<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019c9ac1-acf5-79ea-ae98-b958c721a179,g:9f615d00-f48b-491d-8614-00e244a2e814-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.recursion.com/role/Cover" xlink:type="simple" xlink:href="rxrx-20260331.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_019c9ac1-adb4-7207-b5f6-388f9e1e792e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_DocumentInformationTable_019c9ac1-adb4-7207-b5f6-388f9e1e792e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f9b-bb9d-b89532cf4fba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_DocumentInformationTable_019c9ac1-adb4-7207-b5f6-388f9e1e792e" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f9b-bb9d-b89532cf4fba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7f9b-bb9d-b89532cf4fba_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f9b-bb9d-b89532cf4fba" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7f9b-bb9d-b89532cf4fba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-76fa-8770-119ae2fb0f56" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f9b-bb9d-b89532cf4fba" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-76fa-8770-119ae2fb0f56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019c9ac1-adb4-7c08-8c8d-15051495ba10" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-76fa-8770-119ae2fb0f56" xlink:to="loc_us-gaap_CommonClassAMember_019c9ac1-adb4-7c08-8c8d-15051495ba10" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019c9ac1-adb4-7a22-b3ff-1377649fe90c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-76fa-8770-119ae2fb0f56" xlink:to="loc_us-gaap_CommonClassBMember_019c9ac1-adb4-7a22-b3ff-1377649fe90c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019c9ac1-adb4-7eea-b044-c3868fec5507" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_DocumentType_019c9ac1-adb4-7eea-b044-c3868fec5507" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_019c9ac1-adb4-776e-922f-a12c4228d1a8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_DocumentQuarterlyReport_019c9ac1-adb4-776e-922f-a12c4228d1a8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019c9ac1-adb4-73c6-8686-5208b8a28d74" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_DocumentPeriodEndDate_019c9ac1-adb4-73c6-8686-5208b8a28d74" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_019c9ac1-adb4-7aee-9532-fa656e676b84" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_DocumentTransitionReport_019c9ac1-adb4-7aee-9532-fa656e676b84" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019c9ac1-adb4-79f1-b135-5e77592e8faa" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityFileNumber_019c9ac1-adb4-79f1-b135-5e77592e8faa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019c9ac1-adb4-7510-8f2d-bf5c604386f2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityRegistrantName_019c9ac1-adb4-7510-8f2d-bf5c604386f2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019c9ac1-adb4-7f6e-9942-158ba99326f1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019c9ac1-adb4-7f6e-9942-158ba99326f1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019c9ac1-adb4-79c3-9c19-6798e033ed24" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityTaxIdentificationNumber_019c9ac1-adb4-79c3-9c19-6798e033ed24" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019c9ac1-adb4-7d75-90c7-cd32d9a17aa1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityAddressAddressLine1_019c9ac1-adb4-7d75-90c7-cd32d9a17aa1" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019c9ac1-adb4-7d28-a6fb-1ddff74834e9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityAddressCityOrTown_019c9ac1-adb4-7d28-a6fb-1ddff74834e9" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019c9ac1-adb4-71a1-9432-dc879c0f9fd5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityAddressStateOrProvince_019c9ac1-adb4-71a1-9432-dc879c0f9fd5" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019c9ac1-adb4-7c4e-b973-80b996e1432c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityAddressPostalZipCode_019c9ac1-adb4-7c4e-b973-80b996e1432c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019c9ac1-adb4-718a-91d3-4cd0cd8f8786" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_CityAreaCode_019c9ac1-adb4-718a-91d3-4cd0cd8f8786" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019c9ac1-adb4-71d6-9f6c-c0adcfa206e5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_LocalPhoneNumber_019c9ac1-adb4-71d6-9f6c-c0adcfa206e5" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