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  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockAmendedLoanAgreementMember" name="WarrantsToPurchaseCommonStockAmendedLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockFirstAmendmentLoanAgreementMember" name="WarrantsToPurchaseCommonStockFirstAmendmentLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_WarrantsToPurchaseCommonStockFirstAmendmentMember" name="WarrantsToPurchaseCommonStockFirstAmendmentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-earnings-per-share-details" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-details" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-schedule-of-potentially-dilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-tables" name="statement-statement-note-1-organization-and-summary-of-significant-accounting-policies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-disaggregation-of-revenue-details" name="statement-statement-note-2-revenue-disaggregation-of-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-schedules-of-concentration-of-risk-details" name="statement-statement-note-2-revenue-schedules-of-concentration-of-risk-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-2-revenue-tables" name="statement-statement-note-2-revenue-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-schedule-of-investment-securities-details" name="statement-statement-note-3-investment-securities-schedule-of-investment-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-3-investment-securities-tables" name="statement-statement-note-3-investment-securities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-4-inventory-schedule-of-inventory-details" name="statement-statement-note-4-inventory-schedule-of-inventory-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-4-inventory-tables" name="statement-statement-note-4-inventory-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-schedule-of-fair-value-measurements-details" name="statement-statement-note-5-fair-value-measurements-schedule-of-fair-value-measurements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-5-fair-value-measurements-tables" name="statement-statement-note-5-fair-value-measurements-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stock-based-compensation-summary-of-activity-for-restricted-stock-details" name="statement-statement-note-6-stock-based-compensation-summary-of-activity-for-restricted-stock-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stock-based-compensation-summary-of-activity-for-stock-options-details" name="statement-statement-note-6-stock-based-compensation-summary-of-activity-for-stock-options-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-6-stock-based-compensation-tables" name="statement-statement-note-6-stock-based-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-schedule-of-loan-payable-details" name="statement-statement-note-7-loan-payable-schedule-of-loan-payable-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-7-loan-payable-tables" name="statement-statement-note-7-loan-payable-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-classification-of-lease-liabilities-details" name="statement-statement-note-8-leases-schedule-of-classification-of-lease-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-lease-cost-details" name="statement-statement-note-8-leases-schedule-of-lease-cost-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-schedule-of-lease-liability-maturity-details" name="statement-statement-note-8-leases-schedule-of-lease-liability-maturity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-note-8-leases-tables" name="statement-statement-note-8-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="tgtx_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
