<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created with Toppan Merrill Bridge  11.3.0.1 -->
<!--Based on XBRL 2.1-->
<!--Created on: 5/7/2026 1:41:37 AM-->
<!--Modified on: 5/7/2026 1:41:37 AM-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#StatementCondensedConsolidatedBalanceSheets" roleURI="http://www.theravance.com/role/StatementCondensedConsolidatedBalanceSheets" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#StatementCondensedConsolidatedStatementsOfOperations" roleURI="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfOperations" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#StatementCondensedConsolidatedStatementsOfOperationsRestructuringExpenses" roleURI="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfOperationsRestructuringExpenses" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#StatementCondensedConsolidatedStatementsOfComprehensiveIncomeLoss" roleURI="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfComprehensiveIncomeLoss" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#StatementCondensedConsolidatedStatementsOfCashFlows" roleURI="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureNetLossPerShareIncomeLossPerShareDetails" roleURI="http://www.theravance.com/role/DisclosureNetLossPerShareIncomeLossPerShareDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureRevenueCollaborativeArrangementsGeneralInformationDetails" roleURI="http://www.theravance.com/role/DisclosureRevenueCollaborativeArrangementsGeneralInformationDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureSegmentInformationTabularDisclosureDetails" roleURI="http://www.theravance.com/role/DisclosureSegmentInformationTabularDisclosureDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureCashCashEquivalentsAndRestrictedCashDetails" roleURI="http://www.theravance.com/role/DisclosureCashCashEquivalentsAndRestrictedCashDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureInvestmentsAndFairValueMeasurementsFairValueToAmortizedCostAvailableForSaleSecuritiesDetails" roleURI="http://www.theravance.com/role/DisclosureInvestmentsAndFairValueMeasurementsFairValueToAmortizedCostAvailableForSaleSecuritiesDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureInvestmentsAndFairValueMeasurementsFairValueToAmortizedCostTotalDetails" roleURI="http://www.theravance.com/role/DisclosureInvestmentsAndFairValueMeasurementsFairValueToAmortizedCostTotalDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureInvestmentsAndFairValueMeasurementsUnrealizedLossPositionDetails" roleURI="http://www.theravance.com/role/DisclosureInvestmentsAndFairValueMeasurementsUnrealizedLossPositionDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <roleRef xlink:type="simple" xlink:href="tbph-20260331.xsd#DisclosureShareBasedCompensationOrganizationalRestructuringDetails" roleURI="http://www.theravance.com/role/DisclosureShareBasedCompensationOrganizationalRestructuringDetails" xmlns="http://www.xbrl.org/2003/linkbase" />
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item" />
  <calculationLink xlink:role="http://www.theravance.com/role/StatementCondensedConsolidatedBalanceSheets" xlink:type="extended" xlink:title="00100 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_AssetsCurrent_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639137148963714130" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639137148963714130" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_ReceivablesFromCollaborationPartners" xlink:label="tbph_ReceivablesFromCollaborationPartners_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639137148963714130" xlink:to="tbph_ReceivablesFromCollaborationPartners_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_ReceivablesFromMilestoneAndRoyaltyAssetsCurrent" xlink:label="tbph_ReceivablesFromMilestoneAndRoyaltyAssetsCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639137148963714130" xlink:to="tbph_ReceivablesFromMilestoneAndRoyaltyAssetsCurrent_639137148963714130" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherPrepaidExpenseCurrent" xlink:label="us-gaap_OtherPrepaidExpenseCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_AssetsCurrent_639137148963714130" xlink:to="us-gaap_OtherPrepaidExpenseCurrent_639137148963714130" order="5" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_PropertyPlantAndEquipmentNet_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="us-gaap_OperatingLeaseRightOfUseAsset_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_OperatingLeaseRightOfUseAsset_639137148963714130" order="4" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashNoncurrent" xlink:label="us-gaap_RestrictedCashNoncurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_RestrictedCashNoncurrent_639137148963714130" order="5" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="us-gaap_OtherAssetsNoncurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_Assets" xlink:to="us-gaap_OtherAssetsNoncurrent_639137148963714130" order="6" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent" xlink:label="us-gaap_LiabilitiesCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_LiabilitiesCurrent_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent" xlink:label="us-gaap_AccountsPayableCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639137148963714130" xlink:to="us-gaap_AccountsPayableCurrent_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="us-gaap_EmployeeRelatedLiabilitiesCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639137148963714130" xlink:to="us-gaap_EmployeeRelatedLiabilitiesCurrent_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_AccruedClinicalAndDevelopmentExpensesCurrent" xlink:label="tbph_AccruedClinicalAndDevelopmentExpensesCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639137148963714130" xlink:to="tbph_AccruedClinicalAndDevelopmentExpensesCurrent_639137148963