v3.26.1
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2026
Mar. 31, 2025
Operating activities:    
Net income $ 227,357 $ 1,270
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and amortization expense 41,144 32,804
Share-based compensation expenses 123,355 95,478
Amortization of research and development cost share liability (28,645) (19,812)
Non-cash interest expense 21,096 0
Other items, net 6,172 12,369
Changes in operating assets and liabilities:    
Accounts receivable (75,300) (31,866)
Inventories (71,838) 3,987
Other assets 15,270 29,737
Accounts payable (42,187) (31,568)
Accrued expenses and other payables (16,819) (52,360)
Other liabilities 1,731 4,043
Net cash provided by operating activities 201,336 44,082
Investing activities:    
Purchases of property, plant and equipment (40,789) (56,407)
Proceeds from sale or maturity of investments 27 1,800
Purchase of in-process research and development 0 (60,000)
Other investing activities (4,748) (7,334)
Net cash used in investing activities (45,510) (121,941)
Financing activities:    
Repayment of long-term loan (7,641) (4,215)
Proceeds from short-term loans 58,204 80,000
Repayment of short-term loans 0 (172,921)
Repayment of sale of future royalties liability (2,557) 0
Proceeds from option exercises and employee share purchase plan 23,875 63,359
Other financing activities (3,249) 0
Net cash provided by (used in) financing activities 68,632 (33,777)
Effect of foreign exchange rate changes, net 19,320 3,480
Net increase (decrease) in cash, cash equivalents, and restricted cash 243,778 (108,156)
Cash, cash equivalents, and restricted cash at beginning of period 4,609,647 2,638,747
Cash, cash equivalents, and restricted cash at end of period 4,853,425 2,530,591
Supplemental cash flow information:    
Cash and cash equivalents 4,791,676 2,516,411
Short-term restricted cash 40,839 11,333
Long-term restricted cash 20,910 2,847
Income taxes (refunded)/paid (2,737) 9,321
Interest portion of repayment for sale of future royalties 12,834 6,247
Supplemental non-cash information:    
Capital expenditures included in accounts payable and accrued expenses 43,249 60,010
ROU assets obtained in exchange for new operating lease liabilities $ 9,261 $ 15,659