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  <xs:element id="akba_ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent" abstract="false" name="ContractualArrangementRoyaltiesAgreementSettlementLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_TermLoanFacilityTrancheAMember" abstract="true" name="TermLoanFacilityTrancheAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_TermLoanFacilityTrancheBMember" abstract="true" name="TermLoanFacilityTrancheBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_TermLoanFacilityTrancheCMember" abstract="true" name="TermLoanFacilityTrancheCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_LineOfCreditFacilityMaximumBorrowingCapacityNumberOfAvailableTranches" abstract="false" name="LineOfCreditFacilityMaximumBorrowingCapacityNumberOfAvailableTranches" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
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  <xs:element id="akba_DebtInstrumentInterestRateCap" abstract="false" name="DebtInstrumentInterestRateCap" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="akba_DebtInstrumentAnnualInterestRateIncreaseDecrease" abstract="false" name="DebtInstrumentAnnualInterestRateIncreaseDecrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="akba_DebtInstrumentTransactionFeePercentage" abstract="false" name="DebtInstrumentTransactionFeePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="akba_DebtInstrumentExitFeePercentage" abstract="false" name="DebtInstrumentExitFeePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="akba_DebtInstrumentPrepaymentFeePercentage" abstract="false" name="DebtInstrumentPrepaymentFeePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="akba_DebtInstrumentCovenantCashAndCashEquivalents" abstract="false" name="DebtInstrumentCovenantCashAndCashEquivalents" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_DebtInstrumentCovenantRevenue" abstract="false" name="DebtInstrumentCovenantRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_CSLViforMember" abstract="true" name="CSLViforMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ViforInternationalLimitedFirstInvestmentMember" abstract="true" name="ViforInternationalLimitedFirstInvestmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ViforInternationalLimitedSecondInvestmentMember" abstract="true" name="ViforInternationalLimitedSecondInvestmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_HealthCareRoyaltyPartnersIVL.P.Member" abstract="true" name="HealthCareRoyaltyPartnersIVL.P.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_LicenseAgreementMember" abstract="true" name="LicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_RevenueRemainingPerformanceObligationVariableConsiderationProfitSharePercentage" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationProfitSharePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="akba_TieredRoyaltyPaymentsAsAPercentageOfNetSales" abstract="false" name="TieredRoyaltyPaymentsAsAPercentageOfNetSales" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_ContractWithCustomerRefundLiabilityGross" abstract="false" name="ContractWithCustomerRefundLiabilityGross" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_TieredRoyaltyPaymentsPercentage" abstract="false" name="TieredRoyaltyPaymentsPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="akba_RoyaltyTrueUpPayments" abstract="false" name="RoyaltyTrueUpPayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_ContractWithCustomerRefundLiabilityAmortizationOfDiscount" abstract="false" name="ContractWithCustomerRefundLiabilityAmortizationOfDiscount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_ContractualArrangementRoyaltiesAgreementMaximumAggregateRoyaltyPayoutCapacity" abstract="false" name="ContractualArrangementRoyaltiesAgreementMaximumAggregateRoyaltyPayoutCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_OfficeAndStorageSpaceMember" abstract="true" name="OfficeAndStorageSpaceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_LaboratorySpaceMember" abstract="true" name="LaboratorySpaceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_OfficeSpaceMember" abstract="true" name="OfficeSpaceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="akba_LesseeOperatingLeaseLeasedSquareFeet" abstract="false" name="LesseeOperatingLeaseLeasedSquareFeet" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:areaItemType"/>
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  <xs:element id="akba_PanionBFBiotechIncMember" abstract="true" name="PanionBFBiotechIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_CyclerionMember" abstract="true" name="CyclerionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_Q32Member" abstract="true" name="Q32Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="akba_AcquiredLicensesMember" abstract="true" name="AcquiredLicensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_Q32AssetPurchaseAgreementMember" abstract="true" name="Q32AssetPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="akba_CostOfPurchasedMinimumQuantityProduct" abstract="false" name="CostOfPurchasedMinimumQuantityProduct" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_PurchaseCommitmentOptionForNonAutoRenewalPriorWrittenNoticePeriod" abstract="false" name="PurchaseCommitmentOptionForNonAutoRenewalPriorWrittenNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
