<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019cf72f-2978-7eec-9f7b-2c3ca1840a15,g:4995136a-588b-432f-8ead-5a773e5f5f2f-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:qdel="http://www.quidelortho.com/20260329" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.quidelortho.com/20260329">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qdel-20260329_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qdel-20260329_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qdel-20260329_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qdel-20260329_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="CoverPage" roleURI="http://www.quidelortho.com/role/CoverPage">
        <link:definition>0000001 - Document - Cover Page</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedBalanceSheetsUnaudited" roleURI="http://www.quidelortho.com/role/ConsolidatedBalanceSheetsUnaudited">
        <link:definition>9952151 - Statement - Consolidated Balance Sheets (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedBalanceSheetsUnauditedParenthetical" roleURI="http://www.quidelortho.com/role/ConsolidatedBalanceSheetsUnauditedParenthetical">
        <link:definition>9952152 - Statement - Consolidated Balance Sheets (Unaudited) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsofLossUnaudited" roleURI="http://www.quidelortho.com/role/ConsolidatedStatementsofLossUnaudited">
        <link:definition>9952153 - Statement - Consolidated Statements of Loss (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsofComprehensiveLossUnaudited" roleURI="http://www.quidelortho.com/role/ConsolidatedStatementsofComprehensiveLossUnaudited">
        <link:definition>9952154 - Statement - Consolidated Statements of Comprehensive Loss (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsofStockholdersEquityUnaudited" roleURI="http://www.quidelortho.com/role/ConsolidatedStatementsofStockholdersEquityUnaudited">
        <link:definition>9952155 - Statement - Consolidated Statements of Stockholders' Equity (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConsolidatedStatementsofCashFlowsUnaudited" roleURI="http://www.quidelortho.com/role/ConsolidatedStatementsofCashFlowsUnaudited">
        <link:definition>9952156 - Statement - Consolidated Statements of Cash Flows (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPolicies" roleURI="http://www.quidelortho.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies">
        <link:definition>9952157 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComputationofEarningsPerShare" roleURI="http://www.quidelortho.com/role/ComputationofEarningsPerShare">
        <link:definition>9952158 - Disclosure - Computation of Earnings Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Revenue" roleURI="http://www.quidelortho.com/role/Revenue">
        <link:definition>9952159 - Disclosure - Revenue</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentandGeographicInformation" roleURI="http://www.quidelortho.com/role/SegmentandGeographicInformation">
        <link:definition>9952160 - Disclosure - Segment and Geographic Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.quidelortho.com/role/IncomeTaxes">
        <link:definition>9952161 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetails" roleURI="http://www.quidelortho.com/role/BalanceSheetAccountDetails">
        <link:definition>9952162 - Disclosure - Balance Sheet Account Details</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Borrowings" roleURI="http://www.quidelortho.com/role/Borrowings">
        <link:definition>9952163 - Disclosure - Borrowings</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockbasedCompensation" roleURI="http://www.quidelortho.com/role/StockbasedCompensation">
        <link:definition>9952164 - Disclosure - Stock-based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingencies" roleURI="http://www.quidelortho.com/role/CommitmentsandContingencies">
        <link:definition>9952165 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivities" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivities">
        <link:definition>9952166 - Disclosure - Derivative Instruments and Hedging Activities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccumulatedOtherComprehensiveLoss" roleURI="http://www.quidelortho.com/role/AccumulatedOtherComprehensiveLoss">
        <link:definition>9952167 - Disclosure - Accumulated Other Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringIntegrationandOtherCharges" roleURI="http://www.quidelortho.com/role/RestructuringIntegrationandOtherCharges">
        <link:definition>9952168 - Disclosure - Restructuring, Integration and Other Charges</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEvent" roleURI="http://www.quidelortho.com/role/SubsequentEvent">
        <link:definition>9952169 - Disclosure - Subsequent Event</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" roleURI="http://www.quidelortho.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies">
        <link:definition>9955511 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComputationofEarningsPerShareTables" roleURI="http://www.quidelortho.com/role/ComputationofEarningsPerShareTables">
        <link:definition>9955512 - Disclosure - Computation of Earnings Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueTables" roleURI="http://www.quidelortho.com/role/RevenueTables">
        <link:definition>9955513 - Disclosure - Revenue (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentandGeographicInformationTables" roleURI="http://www.quidelortho.com/role/SegmentandGeographicInformationTables">
        <link:definition>9955514 - Disclosure - Segment and Geographic Information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsTables" roleURI="http://www.quidelortho.com/role/BalanceSheetAccountDetailsTables">
