<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c7730-46e9-7212-bc71-75c229f2667a,g:9ff11a8a-3051-4cda-8828-c63f363e56da-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.geron.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="gern-20260331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019c7730-47b6-7c02-a865-e60b75802733" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019c7730-47b6-77ee-94bb-4e12190c0268" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c7730-47b6-7c02-a865-e60b75802733" xlink:to="loc_us-gaap_AccountsPayableCurrent_019c7730-47b6-77ee-94bb-4e12190c0268" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019c7730-47b6-7750-9319-4611e0e6d719" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c7730-47b6-7c02-a865-e60b75802733" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019c7730-47b6-7750-9319-4611e0e6d719" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019c7730-47b6-737a-b254-12e73d7713e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c7730-47b6-7c02-a865-e60b75802733" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019c7730-47b6-737a-b254-12e73d7713e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_LiabilityRelatedToSaleOfFutureRoyaltiesCurrent_019c7730-47b6-7346-b830-4a2f4bfd627a" xlink:href="gern-20260331.xsd#gern_LiabilityRelatedToSaleOfFutureRoyaltiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c7730-47b6-7c02-a865-e60b75802733" xlink:to="loc_gern_LiabilityRelatedToSaleOfFutureRoyaltiesCurrent_019c7730-47b6-7346-b830-4a2f4bfd627a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-47b6-71c3-94b6-7849c2e8a9f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019c7730-47b6-7c02-a865-e60b75802733" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-47b6-71c3-94b6-7849c2e8a9f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7730-47b6-77fa-8d0d-a45f29e690a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019c7730-47b6-77fa-8d0d-a45f29e690a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019c7730-47b6-76c3-a9ab-a35d0698622a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019c7730-47b6-76c3-a9ab-a35d0698622a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_019c7730-47b6-7cd0-8ee7-0e79c21c0b2c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_019c7730-47b6-7cd0-8ee7-0e79c21c0b2c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019c7730-47b6-7730-b083-ff1e98333cd7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019c7730-47b6-7730-b083-ff1e98333cd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NontradeReceivablesCurrent_019c7730-47b6-77b9-b77b-f75073ae7db2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NontradeReceivablesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:to="loc_us-gaap_NontradeReceivablesCurrent_019c7730-47b6-77b9-b77b-f75073ae7db2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019c7730-47b6-7077-80e8-2ea9c37776f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:to="loc_us-gaap_InventoryNet_019c7730-47b6-7077-80e8-2ea9c37776f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c7730-47b6-7b61-88c7-adcc04ab5ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019c7730-47b6-7e4c-a7c7-ea9227f68131" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019c7730-47b6-7b61-88c7-adcc04ab5ba6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019dbfe2-08a0-74a3-b247-330464ef4728" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019dbfe2-08a0-7dcc-bd3d-7f041698eb96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019dbfe2-08a0-74a3-b247-330464ef4728" xlink:to="loc_us-gaap_LiabilitiesCurrent_019dbfe2-08a0-7dcc-bd3d-7f041698eb96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019dbfe2-08a0-7bd9-a4bf-226009bba732" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019dbfe2-08a0-74a3-b247-330464ef4728" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019dbfe2-08a0-7bd9-a4bf-226009bba732" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_LiabilityRelatedToSaleOfFutureRoyaltiesNoncurrent_019dbfe2-08a0-74c4-a592-8d983539aa89" xlink:href="gern-20260331.xsd#gern_LiabilityRelatedToSaleOfFutureRoyaltiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019dbfe2-08a0-74a3-b247-330464ef4728" xlink:to="loc_gern_LiabilityRelatedToSaleOfFutureRoyaltiesNoncurrent_019dbfe2-08a0-74c4-a592-8d983539aa89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019dbfe2-08a0-7bcc-ba4e-2304ee4ca73b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019dbfe2-08a0-74a3-b247-330464ef4728" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019dbfe2-08a0-7bcc-ba4e-2304ee4ca73b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019c7730-47b6-738d-a5f4-4a58301978c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019c7730-47b6-776f-8a16-0adf5ced25b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c7730