<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019cb6f1-e708-7608-8b53-737dd260c497,g:8a872742-11e5-4052-b79d-f8ba0b8ee703-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://beigene.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="bgne-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019cb6f1-e864-7379-abc4-36dfff0a6010" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_StatementTable_019cb6f1-e864-7379-abc4-36dfff0a6010" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cb6f1-e864-7ef9-91fd-7e5937307f64" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019cb6f1-e864-7379-abc4-36dfff0a6010" xlink:to="loc_srt_ProductOrServiceAxis_019cb6f1-e864-7ef9-91fd-7e5937307f64" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e864-7ef9-91fd-7e5937307f64_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e864-7ef9-91fd-7e5937307f64" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e864-7ef9-91fd-7e5937307f64_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e864-70a1-8cb8-6671e88c8996" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e864-7ef9-91fd-7e5937307f64" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e864-70a1-8cb8-6671e88c8996" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_019cb6f1-e864-7d85-8ee5-422bc3e32396" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cb6f1-e864-70a1-8cb8-6671e88c8996" xlink:to="loc_us-gaap_ProductMember_019cb6f1-e864-7d85-8ee5-422bc3e32396" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_OtherRevenueMember_019cb6f1-e864-7c33-9adf-2bd2196c289b" xlink:href="bgne-20260331.xsd#bgne_OtherRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cb6f1-e864-70a1-8cb8-6671e88c8996" xlink:to="loc_bgne_OtherRevenueMember_019cb6f1-e864-7c33-9adf-2bd2196c289b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019cb6f1-e864-7c3e-a52a-0de40e517473" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_RevenuesAbstract_019cb6f1-e864-7c3e-a52a-0de40e517473" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e864-70c0-bf76-8564410d0905" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019cb6f1-e864-7c3e-a52a-0de40e517473" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e864-70c0-bf76-8564410d0905" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019cb6f1-e864-7d01-a2ba-b81d147d22b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019cb6f1-e864-7d01-a2ba-b81d147d22b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019cb6f1-e864-79bd-b605-b5af58009be9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_GrossProfit_019cb6f1-e864-79bd-b605-b5af58009be9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_019cb6f1-e864-74e4-8c11-b5d0f9be8a23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_019cb6f1-e864-74e4-8c11-b5d0f9be8a23" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019cb6f1-e864-7a0b-b461-311c532702de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_019cb6f1-e864-74e4-8c11-b5d0f9be8a23" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019cb6f1-e864-7a0b-b461-311c532702de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019cb6f1-e864-7446-b2ab-883ae50acc2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_019cb6f1-e864-74e4-8c11-b5d0f9be8a23" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019cb6f1-e864-7446-b2ab-883ae50acc2d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019cb6f1-e864-72a6-ad6a-e51a75017cdc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_019cb6f1-e864-74e4-8c11-b5d0f9be8a23" xlink:to="loc_us-gaap_CostsAndExpenses_019cb6f1-e864-72a6-ad6a-e51a75017cdc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019cb6f1-e864-7e6e-852c-217961dca428" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_OperatingIncomeLoss_019cb6f1-e864-7e6e-852c-217961dca428" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019cd55d-9131-7f8d-85ba-b653397d19e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019cd55d-9131-7f8d-85ba-b653397d19e6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019d0989-1dc3-7ecf-9ea3-2578a710e07a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019d0989-1dc3-7ecf-9ea3-2578a710e07a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019cb6f1-e864-71e8-810b-a225720f33af" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019cb6f1-e864-71e8-810b-a225720f33af" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019cb6f1-e864-7765-a8c9-0b359a21ce75" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019cb6f1-e864-7765-a8c9-0b359a21ce75" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019cb6f1-e864-7d64-8016-35d084a0a463" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019cb6f1-e864-7d64-8016-35d084a0a463" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019cb6f1-e864-7f9d-9b62-6f57e28618e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_NetIncomeLoss_019cb6f1-e864-7f9d-9b62-6f57e28618e0" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_019cb6f1-e864-735a-b58c-1259fd235863" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_EarningsPerShareAbstract_019cb6f1-e864-735a-b58c-1259fd235863" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019cb6f1-e864-772b-8c0d-7f10dffca881" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019cb6f1-e864-735a-b58c-1259fd235863" xlink:to="loc_us-gaap_EarningsPerShareBasic_019cb6f1-e864-772b-8c0d-7f10dffca881" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019cb6f1-e864-7b44-b547-401162165ae5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019cb6f1-e864-735a-b58c-1259fd235863" xlink:to="loc_us-gaap_EarningsPerShareDiluted_019cb6f1-e864-7b44-b547-401162165ae5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019cb6f1-e864-7594-b607-e85b2be5fe90" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019cb6f1-e864-7594-b607-e85b2be5fe90" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019cb6f1-e864-7807-ac3d-8e3ef608333c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019cb6f1-e864-7807-ac3d-8e3ef608333c" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EarningsPerAmericanDepositoryShareAbstract_019cb6f1-e864-776f-99f9-216bdbe1aa82" xlink:href="bgne-20260331.xsd#bgne_EarningsPerAmericanDepositoryShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_bgne_EarningsPerAmericanDepositoryShareAbstract_019cb6f1-e864-776f-99f9-216bdbe1aa82" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EarningsPerAmericanDepositoryShareBasic_019cb6f1-e864-7a21-a0fa-0f9a7e34d40b" xlink:href="bgne-20260331.xsd#bgne_EarningsPerAmericanDepositoryShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_EarningsPerAmericanDepositoryShareAbstract_019cb6f1-e864-776f-99f9-216bdbe1aa82" xlink:to="loc_bgne_EarningsPerAmericanDepositoryShareBasic_019cb6f1-e864-7a21-a0fa-0f9a7e34d40b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EarningsPerAmericanDepositoryShareDiluted_019cb6f1-e864-78b6-b0e1-ffe7cf6ecfe6" xlink:href="bgne-20260331.xsd#bgne_EarningsPerAmericanDepositoryShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_EarningsPerAmericanDepositoryShareAbstract_019cb6f1-e864-776f-99f9-216bdbe1aa82" xlink:to="loc_bgne_EarningsPerAmericanDepositoryShareDiluted_019cb6f1-e864-78b6-b0e1-ffe7cf6ecfe6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_WeightedAverageNumberOfAmericanDepositorySharesOutstandingBasic_019cb6f1-e864-75ad-982c-fde0e7ccc385" xlink:href="bgne-20260331.xsd#bgne_WeightedAverageNumberOfAmericanDepositorySharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_bgne_WeightedAverageNumberOfAmericanDepositorySharesOutstandingBasic_019cb6f1-e864-75ad-982c-fde0e7ccc385" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_WeightedAverageNumberOfAmericanDepositorySharesOutstandingDiluted_019cb6f1-e864-7fd4-9b8e-5790970ac59c" xlink:href="bgne-20260331.xsd#bgne_WeightedAverageNumberOfAmericanDepositorySharesOutstandingDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-78f0-ba7e-5f004a91adfa" xlink:to="loc_bgne_WeightedAverageNumberOfAmericanDepositorySharesOutstandingDiluted_019cb6f1-e864-7fd4-9b8e-5790970ac59c" xlink:type="arc" order="16"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="simple" xlink:href="bgne-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019cb6f1-e864-7481-afee-6ebf3705eb6a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019cb6f1-e864-7971-8dfd-9823dd23711a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-7481-afee-6ebf3705eb6a" xlink:to="loc_us-gaap_StatementTable_019cb6f1-e864-7971-8dfd-9823dd23711a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e864-7c83-99a7-0be10a8d5165" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019cb6f1-e864-7971-8dfd-9823dd23711a" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e864-7c83-99a7-0be10a8d5165" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-7c83-99a7-0be10a8d5165_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e864-7c83-99a7-0be10a8d5165" xlink:to="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-7c83-99a7-0be10a8d5165_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-74ff-b86a-f87c3b809c46" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e864-7c83-99a7-0be10a8d5165" xlink:to="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-74ff-b86a-f87c3b809c46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019cb6f1-e864-7e9c-9c60-583788d271cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-74ff-b86a-f87c3b809c46" xlink:to="loc_us-gaap_CommonStockMember_019cb6f1-e864-7e9c-9c60-583788d271cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019cb6f1-e864-7cde-bcde-b2fb9c56ed3e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-74ff-b86a-f87c3b809c46" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019cb6f1-e864-7cde-bcde-b2fb9c56ed3e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cb6f1-e864-799f-b801-ec6928c67ea8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-74ff-b86a-f87c3b809c46" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cb6f1-e864-799f-b801-ec6928c67ea8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019cb6f1-e864-7c49-9db8-ed4d404e324c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cb6f1-e864-74ff-b86a-f87c3b809c46" xlink:to="loc_us-gaap_RetainedEarningsMember_019cb6f1-e864-7c49-9db8-ed4d404e324c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019cb6f1-e864-7481-afee-6ebf3705eb6a" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_019cb6f1-e864-76c8-a2c8-5b3f9f6be249" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_CommonStockSharesIssued_019cb6f1-e864-76c8-a2c8-5b3f9f6be249" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_SharesIssuesReductionInCapital_019cb6f1-e864-7f4d-9d8d-999141f96dc2" xlink:href="bgne-20260331.xsd#bgne_SharesIssuesReductionInCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_bgne_SharesIssuesReductionInCapital_019cb6f1-e864-7f4d-9d8d-999141f96dc2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019cb6f1-e864-773f-9001-e24a0712b6f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019cb6f1-e864-773f-9001-e24a0712b6f6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cb6f1-e864-786f-ab11-8ea9027234b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_StockholdersEquity_019cb6f1-e864-786f-ab11-8ea9027234b7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019cb6f1-e864-7ea8-854f-8b2ab17492c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019cb6f1-e864-7ea8-854f-8b2ab17492c7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodNet_019cb6f1-e864-711e-b7cf-d7ceb547cd1e" xlink:href="bgne-20260331.xsd#bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodNet_019cb6f1-e864-711e-b7cf-d7ceb547cd1e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019cb6f1-e864-7e63-9c61-45b434d0c581" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019cb6f1-e864-7e63-9c61-45b434d0c581" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_StockIssuedDuringPeriodSharesRestrictedStockAwardNetReductionOfIssuedCapital_019de245-b240-7395-9191-2489ec9586e8" xlink:href="bgne-20260331.xsd#bgne_StockIssuedDuringPeriodSharesRestrictedStockAwardNetReductionOfIssuedCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_bgne_StockIssuedDuringPeriodSharesRestrictedStockAwardNetReductionOfIssuedCapital_019de245-b240-7395-9191-2489ec9586e8" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019cb6f1-e864-7e04-ac90-f1e781809a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019cb6f1-e864-7e04-ac90-f1e781809a9d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationRestrictedStockUnitsRequisiteServicePeriodRecognition_019cb6f1-e864-712f-823b-31e271b9b621" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationRestrictedStockUnitsRequisiteServicePeriodRecognition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationRestrictedStockUnitsRequisiteServicePeriodRecognition_019cb6f1-e864-712f-823b-31e271b9b621" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019cb6f1-e864-7c81-8fa3-ca28a892ecf9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019cb6f1-e864-7c81-8fa3-ca28a892ecf9" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019cb6f1-e864-73c1-8249-c4b37d8ab84b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019cb6f1-e864-70f5-8de8-2b1e1ca6bf52" xlink:to="loc_us-gaap_NetIncomeLoss_019cb6f1-e864-73c1-8249-c4b37d8ab84b" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_019cb6f1-e864-73f6-be13-d0bd48f5c277" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_SharesIssuesReductionInCapital_019cb6f1-e864-704e-a583-e1125b70b61c" xlink:href="bgne-20260331.xsd#bgne_SharesIssuesReductionInCapital"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019cb6f1-e864-7b94-b9b7-ec090ac97614" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cb6f1-e864-7390-b6c6-c497662825f9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7034-92d6-617c5b35da66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e864-7783-a3bd-475a5fe5cec1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7034-92d6-617c5b35da66" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e864-7783-a3bd-475a5fe5cec1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7a95-b7c5-e289a65ab291" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e864-7783-a3bd-475a5fe5cec1" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7a95-b7c5-e289a65ab291" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7a95-b7c5-e289a65ab291_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7a95-b7c5-e289a65ab291" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7a95-b7c5-e289a65ab291_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7b0c-82f3-bc8f5a869f15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7a95-b7c5-e289a65ab291" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7b0c-82f3-bc8f5a869f15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019cb6f1-e915-7e3b-85de-dc71bc6c11ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7b0c-82f3-bc8f5a869f15" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019cb6f1-e915-7e3b-85de-dc71bc6c11ab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019cb6f1-e915-7ac5-a92a-d8de7fbe3a8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7b0c-82f3-bc8f5a869f15" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019cb6f1-e915-7ac5-a92a-d8de7fbe3a8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019cb6f1-e915-7db0-a0c5-695de92f3696" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7b0c-82f3-bc8f5a869f15" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019cb6f1-e915-7db0-a0c5-695de92f3696" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019cb6f1-e915-77bf-b25b-942a62284dd1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e864-7783-a3bd-475a5fe5cec1" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019cb6f1-e915-77bf-b25b-942a62284dd1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019cb6f1-e915-77bf-b25b-942a62284dd1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019cb6f1-e915-77bf-b25b-942a62284dd1" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019cb6f1-e915-77bf-b25b-942a62284dd1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019cb6f1-e915-752c-aee5-15425de2905c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019cb6f1-e915-77bf-b25b-942a62284dd1" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019cb6f1-e915-752c-aee5-15425de2905c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_019cb6f1-e915-7b2b-bccd-ae79cb8fe15d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019cb6f1-e915-752c-aee5-15425de2905c" xlink:to="loc_us-gaap_MoneyMarketFundsMember_019cb6f1-e915-7b2b-bccd-ae79cb8fe15d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-71f6-b8ba-d2af7206fd9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e864-7783-a3bd-475a5fe5cec1" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-71f6-b8ba-d2af7206fd9f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-71f6-b8ba-d2af7206fd9f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-71f6-b8ba-d2af7206fd9f" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-71f6-b8ba-d2af7206fd9f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7c07-9b59-9950d8b83421" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-71f6-b8ba-d2af7206fd9f" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7c07-9b59-9950d8b83421" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesMember_019cb6f1-e915-7473-8fc8-3d2cc6e8b45f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7c07-9b59-9950d8b83421" xlink:to="loc_us-gaap_EquitySecuritiesMember_019cb6f1-e915-7473-8fc8-3d2cc6e8b45f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_019cb6f1-e915-734e-bdfe-4c0d6d1e2615" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7c07-9b59-9950d8b83421" xlink:to="loc_us-gaap_ConvertibleDebtMember_019cb6f1-e915-734e-bdfe-4c0d6d1e2615" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentOtherMember_019cb6f1-e915-7155-bf61-74a66f9040ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7c07-9b59-9950d8b83421" xlink:to="loc_us-gaap_FinancialInstrumentOtherMember_019cb6f1-e915-7155-bf61-74a66f9040ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetAssetLiabilityAbstract_019cb6f1-e915-7c19-85ff-7be4bc4f9d67" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueNetAssetLiabilityAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7034-92d6-617c5b35da66" xlink:to="loc_us-gaap_FairValueNetAssetLiabilityAbstract_019cb6f1-e915-7c19-85ff-7be4bc4f9d67" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019cb6f1-e915-7ee7-a191-8ad02dd81b99" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetAssetLiabilityAbstract_019cb6f1-e915-7c19-85ff-7be4bc4f9d67" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019cb6f1-e915-7ee7-a191-8ad02dd81b99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrentAbstract_019cb6f1-e915-7907-8f58-7c5628d70664" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsNoncurrentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7034-92d6-617c5b35da66" xlink:to="loc_us-gaap_AssetsNoncurrentAbstract_019cb6f1-e915-7907-8f58-7c5628d70664" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_019cb6f1-e915-7a36-8fc6-871b5ce716fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_019cb6f1-e915-7907-8f58-7c5628d70664" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_019cb6f1-e915-7a36-8fc6-871b5ce716fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_InvestmentInDebtSecuritiesNonCurrent_019cb6f1-e915-7071-a53b-23c44a05a924" xlink:href="bgne-20260331.xsd#bgne_InvestmentInDebtSecuritiesNonCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_019cb6f1-e915-7907-8f58-7c5628d70664" xlink:to="loc_bgne_InvestmentInDebtSecuritiesNonCurrent_019cb6f1-e915-7071-a53b-23c44a05a924" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsFairValueDisclosure_019cb6f1-e915-7f9c-b4d0-e358dbe7a3a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsNoncurrentAbstract_019cb6f1-e915-7907-8f58-7c5628d70664" xlink:to="loc_us-gaap_OtherAssetsFairValueDisclosure_019cb6f1-e915-7f9c-b4d0-e358dbe7a3a4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019cb6f1-e915-716f-8215-3273a9b5cc5e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7034-92d6-617c5b35da66" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_019cb6f1-e915-716f-8215-3273a9b5cc5e" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/FairValueMeasuresandDisclosuresNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#FairValueMeasuresandDisclosuresNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/FairValueMeasuresandDisclosuresNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7b4c-9c3d-b310fede483b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e915-71ee-8249-975a3d4f6cb0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7b4c-9c3d-b310fede483b" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e915-71ee-8249-975a3d4f6cb0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7836-bb64-3cff742f2934" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e915-71ee-8249-975a3d4f6cb0" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7836-bb64-3cff742f2934" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7836-bb64-3cff742f2934_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7836-bb64-3cff742f2934" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7836-bb64-3cff742f2934_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7a10-a972-955bc4fd2e08" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019cb6f1-e915-7836-bb64-3cff742f2934" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7a10-a972-955bc4fd2e08" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019cb6f1-e915-793a-853a-1960d67c808d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019cb6f1-e915-7a10-a972-955bc4fd2e08" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019cb6f1-e915-793a-853a-1960d67c808d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-774c-97e3-0ba3129bfb93" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_019cb6f1-e915-71ee-8249-975a3d4f6cb0" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-774c-97e3-0ba3129bfb93" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-774c-97e3-0ba3129bfb93_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-774c-97e3-0ba3129bfb93" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-774c-97e3-0ba3129bfb93_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7e73-adc8-7a90deadd3c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019cb6f1-e915-774c-97e3-0ba3129bfb93" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7e73-adc8-7a90deadd3c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_019cb6f1-e915-711a-91be-62f669cf51ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019cb6f1-e915-7e73-adc8-7a90deadd3c9" xlink:to="loc_us-gaap_ConvertibleDebtMember_019cb6f1-e915-711a-91be-62f669cf51ca" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_019cb6f1-e915-7006-880e-0afb5699ad2b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7b4c-9c3d-b310fede483b" xlink:to="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_019cb6f1-e915-7006-880e-0afb5699ad2b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimeDepositsAtCarryingValue_019d4d48-a672-7998-9bae-a7d2a3bbe822" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TimeDepositsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_019cb6f1-e915-7b4c-9c3d-b310fede483b" xlink:to="loc_us-gaap_TimeDepositsAtCarryingValue_019d4d48-a672-7998-9bae-a7d2a3bbe822" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofRecognizedRevenueDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#CollaborativeLicensingandOtherArrangementsScheduleofRecognizedRevenueDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofRecognizedRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e915-712b-a5e0-139de54298e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e915-7c5a-acea-77fb17f14c30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e915-712b-a5e0-139de54298e6" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e915-7c5a-acea-77fb17f14c30" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cb6f1-e915-7f8c-bd28-5c478b868fd0" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e915-7c5a-acea-77fb17f14c30" xlink:to="loc_srt_ProductOrServiceAxis_019cb6f1-e915-7f8c-bd28-5c478b868fd0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e915-7f8c-bd28-5c478b868fd0_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e915-7f8c-bd28-5c478b868fd0" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e915-7f8c-bd28-5c478b868fd0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e915-7caf-a4fe-468aba3ea1f8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e915-7f8c-bd28-5c478b868fd0" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e915-7caf-a4fe-468aba3ea1f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_OtherRevenueMember_019cb6f1-e915-7da7-93ed-a85648576043" xlink:href="bgne-20260331.xsd#bgne_OtherRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cb6f1-e915-7caf-a4fe-468aba3ea1f8" xlink:to="loc_bgne_OtherRevenueMember_019cb6f1-e915-7da7-93ed-a85648576043" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AmgenRoyaltyRevenueMember_019cb6f1-e915-762d-88f0-6adeb13ecbb2" xlink:href="bgne-20260331.xsd#bgne_AmgenRoyaltyRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_OtherRevenueMember_019cb6f1-e915-7da7-93ed-a85648576043" xlink:to="loc_bgne_AmgenRoyaltyRevenueMember_019cb6f1-e915-762d-88f0-6adeb13ecbb2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_NovartisBroadMarketsRevenueMember_019cb6f1-e915-7f23-9258-8437ca613fa6" xlink:href="bgne-20260331.xsd#bgne_NovartisBroadMarketsRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_OtherRevenueMember_019cb6f1-e915-7da7-93ed-a85648576043" xlink:to="loc_bgne_NovartisBroadMarketsRevenueMember_019cb6f1-e915-7f23-9258-8437ca613fa6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_CollaborationOtherMember_019cb6f1-e915-70ee-98e2-d2ee667b0b07" xlink:href="bgne-20260331.xsd#bgne_CollaborationOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_OtherRevenueMember_019cb6f1-e915-7da7-93ed-a85648576043" xlink:to="loc_bgne_CollaborationOtherMember_019cb6f1-e915-70ee-98e2-d2ee667b0b07" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7165-aa20-396bc611df4e" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e915-7c5a-acea-77fb17f14c30" xlink:to="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7165-aa20-396bc611df4e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7165-aa20-396bc611df4e_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7165-aa20-396bc611df4e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7165-aa20-396bc611df4e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7f48-8afe-21c6cb202e60" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7165-aa20-396bc611df4e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7f48-8afe-21c6cb202e60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_NovartisMember_019cb6f1-e915-7b69-847f-3b6b9e011de0" xlink:href="bgne-20260331.xsd#bgne_NovartisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7f48-8afe-21c6cb202e60" xlink:to="loc_bgne_NovartisMember_019cb6f1-e915-7b69-847f-3b6b9e011de0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019cb6f1-e915-782d-ae50-844f138cc0f5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e915-712b-a5e0-139de54298e6" xlink:to="loc_us-gaap_RevenuesAbstract_019cb6f1-e915-782d-ae50-844f138cc0f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e915-7f69-866e-4738f741d2ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019cb6f1-e915-782d-ae50-844f138cc0f5" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e915-7f69-866e-4738f741d2ad" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofFundingExpensesDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#CollaborativeLicensingandOtherArrangementsScheduleofFundingExpensesDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofFundingExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7c3e-a3cc-44c9a99331a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-7513-ab1b-d9b2592a49e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7c3e-a3cc-44c9a99331a4" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-7513-ab1b-d9b2592a49e3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cb6f1-e915-79f5-ba05-653eeaaab6d6" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-7513-ab1b-d9b2592a49e3" xlink:to="loc_srt_CounterpartyNameAxis_019cb6f1-e915-79f5-ba05-653eeaaab6d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-79f5-ba05-653eeaaab6d6_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-79f5-ba05-653eeaaab6d6" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-79f5-ba05-653eeaaab6d6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7d9d-8ce0-02c109a878cc" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-79f5-ba05-653eeaaab6d6" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7d9d-8ce0-02c109a878cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AmgenIncMember_019cb6f1-e915-7afb-bd8b-9e8c12234a3d" xlink:href="bgne-20260331.xsd#bgne_AmgenIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7d9d-8ce0-02c109a878cc" xlink:to="loc_bgne_AmgenIncMember_019cb6f1-e915-7afb-bd8b-9e8c12234a3d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_FinancingCommitmentExpenses_019cb6f1-e915-785c-95d9-0250c27dc3d0" xlink:href="bgne-20260331.xsd#bgne_FinancingCommitmentExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7c3e-a3cc-44c9a99331a4" xlink:to="loc_bgne_FinancingCommitmentExpenses_019cb6f1-e915-785c-95d9-0250c27dc3d0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AmortizationOfFinancingCommitment_019cb6f1-e915-73cc-9a07-0b1d917676bc" xlink:href="bgne-20260331.xsd#bgne_AmortizationOfFinancingCommitment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7c3e-a3cc-44c9a99331a4" xlink:to="loc_bgne_AmortizationOfFinancingCommitment_019cb6f1-e915-73cc-9a07-0b1d917676bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019cb6f1-e915-7ab5-8272-aee687f10f27" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7c3e-a3cc-44c9a99331a4" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019cb6f1-e915-7ab5-8272-aee687f10f27" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitment_019cb6f1-e915-7434-b322-eaa0452942b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7c3e-a3cc-44c9a99331a4" xlink:to="loc_us-gaap_OtherCommitment_019cb6f1-e915-7434-b322-eaa0452942b0" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofFinancingLiabilityDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#CollaborativeLicensingandOtherArrangementsScheduleofFinancingLiabilityDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofFinancingLiabilityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-76be-b18b-dab87fc94a36" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-75bb-b4e9-38587626b739" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-76be-b18b-dab87fc94a36" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-75bb-b4e9-38587626b739" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7c41-8c4d-65e174f2c5bb" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-75bb-b4e9-38587626b739" xlink:to="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7c41-8c4d-65e174f2c5bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7c41-8c4d-65e174f2c5bb_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7c41-8c4d-65e174f2c5bb" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7c41-8c4d-65e174f2c5bb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7800-880d-30202446d4f9" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7c41-8c4d-65e174f2c5bb" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7800-880d-30202446d4f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AmgenIncMember_019cb6f1-e915-7402-af17-a7515e500132" xlink:href="bgne-20260331.xsd#bgne_AmgenIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7800-880d-30202446d4f9" xlink:to="loc_bgne_AmgenIncMember_019cb6f1-e915-7402-af17-a7515e500132" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_FinancingCommitmentCarryingValueCurrent_019cb6f1-e915-73d6-a155-6d2d81394bd7" xlink:href="bgne-20260331.xsd#bgne_FinancingCommitmentCarryingValueCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-76be-b18b-dab87fc94a36" xlink:to="loc_bgne_FinancingCommitmentCarryingValueCurrent_019cb6f1-e915-73d6-a155-6d2d81394bd7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_FinancingCommitmentCarryingValue_019cb6f1-e915-760d-8867-c8e4af3dda9f" xlink:href="bgne-20260331.xsd#bgne_FinancingCommitmentCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-76be-b18b-dab87fc94a36" xlink:to="loc_bgne_FinancingCommitmentCarryingValue_019cb6f1-e915-760d-8867-c8e4af3dda9f" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofAmountsandClassificationofPaymentsIncomeExpenseDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#CollaborativeLicensingandOtherArrangementsScheduleofAmountsandClassificationofPaymentsIncomeExpenseDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofAmountsandClassificationofPaymentsIncomeExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7f38-b55a-2af2d69c2eb8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-7fb0-b49f-949e28c3698e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7f38-b55a-2af2d69c2eb8" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-7fb0-b49f-949e28c3698e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7301-b147-46d8a2993819" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_019cb6f1-e915-7fb0-b49f-949e28c3698e" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7301-b147-46d8a2993819" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7301-b147-46d8a2993819_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7301-b147-46d8a2993819" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7301-b147-46d8a2993819_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7727-8bcf-b99fe9ad7f04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7301-b147-46d8a2993819" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7727-8bcf-b99fe9ad7f04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_019cb6f1-e915-7deb-b478-9054750b5208" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7727-8bcf-b99fe9ad7f04" xlink:to="loc_us-gaap_CostOfSalesMember_019cb6f1-e915-7deb-b478-9054750b5208" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019cb6f1-e915-7d17-a8f1-839b5668021a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7727-8bcf-b99fe9ad7f04" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019cb6f1-e915-7d17-a8f1-839b5668021a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_019cb6f1-e915-761f-be52-37cca647fe9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7727-8bcf-b99fe9ad7f04" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_019cb6f1-e915-761f-be52-37cca647fe9f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ReimbursementExpense_019cb6f1-e915-72c1-b4a0-f294916b6672" xlink:href="bgne-20260331.xsd#bgne_ReimbursementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_019cb6f1-e915-7f38-b55a-2af2d69c2eb8" xlink:to="loc_bgne_ReimbursementExpense_019cb6f1-e915-72c1-b4a0-f294916b6672" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#CollaborativeLicensingandOtherArrangementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019cb6f1-e915-70fe-819b-3ab27ef6bb9c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7f77-b6c7-e2c97ea0da3b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019cb6f1-e915-70fe-819b-3ab27ef6bb9c" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7f77-b6c7-e2c97ea0da3b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7cdb-b454-e9aaa6a7563a" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7f77-b6c7-e2c97ea0da3b" xlink:to="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7cdb-b454-e9aaa6a7563a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7cdb-b454-e9aaa6a7563a_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7cdb-b454-e9aaa6a7563a" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7cdb-b454-e9aaa6a7563a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-72d6-9f83-3d81d4897c03" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-7cdb-b454-e9aaa6a7563a" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-72d6-9f83-3d81d4897c03" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AmgenIncMember_019cb6f1-e915-7e5f-9be8-e0700c401dec" xlink:href="bgne-20260331.xsd#bgne_AmgenIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-72d6-9f83-3d81d4897c03" xlink:to="loc_bgne_AmgenIncMember_019cb6f1-e915-7e5f-9be8-e0700c401dec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019cb6f1-e915-7fd0-8061-18f70d8e9fc4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7f77-b6c7-e2c97ea0da3b" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019cb6f1-e915-7fd0-8061-18f70d8e9fc4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cb6f1-e915-7fd0-8061-18f70d8e9fc4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019cb6f1-e915-7fd0-8061-18f70d8e9fc4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cb6f1-e915-7fd0-8061-18f70d8e9fc4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cb6f1-e915-7a4e-a162-b929da6dc525" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019cb6f1-e915-7fd0-8061-18f70d8e9fc4" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cb6f1-e915-7a4e-a162-b929da6dc525" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_019cb6f1-e915-71dd-aace-d44a0163db16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019cb6f1-e915-7a4e-a162-b929da6dc525" xlink:to="loc_us-gaap_CollaborativeArrangementMember_019cb6f1-e915-71dd-aace-d44a0163db16" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019cb6f1-e915-7d51-9b60-dd9996028579" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7f77-b6c7-e2c97ea0da3b" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019cb6f1-e915-7d51-9b60-dd9996028579" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019cb6f1-e915-7d51-9b60-dd9996028579_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019cb6f1-e915-7d51-9b60-dd9996028579" xlink:to="loc_us-gaap_RelatedPartyDomain_019cb6f1-e915-7d51-9b60-dd9996028579_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_019cb6f1-e915-71ca-bc4e-9941eb440040" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_019cb6f1-e915-7d51-9b60-dd9996028579" xlink:to="loc_us-gaap_RelatedPartyDomain_019cb6f1-e915-71ca-bc4e-9941eb440040" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyMember_019cb6f1-e915-7a51-ab93-5c882049b080" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_019cb6f1-e915-71ca-bc4e-9941eb440040" xlink:to="loc_us-gaap_RelatedPartyMember_019cb6f1-e915-7a51-ab93-5c882049b080" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionPurchasesFromRelatedParty_019cb6f1-e915-78b9-beae-4cc74b2c952a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RelatedPartyTransactionPurchasesFromRelatedParty"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019cb6f1-e915-70fe-819b-3ab27ef6bb9c" xlink:to="loc_us-gaap_RelatedPartyTransactionPurchasesFromRelatedParty_019cb6f1-e915-78b9-beae-4cc74b2c952a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019cb6f1-e915-72ba-92a1-2534c324798a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019cb6f1-e915-70fe-819b-3ab27ef6bb9c" xlink:to="loc_us-gaap_AccountsPayableCurrent_019cb6f1-e915-72ba-92a1-2534c324798a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofInLicensingAgreementsDevelopmentDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#CollaborativeLicensingandOtherArrangementsScheduleofInLicensingAgreementsDevelopmentDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CollaborativeLicensingandOtherArrangementsScheduleofInLicensingAgreementsDevelopmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019cb6f1-e915-70c2-8d54-5737d3e78c99" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7c3a-b68b-54c28898457c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019cb6f1-e915-70c2-8d54-5737d3e78c99" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7c3a-b68b-54c28898457c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_CollaborativeArrangementCompensationTypeAxis_019cb6f1-e915-73ce-9f97-4ccbb2fd4a33" xlink:href="bgne-20260331.xsd#bgne_CollaborativeArrangementCompensationTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7c3a-b68b-54c28898457c" xlink:to="loc_bgne_CollaborativeArrangementCompensationTypeAxis_019cb6f1-e915-73ce-9f97-4ccbb2fd4a33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_CollaborativeArrangementCompensationTypeDomain_019cb6f1-e915-73ce-9f97-4ccbb2fd4a33_default" xlink:href="bgne-20260331.xsd#bgne_CollaborativeArrangementCompensationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_bgne_CollaborativeArrangementCompensationTypeAxis_019cb6f1-e915-73ce-9f97-4ccbb2fd4a33" xlink:to="loc_bgne_CollaborativeArrangementCompensationTypeDomain_019cb6f1-e915-73ce-9f97-4ccbb2fd4a33_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_CollaborativeArrangementCompensationTypeDomain_019cb6f1-e915-7380-8cc9-361ecacefd4b" xlink:href="bgne-20260331.xsd#bgne_CollaborativeArrangementCompensationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_bgne_CollaborativeArrangementCompensationTypeAxis_019cb6f1-e915-73ce-9f97-4ccbb2fd4a33" xlink:to="loc_bgne_CollaborativeArrangementCompensationTypeDomain_019cb6f1-e915-7380-8cc9-361ecacefd4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_UpfrontPaymentsMember_019cb6f1-e915-7b10-8617-0d0e49a80da7" xlink:href="bgne-20260331.xsd#bgne_UpfrontPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_CollaborativeArrangementCompensationTypeDomain_019cb6f1-e915-7380-8cc9-361ecacefd4b" xlink:to="loc_bgne_UpfrontPaymentsMember_019cb6f1-e915-7b10-8617-0d0e49a80da7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7337-a5ee-c453bc6cf737" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019cb6f1-e915-7c3a-b68b-54c28898457c" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7337-a5ee-c453bc6cf737" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7337-a5ee-c453bc6cf737_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7337-a5ee-c453bc6cf737" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7337-a5ee-c453bc6cf737_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7990-b1b6-875ca2a19082" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-7337-a5ee-c453bc6cf737" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7990-b1b6-875ca2a19082" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ResearchAndDevelopmentMember_019cb6f1-e915-7562-8b0d-89577fc562c0" xlink:href="bgne-20260331.xsd#bgne_ResearchAndDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7990-b1b6-875ca2a19082" xlink:to="loc_bgne_ResearchAndDevelopmentMember_019cb6f1-e915-7562-8b0d-89577fc562c0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_UpfrontAndMilestonePayments_019cb6f1-e915-7573-82a4-65cf423d5091" xlink:href="bgne-20260331.xsd#bgne_UpfrontAndMilestonePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019cb6f1-e915-70c2-8d54-5737d3e78c99" xlink:to="loc_bgne_UpfrontAndMilestonePayments_019cb6f1-e915-7573-82a4-65cf423d5091" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#SaleofFutureIMDELLTRARoyaltiesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019cb6f1-e915-7f88-b06c-7f46f0a21197" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:to="loc_us-gaap_DebtInstrumentTable_019cb6f1-e915-7f88-b06c-7f46f0a21197" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7850-8b84-c65b18914302" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e915-7f88-b06c-7f46f0a21197" xlink:to="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7850-8b84-c65b18914302" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-7850-8b84-c65b18914302_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7850-8b84-c65b18914302" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-7850-8b84-c65b18914302_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-7eb4-b7d7-96d3d7fda896" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7850-8b84-c65b18914302" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-7eb4-b7d7-96d3d7fda896" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RoyaltyPaymentsMember_019cb6f1-e915-7afc-8118-4a2fc57c9f09" xlink:href="bgne-20260331.xsd#bgne_RoyaltyPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-7eb4-b7d7-96d3d7fda896" xlink:to="loc_bgne_RoyaltyPaymentsMember_019cb6f1-e915-7afc-8118-4a2fc57c9f09" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_019cb6f1-e915-7791-a36d-3a89bb4d763b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_019cb6f1-e915-7791-a36d-3a89bb4d763b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt_019cb6f1-e915-7a39-aded-1b0520df8ef9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt_019cb6f1-e915-7a39-aded-1b0520df8ef9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ProceedsFromIssuanceOfOtherLongTermDebtAdditionalProceeds_019cb6f1-e915-7a9c-b43b-4d272b079540" xlink:href="bgne-20260331.xsd#bgne_ProceedsFromIssuanceOfOtherLongTermDebtAdditionalProceeds"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:to="loc_bgne_ProceedsFromIssuanceOfOtherLongTermDebtAdditionalProceeds_019cb6f1-e915-7a9c-b43b-4d272b079540" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RoyaltyRevenueThresholdAnnualSalesForProfitSharing_019cb6f1-e915-7db0-9e96-3306b976e545" xlink:href="bgne-20260331.xsd#bgne_RoyaltyRevenueThresholdAnnualSalesForProfitSharing"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:to="loc_bgne_RoyaltyRevenueThresholdAnnualSalesForProfitSharing_019cb6f1-e915-7db0-9e96-3306b976e545" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrentAndNoncurrent_019cb6f1-e915-7a8d-b145-925dc6349bcb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestPayableCurrentAndNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:to="loc_us-gaap_InterestPayableCurrentAndNoncurrent_019cb6f1-e915-7a8d-b145-925dc6349bcb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019cb6f1-e915-7e98-8b2e-22a957432af0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-751a-a0cb-daf5a3d8ff50" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019cb6f1-e915-7e98-8b2e-22a957432af0" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesScheduleofSaleofFutureRoyaltyLiabilityDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#SaleofFutureIMDELLTRARoyaltiesScheduleofSaleofFutureRoyaltyLiabilityDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesScheduleofSaleofFutureRoyaltyLiabilityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-7108-93df-3f1e668ed013" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019cb6f1-e915-7207-ae88-cc3631e6f04f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-7108-93df-3f1e668ed013" xlink:to="loc_us-gaap_DebtInstrumentTable_019cb6f1-e915-7207-ae88-cc3631e6f04f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7a57-8908-f9854b4e5c0c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e915-7207-ae88-cc3631e6f04f" xlink:to="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7a57-8908-f9854b4e5c0c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-7a57-8908-f9854b4e5c0c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7a57-8908-f9854b4e5c0c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-7a57-8908-f9854b4e5c0c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-784c-a85d-e4144d4a1e9c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e915-7a57-8908-f9854b4e5c0c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-784c-a85d-e4144d4a1e9c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RoyaltyPaymentsMember_019cb6f1-e915-734b-9416-ee5b3cbcb12a" xlink:href="bgne-20260331.xsd#bgne_RoyaltyPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e915-784c-a85d-e4144d4a1e9c" xlink:to="loc_bgne_RoyaltyPaymentsMember_019cb6f1-e915-734b-9416-ee5b3cbcb12a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebtCurrent_019cb6f1-e915-7f01-a381-fef68a78ff60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-7108-93df-3f1e668ed013" xlink:to="loc_us-gaap_OtherLongTermDebtCurrent_019cb6f1-e915-7f01-a381-fef68a78ff60" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebtNoncurrent_019cb6f1-e915-7ce0-acc8-fd96ee10f317" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-7108-93df-3f1e668ed013" xlink:to="loc_us-gaap_OtherLongTermDebtNoncurrent_019cb6f1-e915-7ce0-acc8-fd96ee10f317" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLongTermDebt_019cb6f1-e915-7eab-8f35-cd7c5c49b116" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e915-7108-93df-3f1e668ed013" xlink:to="loc_us-gaap_OtherLongTermDebt_019cb6f1-e915-7eab-8f35-cd7c5c49b116" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesScheduleofRoyaltySaleLiabilityActivityDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#SaleofFutureIMDELLTRARoyaltiesScheduleofRoyaltySaleLiabilityActivityDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesScheduleofRoyaltySaleLiabilityActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019d09c7-35f2-77b8-991e-d49b2497a71a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019d09c7-35f2-70bf-a2d3-b67e161e9386" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09c7-35f2-77b8-991e-d49b2497a71a" xlink:to="loc_us-gaap_DebtInstrumentTable_019d09c7-35f2-70bf-a2d3-b67e161e9386" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019d09c7-35f2-7ac6-a829-91d5eee062eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d09c7-35f2-70bf-a2d3-b67e161e9386" xlink:to="loc_us-gaap_DebtInstrumentAxis_019d09c7-35f2-7ac6-a829-91d5eee062eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d09c7-35f2-7ac6-a829-91d5eee062eb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d09c7-35f2-7ac6-a829-91d5eee062eb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d09c7-35f2-7ac6-a829-91d5eee062eb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d09c7-35f2-7ca9-98d8-dce23811efd9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d09c7-35f2-7ac6-a829-91d5eee062eb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d09c7-35f2-7ca9-98d8-dce23811efd9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RoyaltyPaymentsMember_019d09c7-35f2-72b3-bc2a-22c38f58f728" xlink:href="bgne-20260331.xsd#bgne_RoyaltyPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d09c7-35f2-7ca9-98d8-dce23811efd9" xlink:to="loc_bgne_RoyaltyPaymentsMember_019d09c7-35f2-72b3-bc2a-22c38f58f728" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RoyaltyFinancingObligationRollForward_019d09c7-35f2-77fe-9625-cc96d4a5189a" xlink:href="bgne-20260331.xsd#bgne_RoyaltyFinancingObligationRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09c7-35f2-77b8-991e-d49b2497a71a" xlink:to="loc_bgne_RoyaltyFinancingObligationRollForward_019d09c7-35f2-77fe-9625-cc96d4a5189a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019d09c7-35f2-783f-b605-9bca4ebd3c15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_RoyaltyFinancingObligationRollForward_019d09c7-35f2-77fe-9625-cc96d4a5189a" xlink:to="loc_us-gaap_Liabilities_019d09c7-35f2-783f-b605-9bca4ebd3c15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RoyaltySaleLiabilityDecreaseForRoyaltiesRecognizedAndSettled_019d09c7-35f2-7b07-ba51-5b9a1829111d" xlink:href="bgne-20260331.xsd#bgne_RoyaltySaleLiabilityDecreaseForRoyaltiesRecognizedAndSettled"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_RoyaltyFinancingObligationRollForward_019d09c7-35f2-77fe-9625-cc96d4a5189a" xlink:to="loc_bgne_RoyaltySaleLiabilityDecreaseForRoyaltiesRecognizedAndSettled_019d09c7-35f2-7b07-ba51-5b9a1829111d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019d09c7-35f2-77f9-8f2d-add0133ada32" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesScheduleofInterestExpenseDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#SaleofFutureIMDELLTRARoyaltiesScheduleofInterestExpenseDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/SaleofFutureIMDELLTRARoyaltiesScheduleofInterestExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019d09c4-c499-7b23-a0a6-3694f36476ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019d09c4-17ea-74e9-8016-9c1aa73dd184" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09c4-c499-7b23-a0a6-3694f36476ae" xlink:to="loc_us-gaap_DebtInstrumentTable_019d09c4-17ea-74e9-8016-9c1aa73dd184" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019d09c4-c499-75b6-9f7c-0cb495a14b42" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d09c4-17ea-74e9-8016-9c1aa73dd184" xlink:to="loc_us-gaap_DebtInstrumentAxis_019d09c4-c499-75b6-9f7c-0cb495a14b42" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d09c4-c499-75b6-9f7c-0cb495a14b42_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d09c4-c499-75b6-9f7c-0cb495a14b42" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d09c4-c499-75b6-9f7c-0cb495a14b42_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d09c4-c499-77da-b6be-62e8cdb617e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d09c4-c499-75b6-9f7c-0cb495a14b42" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d09c4-c499-77da-b6be-62e8cdb617e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RoyaltyPaymentsMember_019d09c4-c499-7c4b-8c37-020830c06c13" xlink:href="bgne-20260331.xsd#bgne_RoyaltyPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d09c4-c499-77da-b6be-62e8cdb617e8" xlink:to="loc_bgne_RoyaltyPaymentsMember_019d09c4-c499-7c4b-8c37-020830c06c13" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_019d09c4-c499-7e17-a119-a6626e842c28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09c4-c499-7b23-a0a6-3694f36476ae" xlink:to="loc_us-gaap_InterestExpenseDebt_019d09c4-c499-7e17-a119-a6626e842c28" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/RestrictedCashandInvestmentsNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#RestrictedCashandInvestmentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/RestrictedCashandInvestmentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_019cb6f1-e915-7d0e-953b-a907ce61a11e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_019cb6f1-e915-79c3-8468-720abf732d89" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_019cb6f1-e915-7d0e-953b-a907ce61a11e" xlink:to="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_019cb6f1-e915-79c3-8468-720abf732d89" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cb6f1-e915-70ec-9018-d7672e62bbea" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_019cb6f1-e915-79c3-8468-720abf732d89" xlink:to="loc_srt_CounterpartyNameAxis_019cb6f1-e915-70ec-9018-d7672e62bbea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-70ec-9018-d7672e62bbea_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-70ec-9018-d7672e62bbea" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-70ec-9018-d7672e62bbea_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7dda-98cb-94f95fa6188f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e915-70ec-9018-d7672e62bbea" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7dda-98cb-94f95fa6188f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_STARMarketMember_019cb6f1-e915-7131-a0a9-eeb41d179dfb" xlink:href="bgne-20260331.xsd#bgne_STARMarketMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e915-7dda-98cb-94f95fa6188f" xlink:to="loc_bgne_STARMarketMember_019cb6f1-e915-7131-a0a9-eeb41d179dfb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019cb6f1-e915-7d43-a4f6-fcbd5f1d1ef0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTable_019cb6f1-e915-79c3-8468-720abf732d89" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019cb6f1-e915-7d43-a4f6-fcbd5f1d1ef0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019cb6f1-e915-7d43-a4f6-fcbd5f1d1ef0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019cb6f1-e915-7d43-a4f6-fcbd5f1d1ef0" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019cb6f1-e915-7d43-a4f6-fcbd5f1d1ef0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019cb6f1-e915-79fa-a677-61e975cdad43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019cb6f1-e915-7d43-a4f6-fcbd5f1d1ef0" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019cb6f1-e915-79fa-a677-61e975cdad43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IPOMember_019cb6f1-e915-7f12-a9fb-fc94bd29f50b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IPOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019cb6f1-e915-79fa-a677-61e975cdad43" xlink:to="loc_us-gaap_IPOMember_019cb6f1-e915-7f12-a9fb-fc94bd29f50b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCash_019cb6f1-e915-7d4c-9053-19f28e584609" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsItemsLineItems_019cb6f1-e915-7d0e-953b-a907ce61a11e" xlink:to="loc_us-gaap_RestrictedCash_019cb6f1-e915-7d4c-9053-19f28e584609" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/RestrictedCashandInvestmentsScheduleofInvestmentsInEquitySecuritiesDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#RestrictedCashandInvestmentsScheduleofInvestmentsInEquitySecuritiesDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/RestrictedCashandInvestmentsScheduleofInvestmentsInEquitySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable_019cb6f1-e915-709d-bdd6-6590f8bdc80c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_us-gaap_ScheduleOfInvestmentsTable_019cb6f1-e915-709d-bdd6-6590f8bdc80c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019cb6f1-e915-7817-9edd-7c31200a7a75" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_019cb6f1-e915-709d-bdd6-6590f8bdc80c" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019cb6f1-e915-7817-9edd-7c31200a7a75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_019cb6f1-e915-7817-9edd-7c31200a7a75_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019cb6f1-e915-7817-9edd-7c31200a7a75" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_019cb6f1-e915-7817-9edd-7c31200a7a75_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_019cb6f1-e915-7835-94a1-daeeaa189709" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019cb6f1-e915-7817-9edd-7c31200a7a75" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_019cb6f