Interest and other receivables Nontrade Receivables, Current Statistical Measurement Statistical Measurement [Domain] Scenario Two Scenario Two [Member] Scenario two . Award Timing Predetermined Award Timing Predetermined [Flag] Entity File Number Entity File Number Additional Paid-In Capital Additional Paid-in Capital [Member] Commercial paper (due in less than one year) Commercial Paper Due In Less Than One Year [Member] Represents information pertaining to unsecured promissory note (generally negotiable) that provides institutions with short-term funds ), due in less than one year. Gross Unrealized Losses Restricted Cash And Cash Equivalents, Gross Unrealized Losses Restricted cash and cash equivalents gross unrealized losses. Tabular List, Table Tabular List [Table Text Block] Operating lease liabilities Increase (Decrease) In Operating Lease Liabilities Increase (Decrease) In Operating Lease Liabilities Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Accounts payable Increase (Decrease) in Accounts Payable Prepayment premium on percentage of term loan Prepayment Premium on Percentage of Term Loan The prepayment premium on percentage of term loan. Schedule of Cash Equivalents, Restricted Cash and Marketable Securities Fair Value, by Balance Sheet Grouping [Table Text Block] Total interest and other income (expense) Interest Income (Expense), Nonoperating Payments on royalty agreement Royalty payments Payments for Royalties Stock options and warrants excluded from diluted net loss per share calculation due to net loss position Share-Based Payment Arrangement [Member] Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Trading Arrangements, by Individual Trading Arrangements, by Individual [Table] Basic net loss per share (in dollars per share) Earnings Per Share, Basic Adjustment to Compensation: Adjustment to Compensation [Axis] Named Executive Officers, Footnote Named Executive Officers, Footnote [Text Block] Commercial paper Commercial paper (cash equivalent) Commercial paper Commercial Paper [Member] Liabilities: Liabilities, Fair Value Disclosure [Abstract] REVENUE RECOGNITION Revenue from Contract with Customer [Text Block] Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Prepaid Prior To Third Anniversary Of Funding Date Prepaid Prior To Third Anniversary Of Funding Date [Member] Prepaid prior to third anniversary of funding date. Gross Unrealized Losses Cash And Cash Equivalents, Unrealized Losses Represents the gross unrealized losses for cash and cash equivalents. Adjustment to Compensation, Amount Adjustment to Compensation Amount Less: unamortized debt discount and issuance costs Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Principles of Consolidation Consolidation, Policy [Policy Text Block] Stock-based compensation expense Share-Based Payment Arrangement, Noncash Expense Employee Stock Option Share-Based Payment Arrangement, Option [Member] Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Antidilutive Securities Antidilutive Securities [Axis] Total stockholders' equity Balance at beginning of period Balance at end of period Equity, Attributable to Parent Debt Securities Available For Sale [Table] Debt Securities, Available-for-Sale [Table] Insider Trading Policies and Procedures [Line Items] Segment Reporting, Asset Reconciling Item [Line Items] Segment Reporting, Asset Reconciling Item [Line Items] Current assets: Assets, Current [Abstract] Total liabilities and stockholders' equity Liabilities and Equity Increase in allowance for doubtful accounts Increase (Decrease) In Allowance For Doubtful Accounts Increase (Decrease) In Allowance For Doubtful Accounts Cash, cash equivalents and restricted cash at the beginning of the period Cash, cash equivalents and restricted cash at the end of the period Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities and Equity [Abstract] Cover [Abstract] Cover [Abstract] Restructuring and related cost, incurred cost Restructuring and Related Cost, Incurred Cost Fair Value Cash and Cash Equivalents, Fair Value Disclosure Maximum Maximum [Member] Accounting Policies [Abstract] Accounting Policies [Abstract] Total Debt Securities, Available-for-Sale, Unrealized Loss Position Line of credit, maturity period Line of Credit Facility, Expiration Period Government-sponsored enterprise securities (due in less than one year) U S Government Sponsored Enterprises Debt Securities Due In Less Than One Year [Member] Represents information pertaining to debentures, bonds and other debt securities issued by US government sponsored entities (GSEs), for example, but not limited to, Federal Home Loan Mortgage Corporation (FHLMC or Freddie Mac), Federal National Mortgage Association (FNMA or Fannie Mae), and the Federal Home Loan Bank (FHLB). Excludes debt issued by the Government National Mortgage Association (GNMA or Ginnie Mae, due in less than one year. Non-PEO NEO Average Total Compensation Amount Non-PEO NEO Average Total Compensation Amount Debt Instrument [Line Items] Debt