<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019dfee7-653d-70fd-8780-e644cdd106b7,g:9e5fb551-be76-42bc-90a2-8dc755788933-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://rockwellmed.com/role/Cover" xlink:type="simple" xlink:href="rmti-20260507.xsd#Cover"/>
  <link:presentationLink xlink:role="http://rockwellmed.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019dfee7-653d-7348-bf93-9afaecd4b7f5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_DocumentType_019dfee7-653d-7348-bf93-9afaecd4b7f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019dfee7-653d-7014-8065-c45028fb62d8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityRegistrantName_019dfee7-653d-7014-8065-c45028fb62d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019dfee7-653d-713c-99b1-67041fe6e10d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019dfee7-653d-713c-99b1-67041fe6e10d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019dfee7-653d-7b23-a672-50ac02465b3e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityFileNumber_019dfee7-653d-7b23-a672-50ac02465b3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019dfee7-653d-7e81-936e-fc9781b43985" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityTaxIdentificationNumber_019dfee7-653d-7e81-936e-fc9781b43985" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019dfee7-653d-79de-b4a0-62c5615e4af5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityAddressAddressLine1_019dfee7-653d-79de-b4a0-62c5615e4af5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019dfee7-653d-76d8-9d94-5d11e78d5e4d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityAddressCityOrTown_019dfee7-653d-76d8-9d94-5d11e78d5e4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019dfee7-653d-7b11-8d5f-e8240432755d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityAddressStateOrProvince_019dfee7-653d-7b11-8d5f-e8240432755d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019dfee7-653d-7f55-98f2-73932c6ce099" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityAddressPostalZipCode_019dfee7-653d-7f55-98f2-73932c6ce099" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019dfee7-653d-7afa-b4e6-494a986864b0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_CityAreaCode_019dfee7-653d-7afa-b4e6-494a986864b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019dfee7-653d-7191-9e0e-dfe8c20ef3a2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_LocalPhoneNumber_019dfee7-653d-7191-9e0e-dfe8c20ef3a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019dfee7-653d-7e8a-8fda-0ca25b0b5236" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_WrittenCommunications_019dfee7-653d-7e8a-8fda-0ca25b0b5236" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019dfee7-653d-77c6-a7e0-da14233424ef" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_SolicitingMaterial_019dfee7-653d-77c6-a7e0-da14233424ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019dfee7-653d-77c7-b032-4d9fd4496bb8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_PreCommencementTenderOffer_019dfee7-653d-77c7-b032-4d9fd4496bb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019dfee7-653d-7593-842d-4da60d0e8201" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019dfee7-653d-7593-842d-4da60d0e8201" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019dfee7-653d-7d07-ad7c-c4d6791a8feb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_Security12bTitle_019dfee7-653d-7d07-ad7c-c4d6791a8feb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019dfee7-653d-7264-8480-95caf21446c2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_TradingSymbol_019dfee7-653d-7264-8480-95caf21446c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019dfee7-653d-7be9-8a64-346a809f70e1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_SecurityExchangeName_019dfee7-653d-7be9-8a64-346a809f70e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019dfee7-653d-7def-a7ad-e69361f1b812" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityEmergingGrowthCompany_019dfee7-653d-7def-a7ad-e69361f1b812" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019dfee7-653d-76d3-adf1-0d58e3c81074" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_EntityCentralIndexKey_019dfee7-653d-76d3-adf1-0d58e3c81074" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019dfee7-653d-79d4-92fc-7e628390c15e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_AmendmentFlag_019dfee7-653d-79d4-92fc-7e628390c15e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019dfee7-653d-7d48-883d-4a7fac08dcd9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019dfee7-653d-7e88-8487-905e1f02c2fe" xlink:to="loc_dei_DocumentPeriodEndDate_019dfee7-653d-7d48-883d-4a7fac08dcd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
