75000 - Document - Document and Entity Information
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75010 - Statement - Condensed Consolidated Balance Sheets (Unaudited)
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75020 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical)
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75030 - Statement - Condensed Consolidated Statements of Operations (Unaudited)
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75040 - Statement - Condensed Consolidated Statements of Comprehensive Loss (Unaudited)
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75050 - Statement - Condensed Consolidated Statements of Stockholders' Equity (Unaudited)
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75060 - Statement - Condensed Consolidated Statements of Stockholders' (Deficit) Equity (Parenthetical)
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75070 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)
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995455 - Disclosure - Organization and Description of Business Operations
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995465 - Disclosure - Summary of Significant Accounting Policies
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995475 - Disclosure - Fair Value Measurements
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995485 - Disclosure - Balance Sheet Components
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995495 - Disclosure - Leases
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995505 - Disclosure - Astellas Agreements
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995515 - Disclosure - Term Loans
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995525 - Disclosure - Research, Collaboration and License Agreements
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995535 - Disclosure - Stock-Based Compensation
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995545 - Disclosure - Warrants
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995555 - Disclosure - Net Loss Per Common Share
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995565 - Disclosure - Income Taxes
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995575 - Disclosure - Commitments and Contingencies
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995585 - Disclosure - Strategic Reprioritization
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995595 - Disclosure - Retirement Plan
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995605 - Disclosure - Segment Information
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995615 - Disclosure - Subsequent Events
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995625 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995635 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995645 - Disclosure - Fair Value Measurements (Tables)
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995655 - Disclosure - Balance Sheet Components (Tables)
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995665 - Disclosure - Leases (Tables)
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995675 - Disclosure - Astellas Agreements (Tables)
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995685 - Disclosure - Term Loans (Tables)
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995695 - Disclosure - Stock-Based Compensation (Tables)
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995705 - Disclosure - Warrants (Tables)
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995715 - Disclosure - Net Loss Per Common Share (Tables)
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995725 - Disclosure - Strategic Reprioritization (Tables)
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995735 - Disclosure - Segment Information (Tables)
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995745 - Disclosure - Organization and Description of Business Operations - Additional Information (Details)
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995755 - Disclosure - Significant Accounting Policies - Additional Information (Details)
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995765 - Disclosure - Fair Value Measurements - Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details)
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995775 - Disclosure - Balance Sheet Components - Schedule of Prepaid Expenses and Other Current Assets (Details)
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995785 - Disclosure - Balance Sheet Components - Schedule of Property, Plant and Equipment Net (Details)
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995795 - Disclosure - Balance Sheet Components - Additional Information (Details)
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995805 - Disclosure - Balance Sheet Components - Schedule of Accrued Expenses and Other Current Liabilities (Details)
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995815 - Disclosure - Leases - Additional Information (Details)
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995825 - Disclosure - Leases - Schedule of Lease Cost (Details)
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995835 - Disclosure - Leases - Supplemental Information Related to Remaining Lease Term and Discount Rate (Details)
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995845 - Disclosure - Leases - Schedule of Supplemental Cash Flow Information Related to Operating Leases (Details)
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995855 - Disclosure - Leases - Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases (Details)
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995865 - Disclosure - Leases - Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases (Details) 2
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995875 - Disclosure - Leases - Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases (Details) 3
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995885 - Disclosure - Leases - Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases (Details) 4
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995895 - Disclosure - Astellas Agreements - Additional Information (Details)
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995905 - Disclosure - Astellas Agreements - Additional Information 1 (Details)
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995915 - Disclosure - Astellas Agreements - Summary of Allocation for Transaction Price to the Three Performance Obligations (Details)
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995925 - Disclosure - Term Loans - Additional Information (Details)
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995935 - Disclosure - Term Loans - Schedule of Future Principal Debt Payments on Term Loan Agreement (Details)
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995945 - Disclosure - Term Loans - Schedule of Reconcile of Change in Fair Value of Debt (Details)
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995955 - Disclosure - Research, Collaboration and License Agreements - Additional Information (Details)
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995965 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995975 - Disclosure - Stock-Based Compensation - Schedule of Share Based Compensation Available for Grant under Incentive Plans (Details)
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995985 - Disclosure - Stock-Based Compensation - Schedule of Assumptions Used to Estimate Fair Value of Stock Options (Details)
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995995 - Disclosure - Stock-Based Compensation - Schedule of Stock Option Activity (Details)
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996005 - Disclosure - Stock-Based Compensation - Schedule of Restricted Stock Units Activity (Details)
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996015 - Disclosure - Stock-Based Compensation - Schedule of Total Stock-Based Compensation Expense for Stock Options, ESPP, RSAs and RSUs (Details)
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996025 - Disclosure - Warrants - Additional Information (Details)
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996035 - Disclosure - Net Loss Per Common Share - Additional Information (Details)
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996045 - Disclosure - Net Loss Per Common Share - Schedule of Calculation of Basic and Diluted Net Loss Per Common Share (Details)
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996055 - Disclosure - Net Loss Per Common Share - Schedule of Common Stock Equivalents Outstanding Excluded from Computation of Diluted Net Loss Per Share Attributable to Common Stockholders (Details)
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996065 - Disclosure - Income Taxes - Additional Information (Details)
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996075 - Disclosure - Strategic Reprioritization - Additional Information (Details)
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996085 - Disclosure - Strategic Reprioritization - Summary of Accrued Severance Activity Recorded (Details)
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996095 - Disclosure - Retirement Plan - Additional Information (Details)
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996105 - Disclosure - Segment Information - Additional Information (Details)
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996115 - Disclosure - Segment Information - Summary of Significant Segment Expenses (Details)
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996125 - Disclosure - Subsequent Events (Additional Information) (Details)
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Proceeds from issuance of common stock and pre-funded warrants from private placement, net of placement agent commissions and other offering costs
Proceeds from issuance of common stock and prefunded warrants from private placement net of placement agent commissions and other offering costs.
Proceeds From Issuance Of Common Stock And Prefunded Warrants From Private Placement Net Of Placement Agent Commissions And Other Offering Costs
Vested, weighted average grant date fair value
Vested, Weighted Average Grant Date Fair Value per Share
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
TSHA-120
Acquisition Of Worldwide Rights For T S H A120 For Treatment Of Giant Axonal Neuropathy [Member]
Acquisition of worldwide rights for TSHA 120 for treatment of giant axonal neuropathy.
Total lease liabilities
Total lease liabilities
Finance Lease, Liability
Pre-Funded Warrants Option Two
Pre-Funded Warrants Option Two [Member]
Pre-Funded Warrants Option Two
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Finance Lease, Liability, to be Paid, Year Four
2029
Preferred stock, shares issued
Preferred Stock Shares Issued
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase Decrease In Accounts Payable
Success Fees
Success fees.