Instrument [Line Items] Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Pay vs Performance Disclosure [Line Items] Forgone Recovery due to Disqualification of Tax Benefits, Amount Forgone Recovery due to Disqualification of Tax Benefits, Amount Manufacturing activities Accrued Manufacturing Activities, Current Carrying value as of the balance sheet of obligations incurred through the date and payable for manufacturing related costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Non-cash interest expense on liabilities for sales of future royalties Noncash Interest Expense On Liabilities For Sales Of Future Royalties Noncash Interest Expense On Liabilities For Sales Of Future Royalties Investment Holdings [Table] Investment Holdings [Table] Non-Rule 10b5-1 Arrangement Terminated Non-Rule 10b5-1 Arrangement Terminated [Flag] Depreciation and amortization Depreciation, Depletion and Amortization, Nonproduction Entity Shell Company Entity Shell Company Debt Instrument [Table] Schedule of Long-Term Debt Instruments [Table] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Company Selected Measure Amount Company Selected Measure Amount Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Accrued bonuses Accrued Bonuses, Current Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Noncurrent marketable securities Debt Securities, Available-for-Sale, Excluding Accrued Interest, Noncurrent Name Measure Name Accrued, beginning balance Accrued, ending balance Restructuring Reserve Operating lease liabilities Operating Lease, Liability, Current Document Fiscal Period Focus Document Fiscal Period Focus Less: amount representing interest Accumulated Capitalized Interest Costs Purchases of property and equipment Payments (Unpaid) To Acquire Property, Plant, And Equipment Payments (Unpaid) To Acquire Property, Plant, And Equipment Award Timing Method Award Timing Method [Text Block] Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost, Excluding Accrued Interest, after Allowance for Credit Loss Award Type Award Type [Axis] Total assets Assets Trading Symbol Trading Symbol Issuance of common stock under equity plans (in shares) Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture Entity Address, City or Town Entity Address, City or Town Cash flows from operating activities: Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] BASIS OF PRESENTATION, PRINCIPLES OF CONSOLIDATION USE OF ESTIMATES AND RECENT ACCOUNTING PRONOUNCEMENTS Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block] Other segment expenses Segment Reporting, Other Segment Item, Amount Net effect of exchange rates on cash, cash equivalents and restricted cash Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation INVENTORY Inventory Disclosure [Text Block] Non-PEO NEO Average Compensation Actually Paid Amount Non-PEO NEO Average Compensation Actually Paid Amount Income Statement Location Statement of Income Location, Balance [Domain] Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] Assets: Assets, Fair Value Disclosure [Abstract] Entity Emerging Growth Company Entity Emerging Growth Company 2029 Long-Term Debt, Maturity, Year Three Accrued restructuring charges Restructuring Reserve, Current Research and development Research and Development Expense (Excluding Acquired in Process Cost) Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Number of severance plan Number Of Severance Plan Number of severance plan. Schedule of Available For Sale Securities [Line Items] Debt Securities, Available-for-Sale [Line Items] Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member] Revenue interest payments Revenue from Contract with Customer, Including Assessed Tax Level 2 Fair Value, Inputs, Level 2 [Member] Restructuring Reserve [Roll Forward] Restructuring Reserve [Roll Forward] Insider Trading Policies and Procedures Not Adopted Insider Trading Policies and Procedures Not Adopted [Text Block] Royalties [Roll Forward] Royalties [Roll Forward] Royalties Balance at beginning of period (in shares) Balance at end of period (in shares) Common Stock, Shares, Outstanding Gross Unrealized Gains Cash And Cash Equivalents, Unrealized Gains Represents the gross unrealized gains for cash and cash equivalents. PEO PEO [Member] Chemistry, manufacturing, and control expenses Chemistry Manufacturing And Control Expenses [Member] Chemistry, manufacturing, and control expenses. Accrued vacation Accrued Vacation, Current Interest income Investment Income, Interest Changes in assets and liabilities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member] Accumulated Deficit Retained Earnings [Member] Prepaid and other current assets Prepaid Expense and Other Assets, Current Effective interest rate Debt Instrument, Interest Rate, Effective Percentage Schedule of Accrued Liabilities Schedule of Accrued Liabilities [Table Text Block] Entity Address, Postal Zip Code Entity Address, Postal Zip Code Restatement Determination Date Restatement Determination Date Income Statement [Abstract] Income