019c9ac1-adb4-7619-93d0-1888d9a43650" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_Security12bTitle_019c9ac1-adb4-7619-93d0-1888d9a43650" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019c9ac1-adb4-7ccf-b830-a48f9839eb80" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_TradingSymbol_019c9ac1-adb4-7ccf-b830-a48f9839eb80" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019c9ac1-adb4-7ff5-9803-4ca4efddd8cf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_SecurityExchangeName_019c9ac1-adb4-7ff5-9803-4ca4efddd8cf" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_019c9ac1-adb4-7407-9a0a-ef39e5cbad60" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityCurrentReportingStatus_019c9ac1-adb4-7407-9a0a-ef39e5cbad60" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_019c9ac1-adb4-74c4-b211-661f23d88d60" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityInteractiveDataCurrent_019c9ac1-adb4-74c4-b211-661f23d88d60" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_019c9ac1-adb4-7a7d-9fe1-c33d10da02d1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityFilerCategory_019c9ac1-adb4-7a7d-9fe1-c33d10da02d1" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_019c9ac1-adb4-741c-98e1-3f393aa216a6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntitySmallBusiness_019c9ac1-adb4-741c-98e1-3f393aa216a6" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019c9ac1-adb4-7f77-8f72-159fb9e1d74e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityEmergingGrowthCompany_019c9ac1-adb4-7f77-8f72-159fb9e1d74e" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_019c9ac1-adb4-7f10-927e-4f1f9dc427ca" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityShellCompany_019c9ac1-adb4-7f10-927e-4f1f9dc427ca" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_019c9ac1-adb4-7579-ae31-eef58a3b4f57" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_019c9ac1-adb4-7579-ae31-eef58a3b4f57" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019c9ac1-adb4-7e33-94e0-060e654ff6b5" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_EntityCentralIndexKey_019c9ac1-adb4-7e33-94e0-060e654ff6b5" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019c9ac1-adb4-707b-a536-8afc7cec11d0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_AmendmentFlag_019c9ac1-adb4-707b-a536-8afc7cec11d0" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_019c9ac1-adb4-79c5-9faa-45a660b4f44d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_DocumentFiscalYearFocus_019c9ac1-adb4-79c5-9faa-45a660b4f44d" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_019c9ac1-adb4-76a7-b53f-3c7c6d02a12e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_DocumentFiscalPeriodFocus_019c9ac1-adb4-76a7-b53f-3c7c6d02a12e" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_019c9ac1-adb4-730e-a482-62cf712b2ce7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_DocumentInformationLineItems_019c9ac1-adb4-7434-b5b3-e0528cb3afbf" xlink:to="loc_dei_CurrentFiscalYearEndDate_019c9ac1-adb4-730e-a482-62cf712b2ce7" xlink:type="arc" order="28"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CondensedConsolidatedBalanceSheetsunauditedParenthetical" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CondensedConsolidatedBalanceSheetsunauditedParenthetical"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CondensedConsolidatedBalanceSheetsunauditedParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7bec-8072-2a991df753cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019c9ac1-adb4-7f72-8bb0-5e1901eab234" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7bec-8072-2a991df753cb" xlink:to="loc_us-gaap_StatementTable_019c9ac1-adb4-7f72-8bb0-5e1901eab234" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f98-b5ea-34ed70b806b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019c9ac1-adb4-7f72-8bb0-5e1901eab234" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f98-b5ea-34ed70b806b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7f98-b5ea-34ed70b806b1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f98-b5ea-34ed70b806b1" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7f98-b5ea-34ed70b806b1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7907-951f-1d4b0dc1c314" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-adb4-7f98-b5ea-34ed70b806b1" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7907-951f-1d4b0dc1c314" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019c9ac1-adb4-7084-abe6-856623affe67" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7907-951f-1d4b0dc1c314" xlink:to="loc_us-gaap_CommonClassAMember_019c9ac1-adb4-7084-abe6-856623affe67" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019c9ac1-adb4-72ce-a01b-1aa7cf80ce94" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7907-951f-1d4b0dc1c314" xlink:to="loc_us-gaap_CommonClassBMember_019c9ac1-adb4-72ce-a01b-1aa7cf80ce94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExchangeableStockMember_019c9ac1-adb4-713e-a01f-f68aee158b6b" xlink:href="rxrx-20260331.xsd#rxrx_ExchangeableStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-adb4-7907-951f-1d4b0dc1c314" xlink:to="loc_rxrx_ExchangeableStockMember_019c9ac1-adb4-713e-a01f-f68aee158b6b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019c9ac1-adb4-7e9b-9d49-070eafc448e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7bec-8072-2a991df753cb" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019c9ac1-adb4-7e9b-9d49-070eafc448e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_019c9ac1-adb4-7fed-88da-f3cb3aa276c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7bec-8072-2a991df753cb" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_019c9ac1-adb4-7fed-88da-f3cb3aa276c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_019c9ac1-adb4-74dd-9600-c40b6bd294b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7bec-8072-2a991df753cb" xlink:to="loc_us-gaap_CommonStockSharesIssued_019c9ac1-adb4-74dd-9600-c40b6bd294b5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019c9ac1-adb4-7011-a3dd-751716ce262e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7bec-8072-2a991df753cb" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019c9ac1-adb4-7011-a3dd-751716ce262e" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CondensedConsolidatedStatementsofOperationsunaudited" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CondensedConsolidatedStatementsofOperationsunaudited"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CondensedConsolidatedStatementsofOperationsunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019c9ac1-adb4-7c1b-8d9f-dd373d44db00" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_StatementTable_019c9ac1-adb4-7c1b-8d9f-dd373d44db00" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019c9ac1-adb4-795e-a5fd-883c07890612" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019c9ac1-adb4-7c1b-8d9f-dd373d44db00" xlink:to="loc_srt_ProductOrServiceAxis_019c9ac1-adb4-795e-a5fd-883c07890612" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019c9ac1-adb4-795e-a5fd-883c07890612_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019c9ac1-adb4-795e-a5fd-883c07890612" xlink:to="loc_srt_ProductsAndServicesDomain_019c9ac1-adb4-795e-a5fd-883c07890612_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019c9ac1-adb4-7555-bef9-e7ead5c2cd5c" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019c9ac1-adb4-795e-a5fd-883c07890612" xlink:to="loc_srt_ProductsAndServicesDomain_019c9ac1-adb4-7555-bef9-e7ead5c2cd5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseAndServiceMember_019c9ac1-adb4-7a04-901c-78dac51816b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LicenseAndServiceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019c9ac1-adb4-7555-bef9-e7ead5c2cd5c" xlink:to="loc_us-gaap_LicenseAndServiceMember_019c9ac1-adb4-7a04-901c-78dac51816b7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrantMember_019c9ac1-adb4-734b-a567-1be763ed4d2f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019c9ac1-adb4-7555-bef9-e7ead5c2cd5c" xlink:to="loc_us-gaap_GrantMember_019c9ac1-adb4-734b-a567-1be763ed4d2f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_019c9ac1-adb4-7bc8-bb7f-6a096a016641" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_RevenuesAbstract_019c9ac1-adb4-7bc8-bb7f-6a096a016641" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c9ac1-adb4-74fe-8613-d94e0045ef32" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_019c9ac1-adb4-7bc8-bb7f-6a096a016641" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c9ac1-adb4-74fe-8613-d94e0045ef32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_019c9ac1-adb4-7f08-9370-44959c94bc83" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_OperatingExpensesAbstract_019c9ac1-adb4-7f08-9370-44959c94bc83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019c9ac1-adb4-7736-aa9b-4ce0d45f79ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019c9ac1-adb4-7f08-9370-44959c94bc83" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