-47b6-738d-a5f4-4a58301978c6" xlink:to="loc_us-gaap_AssetsCurrent_019c7730-47b6-776f-8a16-0adf5ced25b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent_019c7730-47b6-7b13-94f7-552d97d3d033" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c7730-47b6-738d-a5f4-4a58301978c6" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestNoncurrent_019c7730-47b6-7b13-94f7-552d97d3d033" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019c7730-47b6-73de-991b-7c9f10c3737c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c7730-47b6-738d-a5f4-4a58301978c6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019c7730-47b6-73de-991b-7c9f10c3737c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c7730-47b6-71b1-92ea-bc722604146c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c7730-47b6-738d-a5f4-4a58301978c6" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019c7730-47b6-71b1-92ea-bc722604146c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_DepositsAndOtherAssetsNoncurrent_019c7730-47b6-7385-8773-ccc850960a34" xlink:href="gern-20260331.xsd#gern_DepositsAndOtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019c7730-47b6-738d-a5f4-4a58301978c6" xlink:to="loc_gern_DepositsAndOtherAssetsNoncurrent_019c7730-47b6-7385-8773-ccc850960a34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c7730-47b6-7bd2-a28c-683a978afe2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019c7730-47b6-792c-b169-df8c86f6ee6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c7730-47b6-7bd2-a28c-683a978afe2d" xlink:to="loc_us-gaap_PreferredStockValue_019c7730-47b6-792c-b169-df8c86f6ee6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019c7730-47b6-7329-92c0-8d88aa5a8a31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c7730-47b6-7bd2-a28c-683a978afe2d" xlink:to="loc_us-gaap_CommonStockValue_019c7730-47b6-7329-92c0-8d88aa5a8a31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019c7730-47b6-7cdf-9444-77923f126c04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c7730-47b6-7bd2-a28c-683a978afe2d" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019c7730-47b6-7cdf-9444-77923f126c04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c7730-47b6-7c76-812f-5493b63f2895" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c7730-47b6-7bd2-a28c-683a978afe2d" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019c7730-47b6-7c76-812f-5493b63f2895" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019dbfe3-df03-7f55-adac-8c2af23b22d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019c7730-47b6-7bd2-a28c-683a978afe2d" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019dbfe3-df03-7f55-adac-8c2af23b22d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c7730-47b6-744e-8fc5-384503c0b738" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019c7730-47b6-794b-bf83-2868946ba16a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c7730-47b6-744e-8fc5-384503c0b738" xlink:to="loc_us-gaap_Liabilities_019c7730-47b6-794b-bf83-2868946ba16a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019c7730-47b6-79b7-bb12-9eaba50ca67e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c7730-47b6-744e-8fc5-384503c0b738" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019c7730-47b6-79b7-bb12-9eaba50ca67e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c7730-47b6-7f7e-a656-834f25d256d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019c7730-47b6-744e-8fc5-384503c0b738" xlink:to="loc_us-gaap_StockholdersEquity_019c7730-47b6-7f7e-a656-834f25d256d5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="gern-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7718-95ef-02c22df1662a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c7730-47b6-7824-85cf-487f3233cdce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7718-95ef-02c22df1662a" xlink:to="loc_us-gaap_OperatingIncomeLoss_019c7730-47b6-7824-85cf-487f3233cdce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019c7730-47b6-7a2e-a3ac-3134aa1172ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7718-95ef-02c22df1662a" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019c7730-47b6-7a2e-a3ac-3134aa1172ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019c7730-47b6-7a9c-a6d5-1e6f8ca27dd7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7718-95ef-02c22df1662a" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019c7730-47b6-7a9c-a6d5-1e6f8ca27dd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019c7730-47b6-7b19-bd90-e241afe396da" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7718-95ef-02c22df1662a" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019c7730-47b6-7b19-bd90-e241afe396da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c7730-47b6-768e-ad53-c3d2b64cd289" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c7730-47b6-767e-944a-bc9490aab496" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019c7730-47b6-768e-ad53-c3d2b64cd289" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c7730-47b6-767e-944a-bc9490aab496" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019c7730-47b6-7542-a1f9-6a27685ec131" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019c7730-47b6-768e-ad53-c3d2b64cd289" xlink:to="loc_us-gaap_OperatingExpenses_019c7730-47b6-7542-a1f9-6a27685ec131" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019c7730-47b6-7aa9-8e9d-42a38afd4716" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses_019c7730-47b6-7b4a-ba27-9e73d5e22917" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c7730-47b6-7aa9-8e9d-42a38afd4716" xlink:to="loc_us-gaap_OperatingCostsAndExpenses_019c7730-47b6-7b4a-ba27-9e73d5e22917" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019c7730-47b6-70de-a12c-33e3ad8b94d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c7730-47b6-7aa9-8e9d-42a38afd4716" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_019c7730-47b6-70de-a12c-33e3ad8b94d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019c7730-47b6-7f0d-8a0b-4a19afc9e916" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c7730-47b6-7aa9-8e9d-42a38afd4716" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019c7730-47b6-7f0d-8a0b-4a19afc9e916" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_019dc3e7-4a01-7ac6-aeaf-eaedce846386" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019c7730-47b6-7aa9-8e9d-42a38afd4716" xlink:to="loc_us-gaap_RestructuringCharges_019dc3e7-4a01-7ac6-aeaf-eaedce846386" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="gern-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c7730-47b6-760e-83da-4f5a362a2f20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7a70-b6ce-ebbccc1d6334" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c7730-47b6-760e-83da-4f5a362a2f20" xlink:to="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7a70-b6ce-ebbccc1d6334" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019c7730-47b6-79a3-91a6-5668a1e23516" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c7730-47b6-760e-83da-4f5a362a2f20" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019c7730-47b6-79a3-91a6-5668a1e23516" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019c7730-47b6-7618-82a8-0d05e6e8efb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019c7730-47b6-760e-83da-4f5a362a2f20" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019c7730-47b6-7618-82a8-0d05e6e8efb9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="gern-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c7730-47b6-766f-907d-4a8745cd4281" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_PaymentsUnpaidToAcquirePropertyPlantAndEquipment_019c7730-47b6-7990-a37f-095a87493d0c" xlink:href="gern-20260331.xsd#gern_PaymentsUnpaidToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c7730-47b6-766f-907d-4a8745cd4281" xlink:to="loc_gern_PaymentsUnpaidToAcquirePropertyPlantAndEquipment_019c7730-47b6-7990-a37f-095a87493d0c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019c7730-47b6-75d8-9fd4-61ec1653b32a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c7730-47b6-766f-907d-4a8745cd4281" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019c7730-47b6-75d8-9fd4-61ec1653b32a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019c7730-47b6-7572-b5be-79bb9a094342" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c7730-47b6-766f-907d-4a8745cd4281" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019c7730-47b6-7572-b5be-79bb9a094342" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7793-be70-6f4a01d69c79" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_NetIncomeLoss_019c7730-47b6-7793-be70-6f4a01d69c79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_019c7730-47b6-7462-8275-fce2bac8caff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_DepreciationAndAmortization_019c7730-47b6-7462-8275-fce2bac8caff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019c7730-47b6-76c8-a272-a5e651c066e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019c7730-47b6-76c8-a272-a5e651c066e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019c7730-47b6-7e2d-91a3-acb2ef992bf4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019c7730-47b6-7e2d-91a3-acb2ef992bf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_NoncashInterestExpenseOnLiabilitiesForSalesOfFutureRoyalties_019c7730-47b6-7696-9034-dd84a8834acc" xlink:href="gern-20260331.xsd#gern_NoncashInterestExpenseOnLiabilitiesForSalesOfFutureRoyalties"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_gern_NoncashInterestExpenseOnLiabilitiesForSalesOfFutureRoyalties_019c7730-47b6-7696-9034-dd84a8834acc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019c7730-47b6-7c26-9b26-ddc07b221