Success fees
Long-Term Debt, Excluding Current Maturities, Total
Term loan, net
Long Term Debt Noncurrent
Plan Name
Plan Name [Axis]
Research and development program expense
Research and Development Expense [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Proceeds from exercise of warrants
Proceeds from Warrant Exercises
2023 Trinity Term Loan Agreement
Two Thousand Twenty Three Trinity Term Loan Agreement [Member]
Two Thousand Twenty Three Trinity Term Loan Agreement.
Option to obtain license for GAN
License For GAN [Member]
License For GAN
Operating expenses:
Operating Expenses [Abstract]
Fair Value, Inputs, Level 2 [Member]
Level 2
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Forfeitures
Forfeitures
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Cancelled In Period
Share based compensation arrangement by share based payment award number of shares available for grant cancelled in period.
Common stock, shares authorized
Common Stock Shares Authorized
Proceeds from issuance of common stock and pre-funded warrants from underwritten public offering, net of underwriting discounts and sales commissions and other offering costs
Proceeds from Issuance of Common Stock and Pre-funded Warrants from Underwritten Public Offering, Net of Underwriting Discounts and Sales Commissions and Other Offering Costs
Proceeds from issuance of common stock and pre-funded warrants from underwritten public offering, net of underwriting discounts and sales commissions and other offering costs.
Product and Service
Product Or Service [Axis]
Document Fiscal Period Focus
Document Fiscal Period Focus
OperatingLeaseLiability
Total lease payments
Finance Lease, Liability, to be Paid
Percentage of interest rate
Debt Instrument Interest Rate Stated Percentage
Entity Shell Company
Entity Shell Company
Inducement Plan.
Inducement Plan [Member]
Inducement Plan
Schedule of Supplemental Cash Flow Information Related to Operating Leases
Schedule Of Supplemental Cash Flow Information Related To Operating Leases [Table Text Block]
Schedule Of Supplemental Cash Flow Information Related To Operating Leases
Other
Other Accrued Liabilities Current
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Cash and Cash Equivalents, at Carrying Value, Total
Schedule Of Maturities Of Long Term Debt Table [Text Block]
Schedule of Future Principal Debt Payments on Term Loan Agreement
Abeona
Abeona Therapeutics Inc [Member]
Abeona Therapeutics Inc.
Common stock, shares issued
Common Stock Shares Issued
Change in fair value of term loan.
Change in fair value of term loan
Change in fair value of term loan
Change in fair value of term loan
Percentage of principal amount of terms regarding fee.
Percentage Of Principal Amount Of Terms Regarding Fee
Percentage of principal amount of terms regarding fee
Statement [Table]
Statement [Table]
Restricted Cash, Noncurrent
Restricted cash, noncurrent
Restricted cash
Assets Capitalized as Finance Leases [Member]
Assets capitalized as finance leases.
Assets Capitalized as Finance Leases
Share-based payment award, options, weighted-average grant date fair value
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Statement [Line Items]
Statement [Line Items]
Underwriting Agreement
Underwriting Agreement [Member]
Underwriting agreement member.
Options expired, Weighted Average Exercise Price
Share Based Compensation Arrangements By Share Based Payment Award Options Expirations In Period Weighted Average Exercise Price
Warrant [Member]
SSI Warrants
Entity Filer Category
Entity Filer Category
Liabilities And Stockholders Equity
Total liabilities and stockholders' equity
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Summary of Effect of the Adoption of ASC 842 on Statement of Operation and Cash Flows
Accounting Standards Update and Change in Accounting Principle [Table Text Block]
Long Term Debt Maturities Repayments Of Principal In Year Three
2029
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Options exercisable at March 31, 2026, Weighted Average Exercise Price
Restructuring Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Severance paid
Severance and termination-related costs
Severance Costs1
2028
Finance Lease, Liability, to be Paid, Year Three
Summary of Accrued Severance Activity Recorded
Schedule Of Accrued Severance Activity Recorded [Table Text Block]
Schedule of accrued severance activity table text block.
May Twenty Twenty Five Pre Funded Warrants Option One [Member]
May 2025 Pre Funded Warrants Option One
May 2025 Pre Funded Warrants Option One.
Cash and Cash Equivalents, Fair Value Disclosure
Cash equivalents - money market funds
Purchase price per share of common stock
Offering price per share of common stock
Shares Issued, Price Per Share
Share-based payment award, commencement date
Share Based Compensation Arrangement By Share Based Payment Award Commencement Date
Share based compensation arrangement by share based payment award commencement date.
Other Noncash Income (Expense)
Other Noncash Income (Expense), Total
Other
Stock Options
Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Finance Lease, Liability, to be Paid, Remainder of Fiscal Year
2026
Investment Income, Interest
Interest income
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Share-based payment award, terms of award issuance
Share Based Compensation Arrangement By Share Based Payment Award Terms Of Award
Share-based payment award, options granted
Options granted, Stock Options
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Schedule of Calculation of Basic and Diluted Net Loss Per Common Share
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Closing Date through November 13, 2024.
Closing Date through November 13, 2024 [Member]
Closing Date through November 13, 2024
Earnings Per Share, Basic, Total
Net loss per common share, basic
Earnings Per Share Basic
Retirement Plan
Pension And Other Postretirement Benefits Disclosure [Text Block]
Organization And Description Of Business Operations [Table]
Organization And Description Of Business Operations [Table]
Organization and description of business operations.
Outstanding performance and market-based options
Outstanding. Stock Options, Beginning Balance
Outstanding. Stock Options, Ending Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Total current liabilities
Liabilities Current
Two Thousand Twenty Five Trinity Term Loan Agreement [Member]
Two Thousand Twenty Five Trinity Term Loan Agreement.
2025 Trinity Term Loan Agreement
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Payments of Debt Issuance Costs
Debt issuance costs for term loan
Accounting Standards Update [Axis]
Percentage of headcount reduced
Restructuring And Related Cost Number Of Positions Eliminated Period Percent
Stockholders Equity [Abstract]
Stockholders' equity
Entity Small Business
Entity Small Business
TSHA-120
T S H A 120 For Treatment Of Giant Axonal Neuropathy [Member]
TSHA-120 for treatment of giant axonal neuropathy.
Line of Credit Facility, Commitment Fee Amount
Commitment fee
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings Accumulated Deficit
ASU 2016-02
Accounting Standards Update 2016-02 [Member]
Operating lease commencement date
Operations Commenced Date1
Options cancelled or forfeited, Stock Options
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Options forfeited
2023 Success Fee Agreement
Two Thousand Twenty Three Success Fee Agreement [Member]
Two Thousand Twenty Three Success Fee Agreement.
Prepaid clinical trial
Prepaid Clinical Trial
Prepaid clinical trial.
Offering price per share
Sale of Stock, Price Per Share
Stock-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Leases [Abstract]
Trinity Refinance Date through August 2026 [Member]
Trinity refinance date through August 2026.
Trinity Refinance Date through August 2026
Lessee, Lease, Description [Line Items]
Amendment Flag
Amendment Flag
Product and Service
Products And Services [Domain]
Warrants issued
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Additional warrants sold upon exercise of underwriters option
Number of Additional Warrants Issued Upon Exercise of Underwriters Option
Number of additional warrants issued upon exercise of underwriters option.
Exit and Disposal Activities
Exit And Disposal Activities [Member]
Exit and disposal activities.
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities And Stockholders Equity [Abstract]
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
Research and development license expense.
Research And Development License Expense
Research and development license expense
Warrants note disclosure.
Warrants Note Disclosure [Text Block]
Warrants
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
Common Stock
Common Stock [Member]
PIPE Shares
Contribution to retirement savings plan
Defined Contribution Plan Employer Discretionary Contribution Amount
Long Term Debt Maturities Repayments Of Principal In Next Twelve Months
2027
Share-based payment award, options granted, exercise price per share
Options granted, Weighted Average Exercise Price
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Lessee, Operating Lease, Liability, to be Paid, Year Three
2029
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
August two thousand and twenty three private placement.
August Two Thousand And Twenty Three Private Placement [Member]
August 2023 Private Placement
Amount required to place in escrow account
Escrow Deposit
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering
Performance-Based Restricted Stock Units [Member]
Performance-Based Restricted Stock Units.
Performance-Based Restricted Stock Units
Entity Address, Address Line One
Entity Address Address Line1
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Schedule of Assumptions Used to Estimate Fair Value of Stock Options
Debt Issuance Costs Incurred
Debt issuance costs incurred.
Debt issuance costs incurred
Fair Value Hierarchy and NAV [Axis]
Earnings Per Share [Abstract]
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
May Twenty Twenty Five Pre Funded Warrants Option Two [Member]
May 2025 Pre Funded Warrants Option Two.
May 2025 Pre Funded Warrants Option Two
Durham Lease [Member]
Durham lease.
Durham Lease
Line of Credit Facility, Expiration Period
Expiration Period
Through March Thirty One Twenty Twenty Nine [Member]
Through March 31,2029.
Through March 31,2029
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Less: imputed interest
Finance Lease, Liability, Undiscounted Excess Amount
Maximum number of shares employees may purchase during offering period
Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Shares Per Employee
Class of Warrant or Right [Axis]
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Entity Central Index Key
Entity Central Index Key
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Net Of Reserve
Share based compensation arrangement by share based payment award number of shares available for grant net of reserve.
Available for grant net of reserve - January 1, 2026
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Net decrease in cash, cash equivalents and restricted cash
Subsequent Event Type [Domain]
Fair Value Adjustment of Warrants
Change in fair value of warrant liability
Warrant liability fair value adjustment
Anti-dilutive securities excluded from computation of diluted net loss per share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Balance Sheet Related Disclosures [Abstract]
Issuance of common stock and pre-funded warrants upon closing of underwritten public offering, net of underwriting discounts and commissions, and other offering costs
Issuance of Common Stock and Pre Funded Warrants Upon Closing of Public Offering Value
Issuance of common stock and pre funded warrants upon closing of public offering value.
Common stock, par value per share
Common Stock Par Or Stated Value Per Share
Accounting Standards Update [Domain]
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash lease expense
Outstanding, Weighted Average Remaining Contractual Life
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Time Based Vesting Stock Option [Member]
Time Based Vesting Stock Option.
Time Based Vesting Stock Option
2023 Pre-Funded Warrants
Pre Funded Warrants.
Pre Funded Warrants [Member]
Pre-Funded Warrants
Exercised, Stock Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Options exercised, Stock Options
Issuance of stock upon exercise of stock options, shares
Debt Disclosure [Abstract]
Percentage Of Combined Voting Power Beneficially Owned
Combined voting power beneficially owned
Percentage of combined voting power beneficially owned.
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Current Fiscal Year End Date
Current Fiscal Year End Date
Debt Instrument [Table]
Debt Instrument [Table]
Organization and Description of Business Operations [Line Items]
Organization And Description Of Business Operations [Line Items]
Organization and description of business operations.
Percentage of aggregate shares beneficially owned.
Shares beneficially owned
Percentage of Aggregate Shares Beneficially Owned
Queens Agreement
Queens Agreement [Member]
Queen's agreement.
Document Quarterly Report
Document Quarterly Report
Grants
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Granted In Period
Share based compensation arrangement by share based payment award number of shares available for grant granted in period..
Grants
Sales Agents
Sales Agent [Member]
Sales agent.
Entity Address, State or Province
Entity Address State Or Province
Nonvested, Number of Shares, Beginning Balance
Nonvested, Number of Shares, Ending Balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Number of shares, outstanding
Outstsanding performance and market-based RSU's and RSAs
T S H A120 Rett Syndrome.
T S H A120 Rett Syndrome [Member]
Rett Option
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock reserved for future issuance
Common Stock Capital Shares Reserved For Future Issuance
Class of Warrant or Right [Domain]
Line of Credit Facility, Lender [Domain]
Line of Credit Facility, Lender
Decrease in revenue previously recognized
Contract with Customer, Liability, Revenue Recognized
Underwriting discounts and commissions and other offering costs
Underwriting Discounts And Commissions and Other Offering Costs
Underwriting discounts and commissions and other offering costs.
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Schedule of Total Stock-Based Compensation Expense for Stock Options, ESPP and RSUs
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration]
Stock options were exercised during the period
Stock Issued During Period Value Stock Options Exercised
Issuance of stock upon exercise of stock options
Two Thousand Twenty Three Trinity Term Loans [Member]
Two Thousand Twenty Three Trinity Term Loans.
2023 Trinity Term Loans
Comprehensive Loss
Comprehensive Income Policy Policy [Text Block]
Research, Collaboration and License Agreements
Astellas Agreements
Collaborative Arrangement Disclosure [Text Block]
Performance Shares [Member]
Performance Stock Options
Significant Accounting Policies.
Significant Accounting Policies [Policy Text Block]
Significant Accounting Policies
Schedule of assumptions used to estimate fair value of warrants.