714130" order="3" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="us-gaap_OtherAccruedLiabilitiesCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639137148963714130" xlink:to="us-gaap_OtherAccruedLiabilitiesCurrent_639137148963714130" order="4" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_AccruedGeneralAndAdministrativeExpenses" xlink:label="tbph_AccruedGeneralAndAdministrativeExpenses_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639137148963714130" xlink:to="tbph_AccruedGeneralAndAdministrativeExpenses_639137148963714130" order="5" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="us-gaap_OperatingLeaseLiabilityCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639137148963714130" xlink:to="us-gaap_OperatingLeaseLiabilityCurrent_639137148963714130" order="6" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedIncomeTaxesCurrent" xlink:label="us-gaap_AccruedIncomeTaxesCurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesCurrent_639137148963714130" xlink:to="us-gaap_AccruedIncomeTaxesCurrent_639137148963714130" order="7" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent" xlink:label="us-gaap_OperatingLeaseLiabilityNoncurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_OperatingLeaseLiabilityNoncurrent_639137148963714130" order="2" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_FutureRoyaltyPaymentContingencies" xlink:label="tbph_FutureRoyaltyPaymentContingencies_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="tbph_FutureRoyaltyPaymentContingencies_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_UnrecognizedTaxBenefitsNoncurrent" xlink:label="tbph_UnrecognizedTaxBenefitsNoncurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="tbph_UnrecognizedTaxBenefitsNoncurrent_639137148963714130" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="us-gaap_OtherLiabilitiesNoncurrent_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_OtherLiabilitiesNoncurrent_639137148963714130" order="5" use="optional" weight="1" priority="2" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity" xlink:label="us-gaap_StockholdersEquity_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_StockholdersEquity_639137148963714130" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue" xlink:label="us-gaap_PreferredStockValue_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639137148963714130" xlink:to="us-gaap_PreferredStockValue_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue" xlink:label="us-gaap_CommonStockValue_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639137148963714130" xlink:to="us-gaap_CommonStockValue_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="us-gaap_AdditionalPaidInCapital_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639137148963714130" xlink:to="us-gaap_AdditionalPaidInCapital_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639137148963714130" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_639137148963714130" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_StockholdersEquity_639137148963714130" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit_639137148963714130" order="5" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfOperations" xlink:type="extended" xlink:title="00200 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_1" xlink:to="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss" xlink:label="us-gaap_OperatingIncomeLoss_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_639137148963714130" xlink:to="us-gaap_OperatingIncomeLoss_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingIncomeLoss_639137148963714130" xlink:to="us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses" xlink:label="us-gaap_OperatingExpenses_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingIncomeLoss_639137148963714130" xlink:to="us-gaap_OperatingExpenses_639137148963714130" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="us-gaap_ResearchAndDevelopmentExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_639137148963714130" xlink:to="us-gaap_ResearchAndDevelopmentExpense_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="us-gaap_SellingGeneralAndAdministrativeExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_639137148963714130" xlink:to="us-gaap_SellingGeneralAndAdministrativeExpense_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_RestructuringAndRelatedExpenses" xlink:label="tbph_RestructuringAndRelatedExpenses_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_639137148963714130" xlink:to="tbph_RestructuringAndRelatedExpenses_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating" xlink:label="us-gaap_InterestExpenseNonoperating_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_639137148963714130" xlink:to="us-gaap_InterestExpenseNonoperating_639137148963714130" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="us-gaap_OtherNonoperatingIncomeExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_639137148963714130" xlink:to="us-gaap_OtherNonoperatingIncomeExpense_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="us-gaap_IncomeTaxExpenseBenefit_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_1" xlink:to="us-gaap_IncomeTaxExpenseBenefit_639137148963714130" order="2" use="optional" weight="-1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfOperationsRestructuringExpenses" xlink:type="extended" xlink:title="00210 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - Restructuring