f63" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_ShareBasedCompensation_019c7730-47b6-7c26-9b26-ddc07b221f63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019c7730-47b6-7878-a69e-b25a7443e439" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019c7730-47b6-7878-a69e-b25a7443e439" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_IncreaseDecreaseInAllowanceForDoubtfulAccounts_019c7730-47b6-7be0-9ca4-78d7cf400f9d" xlink:href="gern-20260331.xsd#gern_IncreaseDecreaseInAllowanceForDoubtfulAccounts"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_gern_IncreaseDecreaseInAllowanceForDoubtfulAccounts_019c7730-47b6-7be0-9ca4-78d7cf400f9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019c7730-47b6-78ca-84be-4fbcee62dd4c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019c7730-47b6-78ca-84be-4fbcee62dd4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019c7730-47b6-716f-9a85-ce86a1f18752" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019c7730-47b6-716f-9a85-ce86a1f18752" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019c7730-47b6-748d-bbe3-9d99a716a50f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019c7730-47b6-748d-bbe3-9d99a716a50f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019c7730-47b6-7ede-b28c-dcfb32b8a00d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019c7730-47b6-7ede-b28c-dcfb32b8a00d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_019c7730-47b6-72f7-99c4-df7e366b0cf2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_019c7730-47b6-72f7-99c4-df7e366b0cf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_019dc299-1cb5-7689-b695-327027478c42" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherAccruedLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccruedLiabilities_019dc299-1cb5-7689-b695-327027478c42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRoyalties_019dc299-1cb5-7389-8561-f862c9d6e9d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRoyalties"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_us-gaap_PaymentsForRoyalties_019dc299-1cb5-7389-8561-f862c9d6e9d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_IncreaseDecreaseInOperatingLeaseLiabilities_019df8b4-0835-7c48-bd67-e361428db076" xlink:href="gern-20260331.xsd#gern_IncreaseDecreaseInOperatingLeaseLiabilities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7637-86e0-4ae2738b0afb" xlink:to="loc_gern_IncreaseDecreaseInOperatingLeaseLiabilities_019df8b4-0835-7c48-bd67-e361428db076" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c7730-47b6-74f5-b5d0-5c8d292f58d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019c7730-47b6-791b-9e4d-e6253144d614" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c7730-47b6-74f5-b5d0-5c8d292f58d0" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019c7730-47b6-791b-9e4d-e6253144d614" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_019c7730-47b6-7599-a7b3-236e3aa9cb28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromWarrantExercises"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c7730-47b6-74f5-b5d0-5c8d292f58d0" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_019c7730-47b6-7599-a7b3-236e3aa9cb28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c7730-47b6-76e4-8b3f-50689bfa799b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7cde-a6c0-398c19957169" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c7730-47b6-76e4-8b3f-50689bfa799b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019c7730-47b6-7cde-a6c0-398c19957169" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c7730-47b6-7774-b81b-21e8624dfd35" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c7730-47b6-76e4-8b3f-50689bfa799b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019c7730-47b6-7774-b81b-21e8624dfd35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c7730-47b6-7696-8da6-b51bf7dcb255" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c7730-47b6-76e4-8b3f-50689bfa799b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019c7730-47b6-7696-8da6-b51bf7dcb255" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019c7730-47b6-7365-af97-11bd7bf34979" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019c7730-47b6-76e4-8b3f-50689bfa799b" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019c7730-47b6-7365-af97-11bd7bf34979" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/INVENTORYDetails" xlink:type="simple" xlink:href="gern-20260331.xsd#INVENTORYDetails"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/INVENTORYDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019c7730-4892-7b9c-98c4-2e244cbe3ec7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019c7730-4892-71e3-9f68-11903fc3a299" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c7730-4892-7b9c-98c4-2e244cbe3ec7" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