000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Condensed Consolidated Balance Sheets (Current Period Unaudited) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Condensed Consolidated Statements of Shareholders' Deficit (Unaudited) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Condensed Consolidated Statements of Cash Flow (Unaudited) link:calculationLink link:definitionLink link:presentationLink 006 - Disclosure - Note 1 - Business and Nature of Operations link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note 2 - Basis of Presentation link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note 3 - Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note 4 - Other Financial Information link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note 5 - Inventories link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note 6 - Fair Value Measurements link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note 7 - Investments link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note 8 - Property and Equipment link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note 9 - Prepaid Forward Obligation link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note 10 - Long-term Debt link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note 11 - Leases link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note 12 - Revenue From Product Sales link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note 13 - License and Collaboration Agreements link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note 14 - Acquisitions link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note 15 - Shareholders' Equity link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note 16 - Share-Based Compensation link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note 17 - Income Taxes link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note 18 - Related Parties link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note 19 - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note 20 - Segment Reporting link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note 21 - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 995473 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 995474 - Disclosure - Note 3 - Significant Accounting Policies (Tables) link:calculationLink link:definitionLink link:presentationLink 995475 - Disclosure - Note 4 - Other Financial Information (Tables) link:calculationLink link:definitionLink link:presentationLink 995476 - Disclosure - Note 5 - Inventories (Tables) link:calculationLink link:definitionLink link:presentationLink 995477 - Disclosure - Note 6 - Fair Value Measurements (Tables) link:calculationLink link:definitionLink link:presentationLink 995478 - Disclosure - Note 7 - Investments (Tables) link:calculationLink link:definitionLink link:presentationLink 995479 - Disclosure - Note 8 - Property and Equipment (Tables) link:calculationLink link:definitionLink link:presentationLink 995480 - Disclosure - Note 9 - Prepaid Forward Obligation (Tables) link:calculationLink link:definitionLink link:presentationLink 995481 - Disclosure - Note 10 - Long-term Debt (Tables) link:calculationLink link:definitionLink link:presentationLink 995482 - Disclosure - Note 11 - Leases (Tables) link:calculationLink link:definitionLink link:presentationLink 995483 - Disclosure - Note 12 - Revenue From Product Sales (Tables) link:calculationLink link:definitionLink link:presentationLink 995484 - Disclosure - Note 16 - Share-Based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 995485 - Disclosure - Note 20 - Segment Reporting (Tables) link:calculationLink link:definitionLink link:presentationLink 995486 - Disclosure - Note 2 - Basis of Presentation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995487 - Disclosure - Note 3 - Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995488 - Disclosure - Note 3 - Significant Accounting Policies - Useful Lives of Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 995489 - Disclosure - Note 4 - Other Financial Information - Accounts Payable and Accrued Expense (Details) link:calculationLink link:definitionLink link:presentationLink 995490 - Disclosure - Note 4 - Other Financial Information - Interest and Other Income (Expense), Net (Details) link:calculationLink link:definitionLink link:presentationLink 995491 - Disclosure - Note 5 - Inventories (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995492 - Disclosure - Note 5 - Inventories - Inventories (Details) link:calculationLink link:definitionLink link:presentationLink 995493 - Disclosure - Note 6 - Fair Value Measurements - Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 995494 - Disclosure - Note 7 - Investments - Summary of Marketable Securities (Details) link:calculationLink link:definitionLink link:presentationLink 995495 - Disclosure - Note 7 - Investments - Fair Values of Marketable Securities by Contractual Maturity (Details) link:calculationLink link:definitionLink link:presentationLink 995496 - Disclosure - Note 8 - Property and Equipment (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995497 - Disclosure - Note 8 - Property and Equipment - Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 995498 - Disclosure - Note 9 - Prepaid Forward Obligation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995499 - Disclosure - Note 9 - Prepaid Forward Obligation - Activity in the Carrying Value of the Prepaid Forward Liability (Details) link:calculationLink link:definitionLink link:presentationLink 995500 - Disclosure - Note 10 - Long-term Debt (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995501 - Disclosure - Note 10 - Long-term Debt - Long Term Debt (Details) link:calculationLink link:definitionLink link:presentationLink 995502 - Disclosure - Note 10 - Long-Term Debt - Schedule of Debt Principal Maturities (Details) link:calculationLink link:definitionLink link:presentationLink 995503 - Disclosure - Note 11 - Leases (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995504 - Disclosure - Note 11 - Leases - Components of Lease Cost (Details) link:calculationLink link:definitionLink link:presentationLink 995505 - Disclosure - Note 11 - Leases - Amounts of Assets and Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995506 - Disclosure - Note 11 - Leases - Amounts of Assets and Liabilities (Details) (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 995507 - Disclosure - Note 11 - Leases - Supplemental Information Related to Leases (Details) link:calculationLink link:definitionLink link:presentationLink 995508 - Disclosure - Note 11 - Leases - Maturities of Finance Lease Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995509 - Disclosure - Note 11 - Leases - Maturities of Operating Lease Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 995510 - Disclosure - Note 12 - Revenue From Product Sales (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995511 - Disclosure - Note 12 - Revenue From Product Sales - Net Product Sales (Details) link:calculationLink link:definitionLink link:presentationLink 995512 - Disclosure - Note 12 - Revenue From Product Sales - Sales Reserves Activity (Details) link:calculationLink link:definitionLink link:presentationLink 995513 - Disclosure - Note 14 - Acquisitions (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995514 - Disclosure - Note 15 - Shareholders' Equity (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995515 - Disclosure - Note 16 - Share-Based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995516 - Disclosure - Note 16 - Share-Based Compensation - Effect of Share-based Compensation on the Condensed Consolidated Statements of Operations (Details) link:calculationLink link:definitionLink link:presentationLink 995517 - Disclosure - Note 17 - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995518 - Disclosure - Note 18 - Related Parties (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995519 - Disclosure - Note 20 - Segment Reporting (Details Textual) link:calculationLink link:definitionLink link:presentationLink 995520 - Disclosure - Note 20 - Segment Reporting - Segment Expenses (Details) link:calculationLink link:definitionLink link:presentationLink