Schedule Of Assumptions Used To Estimate Fair Value Of Warrants [Table Text Block]
Schedule Of Assumptions Used To Estimate Fair Value Of Warrants
Subsequent Event
Subsequent Event [Member]
Long Term Debt Maturities Repayments Of Principal Remainder Of Fiscal Year
2026
Deferred revenue
Deferred Revenue, Current
Deferred Revenue, Current, Total
Deferred revenue current
Percentage of gross sales price per share of common stock
Percentage Of Sale Price Per Share Of Common Stock
Percentage of sale price per share of common stock.
Other non-current assets
Other Assets Noncurrent
November 13, 2025 through, but excluding, the Maturity Date.
November 13, 2025 through, but excluding, the Maturity Date [Member]
November 13, 2025 through, but excluding, the Maturity Date
Summary of Allocation for Transaction Price to the Three Performance Obligations
Summary Of Transaction Price Allocation [Table Text Block]
Summary Of Transaction Price Allocation
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Schedule of Warrant Liability
Schedule of warrant liability.
Schedule Of Warrant Liability [Table Text Block]
Options expired, Stock Options
Share Based Compensation Arrangement By Share Based Payment Award Options Expirations In Period
Sale-related milestones per licensed product and royalties on net sales of licensed products payable
Sale Related Milestones Per Licensed Product And Royalties On Net Sales Of Licensed Products Payable
Sale-related milestones per licensed product and royalties on net sales of licensed products payable.
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Loss
Cash and Cash Equivalents [Domain]
Lease, option to extend description
Lessee, Operating Lease, Option to Extend
Preferred Stock Value
Preferred stock, $0.00001 par value per share; 10,000,000 shares authorized and no shares issued and outstanding as of March 31, 2026 and December 31, 2025
Significant accounting policies table.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Debt instrument, maturity date
Debt Instrument Maturity Date
Minimum
Minimum [Member]
Share-based payment award, RSU/RSA granted, weighted average grant date fair value
Restricted units/stock granted, Weighted Average Grant Date Fair Value per Share
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Current assets:
Assets Current [Abstract]
New Plan and Inducement Plan
Two Thousand Twenty Stock Incentive Plan and Two Thousand Twenty Three Inducement Plan [Member]
Two thousand twenty stock incentive plan and two thousand twenty three inducement plan.
Shares of Common Stock.
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Fair Value, Inputs, Level 3 [Member]
Level 3
November 13, 2024 through November 13, 2025
November 13, 2024 through November 13, 2025 [Member]
November 13, 2024 through November 13, 2025
Segment Reporting [Abstract]
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis
Current liabilities
Liabilities Current [Abstract]
End of term payment percentage
End of term payment percentage
End of term payment percentage
Class of Warrant or Right, Unissued
Warrants Exercised
Operating lease extend term of contract
Lessee Operating Lease Renewal Term
Proceeds from common stock issuances under ESPP
Proceeds From Stock Plans
Commitments And Contingencies
Commitments and contingencies - Note 13
Nonvested, Weighted Average Grant Date Fair Value per Share, Beginning Balance
Nonvested, Weighted Average Grant Date Fair Value per Share, Ending Balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
General and Administrative Expense
General And Administrative Expense [Member]
Total lease liabilities
Total lease liabilities
Operating Lease, Liability
Debt instrument, basis spread on variable rate
Debt Instrument Basis Spread On Variable Rate1
Interest rate period
Interest rate period
Interest rate period
Cash Flow, Operating Activities, Lessee [Abstract]
August Through August [Member]
August Through August.
August, 2026 through August, 2027
Restricted Cash, Current
Restricted cash, current
Restricted cash
Long Term Debt Maturities Repayments Of Principal In Year Two
2028
Finance lease liabilities, current
Finance Lease, Liability, Current
Lessee, Lease, Description [Table]
Weighted average discount rate - Finance leases
Finance Lease, Weighted Average Discount Rate, Percent
Percentage of calculated discounted cash flows of discount rate.
Percentage Of Calculated Discounted Cash Flows Of Discount Rate
Percentage of calculated discounted cash flows of discount rate
Offering costs not yet paid
Capital Expenditures Incurred But Not Yet Paid
Net loss
Profit Loss
Consolidated net loss
Transaction Price Allocation
Transaction price
Transaction Price
Transaction price.
Long-Term Debt, Type
Longterm Debt Type [Domain]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted average common shares outstanding, basic
Weighted Average Number Of Shares Outstanding Basic
Scenario [Axis]
Scenario
Laboratory Equipment
Laboratory Equipment [Member]
Laboratory equipment.
Additional milestone payments
Additional Milestone Payments
Additional Milestone payments.
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Options exercisable at March 31, 2026, Aggregate Intrinsic Value
Property, plant and equipment in accounts payable and accrued expenses
Property And Equipment In Accounts Payable And Accrued Expenses
Property and equipment in accounts payable and accrued expenses.
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Plan adjustments and amendments
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Plan Adjustments And Amendments In Period
Share based compensation arrangement by share based payment award number of shares available for grant plan adjustments and amendments in period.
Aggregate gross proceeds
Proceeds From Issuance Of Private Placement
Issuance of warrants in connection with private placement
Issuance Of Warrants In Connection With Private Placement
Issuance of warrants in connection with private placement.
Subsequent Events
Subsequent Events [Text Block]
Term Loan, net
Long Term Debt
Debt outstanding
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Debt Instrument, Interest Rate Terms
Interest rate terms description
Balance
Balance
Stockholders Equity
Total stockholders' equity
Preferred stock, par value per share
Preferred Stock Par Or Stated Value Per Share
Number of operating lease landlord square feet manufacturing facility
Property Subject To Or Available For Operating Lease Number Of Units
Basis of Presentation
Basis Of Accounting Policy Policy [Text Block]
Program Expense
Program expense.
Program expense
Statement Of Stockholders Equity [Abstract]
Interest rate extension period
Interest rate extension period
Interest rate extension period
Probability of option exercise
Probability Of An Option Exercise
Probability of Option Exercise
SSI Strategy Holdings LLC
SSI Strategy Holdings LLC [Member]
SSI Strategy Holdings LLC.
Type of Restructuring [Domain]
Dallas lease amendment.
Dallas Lease Amendment [Member]
Dallas Lease Amendment
Consultants and Contractors Expense
Consultants and contractors expense.
