<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019dfa50-e33c-71ce-9b71-064ad8ff8998,g:a2ace849-3926-445d-bcb9-6dfa48bba9ae-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://establishmentlabs.com/role/Cover" xlink:type="simple" xlink:href="esta-20260506.xsd#Cover"/>
  <link:definitionLink xlink:role="http://establishmentlabs.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesTable_019dfa50-e33c-77b8-9a52-4a3801e2f26b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityAddressesTable_019dfa50-e33c-77b8-9a52-4a3801e2f26b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressesAddressTypeAxis_019dfa50-e33c-70a7-9d52-9c3391985f7b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntityAddressesTable_019dfa50-e33c-77b8-9a52-4a3801e2f26b" xlink:to="loc_dei_EntityAddressesAddressTypeAxis_019dfa50-e33c-70a7-9d52-9c3391985f7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_019dfa50-e33c-70a7-9d52-9c3391985f7b_default" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AddressTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_019dfa50-e33c-70a7-9d52-9c3391985f7b" xlink:to="loc_dei_AddressTypeDomain_019dfa50-e33c-70a7-9d52-9c3391985f7b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AddressTypeDomain_019dfa50-e33c-7a56-b08e-ebf10ffcb146" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AddressTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_EntityAddressesAddressTypeAxis_019dfa50-e33c-70a7-9d52-9c3391985f7b" xlink:to="loc_dei_AddressTypeDomain_019dfa50-e33c-7a56-b08e-ebf10ffcb146" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_FormerAddressMember_019dfa50-e33c-7d71-8bfb-04b728d62db1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_FormerAddressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_AddressTypeDomain_019dfa50-e33c-7a56-b08e-ebf10ffcb146" xlink:to="loc_dei_FormerAddressMember_019dfa50-e33c-7d71-8bfb-04b728d62db1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019dfa50-e33c-7338-8bde-1a46197c0dfd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_DocumentType_019dfa50-e33c-7338-8bde-1a46197c0dfd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019dfa50-e33c-7eec-aa20-efaf7f075ccf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_DocumentPeriodEndDate_019dfa50-e33c-7eec-aa20-efaf7f075ccf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019dfa50-e33c-71bb-a866-c40822d2ff09" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityRegistrantName_019dfa50-e33c-71bb-a866-c40822d2ff09" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019dfa50-e33c-7e29-87b6-ab0443964e65" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019dfa50-e33c-7e29-87b6-ab0443964e65" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019dfa50-e33c-7ad2-a503-ecf0ec5b543c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityFileNumber_019dfa50-e33c-7ad2-a503-ecf0ec5b543c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019dfa50-e33c-7949-8468-b7700a0e2a64" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityAddressAddressLine1_019dfa50-e33c-7949-8468-b7700a0e2a64" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_019dfa50-e33c-75ce-9e0d-a8b13186c679" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityAddressAddressLine2_019dfa50-e33c-75ce-9e0d-a8b13186c679" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019dfa50-e33c-7277-a946-c9ba4dddb2b0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityAddressCityOrTown_019dfa50-e33c-7277-a946-c9ba4dddb2b0" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019dfa50-e33c-7b79-a043-91cc4661ff4f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityAddressStateOrProvince_019dfa50-e33c-7b79-a043-91cc4661ff4f" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019dfa50-e33c-7563-9245-6b335b7921cd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityAddressPostalZipCode_019dfa50-e33c-7563-9245-6b335b7921cd" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCountry_019dfa50-e33c-770d-bbb6-15a48aaf81b8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCountry"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityAddressCountry_019dfa50-e33c-770d-bbb6-15a48aaf81b8" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CountryRegion_019dfa50-e33c-70e4-8a7a-f5cab9d06188" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CountryRegion"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_CountryRegion_019dfa50-e33c-70e4-8a7a-f5cab9d06188" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019dfa50-e33c-7cb9-baa2-ca9fb434f3c1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_CityAreaCode_019dfa50-e33c-7cb9-baa2-ca9fb434f3c1" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019dfa50-e33c-75b8-a054-c417f6ef8066" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_LocalPhoneNumber_019dfa50-e33c-75b8-a054-c417f6ef8066" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019dfa50-e33c-750b-b91e-2e1b4b9baa48" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_WrittenCommunications_019dfa50-e33c-750b-b91e-2e1b4b9baa48" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019dfa50-e33c-740a-9978-889584e538ce" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_SolicitingMaterial_019dfa50-e33c-740a-9978-889584e538ce" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019dfa50-e33c-71c5-bcf0-bfd858ad2058" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_PreCommencementTenderOffer_019dfa50-e33c-71c5-bcf0-bfd858ad2058" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019dfa50-e33c-7e49-8bf4-378a75205461" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019dfa50-e33c-7e49-8bf4-378a75205461" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019dfa50-e33c-739c-a98b-e6f4f3119afc" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_Security12bTitle_019dfa50-e33c-739c-a98b-e6f4f3119afc" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019dfa50-e33c-7666-8c02-ba81d05655df" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_TradingSymbol_019dfa50-e33c-7666-8c02-ba81d05655df" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019dfa50-e33c-72f5-9b61-486b0b0f5e98" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_SecurityExchangeName_019dfa50-e33c-72f5-9b61-486b0b0f5e98" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019dfa50-e33c-7d6d-883c-ae33765d5e4d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityEmergingGrowthCompany_019dfa50-e33c-7d6d-883c-ae33765d5e4d" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019dfa50-e33c-781e-9bf0-5538932dc973" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityCentralIndexKey_019dfa50-e33c-781e-9bf0-5538932dc973" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019dfa50-e33c-75c3-8e31-a01695912aa4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_AmendmentFlag_019dfa50-e33c-75c3-8e31-a01695912aa4" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019dfa50-e33c-787b-816a-0360fb2412ec" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityAddressesLineItems_019dfa50-e33c-797e-98ec-839b278d6d66" xlink:to="loc_dei_EntityTaxIdentificationNumber_019dfa50-e33c-787b-816a-0360fb2412ec" xlink:type="arc" order="24"/>
  </link:definitionLink>
</link:linkbase>