Expenses" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_RestructuringAndRelatedExpenses" xlink:label="tbph_RestructuringAndRelatedExpenses_1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestructuringCharges" xlink:label="us-gaap_RestructuringCharges_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RestructuringAndRelatedExpenses_1" xlink:to="us-gaap_RestructuringCharges_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_RestructuringChargesNoncashRelatedExpenses" xlink:label="tbph_RestructuringChargesNoncashRelatedExpenses_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RestructuringAndRelatedExpenses_1" xlink:to="tbph_RestructuringChargesNoncashRelatedExpenses_639137148963714130" order="2" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfComprehensiveIncomeLoss" xlink:type="extended" xlink:title="00300 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="us-gaap_ComprehensiveIncomeNetOfTax" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="us-gaap_NetIncomeLoss_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_639137148963714130" order="2" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" xlink:type="extended" xlink:title="00500 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInFinancingActivities_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="us-gaap_ProceedsFromIssuanceOfCommonStock_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_639137148963714130" xlink:to="us-gaap_ProceedsFromIssuanceOfCommonStock_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="us-gaap_ProceedsFromStockOptionsExercised_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_639137148963714130" xlink:to="us-gaap_ProceedsFromStockOptionsExercised_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities_639137148963714130" xlink:to="us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_639137148963714130" order="3" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInInvestingActivities_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities" xlink:label="us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities_639137148963714130" xlink:to="us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt" xlink:label="us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities_639137148963714130" xlink:to="us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_639137148963714130" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProfitLoss" xlink:label="us-gaap_ProfitLoss_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_ProfitLoss_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherDepreciationAndAmortization" xlink:label="us-gaap_OtherDepreciationAndAmortization_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_OtherDepreciationAndAmortization_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_AmortizationAndAccretionIncome" xlink:label="tbph_AmortizationAndAccretionIncome_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="tbph_AmortizationAndAccretionIncome_639137148963714130" order="3" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_InterestAccretionOnFutureRoyaltyPaymentContingencies" xlink:label="tbph_InterestAccretionOnFutureRoyaltyPaymentContingencies_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="tbph_InterestAccretionOnFutureRoyaltyPaymentContingencies_639137148963714130" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation" xlink:label="us-gaap_ShareBasedCompensation_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_ShareBasedCompensation_639137148963714130" order="5" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense" xlink:label="us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_639137148963714130" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits" xlink:label="us-gaap_DeferredIncomeTaxesAndTaxCredits_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_DeferredIncomeTaxesAndTaxCredits_639137148963714130" order="7" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoncashIncomeExpense" xlink:label="us-gaap_OtherNoncashIncomeExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_OtherNoncashIncomeExpense_639137148963714130" order="8" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_IncreaseDecreaseInReceivablesFromCollaborationPartners" xlink:label="tbph_IncreaseDecreaseInReceivablesFromCollaborationPartners_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="tbph_IncreaseDecreaseInReceivablesFromCollaborationPartners_639137148963714130" order="9" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_IncreaseDecreaseInReceivablesForMilestonePayments" xlink:label="tbph_IncreaseDecreaseInReceivablesForMilestonePayments_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="tbph_IncreaseDecreaseInReceivablesForMilestonePayments_639137148963714130" order="10" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_IncreaseDecreaseInPrepaidClinicalAndDevelopmentServices" xlink:label="tbph_IncreaseDecreaseInPrepaidClinicalAndDevelopmentServices_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="tbph_IncreaseDecreaseInPrepaidClinicalAndDevelopmentServices_639137148963714130" order="11" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidExpensesOther" xlink:label="us-gaap_IncreaseDecreaseInPrepaidExpensesOther_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_IncreaseDecreaseInPrepaidExpensesOther_639137148963714130" order="12" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_IncreaseDecreaseInRightOfUseAssets" xlink:label="tbph_IncreaseDecreaseInRightOfUseAssets_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="tbph_IncreaseDecreaseInRightOfUseAssets_639137148963714130" order="13" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="us-gaap_IncreaseDecreaseInOtherOperatingAssets_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_IncreaseDecreaseInOtherOperatingAssets_639137148963714130" order="14" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_IncreaseDecreaseInAccountsPayable_639137148963714130" order="15" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilities_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_IncreaseDecreaseInAccruedLiabilities_639137148963714130" order="16" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability" xlink:label="us-gaap_IncreaseDecreaseInOperatingLeaseLiability_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_IncreaseDecreaseInOperatingLeaseLiability_639137148963714130" order="17" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_PeriodIncreaseDecreaseUnrecognizedTaxBenefits" xlink:label="tbph_PeriodIncreaseDecreaseUnrecognizedTaxBenefits_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="tbph_PeriodIncreaseDecreaseUnrecognizedTaxBenefits_639137148963714130" order="18" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities" xlink:label="us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities_639137148963714130" xlink:to="us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_639137148963714130" order="19" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureNetLossPerShareIncomeLossPerShareDetails" xlink:type="extended" xlink:title="40201 - Disclosure - Net Loss per Share - Income (Loss) Per Share (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted" xlink:to="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_639137148963714130" xlink:to="us-gaap_NetIncomeLoss_639137148963714130" order="1" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureRevenueCollaborativeArrangementsGeneralInformationDetails" xlink:type="extended" xlink:title="40301 - Disclosure - Revenue - Collaborative Arrangements - General Information (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotential" xlink:label="tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotential" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotentialMonotherapy" xlink:label="tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotentialMonotherapy_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotential" xlink:to="tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotentialMonotherapy_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotentialFuturePotentialCombinationProducts" xlink:label="tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotentialFuturePotentialCombinationProducts_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotential" xlink:to="tbph_CollaborativeArrangementMilestonesGlobalSalesAndRegulatoryMilestoneReceivableMaximumPotentialFuturePotentialCombinationProducts_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotential" xlink:label="tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotential" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotentialMonotherapy" xlink:label="tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotentialMonotherapy_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotential" xlink:to="tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotentialMonotherapy_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotentialFuturePotentialCombinationProducts" xlink:label="tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotentialFuturePotentialCombinationProducts_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotential" xlink:to="tbph_CollaborativeArrangementMilestonesSalesAndRegulatoryMilestonesReceivableMaximumPotentialFuturePotentialCombinationProducts_639137148963714130" order="2" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureSegmentInformationTabularDisclosureDetails" xlink:type="extended" xlink:title="40402 - Disclosure - Segment Information - Tabular Disclosure (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss_4" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss" xlink:label="us-gaap_OperatingIncomeLoss_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_4" xlink:to="us-gaap_OperatingIncomeLoss_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating" xlink:label="us-gaap_InterestExpenseNonoperating_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_4" xlink:to="us-gaap_InterestExpenseNonoperating_639137148963714130" order="2" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="us-gaap_OtherNonoperatingIncomeExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_4" xlink:to="us-gaap_OtherNonoperatingIncomeExpense_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="us-gaap_IncomeTaxExpenseBenefit_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_NetIncomeLoss_4" xlink:to="us-gaap_IncomeTaxExpenseBenefit_639137148963714130" order="4" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses" xlink:label="us-gaap_OperatingExpenses_1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_RecurringOperatingExpenses" xlink:label="tbph_RecurringOperatingExpenses_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_1" xlink:to="tbph_RecurringOperatingExpenses_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation" xlink:label="us-gaap_ShareBasedCompensation_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RecurringOperatingExpenses_639137148963714130" xlink:to="us-gaap_ShareBasedCompensation_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingAndMarketingExpense" xlink:label="us-gaap_SellingAndMarketingExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RecurringOperatingExpenses_639137148963714130" xlink:to="us-gaap_SellingAndMarketingExpense_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherGeneralAndAdministrativeExpense" xlink:label="us-gaap_OtherGeneralAndAdministrativeExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RecurringOperatingExpenses_639137148963714130" xlink:to="us-gaap_OtherGeneralAndAdministrativeExpense_639137148963714130" order="3" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_ResearchAndDevelopmentExpenseFacilitiesDepreciationAndOtherAllocatedExpenses" xlink:label="tbph_ResearchAndDevelopmentExpenseFacilitiesDepreciationAndOtherAllocatedExpenses_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RecurringOperatingExpenses_639137148963714130" xlink:to="tbph_ResearchAndDevelopmentExpenseFacilitiesDepreciationAndOtherAllocatedExpenses_639137148963714130" order="4" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_ResearchAndDevelopmentExpenseExternalRelatedExpense" xlink:label="tbph_ResearchAndDevelopmentExpenseExternalRelatedExpense_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RecurringOperatingExpenses_639137148963714130" xlink:to="tbph_ResearchAndDevelopmentExpenseExternalRelatedExpense_639137148963714130" order="5" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_ResearchAndDevelopmentExpenseSalaryAndWages" xlink:label="tbph_ResearchAndDevelopmentExpenseSalaryAndWages_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RecurringOperatingExpenses_639137148963714130" xlink:to="tbph_ResearchAndDevelopmentExpenseSalaryAndWages_639137148963714130" order="6" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_RestructuringAndRelatedExpenses" xlink:label="tbph_RestructuringAndRelatedExpenses_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_OperatingExpenses_1" xlink:to="tbph_RestructuringAndRelatedExpenses_639137148963714130" order="2" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureCashCashEquivalentsAndRestrictedCashDetails" xlink:type="extended" xlink:title="40501 - Disclosure - Cash, Cash Equivalents, and Restricted Cash (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue_639137148963714130" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCash" xlink:label="us-gaap_RestrictedCash_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="us-gaap_RestrictedCash_639137148963714130" order="2" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureInvestmentsAndFairValueMeasurementsFairValueToAmortizedCostAvailableForSaleSecuritiesDetails" xlink:type="extended" xlink:title="40601 - Disclosure - Investments and Fair Value Measurements - Fair Value to Amortized Cost - Available-for-Sale Securities (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss" xlink:label="us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss" xlink:to="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_639137148963714130" order="1" use="optional" weight="-1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss" xlink:to="us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_639137148963714130" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecurities_639137148963714130" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtSecurities_639137148963714130" order="3" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureInvestmentsAndFairValueMeasurementsFairValueToAmortizedCostTotalDetails" xlink:type="extended" xlink:title="40602 - Disclosure - Investments and Fair Value Measurements - Fair Value to Amortized Cost - Total (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFunds" xlink:label="tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFunds" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecurities_639137148963870056" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFunds" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtSecurities_639137148963870056" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MoneyMarketFundsAtCarryingValue" xlink:label="us-gaap_MoneyMarketFundsAtCarryingValue_639137148963870056" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFunds" xlink:to="us-gaap_MoneyMarketFundsAtCarryingValue_639137148963870056" order="2" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFundsAmortizedCost" xlink:label="tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFundsAmortizedCost" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss" xlink:label="us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss_639137148963870056" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFundsAmortizedCost" xlink:to="us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss_639137148963870056" order="1" use="optional" weight="1" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_DebtSecuritiesAvailableForSaleAndMoneyMarketFundsAmortizedCost" xlink:to="us-gaap_MoneyMarketFundsAtCarryingValue_639137148963870056" order="2" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureInvestmentsAndFairValueMeasurementsUnrealizedLossPositionDetails" xlink:type="extended" xlink:title="40605 - Disclosure - Investments and Fair Value Measurements - Unrealized Loss Position (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:label="us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months" xlink:label="us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_639137148963870056" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:to="us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_639137148963870056" order="1" use="optional" weight="1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:label="us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:label="us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_639137148963870056" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:to="us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_639137148963870056" order="1" use="optional" weight="1" />
  </calculationLink>
  <calculationLink xlink:role="http://www.theravance.com/role/DisclosureShareBasedCompensationOrganizationalRestructuringDetails" xlink:type="extended" xlink:title="40802 - Disclosure - Share-Based Compensation - Organizational Restructuring (Details)" xmlns="http://www.xbrl.org/2003/linkbase">
    <loc xlink:type="locator" xlink:href="tbph-20260331.xsd#tbph_RestructuringChargesNoncashRelatedExpenses" xlink:label="tbph_RestructuringChargesNoncashRelatedExpenses_1" />
    <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationIncrementalCompensationCost" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationIncrementalCompensationCost_639137148963870056" />
    <calculationArc xlink:type="arc" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="tbph_RestructuringChargesNoncashRelatedExpenses_1" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPlanModificationIncrementalCompensationCost_639137148963870056" order="1" use="optional" weight="1" />
  </calculationLink>
</link:linkbase>
