0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Description of Business, Basis of Presentation and Consolidation and Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Collaborative, Licensing and Other Arrangements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Sale of Future IMDELLTRA® Royalties link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Restricted Cash and Investments link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Property, Plant and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Intangible Assets link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Supplemental Balance Sheet Information link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Product Revenue link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Earnings Per Share/ADS link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Share-Based Compensation Expense link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Accumulated Other Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Restricted Net Assets link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Segment and Geographic Information link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Description of Business, Basis of Presentation and Consolidation and Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Collaborative, Licensing and Other Arrangements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Sale of Future IMDELLTRA® Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Restricted Cash and Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Property, Plant and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Intangible Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Supplemental Balance Sheet Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Product Revenue (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Earnings Per Share/ADS (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Share-Based Compensation Expense (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Accumulated Other Comprehensive Loss (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Segment and Geographic Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Description of Business, Basis of Presentation and Consolidation and Significant Accounting Policies (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Fair Value Measurements - Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Fair Value Measures and Disclosures - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Collaborative, Licensing and Other Arrangements - Schedule of Recognized Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Collaborative, Licensing and Other Arrangements - Schedule of Funding Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Collaborative, Licensing and Other Arrangements - Schedule of Financing Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Collaborative, Licensing and Other Arrangements - Schedule of Amounts and Classification of Payments (Income/(Expense) (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Collaborative, Licensing and Other Arrangements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Collaborative, Licensing and Other Arrangements - Schedule of In Licensing Agreements - Development (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Sale of Future IMDELLTRA® Royalties - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Sale of Future IMDELLTRA® Royalties - Schedule of Sale of Future Royalty Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Sale of Future IMDELLTRA® Royalties - Schedule of Royalty Sale Liability Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Sale of Future IMDELLTRA® Royalties - Schedule of Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Restricted Cash and Investments - Schedule of Restrictions on Cash and Cash Equivalents (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Restricted Cash and Investments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Restricted Cash and Investments - Schedule of Investments In Equity Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Restricted Cash and Investments - Schedule of Equity Method Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Property, Plant and Equipment, Net- Schedule of Property, Plant and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Property, Plant and Equipment, Net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Property, Plant and Equipment, Net - Schedule of Depreciation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Intangible Assets - Schedule of Intangible Assets Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Intangible Assets - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Intangible Assets - Schedule of Future Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Intangible Assets - Schedule of Expected Amortization Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Supplemental Balance Sheet Information - Schedule Inventories, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Supplemental Balance Sheet Information - Schedule of Prepaid Expenses and Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Supplemental Balance Sheet Information - Schedule of Other Non-current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Supplemental Balance Sheet Information - Schedule of Accrued Expenses and Other Payables (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Supplemental Balance Sheet Information - Schedule of Other Long-term Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Debt - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Debt - Schedule of Short-term and Long-term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Debt - Schedule of Short-term and Long-term Debt Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Debt - Footnotes (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Debt - Schedule of Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Product Revenue - Schedule of Net Product Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Product Revenue - Schedule of Accrued Revenue Rebates and Returns (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Earnings Per Share/ADS - Reconciliation of the Computation of Earnings Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Earnings Per Share/ADS - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Share-Based Compensation Expense - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Share-Based Compensation Expense - Schedule of Shares Issued Under Employee Share Purchase Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Share-Based Compensation Expense - Schedule of Total Compensation Cost Recognized (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Accumulated Other Comprehensive Loss (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Restricted Net Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Segment and Geographic Information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Segment and Geographic Information - Schedule of Revenue by Geographic Area (Details) link:presentationLink link:calculationLink link:definitionLink