Consultants and contractors expense
Use of Estimates
Use Of Estimates
Long-Term Debt, Maturity, Year Five
2031
Leasehold Improvements
Leasehold Improvements [Member]
Entity Address, Address Line Two
Entity Address Address Line2
Fair Value Disclosures [Text Block]
Fair Value Measurements
Warrants and Rights Note Disclosure [Abstract]
Trinity term loans
Trinity Term Loans
Date of incorporation
Entity Incorporation Date Of Incorporation
Debt Instrument, Name
Debt Instrument Name [Domain]
Other
Other Assets Current
Supplemental disclosure of noncash investing and financing activities:
Noncash Investing And Financing Items [Abstract]
Total accrued expenses and other current liabilities
Accrued expenses and other current liabilities
Accrued Liabilities And Other Liabilities
Long-Term Debt, Maturity, Year Four
2030
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Percentage of fully diluted common stock shares outstanding
Percentage Of Fully Diluted Common Stock Shares Outstanding
Percentage of fully diluted common stock shares outstanding.
Segment Reporting, Other Segment Item, Amount
Other segment expense
Plan Name
Plan Name [Domain]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Pre-Funded Warrants Option One
Pre-Funded Warrants Option One [Member]
Pre-Funded Warrants Option One.
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment, Long-Lived Asset, Held-for-Use
Impairment of long-lived assets
Finance Lease, Liability, to be Paid, Year One
2026
Maximum construction allowance provided by landlord per rentable square foot.
Maximum Construction Allowance Provided By Landlord Per Rentable Square Foot
Maximum construction allowance provided by landlord per rentable square foot
Class of Warrant or Right, Outstanding
Outstanding liability classified warrants
Operating Lease
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Initial options and original options.
Initial Options and Original Options [Member]
Initial Options and Original Options
Restructuring Plan
Restructuring Plan [Axis]
Class of Warrant or Right [Table]
2023 Pre-Funded Warrants
Twenty Twenty Three Pre Funded Warrants [Member]
Twenty twenty three pre funded warrants.
Accounting Standards Update [Extensible Enumeration]
Entity Address, City or Town
Entity Address City Or Town
Payment of one-time upfront license fee
Payment Of One Time Upfront License Fee
Payment of one-time upfront license fee.
Trinity Refinance Date until March Thirty One Twenty Twenty Eight[Member]
Trinity Refinance Date until March 31, 2028.
Trinity Refinance Date Until March 31, 2028
Security Exchange Name
Security Exchange Name
Debt Instrument, Variable Interest Rate, Type [Extensible Enumeration]
Total principal payments
Debt Instrument Carrying Amount
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property, plant and equipment, gross
Property Plant And Equipment Gross
Performance and Market-based Stock Options
Performance And Market-Based Stock Options [Member]
Performance and market-based stock options.
Deferred offering costs
Deferred Offering Costs
Counterparty Name
Counterparty Name [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Performance and market-based options vested
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Upfront Payment
Upfront payment.
Upfront Payment
Interest Paid Net
Cash paid for interest
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement
Range [Member]
Exercise price of warrants
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price of warrants Per Share
Assets Current
Total current assets
Stock-based compensation expense
Allocated Share Based Compensation Expense
Document Period End Date
Document Period End Date
Giant axonal neuropathy agreement.
Giant Axonal Neuropathy Agreement [Member]
Option Agreement for GAN
Title of Individual
Title and Position [Axis]
Fair Value Hierarchy and NAV [Domain]
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Issuance costs for pre-funded warrant liability.
Issuance Costs For Pre-funded Warrant Liability.
Issuance costs for pre-funded warrant liability
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Statement of Financial Position [Abstract]
Unvested RSUs
Restricted Stock Units
Restricted Stock Units R S U [Member]
Cumulative Effect, Period of Adoption, Adjustment
Cumulative Effect, Period of Adoption, Adjustment [Member]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Regulatory related milestones obligation payable
Regulatory Related Milestones Obligation Payable
Regulatory related milestones obligation payable.
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive income:
Payment of shelf registration costs
Payment Of Shelf Registration Costs
Payment of shelf registration costs.
Finance Lease
Finance Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Total liabilities
Liabilities
Change in fair value of debt instrument.
Change in Fair Value of Debt Instrument
Change in fair value
Change in fair value of warrant liability.
Change in Fair Value of Warrant Liability
Change in fair value of warrant liability
Change in fair value of warrant liability
Rett research and development activities
Abeona Rett Agreement [Member]
Abeona Rett agreement.
Abeona Rett Agreement
New Plan
Two Thousand Twenty Stock Incentive Plan [Member]
Two thousand twenty stock incentive plan.
Schedule of fair value method to allocate net proceeds received from sale of common stock and warrants.
Schedule Of Fair Value Method To Allocate Net Proceeds Received From Sale Of Common Stock And Warrants [Table Text Block]
Schedule of Fair Value Method to Allocate Net Proceeds Received from Sale of Common Stock and Pre-funded Warrants
Lessee, Operating Lease, Liability, to be Paid, Year Two
2028
Restricted Cash, Total
Restricted cash
Restricted Cash
Unvested RSAs
Restricted Stock Awards
Restricted Stock [Member]
Common stock shares issued and sold
Common Stock Shares Issued And Sold
Common stock shares issued and sold.
Option to obtain license for Rett
License For RETT [Member]
License For RETT
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted average common shares outstanding, diluted
Weighted Average Number Of Diluted Shares Outstanding
Entity File Number
Entity File Number
Cover [Abstract]
Issuance Of Common Stock Upon Vesting And Settlement Of Restricted Stock Units Value
Issuance of common stock upon vesting and settlement of restricted stock units value.
Issuance of common stock, upon vesting and settlement of restricted stock units, net
Schedule of Carrying Values and Estimated Fair Values of Debt Instruments [Table Text Block]
Schedule of Reconcile of Change in Fair Value of Debt
Cumulative Effect, Period of Adoption [Axis]
Total prepaid expenses and other current assets
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Cancelled or forfeited, Number of Shares
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Performance and market-based restricted stock units of other option forfeited during period
Balance Sheet Components
Supplemental Balance Sheet Disclosures [Text Block]
Scenario [Domain]
Scenario
Number of shares authorized for issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Number of Operating Segments
Number of operating segment
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Segment Information
Segment Reporting Disclosure [Text Block]
General and Administrative Expense, Total
General and administrative
General And Administrative Expense
Schedule of Restricted Stock Awards Activity
Nonvested Restricted Stock Shares Activity Table [Text Block]
Existing Plan
2020 Equity Incentive Plan
Two Thousand Twenty Equity Incentive Plan [Member]
Two thousand twenty equity incentive plan.
May Twenty Twenty Five Pre Funded Warrants [Member]
May 2025 Pre Funded Warrants.