        <link:definition>9955515 - Disclosure - Balance Sheet Account Details (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsTables" roleURI="http://www.quidelortho.com/role/BorrowingsTables">
        <link:definition>9955516 - Disclosure - Borrowings (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockbasedCompensationTables" roleURI="http://www.quidelortho.com/role/StockbasedCompensationTables">
        <link:definition>9955517 - Disclosure - Stock-based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivitiesTables" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivitiesTables">
        <link:definition>9955518 - Disclosure - Derivative Instruments and Hedging Activities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccumulatedOtherComprehensiveLossTables" roleURI="http://www.quidelortho.com/role/AccumulatedOtherComprehensiveLossTables">
        <link:definition>9955519 - Disclosure - Accumulated Other Comprehensive Loss (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringIntegrationandOtherChargesTables" roleURI="http://www.quidelortho.com/role/RestructuringIntegrationandOtherChargesTables">
        <link:definition>9955520 - Disclosure - Restructuring, Integration and Other Charges (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComputationofEarningsPerShareCalculationofBasicandDilutedEarningsPerShareDetails" roleURI="http://www.quidelortho.com/role/ComputationofEarningsPerShareCalculationofBasicandDilutedEarningsPerShareDetails">
        <link:definition>9955521 - Disclosure - Computation of Earnings Per Share - Calculation of Basic and Diluted Earnings Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ComputationofEarningsPerShareNarrativeDetails" roleURI="http://www.quidelortho.com/role/ComputationofEarningsPerShareNarrativeDetails">
        <link:definition>9955522 - Disclosure - Computation of Earnings Per Share - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueNarrativeDetails" roleURI="http://www.quidelortho.com/role/RevenueNarrativeDetails">
        <link:definition>9955523 - Disclosure - Revenue - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueDisaggregationofRevenueDetails" roleURI="http://www.quidelortho.com/role/RevenueDisaggregationofRevenueDetails">
        <link:definition>9955524 - Disclosure - Revenue - Disaggregation of Revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentandGeographicInformationNarrativeDetails" roleURI="http://www.quidelortho.com/role/SegmentandGeographicInformationNarrativeDetails">
        <link:definition>9955525 - Disclosure - Segment and Geographic Information - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentandGeographicInformationReconciliationtoIncomeDetails" roleURI="http://www.quidelortho.com/role/SegmentandGeographicInformationReconciliationtoIncomeDetails">
        <link:definition>9955526 - Disclosure - Segment and Geographic Information - Reconciliation to Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesDetail" roleURI="http://www.quidelortho.com/role/IncomeTaxesDetail">
        <link:definition>9955527 - Disclosure - Income Taxes (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsAccountsReceivableDetails" roleURI="http://www.quidelortho.com/role/BalanceSheetAccountDetailsAccountsReceivableDetails">
        <link:definition>9955528 - Disclosure - Balance Sheet Account Details Accounts Receivable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsInventoriesDetails" roleURI="http://www.quidelortho.com/role/BalanceSheetAccountDetailsInventoriesDetails">
        <link:definition>9955529 - Disclosure - Balance Sheet Account Details Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsInventoriesDetails_1" roleURI="http://www.quidelortho.com/role/BalanceSheetAccountDetailsInventoriesDetails_1">
        <link:definition>9955529 - Disclosure - Balance Sheet Account Details Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsPrepaidexpensesandothercurrentassetsDetails" roleURI="http://www.quidelortho.com/role/BalanceSheetAccountDetailsPrepaidexpensesandothercurrentassetsDetails">
        <link:definition>9955530 - Disclosure - Balance Sheet Account Details Prepaid expenses and other current assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsOtherCurrentLiabilitiesDetails" roleURI="http://www.quidelortho.com/role/BalanceSheetAccountDetailsOtherCurrentLiabilitiesDetails">
        <link:definition>9955531 - Disclosure - Balance Sheet Account Details Other Current Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsScheduleofBorrowingsDetails" roleURI="http://www.quidelortho.com/role/BorrowingsScheduleofBorrowingsDetails">
        <link:definition>9955532 - Disclosure - Borrowings - Schedule of Borrowings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsScheduleofBorrowingsDetails_1" roleURI="http://www.quidelortho.com/role/BorrowingsScheduleofBorrowingsDetails_1">
        <link:definition>9955532 - Disclosure - Borrowings - Schedule of Borrowings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsNarrativeDetails" roleURI="http://www.quidelortho.com/role/BorrowingsNarrativeDetails">
        <link:definition>9955533 - Disclosure - Borrowings - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BorrowingsInterestExpenseDetails" roleURI="http://www.quidelortho.com/role/BorrowingsInterestExpenseDetails">
        <link:definition>9955534 - Disclosure - Borrowings - Interest Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockbasedCompensationCompensationExpenseRelatedtoStockBasedCompensationPlansDetails" roleURI="http://www.quidelortho.com/role/StockbasedCompensationCompensationExpenseRelatedtoStockBasedCompensationPlansDetails">