019c7730-4892-71e3-9f68-11903fc3a299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019c7730-4892-77f3-a725-84484b534996" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c7730-4892-7b9c-98c4-2e244cbe3ec7" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019c7730-4892-77f3-a725-84484b534996" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019c7730-4892-7a49-abb8-bacad727b1c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019c7730-4892-7b9c-98c4-2e244cbe3ec7" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019c7730-4892-7a49-abb8-bacad727b1c5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/FINANCIALINSTRUMENTSCashEquivalentsandMarketableSecuritiesDetails" xlink:type="simple" xlink:href="gern-20260331.xsd#FINANCIALINSTRUMENTSCashEquivalentsandMarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/FINANCIALINSTRUMENTSCashEquivalentsandMarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019dc2a8-10b3-70b7-a1f3-00910f92b032" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_RestrictedCashAndCashEquivalentsGrossUnrealizedGains_019dc2a8-10b3-7c5e-8062-11be8e298ed0" xlink:href="gern-20260331.xsd#gern_RestrictedCashAndCashEquivalentsGrossUnrealizedGains"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019dc2a8-10b3-70b7-a1f3-00910f92b032" xlink:to="loc_gern_RestrictedCashAndCashEquivalentsGrossUnrealizedGains_019dc2a8-10b3-7c5e-8062-11be8e298ed0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_RestrictedCashAndCashEquivalentsGrossUnrealizedLosses_019dc2a8-10b3-7256-b1f3-da5312d551f5" xlink:href="gern-20260331.xsd#gern_RestrictedCashAndCashEquivalentsGrossUnrealizedLosses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019dc2a8-10b3-70b7-a1f3-00910f92b032" xlink:to="loc_gern_RestrictedCashAndCashEquivalentsGrossUnrealizedLosses_019dc2a8-10b3-7256-b1f3-da5312d551f5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedInvestmentsAtFairValue_019dc2a8-10b3-7523-b379-5c8b9c7d929c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedInvestmentsAtFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019dc2a8-10b3-70b7-a1f3-00910f92b032" xlink:to="loc_us-gaap_RestrictedInvestmentsAtFairValue_019dc2a8-10b3-7523-b379-5c8b9c7d929c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_019dc2a8-10b3-7290-bac2-5baf25ebe53f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_CashAndCashEquivalentsUnrealizedLosses_019dc2a8-10b3-7736-8972-a115c413c26a" xlink:href="gern-20260331.xsd#gern_CashAndCashEquivalentsUnrealizedLosses"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValue_019dc2a8-10b3-7290-bac2-5baf25ebe53f" xlink:to="loc_gern_CashAndCashEquivalentsUnrealizedLosses_019dc2a8-10b3-7736-8972-a115c413c26a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019dc2a8-10b3-7baa-b205-72e4e490c176" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValue_019dc2a8-10b3-7290-bac2-5baf25ebe53f" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019dc2a8-10b3-7baa-b205-72e4e490c176" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_CashAndCashEquivalentsUnrealizedGains_019dc2a8-10b3-750b-bd0d-5be710c338fd" xlink:href="gern-20260331.xsd#gern_CashAndCashEquivalentsUnrealizedGains"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashEquivalentsAtCarryingValue_019dc2a8-10b3-7290-bac2-5baf25ebe53f" xlink:to="loc_gern_CashAndCashEquivalentsUnrealizedGains_019dc2a8-10b3-750b-bd0d-5be710c338fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019dc2a8-10b3-7c10-a2d1-328806371658" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019dc2a8-10b3-780f-86bc-d3304c3795e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019dc2a8-10b3-7c10-a2d1-328806371658" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019dc2a8-10b3-780f-86bc-d3304c3795e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019dc2a8-10b3-745d-b83d-c095f3c91931" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019dc2a8-10b3-7c10-a2d1-328806371658" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019dc2a8-10b3-745d-b83d-c095f3c91931" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019dc2a8-10b3-7296-8350-0bf068bfef14" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLoss_019dc2a8-10b3-7c10-a2d1-328806371658" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019dc2a8-10b3-7296-8350-0bf068bfef14" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/FINANCIALINSTRUMENTSCashEquivalentsandMarketableSecuritieswithUnrealizedLossesDetails" xlink:type="simple" xlink:href="gern-20260331.xsd#FINANCIALINSTRUMENTSCashEquivalentsandMarketableSecuritieswithUnrealizedLossesDetails"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/FINANCIALINSTRUMENTSCashEquivalentsandMarketableSecuritieswithUnrealizedLossesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019dc2a8-10b3-7b29-a90c-d48b4250da4f