the Nasdaq Global Select Market on May 1, 2026.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rule 457(p)
Fee Offset Claims
Fee Offset Sources