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  <xs:element id="akba_AssetAcquisitionConsiderationTransferredContingentConsiderationDevelopmentAndRegulatoryMilestonePayments" abstract="false" name="AssetAcquisitionConsiderationTransferredContingentConsiderationDevelopmentAndRegulatoryMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_ExpirationPeriodBeginningWithFirstCommercialSale" abstract="false" name="ExpirationPeriodBeginningWithFirstCommercialSale" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="akba_TerminationPeriodPriorWrittenNotice" abstract="false" name="TerminationPeriodPriorWrittenNotice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
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  <xs:element id="akba_SalesToAGDistributorMember" abstract="true" name="SalesToAGDistributorMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_DeferredRevenueMember" abstract="true" name="DeferredRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ContractWithCustomerAssetAfterAllowanceForCreditLossCurrentRollForward" abstract="true" name="ContractWithCustomerAssetAfterAllowanceForCreditLossCurrentRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="akba_ContractWithCustomerAssetAdditions" abstract="false" name="ContractWithCustomerAssetAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="akba_RebatesFeesAndOtherDeductionsMember" abstract="true" name="RebatesFeesAndOtherDeductionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="akba_ValuationAllowancesAndReservesAdjustmentsRelatedToPriorPeriodSales" abstract="false" name="ValuationAllowancesAndReservesAdjustmentsRelatedToPriorPeriodSales" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_MEDICEArzneimittelPutterGmbHCoKGMember" abstract="true" name="MEDICEArzneimittelPutterGmbHCoKGMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_TanabePharmaCorporationMember" abstract="true" name="TanabePharmaCorporationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_JapanTobaccoIncorporationAndToriiPharmaceuticalCompanyLimitedMember" abstract="true" name="JapanTobaccoIncorporationAndToriiPharmaceuticalCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_LicenseCollaborationAndOtherRevenueAbstract" abstract="true" name="LicenseCollaborationAndOtherRevenueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="akba_LicenseCollaborationAndOtherRevenueRoyaltiesMember" abstract="true" name="LicenseCollaborationAndOtherRevenueRoyaltiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_SupplyAgreementMember" abstract="true" name="SupplyAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="akba_RevenueRemainingPerformanceObligationVariableConsiderationAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_RevenueRemainingPerformanceObligationVariableConsiderationRoyaltyExpectedTimingOfSatisfactionPeriod" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationRoyaltyExpectedTimingOfSatisfactionPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="akba_CollaborativeArrangementRightsAndObligationsPercentageOfNetProductMarginOnSales" abstract="false" name="CollaborativeArrangementRightsAndObligationsPercentageOfNetProductMarginOnSales" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="akba_ContractWithCustomerTerminationNoticePeriodPeriodAfterEffectiveAgreementDate" abstract="false" name="ContractWithCustomerTerminationNoticePeriodPeriodAfterEffectiveAgreementDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
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  <xs:element id="akba_DevelopmentAndCommercializeCollaborationAgreementMember" abstract="true" name="DevelopmentAndCommercializeCollaborationAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_DevelopmentAndCommercializeResearchAndLicenseAgreementMember" abstract="true" name="DevelopmentAndCommercializeResearchAndLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_MitsubishiTanabePharmaCorporationSupplyAgreementMember" abstract="true" name="MitsubishiTanabePharmaCorporationSupplyAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_RegulatoryMilestonePaymentsMember" abstract="true" name="RegulatoryMilestonePaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_UpfrontCashPaymentReceived" abstract="false" name="UpfrontCashPaymentReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_CostOfResearchServices" abstract="false" name="CostOfResearchServices" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_MilestonePaymentReceived" abstract="false" name="MilestonePaymentReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_SublicenseAgreementMember" abstract="true" name="SublicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_AtTheMarketSaleAgreementAuthorizedApril2022AmendedMember" abstract="true" name="AtTheMarketSaleAgreementAuthorizedApril2022AmendedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_PublicStockOfferingMember" abstract="true" name="PublicStockOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_PublicStockOfferingUnderwritingAgreementMember" abstract="true" name="PublicStockOfferingUnderwritingAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_SaleOfStockConsiderationReceivedOnTransactionGross" abstract="false" name="SaleOfStockConsiderationReceivedOnTransactionGross" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_IssuanceAndSaleOfEquitySecuritiesAmount" abstract="false" name="IssuanceAndSaleOfEquitySecuritiesAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_SaleOfSockOverAllotmentOptionTerm" abstract="false" name="SaleOfSockOverAllotmentOptionTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="akba_ContractWithCustomerNumberOfUnregisteredStockHeldByCustomer" abstract="false" name="ContractWithCustomerNumberOfUnregisteredStockHeldByCustomer" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="akba_ClassOfWarrantOrRightWarrantsPurchased" abstract="false" name="ClassOfWarrantOrRightWarrantsPurchased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="akba_ClassOfWarrantOrRightWarrantsIssued" abstract="false" name="ClassOfWarrantOrRightWarrantsIssued" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="akba_EmployeesMember" abstract="true" name="EmployeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_InducementAwardProgramMember" abstract="true" name="InducementAwardProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_RestrictedStockUnitsRSUsAndPerformanceBasedRestrictedStockUnitsPSUsMember" abstract="true" name="RestrictedStockUnitsRSUsAndPerformanceBasedRestrictedStockUnitsPSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_StockIncentivePlan2023Member" abstract="true" name="StockIncentivePlan2023Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_TwoThousandAndFourteenEmployeeStockPurchasePlanMember" abstract="true" name="TwoThousandAndFourteenEmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedCompensationAwardTrancheFirstAnniversaryOfGrantDateMember" abstract="true" name="ShareBasedCompensationAwardTrancheFirstAnniversaryOfGrantDateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedPaymentArrangementTrancheOneFirstAnniversaryAfterGrantDateSubjectedToIndividualContinuedServiceMember" abstract="true" name="ShareBasedPaymentArrangementTrancheOneFirstAnniversaryAfterGrantDateSubjectedToIndividualContinuedServiceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedPaymentArrangementTrancheTwoSecondAnniversaryAfterGrantDateSubjectedToIndividualContinuedServiceMember" abstract="true" name="ShareBasedPaymentArrangementTrancheTwoSecondAnniversaryAfterGrantDateSubjectedToIndividualContinuedServiceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedPaymentArrangementTrancheThreeThirdAnniversaryAfterGrantDateSubjectedToIndividualContinuedServiceMember" abstract="true" name="ShareBasedPaymentArrangementTrancheThreeThirdAnniversaryAfterGrantDateSubjectedToIndividualContinuedServiceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedPaymentArrangementTrancheOneFirstAnniversaryAfterGrantDateMember" abstract="true" name="ShareBasedPaymentArrangementTrancheOneFirstAnniversaryAfterGrantDateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedPaymentArrangementTrancheTwoFollowingFirstAnniversaryAfterGrantDateMember" abstract="true" name="ShareBasedPaymentArrangementTrancheTwoFollowingFirstAnniversaryAfterGrantDateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodicVestingNumberOfInstallments" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodicVestingNumberOfInstallments" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="akba_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingGracePeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingGracePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="akba_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="akba_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionAmount" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="akba_KeryxEquityPlansMember" abstract="true" name="KeryxEquityPlansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_IncentivePlan2014Member" abstract="true" name="IncentivePlan2014Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOutstandingNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="akba_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValueAtGrantDate" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsFairValueAtGrantDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="akba_CommonStockOptionsAndStockAppreciationRightsSARSMember" abstract="true" name="CommonStockOptionsAndStockAppreciationRightsSARSMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_EarningsPerShareBasicAndDilutedEPSAbstract" abstract="true" name="EarningsPerShareBasicAndDilutedEPSAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="akba_ShareBasedPaymentArrangementOptionAndStockAppreciationRightsMember" abstract="true" name="ShareBasedPaymentArrangementOptionAndStockAppreciationRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="akba_ProductAndOtherRevenueExpense" abstract="false" name="ProductAndOtherRevenueExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