        <link:definition>9955535 - Disclosure - Stock-based Compensation - Compensation Expense Related to Stock-Based Compensation Plans (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingenciesDetails" roleURI="http://www.quidelortho.com/role/CommitmentsandContingenciesDetails">
        <link:definition>9955536 - Disclosure - Commitments and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivitiesNarrativeDetails" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivitiesNarrativeDetails">
        <link:definition>9955537 - Disclosure - Derivative Instruments and Hedging Activities - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivitiesScheduleofInterestRateDerivativesDetails" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivitiesScheduleofInterestRateDerivativesDetails">
        <link:definition>9955538 - Disclosure - Derivative Instruments and Hedging Activities - Schedule of Interest Rate Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivitiesScheduleofCurrencyHedgingInstrumentsDetails" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivitiesScheduleofCurrencyHedgingInstrumentsDetails">
        <link:definition>9955539 - Disclosure - Derivative Instruments and Hedging Activities - Schedule of Currency Hedging Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivitiesScheduleofGainLossDetails" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivitiesScheduleofGainLossDetails">
        <link:definition>9955540 - Disclosure - Derivative Instruments and Hedging Activities - Schedule of Gain (Loss) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivitiesScheduleofNetInvestmentHedgeDetails" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivitiesScheduleofNetInvestmentHedgeDetails">
        <link:definition>9955541 - Disclosure - Derivative Instruments and Hedging Activities - Schedule of Net Investment Hedge (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DerivativeInstrumentsandHedgingActivitiesScheduleofFairValueDetails" roleURI="http://www.quidelortho.com/role/DerivativeInstrumentsandHedgingActivitiesScheduleofFairValueDetails">
        <link:definition>9955542 - Disclosure - Derivative Instruments and Hedging Activities - Schedule of Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccumulatedOtherComprehensiveLossDetails" roleURI="http://www.quidelortho.com/role/AccumulatedOtherComprehensiveLossDetails">
        <link:definition>9955543 - Disclosure - Accumulated Other Comprehensive Loss (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringIntegrationandOtherChargesNarrativeDetails" roleURI="http://www.quidelortho.com/role/RestructuringIntegrationandOtherChargesNarrativeDetails">
        <link:definition>9955544 - Disclosure - Restructuring, Integration and Other Charges - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringIntegrationandOtherChargesScheduleofRestructuringChargesDetails" roleURI="http://www.quidelortho.com/role/RestructuringIntegrationandOtherChargesScheduleofRestructuringChargesDetails">
        <link:definition>9955545 - Disclosure - Restructuring, Integration and Other Charges - Schedule of Restructuring Charges (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringIntegrationandOtherChargesReserveDetails" roleURI="http://www.quidelortho.com/role/RestructuringIntegrationandOtherChargesReserveDetails">
        <link:definition>9955546 - Disclosure - Restructuring, Integration and Other Charges - Reserve (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEventDetails" roleURI="http://www.quidelortho.com/role/SubsequentEventDetails">
        <link:definition>9955547 - Disclosure - Subsequent Event (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="qdel_RestructuringIntegrationAndOtherCharges" abstract="false" name="RestructuringIntegrationAndOtherCharges" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_IncreaseDecreaseInDeferredTaxAssetsAndLiabilities" abstract="false" name="IncreaseDecreaseInDeferredTaxAssetsAndLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_NoncashOrPartNoncashAcquisitionFixedAssetsTransferredFromInventories" abstract="false" name="NoncashOrPartNoncashAcquisitionFixedAssetsTransferredFromInventories" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_PotentialDilutiveEffectOnWeightedAverageNumberOfSharesOutstanding" abstract="false" name="PotentialDilutiveEffectOnWeightedAverageNumberOfSharesOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="qdel_CustomerOneMember" abstract="true" name="CustomerOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_RespiratoryMember" abstract="true" name="RespiratoryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_BusinessUnitAxis" abstract="true" name="BusinessUnitAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="qdel_BusinessUnitDomain" abstract="true" name="BusinessUnitDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_LabsMember" abstract="true" name="LabsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_ImmunohematologyMember" abstract="true" name="ImmunohematologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_DonorScreeningMember" abstract="true" name="DonorScreeningMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_PointOfCareMember" abstract="true" name="PointOfCareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_MolecularDiagnosticsMember" abstract="true" name="MolecularDiagnosticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_NorthAmericaSegmentMember" abstract="true" name="NorthAmericaSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_EMEASegmentMember" abstract="true" name="EMEASegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_ChinaSegmentMember" abstract="true" name="ChinaSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_JPACSegmentMember" abstract="true" name="JPACSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_LatinAmericaSegmentMember" abstract="true" name="LatinAmericaSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_SegmentInformationCostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization" abstract="false" name="SegmentInformationCostOfGoodsAndServiceExcludingDepreciationDepletionAndAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_SegmentInformationSellingGeneralAndAdministrativeExpense" abstract="false" name="SegmentInformationSellingGeneralAndAdministrativeExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_SegmentInformationResearchAndDevelopmentExpense" abstract="false" name="SegmentInformationResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_SegmentInformationOtherIncomeExpense" abstract="false" name="SegmentInformationOtherIncomeExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_SegmentAdjustedEBITDA" abstract="false" name="SegmentAdjustedEBITDA" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_CorporateAdjustedEBITDA" abstract="false" name="CorporateAdjustedEBITDA" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_AmortizationOfDeferredCloudComputingImplementationCosts" abstract="false" name="AmortizationOfDeferredCloudComputingImplementationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_EUMedicalDeviceRegulationTransitionCosts" abstract="false" name="EUMedicalDeviceRegulationTransitionCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_OtherAdjustments" abstract="false" name="OtherAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_AllowanceForContractRebatesAndDiscounts" abstract="false" name="AllowanceForContractRebatesAndDiscounts" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_InventoriesIncludingNoncurrentPortionNet" abstract="false" name="InventoriesIncludingNoncurrentPortionNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_IncomeTaxReceivablesAndOtherTaxReceivablesCurrent" abstract="false" name="IncomeTaxReceivablesAndOtherTaxReceivablesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_CloudComputingCurrent" abstract="false" name="CloudComputingCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_CustomerIncentivePayableCurrent" abstract="false" name="CustomerIncentivePayableCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_LossOnContractTerminationCurrent" abstract="false" name="LossOnContractTerminationCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_BankOfAmericaCreditFacilityTermLoanAMember" abstract="true" name="BankOfAmericaCreditFacilityTermLoanAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_BankOfAmericaCreditFacilityTermLoanBMember" abstract="true" name="BankOfAmericaCreditFacilityTermLoanBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_BankOfAmericaCreditFacilityMember" abstract="true" name="BankOfAmericaCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_BankOfAmericaCreditFacilityDelayedDrawTermLoanAMember" abstract="true" name="BankOfAmericaCreditFacilityDelayedDrawTermLoanAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_DerivativeInstrumentsAndOther" abstract="false" name="DerivativeInstrumentsAndOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_RestructuringIntegrationAndOtherChargesMember" abstract="true" name="RestructuringIntegrationAndOtherChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_LossContingencyNumberOfExecutiveDefendants" abstract="false" name="LossContingencyNumberOfExecutiveDefendants" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qdel_NumberOfStockholdersThatFiledComplaints" abstract="false" name="NumberOfStockholdersThatFiledComplaints" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qdel_InterestRateSwapOneMember" abstract="true" name="InterestRateSwapOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapTwoMember" abstract="true" name="InterestRateSwapTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapThreeMember" abstract="true" name="InterestRateSwapThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapFourMember" abstract="true" name="InterestRateSwapFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapFiveMember" abstract="true" name="InterestRateSwapFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapSixMember" abstract="true" name="InterestRateSwapSixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapSevenMember" abstract="true" name="InterestRateSwapSevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapEightMember" abstract="true" name="InterestRateSwapEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapNineMember" abstract="true" name="InterestRateSwapNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_InterestRateSwapTenMember" abstract="true" name="InterestRateSwapTenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_RestructuringPlansMember" abstract="true" name="RestructuringPlansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_SavannaExitChargesMember" abstract="true" name="SavannaExitChargesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_ImplementationCosts" abstract="false" name="ImplementationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_RestructuringCostsCostOfSales" abstract="false" name="RestructuringCostsCostOfSales" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_RestructuringIntegrationAndOtherChargesIncludedCostOfSales" abstract="false" name="RestructuringIntegrationAndOtherChargesIncludedCostOfSales" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qdel_AssetImpairmentAndWriteOffsMember" abstract="true" name="AssetImpairmentAndWriteOffsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_LEXDiagnosticsMember" abstract="true" name="LEXDiagnosticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qdel_BusinessCombinationContingentConsiderationLiabilityPercentageOfNetRevenueDuringEarnOutPeriod" abstract="false" name="BusinessCombinationContingentConsiderationLiabilityPercentageOfNetRevenueDuringEarnOutPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
</xs:schema>