Statement [Abstract] 12 Months or Longer Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer Percentage added to prime rate for debt instrument interest rate Debt Instrument, Basis Spread on Variable Rate Purchases of marketable securities Payments to Acquire Marketable Securities BioPharma Credit PLC BioPharma Credit PLC [Member] BioPharma credit PLC. Deposits and other assets Deposits And Other Assets, Noncurrent Carrying value of amounts transferred to third parties for security purposes that are expected to be returned or applied towards payment after one year or beyond the operating cycle, if longer; and amount of noncurrent assets classified as other. Pension Adjustments Service Cost Pension Adjustments Service Cost [Member] Product and Service [Domain] Product and Service [Domain] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Axis] Marketable securities: Debt Securities, Available-for-Sale [Abstract] Sales returns and allowances Sales Returns And Allowance [Member] Sales returns and allowance. Noncancelable commercial purchase commitments Recorded Unconditional Purchase Obligation Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Total Liabilities, Fair Value Disclosure RESTRUCTURING Restructuring and Related Activities Disclosure [Text Block] Amortization of right-of-use assets Operating Lease, Right-of-Use Asset, Periodic Reduction Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] City Area Code City Area Code Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] All Trading Arrangements All Trading Arrangements [Member] Equity Awards Adjustments, Footnote Equity Awards Adjustments, Footnote [Text Block] Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] Accrued liabilities Accrued liabilities Accrued Liabilities, Current Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Debt Instrument, Scenario [Domain] Debt Instrument, Scenario [Domain] Debt Instrument, Scenario [Domain] Exercise of pre-funded warrant Stock Issued During Period, Value, Exercise Of Prefunded Warrant Stock Issued During Period, Value, Exercise Of Prefunded Warrant Cash flows from investing activities: Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Net cash used in operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Royalty Pharma Revenue Participation Right Purchase Agreement Royalty Pharma Revenue Participation Right Purchase Agreement [Member] Royalty Pharma Revenue Participation Right Purchase Agreement. Tranche A Tranche A [Member] Tranche A [Member] Fair Value Marketable securities Debt Securities, Available-for-Sale, Excluding Accrued Interest Percentage of commitment amount to fund loan Percentage Of Commitment Amount To Fund Loan Percentage of commitment amount to fund loan. Government rebates Government Rebates [Member] Government rebates. Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Selling, general and administrative Selling, General and Administrative Expenses [Member] Equity Valuation Assumption Difference, Footnote Equity Valuation Assumption Difference, Footnote [Text Block] PEO Total Compensation Amount PEO Total Compensation Amount Money market funds Money market funds Money Market Funds [Member] Equity Components Equity Components [Axis] Non-Rule 10b5-1 Arrangement Adopted Non-Rule 10b5-1 Arrangement Adopted [Flag] Product revenue, net Net product revenue Product [Member] Number of reportable segments Number of Reportable Segments Municipal securities (due in less than one year) Municipal securities (due in less than one year) Municipal Securities Due In Less Than One Year [Member] Municipal securities due in less than one year. Other Performance Measure, Amount Other Performance Measure, Amount Entity Address, State or Province Entity Address, State or Province Term Loans Term Loans [Member] Term loans. Total current liabilities Liabilities, Current Restructuring and related cost, number of positions eliminated, period percent Restructuring and Related Cost, Number of Positions Eliminated, Period Percent Individual: Individual [Axis] Tranche B Tranche B [Member] Tranche B [Member] Research and development Research and Development Expense [Member] Additional paid-in capital Additional Paid in Capital, Common Stock Net cash provided by investing activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member] Liability related to sale of future royalties Liability Related To Sale Of Future Royalties, Current Liability Related To Sale Of Future Royalties, Current Total gross-to-net adjustments Total Gross To Net Adjustments [Member] Total gross to net adjustments. Document Fiscal Year Focus Document Fiscal Year Focus Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Operating leases, right-of-use assets Operating Lease, Right-of-Use Asset Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] Entity Interactive Data Current Entity Interactive Data Current Stock-based compensation related to issuances of common stock and options for services (in shares) APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition, Shares APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition, Shares Accrued other Other Employee-related Liabilities, Current Tranche C Tranche C [Member] Tranche C [Member] Corporate notes (due in one to two years) Corporate Note Securities Due In One To Two Years [Member] This category includes information about short-term debt securities that are issued by either a domestic or foreign corporate business entity with a date certain promise of repayment and a return to the holder for the time value of money (for example, variable or fixed interest), due in one to two years. Thereafter Long-Term Debt, Maturity, After Year Three Long-Term Debt, Maturity, After Year Three SEGMENT REPORTING Segment Reporting Disclosure [Text Block] U.S. Treasury securities US Treasury Notes Securities [Member] Fair Value on a Recurring Basis Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Municipal securities (due in one to two years) Municipal Securities Due In One To Two Years [Member] Municipal Securities Due In One To Two Years Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Gross Unrealized Losses Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss [Abstract] Distributor service fees Distributor Service Fees [Member] Distributor Service Fees Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] Chargebacks Chargebacks [Member] Chargeback and distributor service fees. Fair Value Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Table] Fair Value, Recurring and Nonrecurring [Table] Selling, general and administrative Commercial expenses Selling, General and Administrative Expense Restricted cash Amortized Cost Restricted Cash and Cash Equivalent, Current Interest payable Interest Payable, Current Entity Central Index Key Entity Central Index Key PEO Name PEO Name Schedule of Future Minimum Payments Under Loan Agreement Schedule of Maturities of Long-Term Debt [Table Text Block] Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member] Research and development Research and Development Expense [Abstract] Issuance of common stock in connection with exercise of warrants Issuance Of Common Stock In Connection With Warrant Exercise Value Equity impact of the value of stock issued in connection with exercise of warrants during the period. Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount Arrangement Duration Trading Arrangement Duration FINANCIAL INSTRUMENTS Financial Instruments Disclosure [Text Block] Purchase obligation, written notice term Purchase Obligation, Written Notice Term Purchase Obligation, Written Notice Term Segments [Axis] Segments [Axis] Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Work-in-process Inventory, Work in Process, Net of Reserves Exercise Price Award Exercise Price Entity Filer Category Entity Filer Category Local Phone Number Local Phone Number Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] ASSETS Assets [Abstract] Noncurrent debt Noncurrent portion of debt Long-Term Debt, Excluding Current Maturities Credit Facility Credit Facility [Axis] Underlying Security Market Price Change Underlying Security Market Price Change, Percent Debt Instrument [Axis] Debt Instrument [Axis] FAIR VALUE MEASUREMENTS Fair Value Disclosures [Text Block] Credit Facility Credit Facility [Domain] Stockholders' equity: Equity, Attributable to Parent [Abstract] Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member] Entity Address, Address Line One Entity Address, Address Line One Entity Address, Address Line Two Entity Address, Address Line Two Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Noncurrent operating lease liabilities Operating Lease, Liability, Noncurrent Interest expense recognized Royalty Expense Fair Value as of Grant Date Award Grant Date Fair Value Pharmakon Loan Agreement Pharmakon Loan Agreement [Member] Pharmakon loan agreement. Entity Registrant Name Entity Registrant Name Proceeds from the exercise of warrants Proceeds from Warrant Exercises Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Municipal securities Municipal Bonds [Member] Sale of future royalties Carrying value of liability related to sale of future royalties at beginning of period Carrying value of liability related to sale of future royalties at end of period Accrued Royalties Document Quarterly Report Document Quarterly Report Less Than 12 Months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months Total Assets, Fair Value Disclosure Exercise of pre-funded warrant (in shares) Stock Issued During Period, Shares, Exercise Of Prefunded Warrant Stock Issued During Period, Shares, Exercise Of Prefunded Warrant Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Selling, general and administrative Selling, General and Administrative Expense [Abstract] Counterparty Name [Domain] Counterparty Name [Domain] Government-sponsored enterprise securities US Government-sponsored Enterprises Debt Securities [Member] Number of operating segments Number of Operating Segments Investments, All Other Investments [Abstract] Accretion and amortization on investments, net Accretion (Amortization) of Discounts and Premiums, Investments Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Title Trading Arrangement, Individual Title Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Restatement Determination Date: Restatement Determination Date [Axis] Issuances of common stock under equity plans Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture Non-PEO NEO Non-PEO NEO [Member] 3rd Anniversary But, Prior To 4th Anniversary Of Funding Date Prepaid On Or After Third Anniversary But Prior To Fourth Anniversary Of Funding Date [Member] Prepaid on or after third anniversary but prior to fourth anniversary of funding date. Gross Unrealized Gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Name Trading Arrangement, Individual Name All Award Types Award Type [Domain] Schedule of Accrued Compensation and Benefits Schedule Of Accrued Compensation And Benefits [Table Text Block] Schedule Of Accrued Compensation And Benefits Equity Awards Adjustments Equity Awards Adjustments [Member] Pension Benefits Adjustments, Footnote Pension Benefits Adjustments, Footnote [Text Block] Long-term manufacturing commitments, amount Long-Term Purchase Commitment, Amount Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Scenario One Scenario One [Member] Scenario one. Compensation Amount Outstanding Recovery Compensation Amount Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Cost of goods sold Operating Costs and Expenses Certificate of deposit Certificate of deposit Certificates of Deposit [Member] Recovery of Erroneously Awarded Compensation Disclosure [Line Items] Accrued compensation and benefits Increase (Decrease) in Employee Related Liabilities MNPI Disclosure Timed for Compensation Value MNPI Disclosure Timed for Compensation Value [Flag] Name Awards Close in Time to MNPI Disclosures, Individual Name Payments Payments for Restructuring Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] Debt Instrument, Scenario [Axis] Debt Instrument, Scenario [Axis] Debt Instrument, Scenario Revenues: Revenues [Abstract] Reportable Segment Reportable Segment [Member] Reportable Segment Amortized Cost Cash Equivalents, at Carrying Value Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax 2027 Long-Term Debt, Maturity, Year One Financial Instruments Financial Instruments [Domain] Segments [Domain] Segments [Domain] Income Statement Location Statement of Income Location, Balance [Axis] Aggregate Pension Adjustments Service Cost Aggregate Pension Adjustments Service Cost [Member] Royalties Royalty [Member] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Domain] Inventory Increase (Decrease) in Inventories Inventory Total inventory Inventory, Net Amortization of debt issuance costs/debt discounts Amortization of Debt Issuance Costs and Discounts Minimum Minimum [Member] U.S. Treasury securities (due in less than one year) U S Treasury Securities Due In Less Than One Year [Member] US Treasury Securities Due In less than one Year Member. Company Selected Measure Name Company Selected Measure Name DEBT Debt Disclosure [Text Block] Preferred Stock, Value, Issued Preferred Stock, Value, Issued Aggregate Available Trading Arrangement, Securities Aggregate Available Amount Accounts payable Accounts Payable, Current Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] All Executive Categories All Executive Categories [Member] Finished goods Inventory, Finished Goods, Net of Reserves Common Stock, Value, Issued Common Stock, Value, Issued COMMITMENTS AND CONTINGENCIES Commitments and Contingencies Disclosure [Text Block] Weighted-average shares used in calculating diluted net loss per share (in shares) Weighted Average Number of Shares Outstanding, Diluted Commitments and contingencies Commitments and Contingencies Non-GAAP Measure Description Non-GAAP Measure Description [Text Block] Reconciliation of Assets from Segment to Consolidated [Table] Reconciliation of Assets from Segment to Consolidated [Table] Restricted cash: Restricted Cash and Investments [Abstract] Entity Small Business Entity Small Business Research and clinical expenses Research And Clinical Expenses [Member] Research and clinical expenses. Document Transition Report Document Transition Report Summary of Investment Holdings [Line Items] Summary of Investment Holdings [Line Items] Underlying Securities Award Underlying Securities Amount Corporate notes Corporate Note Securities [Member] Fair Value Restricted Investments, at Fair Value Equity Component Equity Component [Domain] Document Period End Date Document Period End Date PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Awards Close in Time to MNPI Disclosures, Table Awards Close in Time to MNPI Disclosures [Table Text Block] Revenue from Contract with Customer [Abstract] Revenue from Contract with Customer [Abstract] Commercial expenses Commercial Expenses [Member] Commercial expenses. Document Type Document Type Level 3 Fair Value, Inputs, Level 3 [Member] Fair Value Debt Securities, Available-for-Sale, Unrealized Loss Position [Abstract] NET LOSS PER COMMON SHARE Earnings Per Share [Text Block] Name Outstanding Recovery, Individual Name Product and Service [Axis] Product and Service [Axis] Total revenues Net product revenue Revenue from Contract with Customer, Excluding Assessed Tax All Individuals All Individuals [Member] FAIR VALUE MEASUREMENTS Fair Value Disclosures [Abstract] Noncurrent liability related to sale of future royalties Liability Related To Sale Of Future Royalties, Noncurrent Noncurrent liability related to sale of future royalties. Name Forgone Recovery, Individual Name Total current assets Assets, Current Statistical Measurement Statistical Measurement [Axis] Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member] Proceeds from issuances of common stock from equity plans Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised Schedule Of Activity Within Liability Related To Sale Of Future Royalties Schedule Of Activity Within Liability Related To Sale Of Future Royalties [Table Text Block] Schedule of activity within liability related to sale of future royalties. Number of putative securities lawsuits Loss Contingency, New Claims Filed, Number Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Current liabilities: Liabilities, Current [Abstract] Other comprehensive loss OCI, Debt Securities, Available-for-Sale, Gain (Loss), before Adjustment, after Tax Total costs and operating expenses Operating Expenses Rule 10b5-1 Arrangement Terminated Rule 10b5-1 Arrangement Terminated [Flag] Level 1 Fair Value, Inputs, Level 1 [Member] Diluted net loss per share (in dollars per share) Earnings Per Share, Diluted Accrued liabilities Increase (Decrease) in Other Accrued Liabilities Erroneously Awarded Compensation Recovery Erroneously Awarded Compensation Recovery [Table] Accounts receivable, net Accounts Receivable, after Allowance for Credit Loss, Current Title of 12(b) Security Title of 12(b) Security Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Long-Term Debt, Fiscal Year Maturity [Abstract] Long-Term Debt, Fiscal Year Maturity [Abstract] Earnings Per Share [Abstract] Stock-based compensation related to issuances of common stock and options for services APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition Accrued revenue adjustments Gross To Net Adjustments, Current Gross To Net Adjustments, Current Schedule of Reconciliation of Gross Product Sales to Net Product Sales Schedule Of Gross To Net Sales Adjustments [Table Text Block] Schedule of gross to net sales adjustments. Gross Unrealized Gains Restricted Cash And Cash Equivalents, Gross Unrealized Gains Restricted Cash And Cash Equivalents, Gross Unrealized Gains OTHER CONDENSED CONSOLIDATED FINANCIAL STATEMENT DETAILS Accounts Payable and Accrued Liabilities Disclosure [Text Block] Award Timing Disclosures [Line Items] Schedule of Inventory Schedule of Inventory, Current [Table Text Block] Total Long-Term Debt, Gross Gross product revenue Revenues Before Adjustments [Member] Revenues before adjustments. Accrued compensation and benefits Accrued compensation and benefits Employee-related Liabilities, Current Net unrealized gain (loss) on marketable securities OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Net loss Net loss Net loss Net Income (Loss) Attributable to Parent Schedule of Cash Equivalents and Marketable Securities with Unrealized Losses Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block] Expiration Date Trading Arrangement Expiration Date Other Other Accrued Liabilities, Current Property and equipment, net Property, Plant and Equipment, Net Restructuring charges Expenses and adjustments Restructuring Charges Adoption Date Trading Arrangement Adoption Date 4th Anniversary Of Funding Date Prepaid On Or After Fourth Anniversary Of Funding Date [Member] Prepaid on or after fourth anniversary of funding date. Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Accounts receivable, net Increase (Decrease) in Accounts Receivable Entity Current Reporting Status Entity Current Reporting Status Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Summary of Significant Accounting Policies Significant Accounting Policies, Policy [Policy Text Block] Significant Accounting Policies, Policy Income (loss) from operations Operating Income (Loss) Accumulated deficit Retained Earnings (Accumulated Deficit) Financial Instrument Financial Instrument [Axis] Adjustments to reconcile net loss to net cash used in operating activities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Noncash Item [Abstract] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Executive Category: Executive Category [Axis] 12 Months or Longer Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Current Fiscal Year End Date Current Fiscal Year End Date Percentage of annual net sales Percentage Of Annual Net Sales Percentage of annual net sales. Less Than 12 Months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member] Payables