During the three months ended March 31, 2026, the Company granted restricted share units for 778,817 ordinary shares under the Company’s share option and incentive plan. As of March 31, 2026, options, restricted share units, and performance share units for ordinary shares outstanding totaled 47,017,959, 74,129,393, and 4,551,157, respectively. As of March 31, 2026, share-based awards to acquire 61,363,925 ordinary shares were available for future grant under the Company’s share option and incentive plan.

The Company’s employee share purchase plan (the “ESPP”) allows eligible employees to purchase the Company’s ordinary shares (including in the form of ADSs) at the end of each offering period, which will generally be six months, at a 15% discount to the market price of the Company’s ADSs at the beginning or the end of each offering period, whichever is lower, using funds deducted from their payroll during the offering period. Eligible employees are able to authorize payroll deductions of up to 10% of their eligible earnings, subject to applicable limitations.


	Number of Ordinary Shares Issued	Market Price1				Purchase Price2
Issuance Date		ADS		Ordinary		ADS		Ordinary		Proceeds

February 28, 2026	741,299	$	316.99	$	24.38	$	269.44	$	20.73	$	15,364
August 31, 2025	818,506	$	245.53	$	18.89	$	208.70	$	16.05	$	13,140
February 28, 2025	955,396	$	188.26	$	14.48	$	160.02	$	12.31	$	11,760

1 The market price is the lower of the closing price on the Nasdaq Stock Market on the issuance date or the offering date, in accordance with the terms of the ESPP.

2 The purchase price is the price which was discounted from the applicable market price, in accordance with the terms of the ESPP.

The following table summarizes total share-based compensation expense recognized for the three months ended March 31, 2026 and 2025:


	Three Months Ended
	March 31,
	2026	2025
	$	$
Research and development	53,856	41,767
Selling, general and administrative	69,492	53,684
Total	123,348	95,451