1-e915-7835-94a1-daeeaa189709" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_InvestmentInEquitySecurityMember_019cb6f1-e915-7cd9-909e-954061f0e401" xlink:href="bgne-20260331.xsd#bgne_InvestmentInEquitySecurityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_019cb6f1-e915-7835-94a1-daeeaa189709" xlink:to="loc_bgne_InvestmentInEquitySecurityMember_019cb6f1-e915-7cd9-909e-954061f0e401" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_019cb6f1-e915-7f31-9a3f-6a579fba6ddc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_019cb6f1-e915-7f31-9a3f-6a579fba6ddc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_019cb6f1-e915-74ac-9d0f-e63764ee04de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_019cb6f1-e915-74ac-9d0f-e63764ee04de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_019cb6f1-e915-7e51-94c3-bd698dbc1e8c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_us-gaap_EquityMethodInvestments_019cb6f1-e915-7e51-94c3-bd698dbc1e8c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiAndWithoutReadilyDeterminableFairValue_019cb6f1-e915-74f4-8520-a1b3ebe05334" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiAndWithoutReadilyDeterminableFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_us-gaap_EquitySecuritiesFvNiAndWithoutReadilyDeterminableFairValue_019cb6f1-e915-74f4-8520-a1b3ebe05334" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EquityMethodInvestmentInvestmentInImpairmentStatus_019cb6f1-e915-7148-803a-df72483e72a2" xlink:href="bgne-20260331.xsd#bgne_EquityMethodInvestmentInvestmentInImpairmentStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_bgne_EquityMethodInvestmentInvestmentInImpairmentStatus_019cb6f1-e915-7148-803a-df72483e72a2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentsFairValueDisclosure_019cb6f1-e915-7a65-8c6c-497c5bf3c740" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestmentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_us-gaap_EquityMethodInvestmentsFairValueDisclosure_019cb6f1-e915-7a65-8c6c-497c5bf3c740" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment_019cb6f1-e915-767d-b676-724b778dff17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019cb6f1-e915-78bb-a809-51a33e389887" xlink:to="loc_us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment_019cb6f1-e915-767d-b676-724b778dff17" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/RestrictedCashandInvestmentsScheduleofEquityMethodInvestmentsDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#RestrictedCashandInvestmentsScheduleofEquityMethodInvestmentsDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/RestrictedCashandInvestmentsScheduleofEquityMethodInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsLineItems_019d0a05-e6be-7e97-aab5-bf6e7fc709f2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInvestmentsTable_019d0a05-9a7f-7b78-a268-fe7b83947c87" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019d0a05-e6be-7e97-aab5-bf6e7fc709f2" xlink:to="loc_us-gaap_ScheduleOfInvestmentsTable_019d0a05-9a7f-7b78-a268-fe7b83947c87" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019d0a05-e6be-7bc4-a0e3-4f2014a7d7bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfInvestmentsTable_019d0a05-9a7f-7b78-a268-fe7b83947c87" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019d0a05-e6be-7bc4-a0e3-4f2014a7d7bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019d0a05-e6be-7bc4-a0e3-4f2014a7d7bd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019d0a05-e6be-7bc4-a0e3-4f2014a7d7bd" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019d0a05-e6be-7bc4-a0e3-4f2014a7d7bd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019d0a05-e6be-743b-84ee-cfe9230fc029" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019d0a05-e6be-7bc4-a0e3-4f2014a7d7bd" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019d0a05-e6be-743b-84ee-cfe9230fc029" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseMember_019d0a05-e6be-7a4f-8c12-aed9f09c0d7a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherOperatingIncomeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019d0a05-e6be-743b-84ee-cfe9230fc029" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseMember_019d0a05-e6be-7a4f-8c12-aed9f09c0d7a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019cb6f1-e915-7285-bfbb-0b67ae019966" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019d0a05-e6be-7e97-aab5-bf6e7fc709f2" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_019cb6f1-e915-7285-bfbb-0b67ae019966" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EquitySecuritiesWithoutReadilyDeterminableFairValueDownwardPriceAdjustmentAnnualAmountNet_019cb6f1-e915-7f40-9a67-7dbe20d5224d" xlink:href="bgne-20260331.xsd#bgne_EquitySecuritiesWithoutReadilyDeterminableFairValueDownwardPriceAdjustmentAnnualAmountNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019d0a05-e6be-7e97-aab5-bf6e7fc709f2" xlink:to="loc_bgne_EquitySecuritiesWithoutReadilyDeterminableFairValueDownwardPriceAdjustmentAnnualAmountNet_019cb6f1-e915-7f40-9a67-7dbe20d5224d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019cb6f1-e915-7abc-a128-21aa4880eb3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfInvestmentsLineItems_019d0a05-e6be-7e97-aab5-bf6e7fc709f2" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_019cb6f1-e915-7abc-a128-21aa4880eb3a" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentNetDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentNetDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/PropertyPlantandEquipmentNetScheduleofPropertyPlantandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019cb6f1-e915-76be-beea-eb182e0d93f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019cb6f1-e915-7363-ad15-4916aef5ee1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019cb6f1-e915-76be-beea-eb182e0d93f1" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019cb6f1-e915-7363-ad15-4916aef5ee1e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-78f4-bfe6-95a5244a3d05" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019cb6f1-e915-7363-ad15-4916aef5ee1e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-78f4-bfe6-95a5244a3d05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-78f4-bfe6-95a5244a3d05_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-78f4-bfe6-95a5244a3d05" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-78f4-bfe6-95a5244a3d05_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-78f4-bfe6-95a5244a3d05" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandMember_019cb6f1-e915-7d00-b38c-02a26438beda" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LandMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:to="loc_us-gaap_LandMember_019cb6f1-e915-7d00-b38c-02a26438beda" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingMember_019cb6f1-e915-71a9-8ace-d51711c7ee90" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:to="loc_us-gaap_BuildingMember_019cb6f1-e915-71a9-8ace-d51711c7ee90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ManufacturingEquipmentMember_019cb6f1-e915-7a3f-9a63-d20bc5d03482" xlink:href="bgne-20260331.xsd#bgne_ManufacturingEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:to="loc_bgne_ManufacturingEquipmentMember_019cb6f1-e915-7a3f-9a63-d20bc5d03482" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LaboratoryEquipmentMember_019cb6f1-e915-7252-8969-2a6a21168731" xlink:href="bgne-20260331.xsd#bgne_LaboratoryEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:to="loc_bgne_LaboratoryEquipmentMember_019cb6f1-e915-7252-8969-2a6a21168731" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_019cb6f1-e915-727d-9cb8-26495d791246" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_019cb6f1-e915-727d-9cb8-26495d791246" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_019cb6f1-e915-7e59-aacc-f8a2b73960dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7608-a71b-48abc0747e1a" xlink:to="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_019cb6f1-e915-7e59-aacc-f8a2b73960dc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_019cb6f1-e915-745f-acfc-4605fd425774" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNetAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019cb6f1-e915-76be-beea-eb182e0d93f1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_019cb6f1-e915-745f-acfc-4605fd425774" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019cb6f1-e915-76c9-ad02-67edf9771f1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_019cb6f1-e915-745f-acfc-4605fd425774" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019cb6f1-e915-76c9-ad02-67edf9771f1d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019cb6f1-e915-7bde-8d7f-0b1631111234" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_019cb6f1-e915-745f-acfc-4605fd425774" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019cb6f1-e915-7bde-8d7f-0b1631111234" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressGross_019cb6f1-e915-706c-ab1f-411169b13b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConstructionInProgressGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_019cb6f1-e915-745f-acfc-4605fd425774" xlink:to="loc_us-gaap_ConstructionInProgressGross_019cb6f1-e915-706c-ab1f-411169b13b6a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019cb6f1-e915-706e-9c38-abd5ab1c93b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_019cb6f1-e915-745f-acfc-4605fd425774" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019cb6f1-e915-706e-9c38-abd5ab1c93b6" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/PropertyPlantandEquipmentNetNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#PropertyPlantandEquipmentNetNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/PropertyPlantandEquipmentNetNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019cb6f1-e915-77bb-942a-5b06d8c8e978" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019cb6f1-e915-7f87-a05e-27df0ac84532" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019cb6f1-e915-77bb-942a-5b06d8c8e978" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019cb6f1-e915-7f87-a05e-27df0ac84532" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_019cb6f1-e915-7921-ab16-71769a35dfe6" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019cb6f1-e915-7f87-a05e-27df0ac84532" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_019cb6f1-e915-7921-ab16-71769a35dfe6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_019cb6f1-e915-7921-ab16-71769a35dfe6_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_019cb6f1-e915-7921-ab16-71769a35dfe6" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_019cb6f1-e915-7921-ab16-71769a35dfe6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_019cb6f1-e915-7de4-abac-a94204b93339" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_019cb6f1-e915-7921-ab16-71769a35dfe6" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_019cb6f1-e915-7de4-abac-a94204b93339" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_HopewellFacilityMember_019cb6f1-e915-7d13-bfc5-7c894adaa0ef" xlink:href="bgne-20260331.xsd#bgne_HopewellFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_019cb6f1-e915-7de4-abac-a94204b93339" xlink:to="loc_bgne_HopewellFacilityMember_019cb6f1-e915-7d13-bfc5-7c894adaa0ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-7635-81ae-6b407e6fc433" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019cb6f1-e915-7f87-a05e-27df0ac84532" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-7635-81ae-6b407e6fc433" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7635-81ae-6b407e6fc433_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-7635-81ae-6b407e6fc433" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-7635-81ae-6b407e6fc433_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-70dd-8538-e07ddf2c5bb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_019cb6f1-e915-7635-81ae-6b407e6fc433" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-70dd-8538-e07ddf2c5bb2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandMember_019cb6f1-e915-7ede-9965-0c419a973407" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LandMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_019cb6f1-e915-70dd-8538-e07ddf2c5bb2" xlink:to="loc_us-gaap_LandMember_019cb6f1-e915-7ede-9965-0c419a973407" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressGross_019cb6f1-e915-7b9d-b02a-967c095bac3d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ConstructionInProgressGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019cb6f1-e915-77bb-942a-5b06d8c8e978" xlink:to="loc_us-gaap_ConstructionInProgressGross_019cb6f1-e915-7b9d-b02a-967c095bac3d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/IntangibleAssetsScheduleofIntangibleAssetsOutstandingDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#IntangibleAssetsScheduleofIntangibleAssetsOutstandingDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/IntangibleAssetsScheduleofIntangibleAssetsOutstandingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7841-ad20-905560e9cce7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019cb6f1-e915-7e80-b001-1a73807f276b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7841-ad20-905560e9cce7" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019cb6f1-e915-7e80-b001-1a73807f276b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7140-82a0-56fc9bee5414" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019cb6f1-e915-7e80-b001-1a73807f276b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7140-82a0-56fc9bee5414" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7140-82a0-56fc9bee5414_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7140-82a0-56fc9bee5414" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7140-82a0-56fc9bee5414_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-74a5-bb83-d2bf037fcf2b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7140-82a0-56fc9bee5414" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-74a5-bb83-d2bf037fcf2b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_019cb6f1-e915-7349-ac8e-b557d38ebed4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-74a5-bb83-d2bf037fcf2b" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_019cb6f1-e915-7349-ac8e-b557d38ebed4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_019cb6f1-e915-77c1-b512-49dd2b2b71c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-74a5-bb83-d2bf037fcf2b" xlink:to="loc_us-gaap_LicensingAgreementsMember_019cb6f1-e915-77c1-b512-49dd2b2b71c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019cb6f1-e915-7659-a739-822a1690aadc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNetAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7841-ad20-905560e9cce7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019cb6f1-e915-7659-a739-822a1690aadc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019cb6f1-e915-7938-a08a-a5069e8d2861" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019cb6f1-e915-7659-a739-822a1690aadc" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019cb6f1-e915-7938-a08a-a5069e8d2861" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019cb6f1-e915-7b68-ab23-55ad1f04a9e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019cb6f1-e915-7659-a739-822a1690aadc" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019cb6f1-e915-7b68-ab23-55ad1f04a9e6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019cb6f1-e915-741e-b22e-e48567b7828f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNetAbstract_019cb6f1-e915-7659-a739-822a1690aadc" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019cb6f1-e915-741e-b22e-e48567b7828f" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/IntangibleAssetsNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#IntangibleAssetsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/IntangibleAssetsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7df9-a7e8-4873da6f6b4f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_019cb6f1-e915-77bd-9578-47bec62fba5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7df9-a7e8-4873da6f6b4f" xlink:to="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_019cb6f1-e915-77bd-9578-47bec62fba5a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019cb6f1-e915-7968-ab7f-f1ecb9c4ee71" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_019cb6f1-e915-77bd-9578-47bec62fba5a" xlink:to="loc_srt_RangeAxis_019cb6f1-e915-7968-ab7f-f1ecb9c4ee71" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019cb6f1-e915-7968-ab7f-f1ecb9c4ee71_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019cb6f1-e915-7968-ab7f-f1ecb9c4ee71" xlink:to="loc_srt_RangeMember_019cb6f1-e915-7968-ab7f-f1ecb9c4ee71_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019cb6f1-e915-7778-89ca-c374cee1529a" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019cb6f1-e915-7968-ab7f-f1ecb9c4ee71" xlink:to="loc_srt_RangeMember_019cb6f1-e915-7778-89ca-c374cee1529a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_WeightedAverageMember_019cb6f1-e915-7728-ab80-979d236e53d1" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_WeightedAverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019cb6f1-e915-7778-89ca-c374cee1529a" xlink:to="loc_srt_WeightedAverageMember_019cb6f1-e915-7728-ab80-979d236e53d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7ce0-ae8b-6beae29569be" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_019cb6f1-e915-77bd-9578-47bec62fba5a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7ce0-ae8b-6beae29569be" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7ce0-ae8b-6beae29569be_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7ce0-ae8b-6beae29569be" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7ce0-ae8b-6beae29569be_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7682-a883-5d4e41656c5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7ce0-ae8b-6beae29569be" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7682-a883-5d4e41656c5a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_019cb6f1-e915-7ba0-b5fb-eacd589cdcef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7682-a883-5d4e41656c5a" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_019cb6f1-e915-7ba0-b5fb-eacd589cdcef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherIntangibleAssetsMember_019cb6f1-e915-730f-a253-7afe3502d376" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7682-a883-5d4e41656c5a" xlink:to="loc_us-gaap_OtherIntangibleAssetsMember_019cb6f1-e915-730f-a253-7afe3502d376" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_019cb6f1-e915-7b99-88ac-480c506ef267" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7df9-a7e8-4873da6f6b4f" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_019cb6f1-e915-7b99-88ac-480c506ef267" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/IntangibleAssetsScheduleofFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#IntangibleAssetsScheduleofFutureAmortizationExpenseDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/IntangibleAssetsScheduleofFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7de8-aa15-22d7726e461a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019cb6f1-e915-7ce7-8500-b58ded5e4076" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7de8-aa15-22d7726