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019dc2a8-10b3-70a2-9294-9aef9301bfa5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019dc2a8-10b3-7b29-a90c-d48b4250da4f" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_019dc2a8-10b3-70a2-9294-9aef9301bfa5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019dc2a8-10b3-7c34-858d-3fb16c204a66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019dc2a8-10b3-7b29-a90c-d48b4250da4f" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_019dc2a8-10b3-7c34-858d-3fb16c204a66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019dc2a8-10b3-7767-9e05-8d72dd9fda50" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019dc2a8-10b3-73a5-915f-f8c9df909dbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019dc2a8-10b3-7767-9e05-8d72dd9fda50" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_019dc2a8-10b3-73a5-915f-f8c9df909dbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019dc2a8-10b3-7e8b-9767-545f298b61f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019dc2a8-10b3-7767-9e05-8d72dd9fda50" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_019dc2a8-10b3-7e8b-9767-545f298b61f4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/FAIRVALUEMEASUREMENTSDetails" xlink:type="simple" xlink:href="gern-20260331.xsd#FAIRVALUEMEASUREMENTSDetails"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/FAIRVALUEMEASUREMENTSDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019c7730-4892-7a8b-95ca-629dc3105e18" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_CashAndCashEquivalentsAndRestrictedCashFairValueDisclosure_019c7730-4892-7734-903c-c137e544bdf3" xlink:href="gern-20260331.xsd#gern_CashAndCashEquivalentsAndRestrictedCashFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019c7730-4892-7a8b-95ca-629dc3105e18" xlink:to="loc_gern_CashAndCashEquivalentsAndRestrictedCashFairValueDisclosure_019c7730-4892-7734-903c-c137e544bdf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c7730-4892-7e48-9e5e-36b458b8f0b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019c7730-4892-7a8b-95ca-629dc3105e18" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterest_019c7730-4892-7e48-9e5e-36b458b8f0b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_019dc2da-f54c-70a7-a38f-214f68a4a3f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_019dc2da-f54c-7255-84af-80c363b1ba1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedRoyaltiesCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_019dc2da-f54c-70a7-a38f-214f68a4a3f7" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_019dc2da-f54c-7255-84af-80c363b1ba1e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/OTHERCONDENSEDCONSOLIDATEDFINANCIALSTATEMENTDETAILSScheduleofAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="gern-20260331.xsd#OTHERCONDENSEDCONSOLIDATEDFINANCIALSTATEMENTDETAILSScheduleofAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/OTHERCONDENSEDCONSOLIDATEDFINANCIALSTATEMENTDETAILSScheduleofAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-4892-7824-8322-38498421eece" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_AccruedClinicalResearchOrganizationsAndClinicalTrialCostsCurrent_019c7730-4892-7f25-9b96-435ed53a3100" xlink:href="gern-20260331.xsd#gern_AccruedClinicalResearchOrganizationsAndClinicalTrialCostsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-4892-7824-8322-38498421eece" xlink:to="loc_gern_AccruedClinicalResearchOrganizationsAndClinicalTrialCostsCurrent_019c7730-4892-7f25-9b96-435ed53a3100" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_AccruedManufacturingActivitiesCurrent_019c7730-4892-75aa-b71e-c118197b9ad2" xlink:href="gern-20260331.xsd#gern_AccruedManufacturingActivitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-4892-7824-8322-38498421eece" xlink:to="loc_gern_AccruedManufacturingActivitiesCurrent_019c7730-4892-75aa-b71e-c118197b9ad2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_019c7730-4892-7b38-82fa-6cbc60f1f89f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-4892-7824-8322-38498421eece" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_019c7730-4892-7b38-82fa-6cbc60f1f89f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_019c7730-4892-722f-8b28-9e906226f14e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-4892-7824-8322-38498421eece" xlink:to="loc_us-gaap_InterestPayableCurrent_019c7730-4892-722f-8b28-9e906226f14e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_GrossToNetAdjustmentsCurrent_019c7730-4892-7cf2-88e2-66f6e2e6a9d5" xlink:href="gern-20260331.xsd#gern_GrossToNetAdjustmentsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-4892-7824-8322-38498421eece" xlink:to="loc_gern_GrossToNetAdjustmentsCurrent_019c7730-4892-7cf2-88e2-66f6e2e6a9d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019c7730-4892-7032-b218-