May 2025 Pre Funded Warrants
Subsequent Event [Table]
Trinity Term Loans
Trinity Term Loans [Member]
Trinity Term Loans
Recently Adopted Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Award vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Employee Severance
Employee Severance [Member]
Sales Agreement
Sales Agreement [Member]
Sales Agreement.
Depreciation, Total
Depreciation expense
Depreciation
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Share-based payment award, unvested RSU/RSA granted, compensation cost not yet recognized
Operating lease term of contract
Lessee Operating Lease Term Of Contract
Common Stock Shares Outstanding
Common stock, shares outstanding
Balance, shares
Balance, shares
Operating lease liabilities, current
Operating Lease, Liability, Current
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Document Transition Report
Document Transition Report
Total operating expenses
Operating Expenses
Research and Development Expense, Total
Research and development
Research And Development Expense
Leases
Lessee, Operating Leases [Text Block]
Accrued Severance Balance
Accrued severance balance.
Accrued severance as of January 1, 2024
Accrued severance as of September 30, 2024
Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest
Comprehensive loss
Accrued clinical trial
Accrued Clinical Trial Current
Accrued clinical trial current.
Statement Of Cash Flows [Abstract]
Schedule of Accrued Expense and Other Current Labilities
Schedule Of Accrued Expense And Other Current Labilities Table [Text Block]
Schedule of accrued expense and other current labilities.
Original Options.
Original Options [Member]
Original Options
Issuance of common stock
Stock Issued During Period, Value, New Issues
Issuance of common stock, Value
Net Loss Per Common Share
Earnings Per Share [Text Block]
Share-Based Compensation Arrangement By Share-Based Payment Award, Other Than Options, Grant Date Fair Value Not Yet Recognized
Share-based compensation arrangement by share-based payment award, other than options, grant date fair value not yet recognized.
Grant date fair value of issued units not yet recognized
Computer Equipment
Computer Equipment [Member]
Net loss
Net loss
Outstanding, Aggregate Intrinsic Value, Beginning Balance
Outstanding, Aggregate Intrinsic Value, Ending Balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Operating lease cost
Operating Lease, Cost
Warrants term
Warrants and Rights Outstanding, Term
Schedule of Supplemental Information Related to Remaining Lease Term and Discount Rate
Schedule Of Supplemental Information Related To Remaining Lease Term And Discount Rate [Table Text Block]
Schedule of supplemental information related to remaining lease term and discount rate.
2023 Pre-Funded Warrants
Two Thousand Twenty Three Pre Funded Warrants [Member]
Two Thousand Twenty Three Pre Funded Warrants.
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Other
Proceeds From Payments For Other Financing Activities
Operating cash flows for operating leases
Operating Lease, Payments
ASSETS
Assets [Abstract]
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Construction in Progress
Construction In Progress [Member]
Prepaid expenses and other assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Severance recorded
Severance Recorded
Severance recorded.
Restructuring and Related Activities [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
Underwriter agreed to purchase share price of per share
Underwriter Agreed To Purchase Share Price Of Per Share
Underwriter agreed to purchase share price of per share.
Issuance of common stock upon vesting and settlement of restricted stock unit shares.
Issuance Of Common Stock Upon Vesting And Settlement Of Restricted Stock Unit Shares
Issuance of common stock, upon vesting and settlement of restricted stock units, net, shares
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Cash flows from investing activities
Net Cash Provided By Used In Investing Activities [Abstract]
Securities Purchase Agreement
Securities Purchase Agreement [Member]
Securities purchase agreement member.
Compensation And Retirement Disclosure [Abstract]
Accounts Payable, Current, Total
Accounts payable
Accounts Payable Current
Interest Expense, Nonoperating, Total
Interest Expense, Nonoperating
Interest expense
Interest expense
Interest Expense, Long-Term Debt, Total
Interest expense related to term loan
Interest Expense Long Term Debt
Research and Development Expense
Research And Development Expense [Member]
ASU 2019-12
Accounting Standards Update 2019-12 [Member]
Deferred revenue
Deferred Revenue
Deferred Revenue, Total
Schedule of Prepaid Expenses and Other Current Assets
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Text Block]
Astellas
Astellas [Member]
Astellas [Member]
Restructuring Cost And Reserve [Line Items]
Restructuring Cost and Reserve [Line Items]
June 2024 Pre-Funded Warrants Option Two
June Twenty Twenty Four Pre Funded Warrants Option Two [Member]
June twenty twenty four pre-funded warrants option two.
Accrued expenses and other liabilities
Increase Decrease In Accrued Expense And Other Liabilities
Increase decrease in accrued expense and other liabilities.
Proceeds from Stock Options Exercised
Proceeds from stock option exercises
Fair Value Disclosures [Abstract]
Commitments And Contingencies Disclosure [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Year One
2027
License Agreement for CLN7
License Agreement For C L N7 [Member]
License agreement for CLN7.
Sale of Stock, Consideration Received on Transaction
Net proceeds on sale of common stock
Net Income (Loss) Available to Common Stockholders, Basic, Total
Net loss
Net Income Loss Available To Common Stockholders Basic
Debt Instrument
Debt Instrument [Axis]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Difference of market value paid
Difference Of Market Value Paid
Difference of market value paid
Assets, Fair Value Disclosure
Total assets
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Pegasus Park, LLC.
Pegasus Park L L C [Member]
Pegasus Park L L C
Schedule of Restricted Stock Units Activity
Schedule Of Nonvested Restricted Stock Units Activity Table [Text Block]
Debt Instrument, Fair Value Disclosure, Total
Debt Instrument, Fair Value Disclosure
Fair value of loan at issuance
Beginning fair value balance
Ending fair value balance
Revenue
Revenues
Revenues
Revenues, Total
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
Private Placement
Private Placement [Member]
Weighted average remaining lease term (in years) - Finance leases
Finance Lease, Weighted Average Remaining Lease Term
Title of 12(b) Security
Security12b Title
Options cancelled or forfeited, Weighted Average Exercise Price
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Cancelled or forfeited, Weighted Average Grant Date Fair Value per Share
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Money Market Funds [Member]
Money Market Funds
Income Taxes
Income Tax Disclosure [Text Block]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Class of Warrant or Right [Line Items]
Success fee derivative liability
Success Fee Derivative liability
Success fee liability at fair value
Strategic Reprioritization
Business Acquisition Integration Restructuring And Other Related Costs [Text Block]
Debt instrument, maturity end date
Debt Instrument Maturity Date Range End1
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
2026
Other non-current liabilities
Other Liabilities Noncurrent
Restructuring Plan
Restructuring Plan [Domain]
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Schedule of Property Plant and Equipment Net
Property Plant And Equipment [Text Block]
Outstanding, Weighted Average Exercise Price, Beginning balance
Outstanding, Weighted Average Exercise Price, Ending balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Additional Paid-in Capital
Additional Paid In Capital [Member]
Accrued property, plant and equipment
Accrued Property Plant And Equipment Current
Accrued property, plant, and equipment current.