e461a" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019cb6f1-e915-7ce7-8500-b58ded5e4076" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-753e-b2f5-edb385d91ee8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_019cb6f1-e915-7ce7-8500-b58ded5e4076" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-753e-b2f5-edb385d91ee8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-753e-b2f5-edb385d91ee8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-753e-b2f5-edb385d91ee8" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-753e-b2f5-edb385d91ee8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7e9d-8a37-a26973106598" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e915-753e-b2f5-edb385d91ee8" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7e9d-8a37-a26973106598" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_019cb6f1-e915-7fb3-8e91-18dc459d9971" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7e9d-8a37-a26973106598" xlink:to="loc_us-gaap_CostOfSalesMember_019cb6f1-e915-7fb3-8e91-18dc459d9971" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_019cb6f1-e915-75f1-89d7-eee1d31109c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e915-7e9d-8a37-a26973106598" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_019cb6f1-e915-75f1-89d7-eee1d31109c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019cb6f1-e915-774c-898a-b8cf2c603c87" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7de8-aa15-22d7726e461a" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019cb6f1-e915-774c-898a-b8cf2c603c87" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/IntangibleAssetsScheduleofExpectedAmortizationExpenseDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#IntangibleAssetsScheduleofExpectedAmortizationExpenseDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/IntangibleAssetsScheduleofExpectedAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7111-9f08-6b8c09cc7c48" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_019cb6f1-e915-7b39-8fc8-62bd4e9a94fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7111-9f08-6b8c09cc7c48" xlink:to="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_019cb6f1-e915-7b39-8fc8-62bd4e9a94fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7bc3-9954-3fa64eb0776c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAcquiredFiniteLivedIntangibleAssetByMajorClassTable_019cb6f1-e915-7b39-8fc8-62bd4e9a94fe" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7bc3-9954-3fa64eb0776c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7bc3-9954-3fa64eb0776c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7bc3-9954-3fa64eb0776c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7bc3-9954-3fa64eb0776c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7437-8632-48baed3b49cd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019cb6f1-e915-7bc3-9954-3fa64eb0776c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7437-8632-48baed3b49cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_019cb6f1-e915-7bba-a138-09e804b6a996" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7437-8632-48baed3b49cd" xlink:to="loc_us-gaap_CostOfSalesMember_019cb6f1-e915-7bba-a138-09e804b6a996" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_019cb6f1-e915-7c78-88a7-37093c210c2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019cb6f1-e915-7437-8632-48baed3b49cd" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_019cb6f1-e915-7c78-88a7-37093c210c2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsLineItems_019cb6f1-e915-7111-9f08-6b8c09cc7c48" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019cb6f1-e915-7f4a-ba45-67e80da5d2c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019cb6f1-e915-7f4a-ba45-67e80da5d2c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019cb6f1-e915-76d1-827b-64b439dfa1b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019cb6f1-e915-76d1-827b-64b439dfa1b5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019cb6f1-e915-79cc-bd5f-19606d452610" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019cb6f1-e915-79cc-bd5f-19606d452610" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019cb6f1-e915-728a-bf07-130845ce66d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019cb6f1-e915-728a-bf07-130845ce66d4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019cb6f1-e915-705a-b72a-35d33f30e11c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_019cb6f1-e915-705a-b72a-35d33f30e11c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour_019cb6f1-e915-7212-b3b4-2f512daec397" xlink:href="bgne-20260331.xsd#bgne_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:to="loc_bgne_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour_019cb6f1-e915-7212-b3b4-2f512daec397" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019cb6f1-e915-7f3f-be7c-193adbfcd66c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsFutureAmortizationExpenseAbstract_019cd693-428c-70a9-a79a-e8c26a9a6765" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019cb6f1-e915-7f3f-be7c-193adbfcd66c" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/DebtNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#DebtNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/DebtNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019d09eb-35d4-7242-932b-275a6aa32311" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:to="loc_us-gaap_DebtInstrumentTable_019d09eb-35d4-7242-932b-275a6aa32311" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_019d09eb-35d4-71ba-b045-4ef6e06047b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d09eb-35d4-7242-932b-275a6aa32311" xlink:to="loc_us-gaap_CreditFacilityAxis_019d09eb-35d4-71ba-b045-4ef6e06047b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019d09eb-35d4-71ba-b045-4ef6e06047b4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_019d09eb-35d4-71ba-b045-4ef6e06047b4" xlink:to="loc_us-gaap_CreditFacilityDomain_019d09eb-35d4-71ba-b045-4ef6e06047b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_019d09eb-35d4-785e-8a67-94b813bf80b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_019d09eb-35d4-71ba-b045-4ef6e06047b4" xlink:to="loc_us-gaap_CreditFacilityDomain_019d09eb-35d4-785e-8a67-94b813bf80b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_019d09eb-35d4-7755-87be-445ad44b554b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_019d09eb-35d4-785e-8a67-94b813bf80b4" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_019d09eb-35d4-7755-87be-445ad44b554b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_019d09eb-35d4-7300-9c17-7623f8dab879" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_019d09eb-35d4-785e-8a67-94b813bf80b4" xlink:to="loc_us-gaap_SecuredDebtMember_019d09eb-35d4-7300-9c17-7623f8dab879" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019d09eb-35d4-7b6c-8b74-0174f4009532" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d09eb-35d4-7242-932b-275a6aa32311" xlink:to="loc_us-gaap_DebtInstrumentAxis_019d09eb-35d4-7b6c-8b74-0174f4009532" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7b6c-8b74-0174f4009532_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d09eb-35d4-7b6c-8b74-0174f4009532" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7b6c-8b74-0174f4009532_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7606-938b-a232bd81dbbf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d09eb-35d4-7b6c-8b74-0174f4009532" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7606-938b-a232bd81dbbf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_B1RevolvingLoanFacilityMember_019d09eb-35d4-7f91-b486-bed972d2baf6" xlink:href="bgne-20260331.xsd#bgne_B1RevolvingLoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7606-938b-a232bd81dbbf" xlink:to="loc_bgne_B1RevolvingLoanFacilityMember_019d09eb-35d4-7f91-b486-bed972d2baf6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_B2TermLoanFacilityMember_019d09eb-35d4-745c-983b-4435bc5b6c89" xlink:href="bgne-20260331.xsd#bgne_B2TermLoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7606-938b-a232bd81dbbf" xlink:to="loc_bgne_B2TermLoanFacilityMember_019d09eb-35d4-745c-983b-4435bc5b6c89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ALoanFacilityMember_019d09eb-35d4-7199-87db-a58f4a681346" xlink:href="bgne-20260331.xsd#bgne_ALoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7606-938b-a232bd81dbbf" xlink:to="loc_bgne_ALoanFacilityMember_019d09eb-35d4-7199-87db-a58f4a681346" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_BLoanFacilityMember_019d09eb-35d4-73e7-9371-e425caa2d5a8" xlink:href="bgne-20260331.xsd#bgne_BLoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7606-938b-a232bd81dbbf" xlink:to="loc_bgne_BLoanFacilityMember_019d09eb-35d4-73e7-9371-e425caa2d5a8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LoanFacilitiesMember_019d09eb-35d4-70b3-9b7f-02ed36cda2e2" xlink:href="bgne-20260331.xsd#bgne_LoanFacilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d09eb-35d4-7606-938b-a232bd81dbbf" xlink:to="loc_bgne_LoanFacilitiesMember_019d09eb-35d4-70b3-9b7f-02ed36cda2e2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019d09eb-35d4-7624-abbd-a120058dbc32" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d09eb-35d4-7242-932b-275a6aa32311" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019d09eb-35d4-7624-abbd-a120058dbc32" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019d09eb-35d4-7624-abbd-a120058dbc32_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019d09eb-35d4-7624-abbd-a120058dbc32" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019d09eb-35d4-7624-abbd-a120058dbc32_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019d09eb-35d4-7426-8033-bc320837a945" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019d09eb-35d4-7624-abbd-a120058dbc32" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019d09eb-35d4-7426-8033-bc320837a945" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_019d09eb-35d4-724b-a8d3-65a6658bb38a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019d09eb-35d4-7426-8033-bc320837a945" xlink:to="loc_us-gaap_LineOfCreditMember_019d09eb-35d4-724b-a8d3-65a6658bb38a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019d09eb-35d4-7e66-881b-0755c18e1a43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019d09eb-35d4-7e66-881b-0755c18e1a43" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtTerm_019d09eb-35d4-7d0f-82d8-0465b31772e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:to="loc_us-gaap_LongTermDebtTerm_019d09eb-35d4-7d0f-82d8-0465b31772e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_DebtInstrumentPercentageOfPrincipalAmountRepaid_019d09eb-35d4-7733-9423-f89c28e387f9" xlink:href="bgne-20260331.xsd#bgne_DebtInstrumentPercentageOfPrincipalAmountRepaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:to="loc_bgne_DebtInstrumentPercentageOfPrincipalAmountRepaid_019d09eb-35d4-7733-9423-f89c28e387f9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019d09eb-35d4-716f-bed7-31ffa04c6fdb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_019d09eb-35d4-716f-bed7-31ffa04c6fdb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_019d09eb-35d4-7350-9621-79215b377750" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:to="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_019d09eb-35d4-7350-9621-79215b377750" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019d09eb-35d4-746b-9aac-aa0561cf1598" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d09eb-35d4-7fe9-9498-21b1b5efe4b1" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_019d09eb-35d4-746b-9aac-aa0561cf1598" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/DebtScheduleofShorttermandLongtermDebtDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#DebtScheduleofShorttermandLongtermDebtDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/DebtScheduleofShorttermandLongtermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019d2dc5-6d4d-75d1-8052-0695fe27550b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:to="loc_us-gaap_DebtInstrumentTable_019d2dc5-6d4d-75d1-8052-0695fe27550b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019d2dc5-6d4d-7c10-aa3a-d66afc7fd496" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019d2dc5-6d4d-75d1-8052-0695fe27550b" xlink:to="loc_us-gaap_DebtInstrumentAxis_019d2dc5-6d4d-7c10-aa3a-d66afc7fd496" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d2dc5-6d4d-7c10-aa3a-d66afc7fd496_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d2dc5-6d4d-7c10-aa3a-d66afc7fd496" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d2dc5-6d4d-7c10-aa3a-d66afc7fd496_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019d2dc5-6d4d-73cd-a1f8-3c29a5e2ad20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019d2dc5-6d4d-7c10-aa3a-d66afc7fd496" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019d2dc5-6d4d-73cd-a1f8-3c29a5e2ad20" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ALoanFacilityMember_019d2dc5-6d4d-78f0-ab97-466580195bc0" xlink:href="bgne-20260331.xsd#bgne_ALoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d2dc5-6d4d-73cd-a1f8-3c29a5e2ad20" xlink:to="loc_bgne_ALoanFacilityMember_019d2dc5-6d4d-78f0-ab97-466580195bc0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_B2TermLoanFacilityMember_019d2dc5-6d4d-737b-b3c9-bc080f8a299f" xlink:href="bgne-20260331.xsd#bgne_B2TermLoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019d2dc5-6d4d-73cd-a1f8-3c29a5e2ad20" xlink:to="loc_bgne_B2TermLoanFacilityMember_019d2dc5-6d4d-737b-b3c9-bc080f8a299f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermDebtGross_019d2dc5-6d4d-7377-9f1a-2623fb9e99a5" xlink:href="bgne-20260331.xsd#bgne_ShortTermDebtGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:to="loc_bgne_ShortTermDebtGross_019d2dc5-6d4d-7377-9f1a-2623fb9e99a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_019d2dc5-6d4d-702a-a664-9297229dc65e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnamortizedDebtIssuanceExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_019d2dc5-6d4d-702a-a664-9297229dc65e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019d2dc5-6d4d-7633-9dbf-385849ccae78" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:to="loc_us-gaap_ShortTermBorrowings_019d2dc5-6d4d-7633-9dbf-385849ccae78" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019d2dc5-6d4d-7498-8cc6-36f0329fbac9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019d2dc5-6d4d-7498-8cc6-36f0329fbac9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019d2dc5-6d4d-7e3f-a9af-fb55abd528d6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019d2dc5-6d4d-7e3f-a9af-fb55abd528d6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019d2dc5-6d4d-7f16-80a5-e6c063a50d70" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019d2dc5-6d4d-7232-8795-5ab88233fcf7" xlink:to="loc_us-gaap_LongTermDebt_019d2dc5-6d4d-7f16-80a5-e6c063a50d70" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/DebtScheduleofShorttermandLongtermDebtObligationsDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#DebtScheduleofShorttermandLongtermDebtObligationsDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/DebtScheduleofShorttermandLongtermDebtObligationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-71bc-ac80-5af6134f93c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-7a7a-af80-aeae6fe13269" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-71bc-ac80-5af6134f93c9" xlink:to="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-7a7a-af80-aeae6fe13269" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-7d29-9165-55114e05157a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-7a7a-af80-aeae6fe13269" xlink:to="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-7d29-9165-55114e05157a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7d29-9165-55114e05157a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-7d29-9165-55114e05157a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7d29-9165-55114e05157a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-7d29-9165-55114e05157a" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingJune2027Member_019cfd37-893d-7385-acee-50532a76bdd0" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingJune2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_ShortTermBankLoanMaturingJune2027Member_019cfd37-893d-7385-acee-50532a76bdd0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingJanuary2029Member_019d0930-8c7e-7b86-a8cd-33b8ca5921ec" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingJanuary2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_ShortTermBankLoanMaturingJanuary2029Member_019d0930-8c7e-7b86-a8cd-33b8ca5921ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingNovember2029Member_019d0933-0d7a-739e-bcd0-4b204586370c" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingNovember2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_ShortTermBankLoanMaturingNovember2029Member_019d0933-0d7a-739e-bcd0-4b204586370c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingJuly2032Member_019d0934-1633-7d4c-9566-890434548b74" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingJuly2032Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_ShortTermBankLoanMaturingJuly2032Member_019d0934-1633-7d4c-9566-890434548b74" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingMarch2027Member_019db4c2-256b-7aea-ada2-486e4dd49dd3" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingMarch2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_ShortTermBankLoanMaturingMarch2027Member_019db4c2-256b-7aea-ada2-486e4dd49dd3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingJune2027Member_019d096f-5f2b-741e-ba44-ab21c2d820e7" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingJune2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_LongTermBankLoanMaturingJune2027Member_019d096f-5f2b-741e-ba44-ab21c2d820e7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingJanuary2029Member_019d096e-d083-749c-a5c6-5352179ce45a" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingJanuary2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_LongTermBankLoanMaturingJanuary2029Member_019d096e-d083-749c-a5c6-5352179ce45a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingNovember2029Member_019d2e8d-2372-7fd9-be9c-eef6fc343955" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingNovember2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_LongTermBankLoanMaturingNovember2029Member_019d2e8d-2372-7fd9-be9c-eef6fc343955" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingJuly2032Member_019d0936-ada3-734b-81b5-85ab032f6b7d" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingJuly2032Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7eba-8c1b-4960b6cd114b" xlink:to="loc_bgne_LongTermBankLoanMaturingJuly2032Member_019d0936-ada3-734b-81b5-85ab032f6b7d" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-78d0-b31a-a90d7e008131" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-7a7a-af80-aeae6fe13269" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-78d0-b31a-a90d7e008131" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-78d0-b31a-a90d7e008131_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-78d0-b31a-a90d7e008131" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