91ccdb3cf2f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019c7730-4892-7824-8322-38498421eece" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019c7730-4892-7032-b218-91ccdb3cf2f2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/OTHERCONDENSEDCONSOLIDATEDFINANCIALSTATEMENTDETAILSScheduleofAccruedCompensationandBenefitsDetails" xlink:type="simple" xlink:href="gern-20260331.xsd#OTHERCONDENSEDCONSOLIDATEDFINANCIALSTATEMENTDETAILSScheduleofAccruedCompensationandBenefitsDetails"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/OTHERCONDENSEDCONSOLIDATEDFINANCIALSTATEMENTDETAILSScheduleofAccruedCompensationandBenefitsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019dc2eb-79a4-7ae9-8d1b-c53e946b306c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_019dc2eb-79a4-7c05-9535-409f39a327b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019dc2eb-79a4-7ae9-8d1b-c53e946b306c" xlink:to="loc_us-gaap_AccruedBonusesCurrent_019dc2eb-79a4-7c05-9535-409f39a327b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedVacationCurrent_019dc2eb-79a4-7a4e-a6da-f696e54eb331" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedVacationCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019dc2eb-79a4-7ae9-8d1b-c53e946b306c" xlink:to="loc_us-gaap_AccruedVacationCurrent_019dc2eb-79a4-7a4e-a6da-f696e54eb331" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_019dc2eb-79a4-75e3-9731-525f195f448a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019dc2eb-79a4-7ae9-8d1b-c53e946b306c" xlink:to="loc_us-gaap_RestructuringReserveCurrent_019dc2eb-79a4-75e3-9731-525f195f448a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherEmployeeRelatedLiabilitiesCurrent_019dc2eb-79a4-76e3-95b0-ab3497e661ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherEmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019dc2eb-79a4-7ae9-8d1b-c53e946b306c" xlink:to="loc_us-gaap_OtherEmployeeRelatedLiabilitiesCurrent_019dc2eb-79a4-76e3-95b0-ab3497e661ef" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.geron.com/role/DEBTScheduleofFutureMinimumPaymentsUnderLoanAgreementDetails" xlink:type="simple" xlink:href="gern-20260331.xsd#DEBTScheduleofFutureMinimumPaymentsUnderLoanAgreementDetails"/>
  <link:calculationLink xlink:role="http://www.geron.com/role/DEBTScheduleofFutureMinimumPaymentsUnderLoanAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019c7730-4892-7a63-94c9-ea31fdbd2045" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-73c5-84a1-13e94fbcc3a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019c7730-4892-7a63-94c9-ea31fdbd2045" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-73c5-84a1-13e94fbcc3a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedCapitalizedInterestCosts_019c7730-4892-77e2-9265-cc4abc1158d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedCapitalizedInterestCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019c7730-4892-7a63-94c9-ea31fdbd2045" xlink:to="loc_us-gaap_AccumulatedCapitalizedInterestCosts_019c7730-4892-77e2-9265-cc4abc1158d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019c7730-4892-7557-b604-6c170987c16f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019c7730-4892-7a63-94c9-ea31fdbd2045" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019c7730-4892-7557-b604-6c170987c16f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-7de5-ae17-69b00e4ec3f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019c7730-4892-7e5a-b66f-48e78b0146c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-7de5-ae17-69b00e4ec3f1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019c7730-4892-7e5a-b66f-48e78b0146c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019c7730-4892-773a-8fcc-27fbbb8bb91d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-7de5-ae17-69b00e4ec3f1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019c7730-4892-773a-8fcc-27fbbb8bb91d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019c7730-4892-7dfc-9c3d-b569a4b6c1f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-7de5-ae17-69b00e4ec3f1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019c7730-4892-7dfc-9c3d-b569a4b6c1f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019c7730-4892-7557-a4d3-879b86b2b614" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-7de5-ae17-69b00e4ec3f1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019c7730-4892-7557-a4d3-879b86b2b614" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gern_LongTermDebtMaturityAfterYearThree_019c7730-4892-7054-a022-b68eed71c428" xlink:href="gern-20260331.xsd#gern_LongTermDebtMaturityAfterYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019c7730-4892-7de5-ae17-69b00e4ec3f1" xlink:to="loc_gern_LongTermDebtMaturityAfterYearThree_019c7730-4892-7054-a022-b68eed71c428" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