019c9ac1-adb4-7736-aa9b-4ce0d45f79ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019c9ac1-adb4-70f1-9dec-c73ec06c34b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019c9ac1-adb4-7f08-9370-44959c94bc83" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019c9ac1-adb4-70f1-9dec-c73ec06c34b1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019c9ac1-adb4-7020-8e0a-36cdb572208c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019c9ac1-adb4-7f08-9370-44959c94bc83" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019c9ac1-adb4-7020-8e0a-36cdb572208c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019c9ac1-adb4-73f6-a705-4d36ee56702a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_019c9ac1-adb4-7f08-9370-44959c94bc83" xlink:to="loc_us-gaap_CostsAndExpenses_019c9ac1-adb4-73f6-a705-4d36ee56702a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c9ac1-adb4-7a0a-8754-c57dc5cf4958" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_OperatingIncomeLoss_019c9ac1-adb4-7a0a-8754-c57dc5cf4958" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019c9ac1-adb4-7c57-bfe0-3b5c66f193f5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019c9ac1-adb4-7c57-bfe0-3b5c66f193f5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9ac1-adb4-7c29-8dfd-e0d9fff33d67" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019c9ac1-adb4-7c29-8dfd-e0d9fff33d67" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c9ac1-adb4-76cd-8c85-5510f82b443a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019c9ac1-adb4-76cd-8c85-5510f82b443a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c9ac1-adb4-7504-a18a-5611bd004276" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_NetIncomeLoss_019c9ac1-adb4-7504-a18a-5611bd004276" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_019c9ac1-adb4-7391-a005-c83e4298cc1c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-7590-a02c-e089fed6fc8b" xlink:to="loc_us-gaap_EarningsPerShareAbstract_019c9ac1-adb4-7391-a005-c83e4298cc1c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_019c9ac1-adb4-7e44-a0ca-2c9640a4b709" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019c9ac1-adb4-7391-a005-c83e4298cc1c" xlink:to="loc_us-gaap_EarningsPerShareBasic_019c9ac1-adb4-7e44-a0ca-2c9640a4b709" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_019c9ac1-adb4-75e3-88e4-abf511a977a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019c9ac1-adb4-7391-a005-c83e4298cc1c" xlink:to="loc_us-gaap_EarningsPerShareDiluted_019c9ac1-adb4-75e3-88e4-abf511a977a1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019c9ac1-adb4-7677-9db5-b16f56788e27" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019c9ac1-adb4-7391-a005-c83e4298cc1c" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019c9ac1-adb4-7677-9db5-b16f56788e27" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c9ac1-adb4-7630-8a40-07f5087b6491" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_019c9ac1-adb4-7391-a005-c83e4298cc1c" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019c9ac1-adb4-7630-8a40-07f5087b6491" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CondensedConsolidatedStatementsofStockholdersEquityunaudited" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CondensedConsolidatedStatementsofStockholdersEquityunaudited"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CondensedConsolidatedStatementsofStockholdersEquityunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019c9ac1-adb4-733f-b8e1-4a7da44d231e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019c9ac1-adb4-7c5d-af46-6be86834a669" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-733f-b8e1-4a7da44d231e" xlink:to="loc_us-gaap_StatementTable_019c9ac1-adb4-7c5d-af46-6be86834a669" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019c9ac1-adb4-79f5-a941-71b68935d95c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019c9ac1-adb4-7c5d-af46-6be86834a669" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019c9ac1-adb4-79f5-a941-71b68935d95c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-79f5-a941-71b68935d95c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019c9ac1-adb4-79f5-a941-71b68935d95c" xlink:to="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-79f5-a941-71b68935d95c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-7600-8bb2-f4fa1b9ddc5c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019c9ac1-adb4-79f5-a941-71b68935d95c" xlink:to="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-7600-8bb2-f4fa1b