Income Statement Location
Statement of Income Location, Balance [Axis]
Trading Symbol
Trading Symbol
President and chief executive officer.
President And Chief Executive Officer [Member]
Former President and Chief Executive Officer
Percentage of automatic increase every year in common stock shares reserved for future issuance
Percentage Of Automatic Increase Every Year In Common Stock Shares Reserved For Future Issuance
Percentage of automatic increase every year in common stock shares reserved for future issuance.
Subsequent Event Type [Axis]
Modified Options.
Modified Options [Member]
Modified Options
Issuance of common stock upon release of restricted stock units, net, shares
Issuance of common stock upon release of restricted stock units, net shares
Employee-related Liabilities, Current, Total
Accrued compensation
Employee Related Liabilities Current
Cash flows from financing activities
Net Cash Provided By Used In Financing Activities [Abstract]
Line of Credit Facility, Unused Capacity, Commitment Fee Percentage
Commitment fee percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Expected term (in years)
Entity Ex Transition Period
Entity Ex Transition Period
Total lease payments
Future minimum remianing lease payments
Lessee, Operating Lease, Liability, to be Paid
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Success fee agreement.
Success Fee Agreement [Member]
Success Fee Agreement
Employee Stock Purchase Plan (ESPP)
Employee Stock Purchase Plans [Member]
Employee stock purchase plans.
Percentage of common stock price purchased through payroll deductions
Share Based Compensation Arrangement By Share Based Payment Award Maximum Employee Subscription Rate
Research Collaboration And License Agreements [Abstract]
Research, collaboration and license agreements.
Equity Components
Statement Equity Components [Axis]
Nonoperating Income Expense
Total other income (expense), net
Equity Component
Equity Component [Domain]
Schedule of Stock Option Activity
Schedule Of Share Based Compensation Activity Table [Text Block]
Recently Issued Accounting Pronouncements
Recently Issued Accounting Pronouncements Policy Policy [Text Block]
Recently issued accounting pronouncements policy.
Stock issued during period, value, loss on instrument-specific credit risk.
Stock Issued During Period, Value, Loss On Instrument-specific Credit Risk
Loss on instrument-specific credit risk
Prepaid insurance
Prepaid Insurance
August Through But Excluding The Maturity Date [Member]
August Through But Excluding The Maturity Date.
August, 2027 through, but Excluding, the Maturity Date
Issuance of common stock under ESPP, shares
Number of shares of common stock issued under ESPP
Stock Issued During Period Shares Employee Stock Purchase Plans
Issuance of common stock and pre-funded warrants upon closing of underwritten public offering, net of underwriting discounts and commissions, and other offering costs, Shares
Issuance of Common Stock and Pre Funded Warrants Upon Closing of Public Offering Shares
Issuance of common stock and pre funded warrants upon closing of public offering shares.
Share-based payment award, expiration period
Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period
Statement of Comprehensive Income [Abstract]
Maximum
Maximum [Member]
Percentage of annual default interest rate
Percentage Of Annual Default Interest Rate
Percentage of annual default interest rate.
Liabilities, Fair Value Disclosure
Total liabilities
Statistical Measurement
Range [Axis]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Options exercised, Weighted Average Exercise Price
June 2024 Pre-funded Warrants
June Twenty Twenty Four Pre-funded Warrants [Member]
June twenty twenty four pre-funded warrants.
Common Stock Value
Common stock, $0.00001 par value per share; 700,000,000 shares authorized and 287,276,885 and 285,051,648 issued and outstanding as of March 31, 2026 and December 31, 2025, respectively
Thereafter
Lessee Operating Lease Liability Payments Due After Year Four
Lessee operating lease liability payments due after year four.
Schedule of Share Based Compensation Available for Grant under Incentive Plans
Schedule Of Share Based Compensation Available For Grant [Table Text Block]
Schedule of share based compensation available for grant.
Non cash change in fair value of term loan.
Non Cash Change In Fair Value Of Term Loan
Non-cash change in fair value of term loan
Principles of Consolidation
Consolidation Policy [Text Block]
Warrants and Rights Outstanding
Outstanding liability classified warrants
Success fee liability.
Success Fee Liability [Member]
Success Fees Liability
Aggregate offering price from sale of common stock
Aggregate Offering Price From Sale Of Common Stock
Aggregate offering price from sale of common stock.
Percentage of payroll deductions of employee's compensation during offering period
Share Based Compensation Arrangement By Share Based Payment Award Discount From Market Price Offering Date
Expected volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Preferred stock, shares authorized
Preferred Stock Shares Authorized
2025 Trinity Term Loans
Two Thousand Twenty Five Trinity Term Loans [Member]
Two Thousand Twenty Five Trinity Term Loans.
Schedule of Future Minimum Commitments Under Company's Operating and Finance Leases
Lessee, Operating And Finance Lease, Liability, Maturity [Table Text Block]
Lessee, operating and finance lease, liability, maturity .
Trinity Lenders
Trinity Lenders [Member]
Trinity Lenders
Lender Name [Axis]
Lender Name
Entity Registrant Name
Entity Registrant Name
Debt Disclosure [Text Block]
Term Loans
Debt Instrument, Periodic Payment, Principal
Principal payments
Purchase of research and development license
Payments To Acquire In Process Research And Development
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income (expense)
Additional Paid in Capital, Total
Additional paid-in capital
Additional Paid In Capital
Subsequent Events [Abstract]
Third Parties [Member]
Third parties.
Third Parties
Accrued research and development
Accrued Research And Development Current
Accrued research and development current.
Income Tax Expense (Benefit), Total
Provision for income taxes
Income Tax Expense Benefit
Fair value of shares transferred, Value
Fair Value Of Shares Transferred Value
Fair value of shares transferred value.
Asset, Held-for-Sale, Not Part of Disposal Group, Current, Total
Asset, Held-for-Sale, Not Part of Disposal Group, Current
Assets held for sale
Proceeds from issuance of common stock from private placement
Gross proceeds from issuance of common stock
Net proceeds from issuance of common stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income (loss)
Payments to Acquire Property, Plant, and Equipment, Total
Purchase of property, plant and equipment
Payments To Acquire Property Plant And Equipment
Payment for (Proceeds from) Other Investing Activity
Other
Share-based payment award, RSU/RSA granted
Restricted units/stock granted, Number of Shares
Performance and market-based restricted stock units of other option granted during period
Total assets
Assets
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Options exercisable at March 31, 2026, Weighted Average Remaining Contractual Life
Income Statement [Abstract]
Beneficial ownership limitation notice period.