-78d0-b31a-a90d7e008131_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-741f-bc83-d31eb7275c66" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-78d0-b31a-a90d7e008131" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-741f-bc83-d31eb7275c66" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ChinaConstructionBankMember_019cb6f1-e916-7323-ad1f-c16b7da007a8" xlink:href="bgne-20260331.xsd#bgne_ChinaConstructionBankMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-741f-bc83-d31eb7275c66" xlink:to="loc_bgne_ChinaConstructionBankMember_019cb6f1-e916-7323-ad1f-c16b7da007a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ChinaMerchantsBankMember_019cb6f1-e916-7832-b36a-5de2d23878d6" xlink:href="bgne-20260331.xsd#bgne_ChinaMerchantsBankMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-741f-bc83-d31eb7275c66" xlink:to="loc_bgne_ChinaMerchantsBankMember_019cb6f1-e916-7832-b36a-5de2d23878d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ChinaCITICBankMember_019cb6f1-e916-7ce7-9e70-c49fd6158e41" xlink:href="bgne-20260331.xsd#bgne_ChinaCITICBankMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-741f-bc83-d31eb7275c66" xlink:to="loc_bgne_ChinaCITICBankMember_019cb6f1-e916-7ce7-9e70-c49fd6158e41" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7ba2-9d34-7a812433e65c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-7a7a-af80-aeae6fe13269" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7ba2-9d34-7a812433e65c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-7ba2-9d34-7a812433e65c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7ba2-9d34-7a812433e65c" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-7ba2-9d34-7a812433e65c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-7b4e-b21e-473b4979e390" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7ba2-9d34-7a812433e65c" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-7b4e-b21e-473b4979e390" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansPayableMember_019cb6f1-e916-7c34-a32f-7dd89a685a58" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LoansPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-7b4e-b21e-473b4979e390" xlink:to="loc_us-gaap_LoansPayableMember_019cb6f1-e916-7c34-a32f-7dd89a685a58" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-775c-95d3-8ea248357762" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-7a7a-af80-aeae6fe13269" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-775c-95d3-8ea248357762" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-775c-95d3-8ea248357762_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-775c-95d3-8ea248357762" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-775c-95d3-8ea248357762_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-7d2b-9d71-a67c1bd5d834" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-775c-95d3-8ea248357762" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-7d2b-9d71-a67c1bd5d834" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansPayableMember_019cb6f1-e916-7a3c-a288-22807543a84b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LoansPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-7d2b-9d71-a67c1bd5d834" xlink:to="loc_us-gaap_LoansPayableMember_019cb6f1-e916-7a3c-a288-22807543a84b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_019cb6f1-e916-7f0d-8558-4f28a8465baa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-71bc-ac80-5af6134f93c9" xlink:to="loc_us-gaap_DebtInstrumentTerm_019cb6f1-e916-7f0d-8558-4f28a8465baa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_019cb6f1-e916-7be4-9235-a3628626c9f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-71bc-ac80-5af6134f93c9" xlink:to="loc_us-gaap_ShortTermBorrowings_019cb6f1-e916-7be4-9235-a3628626c9f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019cb6f1-e916-7a25-9108-2824b8d9cfcc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-71bc-ac80-5af6134f93c9" xlink:to="loc_us-gaap_LongTermDebt_019cb6f1-e916-7a25-9108-2824b8d9cfcc" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/DebtFootnotesDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#DebtFootnotesDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/DebtFootnotesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-775b-9125-68920ec77821" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:to="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-775b-9125-68920ec77821" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-71de-821e-ee0b88e25b9b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-775b-9125-68920ec77821" xlink:to="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-71de-821e-ee0b88e25b9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-71de-821e-ee0b88e25b9b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-71de-821e-ee0b88e25b9b" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-71de-821e-ee0b88e25b9b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_019cb6f1-e916-71de-821e-ee0b88e25b9b" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingJune2027Member_019d09de-acff-7881-8869-cb177ab3b57c" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingJune2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_ShortTermBankLoanMaturingJune2027Member_019d09de-acff-7881-8869-cb177ab3b57c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingJune2027Member_019d09de-acff-79ea-8179-e1cff61a7e05" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingJune2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_LongTermBankLoanMaturingJune2027Member_019d09de-acff-79ea-8179-e1cff61a7e05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingJanuary2029Member_019d09de-acff-7ba6-8f9d-1db1d3ded574" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingJanuary2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_ShortTermBankLoanMaturingJanuary2029Member_019d09de-acff-7ba6-8f9d-1db1d3ded574" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingJanuary2029Member_019d8fdb-3115-7a38-9451-42c0c671691f" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingJanuary2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_LongTermBankLoanMaturingJanuary2029Member_019d8fdb-3115-7a38-9451-42c0c671691f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingNovember2029Member_019d09de-acff-71fc-8cb5-8d79b2068f49" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingNovember2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_ShortTermBankLoanMaturingNovember2029Member_019d09de-acff-71fc-8cb5-8d79b2068f49" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingNovember2029Member_019d8fdb-b62f-76f3-b2fa-007c553da664" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingNovember2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_LongTermBankLoanMaturingNovember2029Member_019d8fdb-b62f-76f3-b2fa-007c553da664" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingJuly2032Member_019d8fda-d1d9-746e-ad27-45762da99950" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingJuly2032Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_ShortTermBankLoanMaturingJuly2032Member_019d8fda-d1d9-746e-ad27-45762da99950" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermBankLoanMaturingJuly2032Member_019d2e03-7875-77db-bd3b-387b92771600" xlink:href="bgne-20260331.xsd#bgne_LongTermBankLoanMaturingJuly2032Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_LongTermBankLoanMaturingJuly2032Member_019d2e03-7875-77db-bd3b-387b92771600" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShortTermBankLoanMaturingMarch2027Member_019db4de-f0a8-7b40-bb30-92afc67a6e6a" xlink:href="bgne-20260331.xsd#bgne_ShortTermBankLoanMaturingMarch2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_019cb6f1-e916-7307-9f3d-c04ddb9a915c" xlink:to="loc_bgne_ShortTermBankLoanMaturingMarch2027Member_019db4de-f0a8-7b40-bb30-92afc67a6e6a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-75e7-8c40-efc5a925820e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-775b-9125-68920ec77821" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-75e7-8c40-efc5a925820e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-75e7-8c40-efc5a925820e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-75e7-8c40-efc5a925820e" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-75e7-8c40-efc5a925820e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-7065-8ade-6df35a995142" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_019cb6f1-e916-75e7-8c40-efc5a925820e" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-7065-8ade-6df35a995142" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ChinaConstructionBankMember_019cb6f1-e916-7af3-b6fd-1706804b775c" xlink:href="bgne-20260331.xsd#bgne_ChinaConstructionBankMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-7065-8ade-6df35a995142" xlink:to="loc_bgne_ChinaConstructionBankMember_019cb6f1-e916-7af3-b6fd-1706804b775c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ChinaMerchantsBankMember_019cb6f1-e916-7692-974d-b82381261e08" xlink:href="bgne-20260331.xsd#bgne_ChinaMerchantsBankMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-7065-8ade-6df35a995142" xlink:to="loc_bgne_ChinaMerchantsBankMember_019cb6f1-e916-7692-974d-b82381261e08" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ChinaCITICBankMember_019cb6f1-e916-785b-aa0b-9495ec08ca56" xlink:href="bgne-20260331.xsd#bgne_ChinaCITICBankMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_019cb6f1-e916-7065-8ade-6df35a995142" xlink:to="loc_bgne_ChinaCITICBankMember_019cb6f1-e916-785b-aa0b-9495ec08ca56" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7d8b-8152-649f9b061249" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-775b-9125-68920ec77821" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7d8b-8152-649f9b061249" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-7d8b-8152-649f9b061249_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7d8b-8152-649f9b061249" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-7d8b-8152-649f9b061249_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-74de-9ae5-04edfb5e577e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_019cb6f1-e916-7d8b-8152-649f9b061249" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-74de-9ae5-04edfb5e577e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansPayableMember_019cb6f1-e916-77da-a786-fe27a91bb2ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LoansPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_019cb6f1-e916-74de-9ae5-04edfb5e577e" xlink:to="loc_us-gaap_LoansPayableMember_019cb6f1-e916-77da-a786-fe27a91bb2ab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-76ee-a6ce-f39bb8d1d465" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_019cb6f1-e916-775b-9125-68920ec77821" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-76ee-a6ce-f39bb8d1d465" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-76ee-a6ce-f39bb8d1d465_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-76ee-a6ce-f39bb8d1d465" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-76ee-a6ce-f39bb8d1d465_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-788f-bfd0-aa7c4e416dbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019cb6f1-e916-76ee-a6ce-f39bb8d1d465" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-788f-bfd0-aa7c4e416dbc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansPayableMember_019cb6f1-e916-78e7-9df4-97579ad6d6f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LoansPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019cb6f1-e916-788f-bfd0-aa7c4e416dbc" xlink:to="loc_us-gaap_LoansPayableMember_019cb6f1-e916-78e7-9df4-97579ad6d6f7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019cb6f1-e916-77ca-bf9f-fa30ef8d02a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_019cb6f1-e916-77ca-bf9f-fa30ef8d02a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_019cb6f1-e916-7389-a958-39db73fa0768" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:to="loc_us-gaap_DebtInstrumentInterestRateDuringPeriod_019cb6f1-e916-7389-a958-39db73fa0768" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019cb6f1-e916-779c-a28a-cbef2bf20938" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019cb6f1-e916-779c-a28a-cbef2bf20938" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfShortTermDebt_019cb6f1-e916-7c8e-9fd8-3b760e9ed1e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfShortTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:to="loc_us-gaap_RepaymentsOfShortTermDebt_019cb6f1-e916-7c8e-9fd8-3b760e9ed1e8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromShortTermDebt_019dfa52-d99b-74ea-b08c-911c6739b0f5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromShortTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:to="loc_us-gaap_ProceedsFromShortTermDebt_019dfa52-d99b-74ea-b08c-911c6739b0f5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_DebtInstrumentDropdownAvailabilityPeriod_019db4e3-161a-7fdf-a102-bd5dab7387dd" xlink:href="bgne-20260331.xsd#bgne_DebtInstrumentDropdownAvailabilityPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_019cb6f1-e916-7160-aa0f-2edb237be14d" xlink:to="loc_bgne_DebtInstrumentDropdownAvailabilityPeriod_019db4e3-161a-7fdf-a102-bd5dab7387dd" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/ProductRevenueScheduleofNetProductRevenueDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#ProductRevenueScheduleofNetProductRevenueDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/ProductRevenueScheduleofNetProductRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e916-75d1-96f0-a50646a89211" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e916-7b28-b167-94926680afbf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e916-75d1-96f0-a50646a89211" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e916-7b28-b167-94926680afbf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cb6f1-e916-7d26-83ef-70b8efc77b45" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e916-7b28-b167-94926680afbf" xlink:to="loc_srt_ProductOrServiceAxis_019cb6f1-e916-7d26-83ef-70b8efc77b45" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7d26-83ef-70b8efc77b45_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e916-7d26-83ef-70b8efc77b45" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7d26-83ef-70b8efc77b45_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7de1-98c2-2ff977bdd286" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e916-7d26-83ef-70b8efc77b45" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7de1-98c2-2ff977bdd286" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_019cb6f1-e916-71cd-84a9-2acc1adf21f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7de1-98c2-2ff977bdd286" xlink:to="loc_us-gaap_ProductMember_019cb6f1-e916-71cd-84a9-2acc1adf21f4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ProductNameAxis_019cb6f1-e916-7d89-9671-347f19587195" xlink:href="bgne-20260331.xsd#bgne_ProductNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e916-7b28-b167-94926680afbf" xlink:to="loc_bgne_ProductNameAxis_019cb6f1-e916-7d89-9671-347f19587195" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ProductNameDomain_019cb6f1-e916-7d89-9671-347f19587195_default" xlink:href="bgne-20260331.xsd#bgne_ProductNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_bgne_ProductNameAxis_019cb6f1-e916-7d89-9671-347f19587195" xlink:to="loc_bgne_ProductNameDomain_019cb6f1-e916-7d89-9671-347f19587195_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:href="bgne-20260331.xsd#bgne_ProductNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_bgne_ProductNameAxis_019cb6f1-e916-7d89-9671-347f19587195" xlink:to="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_BRUKINSAMember_019cb6f1-e916-70fd-bacc-f01402c31c94" xlink:href="bgne-20260331.xsd#bgne_BRUKINSAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:to="loc_bgne_BRUKINSAMember_019cb6f1-e916-70fd-bacc-f01402c31c94" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_TEVIMBRAMember_019cb6f1-e916-7358-9cc7-b38fc8c46aa0" xlink:href="bgne-20260331.xsd#bgne_TEVIMBRAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:to="loc_bgne_TEVIMBRAMember_019cb6f1-e916-7358-9cc7-b38fc8c46aa0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_XGEVAMember_019cb6f1-e916-7dde-aa05-2202ce347d74" xlink:href="bgne-20260331.xsd#bgne_XGEVAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:to="loc_bgne_XGEVAMember_019cb6f1-e916-7dde-aa05-2202ce347d74" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_BLINCYTOMember_019cb6f1-e916-7c30-82e5-5812f3bd36f0" xlink:href="bgne-20260331.xsd#bgne_BLINCYTOMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:to="loc_bgne_BLINCYTOMember_019cb6f1-e916-7c30-82e5-5812f3bd36f0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_KYPROLISMember_019cb6f1-e916-79eb-b3cb-5cbcfff4ebd4" xlink:href="bgne-20260331.xsd#bgne_KYPROLISMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:to="loc_bgne_KYPROLISMember_019cb6f1-e916-79eb-b3cb-5cbcfff4ebd4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_POBEVCYMember_019cb6f1-e916-7225-a0d5-62bc5d69684b" xlink:href="bgne-20260331.xsd#bgne_POBEVCYMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:to="loc_bgne_POBEVCYMember_019cb6f1-e916-7225-a0d5-62bc5d69684b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_OtherMember_019cb6f1-e916-73ed-a35f-1ae24b9f6aaa" xlink:href="bgne-20260331.xsd#bgne_OtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_ProductNameDomain_019cb6f1-e916-79a2-9b43-938e52594b83" xlink:to="loc_bgne_OtherMember_019cb6f1-e916-73ed-a35f-1ae24b9f6aaa" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019cb6f1-e916-7ee6-ab3c-15f63fc6ecec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e916-75d1-96f0-a50646a89211" xlink:to="loc_us-gaap_RevenuesAbstract_019cb6f1-e916-7ee6-ab3c-15f63fc6ecec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RevenueFromContractWithCustomerExcludingAssessedTaxGross_019cb6f1-e916-7096-a2d2-7668d93c640f" xlink:href="bgne-20260331.xsd#bgne_RevenueFromContractWithCustomerExcludingAssessedTaxGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019cb6f1-e916-7ee6-ab3c-15f63fc6ecec" xlink:to="loc_bgne_RevenueFromContractWithCustomerExcludingAssessedTaxGross_019cb6f1-e916-7096-a2d2-7668d93c640f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RevenueFromContractWithCustomerRebateAndSalesReturn_019cb6f1-e916-753a-8a2f-cc0971bc4547" xlink:href="bgne-20260331.xsd#bgne_RevenueFromContractWithCustomerRebateAndSalesReturn"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019cb6f1-e916-7ee6-ab3c-15f63fc6ecec" xlink:to="loc_bgne_RevenueFromContractWithCustomerRebateAndSalesReturn_019cb6f1-e916-753a-8a2f-cc0971bc4547" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e916-7e40-9216-71df37c8c5ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019cb6f1-e916-7ee6-ab3c-15f63fc6ecec" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e916-7e40-9216-71df37c8c5ad" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/ProductRevenueScheduleofAccruedRevenueRebatesandReturnsDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#ProductRevenueScheduleofAccruedRevenueRebatesandReturnsDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/ProductRevenueScheduleofAccruedRevenueRebatesandReturnsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