9ddc5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019c9ac1-adb4-7f84-b991-73746db0a1f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-7600-8bb2-f4fa1b9ddc5c" xlink:to="loc_us-gaap_CommonStockMember_019c9ac1-adb4-7f84-b991-73746db0a1f0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019c9ac1-adb4-7f4a-a50e-3c38f2d65f07" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-7600-8bb2-f4fa1b9ddc5c" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019c9ac1-adb4-7f4a-a50e-3c38f2d65f07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019c9ac1-adb4-7b59-aa5c-70c5f83fbf7c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-7600-8bb2-f4fa1b9ddc5c" xlink:to="loc_us-gaap_RetainedEarningsMember_019c9ac1-adb4-7b59-aa5c-70c5f83fbf7c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019c9ac1-adb4-7b31-b2b8-b223afb63b20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019c9ac1-adb4-7600-8bb2-f4fa1b9ddc5c" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019c9ac1-adb4-7b31-b2b8-b223afb63b20" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019c9ac1-adb4-733f-b8e1-4a7da44d231e" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019c9ac1-adb4-7706-ab22-46c94dd7db37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019c9ac1-adb4-7706-ab22-46c94dd7db37" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c9ac1-adb4-73ec-a24d-fe0acf6a2a91" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_StockholdersEquity_019c9ac1-adb4-73ec-a24d-fe0acf6a2a91" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c9ac1-adb4-7d91-af45-350617a8ca72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_NetIncomeLoss_019c9ac1-adb4-7d91-af45-350617a8ca72" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c9ac1-adb4-79c9-9a2d-571c6378c401" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019c9ac1-adb4-79c9-9a2d-571c6378c401" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019c9ac1-adb4-76fe-83ac-43a1747589dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_019c9ac1-adb4-76fe-83ac-43a1747589dc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019c9ac1-adb4-79cb-8ef7-b30a0bb9dbf2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_019c9ac1-adb4-79cb-8ef7-b30a0bb9dbf2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019c9ac1-adb4-7af1-899d-92d270982691" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019c9ac1-adb4-7af1-899d-92d270982691" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019d862f-75f6-76d0-b0c9-dd95433d73ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019d862f-75f6-76d0-b0c9-dd95433d73ea" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019c9ac1-adb4-7826-b242-8d6149904f73" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019c9ac1-adb4-74b4-b632-ff7529637d97" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_019c9ac1-adb4-7826-b242-8d6149904f73" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019c9ac1-adb4-7e3d-a36a-82d0ea46b585" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019c9ac1-adb4-7e7f-b5c5-f619dfc053ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SupplementalFinancialInformationNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#SupplementalFinancialInformationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SupplementalFinancialInformationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019c9ac1-ae72-7087-ab00-81db56fdbdfa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019c9ac1-ae72-7087-ab00-81db56fdbdfa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019c9ac1-ae72-7440-8461-cc4d20e94c3f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019c9ac1-ae72-7087-ab00-81db56fdbdfa" xlink:to="loc_srt_CounterpartyNameAxis_019c9ac1-ae72-7440-8461-cc4d20e94c3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019c9ac1-ae72-7440-8461-cc4d20e94c3f_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019c9ac1-ae72-7440-8461-cc4d20e94c3f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019c9ac1-ae72-7440-8461-cc4d20e94c3f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019c9ac1-ae72-743a-aa6e-b347f4d14ae5" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019c9ac1-ae72-7440-8461-cc4d20e94c3f" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019c9ac1-ae72-743a-aa6e-b347f4d14ae5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TempusLabsIncMember_019c9ac1-ae72-706b-97ac-05992fa2107f" xlink:href="rxrx-20260331.xsd#rxrx_TempusLabsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019c9ac1-ae72-743a-aa6e-b347f4d14ae5" xlink:to="loc