Beneficial Ownership Limitation Notice Period
Beneficial ownership limitation notice period (in days)
Schedule Of Restructuring And Related Costs [Table]
Schedule Of Restructuring And Related Costs [Table]
Sale of Stock, Number of Shares Issued in Transaction
Sale of Common shares
Gain loss on fair value of terms loan attributable to instrument specific credit risk.
Gain Loss on Fair Value of Terms Loan Attributable to Instrument Specific Credit Risk
Change in fair value reported in comprehensive loss
Change in fair value of term loan attributable to instrument specific credit risk
Issuance of common stock, shares
Issuance of common stock in private placement, net of offering costs, Shares
Number of shares issued
Lease, Cost [Abstract]
Restricted stock units, performance and market-based restricted stock units of other option vested during period
Vested, Number of Shares
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Earnings Per Share, Diluted, Total
Net loss per common share, diluted
Earnings Per Share Diluted
Summary of Significant Segment Expenses
Schedule of Segment Reporting Information, by Segment [Table Text Block]
June 2024 Pre-Funded Warrants
June Two Thousand Twenty Four Prefunded Warrants [Member]
June two thousand twenty four prefunded warrants.
Title and Position [Domain]
Title of Individual
City Area Code
City Area Code
June 2024 Pre-Funded Warrants Option One
June Twenty Twenty Four Pre-Funded Warrants Option One [Member]
June twenty twenty four pre-funded warrants option one.
Share-based payment award, expiration date
Share Based Compensation Arrangement By Share Based Payment Award Expiration Date
Debt Instrument, Fee Amount
Debt instrument, fee amount
Finance, lease liabilities, non-current
Finance Lease, Liability, Noncurrent
End of term payment
End Of Term Payment
End of term payment.
Maximum borrowing capacity
Line Of Credit Facility Maximum Borrowing Capacity
Abeona CLN1 Agreements
Abeona CLN1 Agreements
Abeona C L N1 Agreements [Member]
Abeona CLN1 agreements.
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Variable lease cost
Variable Lease, Cost
Issuance of common stock under ESPP
Stock Issued During Period Value Employee Stock Purchase Plan
Weighted average remaining lease term (in years) - Operating leases
Operating Lease, Weighted Average Remaining Lease Term
Total lease cost
Lease, Cost
Property, plant and equipment, net
Property, plant and equipment, net
Property Plant And Equipment Net
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Number
Options exercisable at March 31, 2026, Stock Options
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, cash equivalents and restricted cash at the beginning of the period
Cash, cash equivalents and restricted cash at the end of the period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
Loss from operations
Operating Income Loss
Percentage of prepayment premium
Percentage Of Prepayment Premium
Percentage of prepayment premium
UT Southwestern Agreement
U T Southwestern Agreement [Member]
UT southwestern agreement.
Accumulated Deficit
Retained Earnings [Member]
Cash and Cash Equivalents [Axis]
Share-Based Payment Arrangement, Noncash Expense, Total
Stock-based compensation
Share Based Compensation
SSI Warrants [Member]
SSI Warrants [Member]
SSI Warrants
Stock Issued During Period Value Gain (Loss) On Instrument Specific Credit Risk
Stock issued during period value gain (loss) on instrument specific credit risk.
Gain (loss) on instrument specific credit risk
Weighted average discount rate - Operating leases
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease liability, net of current portion
Operating lease liabilities, non-current
Operating Lease, Liability, Noncurrent
Fair Value, Inputs, Level 1 [Member]
Level 1
Net Cash Provided By Used In Financing Activities
Net cash used in financing activities
Schedule of Lease Cost
Lease, Cost [Table Text Block]
Severance recorded
Severance Cost Recorded
Severance cost recorded.
Nonoperating Income Expense [Abstract]
Other (expense) income:
Schedule of Common Stock Equivalents Outstanding Excluded from Computation of Diluted Net Loss Per Share Attributable to Common Stockholders
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Entity Interactive Data Current
Entity Interactive Data Current
On-site generation lease.
On Site Generation Lease [Member]
On Site Generation Lease
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Income Statement Location
Statement of Income Location, Balance [Domain]
Cash flows from operating activities
Net Cash Provided By Used In Operating Activities [Abstract]
Furniture and Fixtures
Furniture And Fixtures [Member]
SSI warrants.
SSI Warrants
SSI Warrant liability
Cumulative Effect, Period of Adoption [Domain]
Current borrowing capacity
Line of Credit Facility, Current Borrowing Capacity
Entity Tax Identification Number
Entity Tax Identification Number
Share price
Share Price
Preferred stock, issuing price per share
Share Based Compensation Arrangement By Share Based Payment Award Other Than Options Unvested And Outstanding Number
Share based compensation arrangement by share based payment award other than options unvested and outstanding number.
Unvested and Outstanding units
Long-Term Debt, Type
Longterm Debt Type [Axis]
Amended Sales Agreement
Amended Sales Agreement [Member]
Amended Sales Agreement.
Lease liabilities, current portion
Lease Liability Current
Lease liability current.
Increase or decrease in beneficial ownership limitation percentage.
Increase or Decrease in Beneficial Ownership Limitation Percentage
Increase or decrease in beneficial ownership limitation percentage
Organization and Description of Business Operations
Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block]
Percentage of remeasured calculated discounted cash flows of discount rate.
Percentage Of Remeasured Calculated Discounted Cash Flows Of Discount Rate
Percentage of remeasured calculated discounted cash flows of discount rate
Local Phone Number
Local Phone Number
Thereafter
Finance Lease Liability Payments Due After Year Four
Finance lease liability payments due after year four.
Proceeds from issuance of common stock net.
Proceeds From Issuance Of Common Stock Net
Net proceeds from issuance of common stock
Share-based payment award, options, compensation cost not yet recognized
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Finance Lease, Liability, to be Paid, Year Two
2027
Offering costs
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Dallas Lease
Dallas lease.
Dallas Lease [Member]
Accounting Policies [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Year Four
2030
Labor and Related Expense
Compensation expense
Available for grant beginning of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Available for grant - March 31, 2026
Share-based payment award, compensation cost not yet recognized, weighted-average period of recognition
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Accrued professional and consulting fees
Accrued Professional Fees Current
Prepaid research and development
Prepaid Research And Development Contracts
Prepaid research and development contracts.
Entity Emerging Growth Company
Entity Emerging Growth Company