and Accruals [Abstract] Payables and Accruals [Abstract] Other income (expense), net Other Nonoperating Income (Expense) Statement [Table] Statement [Table] Stock-based compensation for equity-based awards to employees and directors APIC, Share-Based Payment Arrangement, ESPP, Increase for Cost Recognition Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table] Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table] Cash flows from financing activities: Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Contract research organization and clinical trial costs Accrued Clinical Research Organizations And Clinical Trial Costs, Current Carrying value as of the balance sheet date of obligations incurred through that date and payable for clinical related costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Upfront payment received Upfront Payment Received Upfront payment received. Total Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss Schedule of Financial Instruments Measured at Fair Value on Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Proceeds from maturities and sales of marketable securities Proceeds from Sale and Maturity of Marketable Securities Included in cash and cash equivalents: Cash and Cash Equivalents [Abstract] Potential dilutive securities excluded from diluted earnings (loss) per share calculation (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount All Adjustments to Compensation All Adjustments to Compensation [Member] Amendment Flag Amendment Flag Floor rate Debt Instrument, Floor Rate Debt instrument floor rate. 2028 Long-Term Debt, Maturity, Year Two Termination Date Trading Arrangement Termination Date Net cash provided by financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Measure: Measure [Axis] Debt instrument, variable interest rate, type flag Debt Instrument, Variable Interest Rate, Type [Extensible Enumeration] Raw materials Inventory, Raw Materials, Net of Reserves Weighted-average shares used in calculating basic net loss per share (in shares) Weighted Average Number of Shares Outstanding, Basic Corporate notes (due in less than one year) Corporate Note Securities Due In Less Than One Year [Member] This category includes information about short-term debt securities that are issued by either a domestic or foreign corporate business entity with a date certain promise of repayment and a return to the holder for the time value of money (for example, variable or fixed interest), due in less than one year. Segment Reporting [Abstract] Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Debt Disclosure [Abstract] Debt Disclosure [Abstract] Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Entity Tax Identification Number Entity Tax Identification Number Cash, cash equivalents and restricted cash Cash And Cash Equivalents And Restricted Cash, Fair Value Disclosure Cash And Cash Equivalents And Restricted Cash, Fair Value Disclosure Restructuring and Related Activities [Abstract] Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Use of Estimates Use of Estimates, Policy [Policy Text Block] Interest expense Interest Expense, Nonoperating Trading Arrangement: Trading Arrangement [Axis] Total Shareholder Return Amount Total Shareholder Return Amount Foreign currency translation adjustment Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax Insider Trading Arrangements [Line Items] Security Exchange Name Security Exchange Name Schedule of Reconciliation of Reported Revenues to Net (Loss) Income Under Significant Expense Principle Reconciliation of Revenue from Segments to Consolidated [Table Text Block] 2026 Long-Term Debt, Maturity, Remainder of Fiscal Year Total liabilities Liabilities Antidilutive Securities, Name Antidilutive Securities, Name [Domain] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Maximum borrowing capacity under term loan Line of Credit Facility, Maximum Borrowing Capacity Marketable securities Debt Securities, Available-for-Sale, Excluding Accrued Interest, Current Pension Adjustments Prior Service Cost Pension Adjustments Prior Service Cost [Member] Costs and operating expenses: Operating expenses: Operating Expenses [Abstract] Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Royalty payment, ratio Debt Instrument, Royalty Payment, Ratio Debt Instrument, Royalty Payment, Ratio Statement [Line Items] Statement [Line Items] Summary of Charges and Spending Related to Restructuring Schedule of Restructuring Reserve by Type of Cost [Table Text Block] Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Cash and cash equivalents Cash and Cash Equivalent Counterparty Name [Axis] Counterparty Name [Axis] Common Stock Common Stock [Member] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Non-NEOs Non-NEOs [Member] Net increase (decrease) in cash, cash equivalents and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Professional, legal and accounting fees Accrued Professional Fees, Current Secured Overnight Financing Rate (SOFR) [Member]