e916-7842-bf67-8e3d8d734e0e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e916-779f-ac18-7d5678ca49e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e916-7842-bf67-8e3d8d734e0e" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e916-779f-ac18-7d5678ca49e3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cb6f1-e916-79da-9c8c-586e0672b4a3" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_019cb6f1-e916-779f-ac18-7d5678ca49e3" xlink:to="loc_srt_ProductOrServiceAxis_019cb6f1-e916-79da-9c8c-586e0672b4a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-79da-9c8c-586e0672b4a3_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e916-79da-9c8c-586e0672b4a3" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-79da-9c8c-586e0672b4a3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-73f7-8e8a-fdadad983b17" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e916-79da-9c8c-586e0672b4a3" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-73f7-8e8a-fdadad983b17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_019cb6f1-e916-79d2-a2e2-9550d1b5a14f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-73f7-8e8a-fdadad983b17" xlink:to="loc_us-gaap_ProductMember_019cb6f1-e916-79d2-a2e2-9550d1b5a14f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RebatesReturnsAndOtherDeductionsMember_019cb6f1-e916-7a2c-a5e1-c231132dbc45" xlink:href="bgne-20260331.xsd#bgne_RebatesReturnsAndOtherDeductionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductMember_019cb6f1-e916-79d2-a2e2-9550d1b5a14f" xlink:to="loc_bgne_RebatesReturnsAndOtherDeductionsMember_019cb6f1-e916-7a2c-a5e1-c231132dbc45" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ContraAccountsReceivableAccrualsMember_019cb6f1-e916-7df6-b49c-1958ddb100df" xlink:href="bgne-20260331.xsd#bgne_ContraAccountsReceivableAccrualsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ProductMember_019cb6f1-e916-79d2-a2e2-9550d1b5a14f" xlink:to="loc_bgne_ContraAccountsReceivableAccrualsMember_019cb6f1-e916-7df6-b49c-1958ddb100df" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AccruedSalesRebatesAndReturnsRollForward_019cb6f1-e916-7170-bde4-7c99638a36ae" xlink:href="bgne-20260331.xsd#bgne_AccruedSalesRebatesAndReturnsRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_019cb6f1-e916-7842-bf67-8e3d8d734e0e" xlink:to="loc_bgne_AccruedSalesRebatesAndReturnsRollForward_019cb6f1-e916-7170-bde4-7c99638a36ae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RevenueRecognitionReserveForSalesReturnsRebatesAndOtherDeductions_019cb6f1-e916-7b51-9037-94ee538bd5fa" xlink:href="bgne-20260331.xsd#bgne_RevenueRecognitionReserveForSalesReturnsRebatesAndOtherDeductions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_AccruedSalesRebatesAndReturnsRollForward_019cb6f1-e916-7170-bde4-7c99638a36ae" xlink:to="loc_bgne_RevenueRecognitionReserveForSalesReturnsRebatesAndOtherDeductions_019cb6f1-e916-7b51-9037-94ee538bd5fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AccountsReceivableAllowanceForChargebacksAndCreditLoss_019cb6f1-e916-713e-9ef2-10cba0b6ae4e" xlink:href="bgne-20260331.xsd#bgne_AccountsReceivableAllowanceForChargebacksAndCreditLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_AccruedSalesRebatesAndReturnsRollForward_019cb6f1-e916-7170-bde4-7c99638a36ae" xlink:to="loc_bgne_AccountsReceivableAllowanceForChargebacksAndCreditLoss_019cb6f1-e916-713e-9ef2-10cba0b6ae4e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RevenueRecognitionAllowanceForChargebacksAndCreditLossAndReservesForSalesReturnsRebatesAndOtherDeductions_019cb6f1-e916-7f6b-9fe0-66cf3cdbd82a" xlink:href="bgne-20260331.xsd#bgne_RevenueRecognitionAllowanceForChargebacksAndCreditLossAndReservesForSalesReturnsRebatesAndOtherDeductions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_AccruedSalesRebatesAndReturnsRollForward_019cb6f1-e916-7170-bde4-7c99638a36ae" xlink:to="loc_bgne_RevenueRecognitionAllowanceForChargebacksAndCreditLossAndReservesForSalesReturnsRebatesAndOtherDeductions_019cb6f1-e916-7f6b-9fe0-66cf3cdbd82a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RebateAndSalesReturn_019cb6f1-e916-7ccb-b9e4-c48b6cfe8376" xlink:href="bgne-20260331.xsd#bgne_RebateAndSalesReturn"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_AccruedSalesRebatesAndReturnsRollForward_019cb6f1-e916-7170-bde4-7c99638a36ae" xlink:to="loc_bgne_RebateAndSalesReturn_019cb6f1-e916-7ccb-b9e4-c48b6cfe8376" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AccruedSalesRebatesAndReturnsPayment_019cb6f1-e916-704b-8eab-03a32ad8070a" xlink:href="bgne-20260331.xsd#bgne_AccruedSalesRebatesAndReturnsPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_bgne_AccruedSalesRebatesAndReturnsRollForward_019cb6f1-e916-7170-bde4-7c99638a36ae" xlink:to="loc_bgne_AccruedSalesRebatesAndReturnsPayment_019cb6f1-e916-704b-8eab-03a32ad8070a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RevenueRecognitionReserveForSalesReturnsRebatesAndOtherDeductions_019cb6f1-e916-738c-b6a1-4a61179ec221" xlink:href="bgne-20260331.xsd#bgne_RevenueRecognitionReserveForSalesReturnsRebatesAndOtherDeductions"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AccountsReceivableAllowanceForChargebacksAndCreditLoss_019cb6f1-e916-7aa9-bdfe-70314fa96e2a" xlink:href="bgne-20260331.xsd#bgne_AccountsReceivableAllowanceForChargebacksAndCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RevenueRecognitionAllowanceForChargebacksAndCreditLossAndReservesForSalesReturnsRebatesAndOtherDeductions_019cb6f1-e916-7528-bb2c-12ad4eb2ff68" xlink:href="bgne-20260331.xsd#bgne_RevenueRecognitionAllowanceForChargebacksAndCreditLossAndReservesForSalesReturnsRebatesAndOtherDeductions"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/ShareBasedCompensationExpenseNarrativeDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#ShareBasedCompensationExpenseNarrativeDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/ShareBasedCompensationExpenseNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cb6f1-e916-7c43-a234-ef0b256ac87c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cb6f1-e916-7c43-a234-ef0b256ac87c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7016-a20a-b78a8ff7b72c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cb6f1-e916-7c43-a234-ef0b256ac87c" xlink:to="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7016-a20a-b78a8ff7b72c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7016-a20a-b78a8ff7b72c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7016-a20a-b78a8ff7b72c" xlink:to="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7016-a20a-b78a8ff7b72c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7e51-967d-5b6ec9cb5a06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7016-a20a-b78a8ff7b72c" xlink:to="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7e51-967d-5b6ec9cb5a06" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShareOptionAndIncentivePlan2016Member_019cb6f1-e916-7b02-873f-605ccf946b48" xlink:href="bgne-20260331.xsd#bgne_ShareOptionAndIncentivePlan2016Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7e51-967d-5b6ec9cb5a06" xlink:to="loc_bgne_ShareOptionAndIncentivePlan2016Member_019cb6f1-e916-7b02-873f-605ccf946b48" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EmployeeSharePurchasePlan2018Member_019cb6f1-e916-7796-aa20-454a4be990a2" xlink:href="bgne-20260331.xsd#bgne_EmployeeSharePurchasePlan2018Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7e51-967d-5b6ec9cb5a06" xlink:to="loc_bgne_EmployeeSharePurchasePlan2018Member_019cb6f1-e916-7796-aa20-454a4be990a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019cb6f1-e916-7ca2-92a8-ef81a49e2fc6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cb6f1-e916-7c43-a234-ef0b256ac87c" xlink:to="loc_us-gaap_AwardTypeAxis_019cb6f1-e916-7ca2-92a8-ef81a49e2fc6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7ca2-92a8-ef81a49e2fc6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019cb6f1-e916-7ca2-92a8-ef81a49e2fc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7ca2-92a8-ef81a49e2fc6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7324-8a71-e7e04a7130b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019cb6f1-e916-7ca2-92a8-ef81a49e2fc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7324-8a71-e7e04a7130b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EmployeeAndNonemployeeStockOptionMember_019cb6f1-e916-7948-9f0f-94f35ad45605" xlink:href="bgne-20260331.xsd#bgne_EmployeeAndNonemployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7324-8a71-e7e04a7130b7" xlink:to="loc_bgne_EmployeeAndNonemployeeStockOptionMember_019cb6f1-e916-7948-9f0f-94f35ad45605" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019cb6f1-e916-7f06-a97f-e47a6b57dbec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7324-8a71-e7e04a7130b7" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019cb6f1-e916-7f06-a97f-e47a6b57dbec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_019cb6f1-e916-76d5-8aea-f22f5280630c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7324-8a71-e7e04a7130b7" xlink:to="loc_us-gaap_PerformanceSharesMember_019cb6f1-e916-76d5-8aea-f22f5280630c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019cb6f1-e916-7667-aaba-c453ef30649e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019cb6f1-e916-7324-8a71-e7e04a7130b7" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019cb6f1-e916-7667-aaba-c453ef30649e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019cb6f1-e916-7e79-b176-b9fa652d59f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_019cb6f1-e916-7e79-b176-b9fa652d59f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019cb6f1-e916-74ac-80fc-f60adcfb813b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_019cb6f1-e916-74ac-80fc-f60adcfb813b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019cb6f1-e916-71cf-b1f3-e846f7d87542" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019cb6f1-e916-71cf-b1f3-e846f7d87542" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod_019cb6f1-e916-74bc-bffe-4d113bead279" xlink:href="bgne-20260331.xsd#bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:to="loc_bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod_019cb6f1-e916-74bc-bffe-4d113bead279" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardDiscountOnPurchasePriceOfCommonStockPercent_019cb6f1-e916-70ec-ab82-e4d11cb3e925" xlink:href="bgne-20260331.xsd#bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardDiscountOnPurchasePriceOfCommonStockPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:to="loc_bgne_ShareBasedCompensationArrangementByShareBasedPaymentAwardDiscountOnPurchasePriceOfCommonStockPercent_019cb6f1-e916-70ec-ab82-e4d11cb3e925" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_MaximumPercentageOfEligibleEarningsSetSideToPurchaseOrdinaryShares_019cb6f1-e916-7274-ae0c-77e5d9afe4e4" xlink:href="bgne-20260331.xsd#bgne_MaximumPercentageOfEligibleEarningsSetSideToPurchaseOrdinaryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-7d29-885d-fbb2399e32c4" xlink:to="loc_bgne_MaximumPercentageOfEligibleEarningsSetSideToPurchaseOrdinaryShares_019cb6f1-e916-7274-ae0c-77e5d9afe4e4" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/ShareBasedCompensationExpenseScheduleofSharesIssuedUnderEmployeeSharePurchasePlanDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#ShareBasedCompensationExpenseScheduleofSharesIssuedUnderEmployeeSharePurchasePlanDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/ShareBasedCompensationExpenseScheduleofSharesIssuedUnderEmployeeSharePurchasePlanDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cb6f1-e916-70c2-a009-bb2205535939" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cb6f1-e916-70c2-a009-bb2205535939" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7b95-a50e-6098b2b8a08a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019cb6f1-e916-70c2-a009-bb2205535939" xlink:to="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7b95-a50e-6098b2b8a08a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7b95-a50e-6098b2b8a08a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7b95-a50e-6098b2b8a08a" xlink:to="loc_us-gaap_PlanNameDomain_019cb6f1-e916-7b95-a50e-6098b2b8a08a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019cb6f1-e916-79b8-b5eb-84039f7d9fc3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019cb6f1-e916-7b95-a50e-6098b2b8a08a" xlink:to="loc_us-gaap_PlanNameDomain_019cb6f1-e916-79b8-b5eb-84039f7d9fc3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_EmployeeSharePurchasePlan2018Member_019cb6f1-e916-7556-878c-bcdfac2c3ae3" xlink:href="bgne-20260331.xsd#bgne_EmployeeSharePurchasePlan2018Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019cb6f1-e916-79b8-b5eb-84039f7d9fc3" xlink:to="loc_bgne_EmployeeSharePurchasePlan2018Member_019cb6f1-e916-7556-878c-bcdfac2c3ae3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_019cb6f1-e916-7416-b06a-aec8f96b5ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_019cb6f1-e916-7416-b06a-aec8f96b5ce0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_SharePriceAmericanDepositoryShares_019cb6f1-e916-7d90-91ad-22fcfea618c1" xlink:href="bgne-20260331.xsd#bgne_SharePriceAmericanDepositoryShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:to="loc_bgne_SharePriceAmericanDepositoryShares_019cb6f1-e916-7d90-91ad-22fcfea618c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_019cb6f1-e916-76c6-be6a-0c43922cb933" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:to="loc_us-gaap_SharePrice_019cb6f1-e916-76c6-be6a-0c43922cb933" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_SharebasedCompensationArrangementbySharebasedPaymentAwardSharesIssuedInPeriodAmericanDepositorySharesExercisePrice_019cb6f1-e916-708e-98d4-a103b41b2256" xlink:href="bgne-20260331.xsd#bgne_SharebasedCompensationArrangementbySharebasedPaymentAwardSharesIssuedInPeriodAmericanDepositorySharesExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:to="loc_bgne_SharebasedCompensationArrangementbySharebasedPaymentAwardSharesIssuedInPeriodAmericanDepositorySharesExercisePrice_019cb6f1-e916-708e-98d4-a103b41b2256" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_SharebasedCompensationArrangementbySharebasedPaymentAwardSharesIssuedInPeriodExercisePrice_019cb6f1-e916-7a04-bf3d-4f1acffdb197" xlink:href="bgne-20260331.xsd#bgne_SharebasedCompensationArrangementbySharebasedPaymentAwardSharesIssuedInPeriodExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:to="loc_bgne_SharebasedCompensationArrangementbySharebasedPaymentAwardSharesIssuedInPeriodExercisePrice_019cb6f1-e916-7a04-bf3d-4f1acffdb197" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_019cb6f1-e916-73fc-9efd-4ed37c5c52e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019cb6f1-e916-725e-a0ff-77156bb4a12a" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_019cb6f1-e916-73fc-9efd-4ed37c5c52e6" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/ShareBasedCompensationExpenseScheduleofTotalCompensationCostRecognizedDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#ShareBasedCompensationExpenseScheduleofTotalCompensationCostRecognizedDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/ShareBasedCompensationExpenseScheduleofTotalCompensationCostRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019cb6f1-e916-7385-b322-2cf5e8fca636" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019cb6f1-e916-74f5-9608-16d1dc3a3c2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019cb6f1-e916-7385-b322-2cf5e8fca636" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019cb6f1-e916-74f5-9608-16d1dc3a3c2a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e916-7b27-af7c-38b069453090" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019cb6f1-e916-74f5-9608-16d1dc3a3c2a" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e916-7b27-af7c-38b069453090" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e916-7b27-af7c-38b069453090_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e916-7b27-af7c-38b069453090" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e916-7b27-af7c-38b069453090_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e916-75b3-9d55-c2f903f4f999" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019cb6f1-e916-7b27-af7c-38b069453090" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e916-75b3-9d55-c2f903f4f999" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019cb6f1-e916-7e9a-b705-0b236e31d9eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e916-75b3-9d55-c2f903f4f999" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019cb6f1-e916-7e9a-b705-0b236e31d9eb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019cb6f1-e916-7d47-8b52-b41edb34050d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019cb6f1-e916-75b3-9d55-c2f903f4f999" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019cb6f1-e916-7d47-8b52-b41edb34050d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_019cb6f1-e916-7111-bbdb-8176f53dc6a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019cb6f1-e916-7385-b322-2cf5e8fca636" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_019cb6f1-e916-7111-bbdb-8176f53dc6a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019cb6f1-e916-74d6-ab76-6ebf34538309" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_019cb6f1-e916-7111-bbdb-8176f53dc6a7" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019cb6f1-e916-74d6-ab76-6ebf34538309" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/AccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#AccumulatedOtherComprehensiveLossDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/AccumulatedOtherComprehensiveLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019cb6f1-e916-7e3a-bd38-9104ae681789" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019cb6f1-e916-7137-ab40-bff57fb5d799" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019cb6f1-e916-7e3a-bd38-9104ae681789" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019cb6f1-e916-7137-ab40-bff57fb5d799" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e916-72c1-bb46-6cbdafe275e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_019cb6f1-e916-7137-ab40-bff57fb5d799" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e916-72c1-bb46-6cbdafe275e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019cb6f1-e916-72c1-bb46-6cbdafe275e8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e916-72c1-bb46-6cbdafe275e8" xlink:to="loc_us-gaap_EquityComponentDomain_019cb6f1-e916-72c1-bb46-6cbdafe275e8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019cb6f1-e916-7bf4-a21e-93a6cfac4917" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019cb6f1-e916-72c1-bb46-6cbdafe275e8" xlink:to="loc_us-gaap_EquityComponentDomain_019cb6f1-e916-7bf4-a21e-93a6cfac4917" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cb6f1-e916-7f29-8871-e4f7d5ec229a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019cb6f1-e916-7bf4-a21e-93a6cfac4917" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cb6f1-e916-7f29-8871-e4f7d5ec229a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019cb6f1-e916-7a8d-9c0c-5e0086636cea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cb6f1-e916-7f29-8871-e4f7d5ec229a" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_019cb6f1-e916-7a8d-9c0c-5e0086636cea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AccumulatedOtherComprehensiveLossOtherAdjustmentsMember_019cb6f1-e916-7370-afe1-d2d435b0fb68" xlink:href="bgne-20260331.xsd#bgne_AccumulatedOtherComprehensiveLossOtherAdjustmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019cb6f1-e916-7f29-8871-e4f7d5ec229a" xlink:to="loc_bgne_AccumulatedOtherComprehensiveLossOtherAdjustmentsMember_019cb6f1-e916-7370-afe1-d2d435b0fb68" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019cb6f1-e916-7a11-9828-d31b07316f8c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_019cb6f1-e916-7e3a-bd38-9104ae681789" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019cb6f1-e916-7a11-9828-d31b07316f8c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cb6f1-e916-74e5-8a16-96e692f940c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019cb6f1-e916-7a11-9828-d31b07316f8c" xlink:to="loc_us-gaap_StockholdersEquity_019cb6f1-e916-74e5-8a16-96e692f940c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019cb6f1-e916-74d1-9bc3-30cc8a04f7c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019cb6f1-e916-7a11-9828-d31b07316f8c" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019cb6f1-e916-74d1-9bc3-30cc8a04f7c7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019cb6f1-e916-78dd-8ced-3aa72fc5fc18" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019cb6f1-e916-7a11-9828-d31b07316f8c" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019cb6f1-e916-78dd-8ced-3aa72fc5fc18" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019cb6f1-e916-76dc-b95e-cea50eea76ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_019cb6f1-e916-7a11-9828-d31b07316f8c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019cb6f1-e916-76dc-b95e-cea50eea76ea" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cb6f1-e916-74fc-9a3d-8389b3bf29e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/RestrictedNetAssetsDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#RestrictedNetAssetsDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/RestrictedNetAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019cb6f1-e916-7f9d-b5ea-ee12c94c0178" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019cb6f1-e916-7379-a992-6d111ce8d4d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019cb6f1-e916-7f9d-b5ea-ee12c94c0178" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019cb6f1-e916-7379-a992-6d111ce8d4d4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7d39-af83-7cfb42d68098" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019cb6f1-e916-7379-a992-6d111ce8d4d4" xlink:to="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7d39-af83-7cfb42d68098" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-7d39-af83-7cfb42d68098_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7d39-af83-7cfb42d68098" xlink:to="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-7d39-af83-7cfb42d68098_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-72b2-8f93-3790f26ab018" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7d39-af83-7cfb42d68098" xlink:to="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-72b2-8f93-3790f26ab018" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_CN_019cb6f1-e916-7385-92b4-f787e1f9910c" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_CN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-72b2-8f93-3790f26ab018" xlink:to="loc_country_CN_019cb6f1-e916-7385-92b4-f787e1f9910c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RestrictedNetAssetsMinimumRequiredStatutoryReserveOfAnnualAfterTaxProfitPercentage_019cb6f1-e916-7d2c-93d5-20f06422d735" xlink:href="bgne-20260331.xsd#bgne_RestrictedNetAssetsMinimumRequiredStatutoryReserveOfAnnualAfterTaxProfitPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019cb6f1-e916-7f9d-b5ea-ee12c94c0178" xlink:to="loc_bgne_RestrictedNetAssetsMinimumRequiredStatutoryReserveOfAnnualAfterTaxProfitPercentage_019cb6f1-e916-7d2c-93d5-20f06422d735" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_RestrictedNetAssetsRequiredStatutoryReserveAsPercentageOfRegisteredCapital_019cb6f1-e916-7cb1-96fe-dd3585866dfc" xlink:href="bgne-20260331.xsd#bgne_RestrictedNetAssetsRequiredStatutoryReserveAsPercentageOfRegisteredCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019cb6f1-e916-7f9d-b5ea-ee12c94c0178" xlink:to="loc_bgne_RestrictedNetAssetsRequiredStatutoryReserveAsPercentageOfRegisteredCapital_019cb6f1-e916-7cb1-96fe-dd3585866dfc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmountOfRestrictedNetAssetsForConsolidatedAndUnconsolidatedSubsidiaries_019cb6f1-e916-77dc-ab14-faa5f4ae4cb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmountOfRestrictedNetAssetsForConsolidatedAndUnconsolidatedSubsidiaries"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019cb6f1-e916-7f9d-b5ea-ee12c94c0178" xlink:to="loc_us-gaap_AmountOfRestrictedNetAssetsForConsolidatedAndUnconsolidatedSubsidiaries_019cb6f1-e916-77dc-ab14-faa5f4ae4cb2" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/CommitmentsandContingenciesDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#CommitmentsandContingenciesDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/CommitmentsandContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationLineItems_019cb6f1-e916-77ca-8edb-31b9460caee1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnrecordedUnconditionalPurchaseObligationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationTable_019cb6f1-e916-7733-ab50-8b5a24dd6b0e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnrecordedUnconditionalPurchaseObligationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationLineItems_019cb6f1-e916-77ca-8edb-31b9460caee1" xlink:to="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationTable_019cb6f1-e916-7733-ab50-8b5a24dd6b0e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationByCategoryOfItemPurchasedAxis_019cb6f1-e916-7753-a544-e3bd51c3fa96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnrecordedUnconditionalPurchaseObligationByCategoryOfItemPurchasedAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationTable_019cb6f1-e916-7733-ab50-8b5a24dd6b0e" xlink:to="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationByCategoryOfItemPurchasedAxis_019cb6f1-e916-7753-a544-e3bd51c3fa96" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_019cb6f1-e916-7753-a544-e3bd51c3fa96_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationByCategoryOfItemPurchasedAxis_019cb6f1-e916-7753-a544-e3bd51c3fa96" xlink:to="loc_us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_019cb6f1-e916-7753-a544-e3bd51c3fa96_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_019cb6f1-e916-7b24-999f-8d7b2997c048" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationByCategoryOfItemPurchasedAxis_019cb6f1-e916-7753-a544-e3bd51c3fa96" xlink:to="loc_us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_019cb6f1-e916-7b24-999f-8d7b2997c048" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_MinimumPurchaseCommitmentsForSupplyPurchasedMember_019cb6f1-e916-7add-ba35-8f45664e7c51" xlink:href="bgne-20260331.xsd#bgne_MinimumPurchaseCommitmentsForSupplyPurchasedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_019cb6f1-e916-7b24-999f-8d7b2997c048" xlink:to="loc_bgne_MinimumPurchaseCommitmentsForSupplyPurchasedMember_019cb6f1-e916-7add-ba35-8f45664e7c51" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoriesMember_019cb6f1-e916-7f64-85a8-17a4659d115e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoriesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_019cb6f1-e916-7b24-999f-8d7b2997c048" xlink:to="loc_us-gaap_InventoriesMember_019cb6f1-e916-7f64-85a8-17a4659d115e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalAdditionsMember_019cb6f1-e916-784a-b98d-e7f652382034" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CapitalAdditionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnconditionalPurchaseObligationCategoryOfGoodsOrServicesAcquiredDomain_019cb6f1-e916-7b24-999f-8d7b2997c048" xlink:to="loc_us-gaap_CapitalAdditionsMember_019cb6f1-e916-784a-b98d-e7f652382034" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019cb6f1-e916-76d6-b86a-32cb00e221d8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationTable_019cb6f1-e916-7733-ab50-8b5a24dd6b0e" xlink:to="loc_srt_CounterpartyNameAxis_019cb6f1-e916-76d6-b86a-32cb00e221d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e916-76d6-b86a-32cb00e221d8_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e916-76d6-b86a-32cb00e221d8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e916-76d6-b86a-32cb00e221d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e916-7578-925b-ec18e9e1d618" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019cb6f1-e916-76d6-b86a-32cb00e221d8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e916-7578-925b-ec18e9e1d618" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AmgenIncMember_019cb6f1-e916-701d-aec7-025352526cc5" xlink:href="bgne-20260331.xsd#bgne_AmgenIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019cb6f1-e916-7578-925b-ec18e9e1d618" xlink:to="loc_bgne_AmgenIncMember_019cb6f1-e916-701d-aec7-025352526cc5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsAxis_019cb6f1-e916-732b-9760-d693adc20676" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationTable_019cb6f1-e916-7733-ab50-8b5a24dd6b0e" xlink:to="loc_us-gaap_OtherCommitmentsAxis_019cb6f1-e916-732b-9760-d693adc20676" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_019cb6f1-e916-732b-9760-d693adc20676_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_OtherCommitmentsAxis_019cb6f1-e916-732b-9760-d693adc20676" xlink:to="loc_us-gaap_OtherCommitmentsDomain_019cb6f1-e916-732b-9760-d693adc20676_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_019cb6f1-e916-7cfd-b684-9d97e703b695" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_OtherCommitmentsAxis_019cb6f1-e916-732b-9760-d693adc20676" xlink:to="loc_us-gaap_OtherCommitmentsDomain_019cb6f1-e916-7cfd-b684-9d97e703b695" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_InvestmentsFundingCommitmentMember_019cb6f1-e916-7999-9c01-7712f19bf58f" xlink:href="bgne-20260331.xsd#bgne_InvestmentsFundingCommitmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherCommitmentsDomain_019cb6f1-e916-7cfd-b684-9d97e703b695" xlink:to="loc_bgne_InvestmentsFundingCommitmentMember_019cb6f1-e916-7999-9c01-7712f19bf58f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnconditionalPurchaseObligationsExcludingCapitalStockRedemptionsAbstract_019cb6f1-e916-7e84-a25f-df89e2ecfdd6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnconditionalPurchaseObligationsExcludingCapitalStockRedemptionsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationLineItems_019cb6f1-e916-77ca-8edb-31b9460caee1" xlink:to="loc_us-gaap_UnconditionalPurchaseObligationsExcludingCapitalStockRedemptionsAbstract_019cb6f1-e916-7e84-a25f-df89e2ecfdd6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationBalanceSheetAmount_019cb6f1-e916-7a7b-a0ad-2cf15718eed9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnrecordedUnconditionalPurchaseObligationBalanceSheetAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnconditionalPurchaseObligationsExcludingCapitalStockRedemptionsAbstract_019cb6f1-e916-7e84-a25f-df89e2ecfdd6" xlink:to="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationBalanceSheetAmount_019cb6f1-e916-7a7b-a0ad-2cf15718eed9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitment_019cb6f1-e916-7d99-9c7e-6757424d83b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherCommitment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnconditionalPurchaseObligationsExcludingCapitalStockRedemptionsAbstract_019cb6f1-e916-7e84-a25f-df89e2ecfdd6" xlink:to="loc_us-gaap_OtherCommitment_019cb6f1-e916-7d99-9c7e-6757424d83b1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_MaximumCashAndServicesDevelopmentCommitment_019cb6f1-e916-718a-aba8-f6d10f1c746e" xlink:href="bgne-20260331.xsd#bgne_MaximumCashAndServicesDevelopmentCommitment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnconditionalPurchaseObligationsExcludingCapitalStockRedemptionsAbstract_019cb6f1-e916-7e84-a25f-df89e2ecfdd6" xlink:to="loc_bgne_MaximumCashAndServicesDevelopmentCommitment_019cb6f1-e916-718a-aba8-f6d10f1c746e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_LongTermFundingCommitmentMaximumAmount_019cb6f1-e916-7d8e-8350-cd1a54c92449" xlink:href="bgne-20260331.xsd#bgne_LongTermFundingCommitmentMaximumAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnconditionalPurchaseObligationsExcludingCapitalStockRedemptionsAbstract_019cb6f1-e916-7e84-a25f-df89e2ecfdd6" xlink:to="loc_bgne_LongTermFundingCommitmentMaximumAmount_019cb6f1-e916-7d8e-8350-cd1a54c92449" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://beigene.com/role/SegmentandGeographicInformationScheduleofRevenuebyGeographicAreaDetails" xlink:type="simple" xlink:href="bgne-20260331.xsd#SegmentandGeographicInformationScheduleofRevenuebyGeographicAreaDetails"/>
  <link:definitionLink xlink:role="http://beigene.com/role/SegmentandGeographicInformationScheduleofRevenuebyGeographicAreaDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019cb6f1-e916-787f-9058-cf2365c60e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019cb6f1-e916-706e-bd90-a12fc7a96ea2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019cb6f1-e916-787f-9058-cf2365c60e8f" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019cb6f1-e916-706e-bd90-a12fc7a96ea2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019cb6f1-e916-741b-a1ab-ae252189c1f8" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019cb6f1-e916-706e-bd90-a12fc7a96ea2" xlink:to="loc_srt_ProductOrServiceAxis_019cb6f1-e916-741b-a1ab-ae252189c1f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-741b-a1ab-ae252189c1f8_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e916-741b-a1ab-ae252189c1f8" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-741b-a1ab-ae252189c1f8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7791-806f-a24d0f8c34a0" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019cb6f1-e916-741b-a1ab-ae252189c1f8" xlink:to="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7791-806f-a24d0f8c34a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_019cb6f1-e916-7bb2-844a-d7c95066d063" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7791-806f-a24d0f8c34a0" xlink:to="loc_us-gaap_ProductMember_019cb6f1-e916-7bb2-844a-d7c95066d063" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_OtherRevenueMember_019cb6f1-e916-7158-9da8-285f8c760383" xlink:href="bgne-20260331.xsd#bgne_OtherRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019cb6f1-e916-7791-806f-a24d0f8c34a0" xlink:to="loc_bgne_OtherRevenueMember_019cb6f1-e916-7158-9da8-285f8c760383" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7a43-bd1f-41048d1c87b9" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_019cb6f1-e916-706e-bd90-a12fc7a96ea2" xlink:to="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7a43-bd1f-41048d1c87b9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-7a43-bd1f-41048d1c87b9_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7a43-bd1f-41048d1c87b9" xlink:to="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-7a43-bd1f-41048d1c87b9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-75d8-a16c-6b9c7bd1c8d6" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_019cb6f1-e916-7a43-bd1f-41048d1c87b9" xlink:to="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-75d8-a16c-6b9c7bd1c8d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_019cb6f1-e916-7f4c-b40e-d40285fcf28c" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-75d8-a16c-6b9c7bd1c8d6" xlink:to="loc_country_US_019cb6f1-e916-7f4c-b40e-d40285fcf28c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_CN_019cb6f1-e916-7572-bd1c-4b41c972a73e" xlink:href="https://xbrl.sec.gov/country/2025/country-2025.xsd#country_CN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-75d8-a16c-6b9c7bd1c8d6" xlink:to="loc_country_CN_019cb6f1-e916-7572-bd1c-4b41c972a73e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_019cb6f1-e916-742f-98ac-787a0b1aaa68" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-75d8-a16c-6b9c7bd1c8d6" xlink:to="loc_srt_EuropeMember_019cb6f1-e916-742f-98ac-787a0b1aaa68" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_AllOtherCountriesExceptChinaAndUnitedStatesOfAmericaMember_019cb6f1-e916-779c-8f21-4a4fcda4ccba" xlink:href="bgne-20260331.xsd#bgne_AllOtherCountriesExceptChinaAndUnitedStatesOfAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_019cb6f1-e916-75d8-a16c-6b9c7bd1c8d6" xlink:to="loc_bgne_AllOtherCountriesExceptChinaAndUnitedStatesOfAmericaMember_019cb6f1-e916-779c-8f21-4a4fcda4ccba" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeographicAreasRevenuesFromExternalCustomersAbstract_019cb6f1-e916-7c86-9a0f-32bd20b328a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeographicAreasRevenuesFromExternalCustomersAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_019cb6f1-e916-787f-9058-cf2365c60e8f" xlink:to="loc_us-gaap_GeographicAreasRevenuesFromExternalCustomersAbstract_019cb6f1-e916-7c86-9a0f-32bd20b328a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e916-7c27-9df5-36a18c395222" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GeographicAreasRevenuesFromExternalCustomersAbstract_019cb6f1-e916-7c86-9a0f-32bd20b328a5" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cb6f1-e916-7c27-9df5-36a18c395222" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#IndividualsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_AllIndividualsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_JohnV.OylerMember_019db4f7-23d7-7125-838e-24dc8c3ca370" xlink:href="bgne-20260331.xsd#bgne_JohnV.OylerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_bgne_JohnV.OylerMember_019db4f7-23d7-7125-838e-24dc8c3ca370" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/TradingArrangementsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#TradingArrangmentsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/TradingArrangementsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllTradingArrangementsMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_AllTradingArrangementsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_JohnV.OylerTradingArrangementSoldByMr.OylerMember_019de24a-62e8-7531-981a-f865e98f1806" xlink:href="bgne-20260331.xsd#bgne_JohnV.OylerTradingArrangementSoldByMr.OylerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllTradingArrangementsMember" xlink:to="loc_bgne_JohnV.OylerTradingArrangementSoldByMr.OylerMember_019de24a-62e8-7531-981a-f865e98f1806" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_bgne_JohnV.OylerTradingArrangementSoldByPanOylerFoundationMember_019de24a-dad4-730b-8d63-ebd1debf582d" xlink:href="bgne-20260331.xsd#bgne_JohnV.OylerTradingArrangementSoldByPanOylerFoundationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllTradingArrangementsMember" xlink:to="loc_bgne_JohnV.OylerTradingArrangementSoldByPanOylerFoundationMember_019de24a-dad4-730b-8d63-ebd1debf582d" xlink:type="arc" order="2"/>
  </link:definitionLink>
</link:linkbase>