_rxrx_TempusLabsIncMember_019c9ac1-ae72-706b-97ac-05992fa2107f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019c9ac1-ae72-7305-959d-ea4a56a76785" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_019c9ac1-ae72-7087-ab00-81db56fdbdfa" xlink:to="loc_srt_RangeAxis_019c9ac1-ae72-7305-959d-ea4a56a76785" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019c9ac1-ae72-7305-959d-ea4a56a76785_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019c9ac1-ae72-7305-959d-ea4a56a76785" xlink:to="loc_srt_RangeMember_019c9ac1-ae72-7305-959d-ea4a56a76785_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019c9ac1-ae72-7ffe-b114-fcf51448781f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019c9ac1-ae72-7305-959d-ea4a56a76785" xlink:to="loc_srt_RangeMember_019c9ac1-ae72-7ffe-b114-fcf51448781f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019c9ac1-ae72-7933-a972-b673730c02ee" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019c9ac1-ae72-7ffe-b114-fcf51448781f" xlink:to="loc_srt_MinimumMember_019c9ac1-ae72-7933-a972-b673730c02ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019c9ac1-ae72-7ebf-9b52-d19b60574333" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019c9ac1-ae72-7ffe-b114-fcf51448781f" xlink:to="loc_srt_MaximumMember_019c9ac1-ae72-7ebf-9b52-d19b60574333" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementTerm_019c9ac1-ae72-71bc-bb95-97337792af6c" xlink:href="rxrx-20260331.xsd#rxrx_LicenseAgreementTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:to="loc_rxrx_LicenseAgreementTerm_019c9ac1-ae72-71bc-bb95-97337792af6c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementAnnualPayments_019c9ac1-ae72-7c4d-9de3-6f60bad46fb6" xlink:href="rxrx-20260331.xsd#rxrx_LicenseAgreementAnnualPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:to="loc_rxrx_LicenseAgreementAnnualPayments_019c9ac1-ae72-7c4d-9de3-6f60bad46fb6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementAggregatePayments_019c9ac1-ae72-7fb4-b6cf-c75ab18c2392" xlink:href="rxrx-20260331.xsd#rxrx_LicenseAgreementAggregatePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:to="loc_rxrx_LicenseAgreementAggregatePayments_019c9ac1-ae72-7fb4-b6cf-c75ab18c2392" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementTradingPeriodUsedForEquityValueDetermination_019c9ac1-ae72-7503-95bd-37073ecfd4e6" xlink:href="rxrx-20260331.xsd#rxrx_LicenseAgreementTradingPeriodUsedForEquityValueDetermination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:to="loc_rxrx_LicenseAgreementTradingPeriodUsedForEquityValueDetermination_019c9ac1-ae72-7503-95bd-37073ecfd4e6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementAmountOfTimePriorToThePaymentDate_019c9ac1-ae72-7874-a3a8-88737541d1d8" xlink:href="rxrx-20260331.xsd#rxrx_LicenseAgreementAmountOfTimePriorToThePaymentDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:to="loc_rxrx_LicenseAgreementAmountOfTimePriorToThePaymentDate_019c9ac1-ae72-7874-a3a8-88737541d1d8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LicenseAgreementIncreaseDecreaseAccruedLiabilities_019c9ac1-ae72-79a6-992a-6ea7827fc84b" xlink:href="rxrx-20260331.xsd#rxrx_LicenseAgreementIncreaseDecreaseAccruedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_019c9ac1-ae72-7304-a243-fae2c193725f" xlink:to="loc_rxrx_LicenseAgreementIncreaseDecreaseAccruedLiabilities_019c9ac1-ae72-79a6-992a-6ea7827fc84b" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d8679-589d-742f-9fe1-c7367563e24b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d8679-589d-742f-9fe1-c7367563e24b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_019d8679-589d-7e85-ab52-061d916becc2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d8679-589d-742f-9fe1-c7367563e24b" xlink:to="loc_us-gaap_AssetAcquisitionAxis_019d8679-589d-7e85-ab52-061d916becc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019d8679-589d-7e85-ab52-061d916becc2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019d8679-589d-7e85-ab52-061d916becc2" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019d8679-589d-7e85-ab52-061d916becc2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_019d8679-589d-76e9-8662-5276f48b0d45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_019d8679-589d-7e85-ab52-061d916becc2" xlink:to="loc_us-gaap_AssetAcquisitionDomain_019d8679-589d-76e9-8662-5276f48b0d45" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_REVenturesIMember_019d8679-589d-7a27-bb5e-4cebc19c24a8" xlink:href="rxrx-20260331.xsd#rxrx_REVenturesIMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_019d8679-589d-76e9-8662-5276f48b0d45" xlink:to="loc_rxrx_REVenturesIMember_019d8679-589d-7a27-bb5e-4cebc19c24a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019d867a-ed43-76cf-afd8-12081860ac4f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d8679-589d-742f-9fe1-c7367563e24b" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019d867a-ed43-76cf-afd8-12081860ac4f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_019d867a-ed43-76cf-afd8-12081860ac4f_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019d867a-ed43-76cf-afd8-12081860ac4f" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_019d867a-ed43-76cf-afd8-12081860ac4f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_019d867a-ed43-79f6-98c8-61c969bbfb19" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_019d867a-ed43-76cf-afd8-12081860ac4f" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_019d867a-ed43-79f6-98c8-61c969bbfb19" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AlphaBiotechnologyGmbHAlphaMember_019d867a-ed43-7191-bc9e-ad4dc2390b19" xlink:href="rxrx-20260331.xsd#rxrx_AlphaBiotechnologyGmbHAlphaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_019d867a-ed43-79f6-98c8-61c969bbfb19" xlink:to="loc_rxrx_AlphaBiotechnologyGmbHAlphaMember_019d867a-ed43-7191-bc9e-ad4dc2390b19" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_019d867a-ed43-7b14-b9c3-d2c3c4f156d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d8679-589d-742f-9fe1-c7367563e24b" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_019d867a-ed43-7b14-b9c3-d2c3c4f156d7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_019d867a-ed43-7b14-b9c3-d2c3c4f156d7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_019d867a-ed43-7b14-b9c3-d2c3c4f156d7" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_019d867a-ed43-7b14-b9c3-d2c3c4f156d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_019d867a-ed43-76cd-a568-ede177bd89b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_019d867a-ed43-7b14-b9c3-d2c3c4f156d7" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_019d867a-ed43-76cd-a568-ede177bd89b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_019d867a-ed43-717a-84c0-be28d3cc0035" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_019d867a-ed43-76cd-a568-ede177bd89b5" xlink:to="loc_us-gaap_DisposalGroupDisposedOfBySaleNotDiscontinuedOperationsMember_019d867a-ed43-717a-84c0-be28d3cc0035" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019d867a-ed43-750b-ad52-4a90a0d5b1ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_019d8679-589d-742f-9fe1-c7367563e24b" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019d867a-ed43-750b-ad52-4a90a0d5b1ab" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019d867a-ed43-750b-ad52-4a90a0d5b1ab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019d867a-ed43-750b-ad52-4a90a0d5b1ab" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019d867a-ed43-750b-ad52-4a90a0d5b1ab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019d867a-ed43-75f1-8eae-e94e534e0ced" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_019d867a-ed43-750b-ad52-4a90a0d5b1ab" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019d867a-ed43-75f1-8eae-e94e534e0ced" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExscientiaGmbHMember_019d867a-ed43-7110-acce-893dd3bb0abe" xlink:href="rxrx-20260331.xsd#rxrx_ExscientiaGmbHMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_019d867a-ed43-75f1-8eae-e94e534e0ced" xlink:to="loc_rxrx_ExscientiaGmbHMember_019d867a-ed43-7110-acce-893dd3bb0abe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AssetAcquisitionEquityOwnershipPercentage_019d8679-589d-79e4-a1ec-fccdbd266e91" xlink:href="rxrx-20260331.xsd#rxrx_AssetAcquisitionEquityOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:to="loc_rxrx_AssetAcquisitionEquityOwnershipPercentage_019d8679-589d-79e4-a1ec-fccdbd266e91" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019d8679-589d-7340-95e5-1bcb54f768f9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetAcquisitionConsiderationTransferred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferred_019d8679-589d-7340-95e5-1bcb54f768f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_019d8679-589d-745c-8972-ca21b8f4a406" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:to="loc_us-gaap_PaymentsToAcquireInProcessResearchAndDevelopment_019d8679-589d-745c-8972-ca21b8f4a406" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_019d867a-ed43-7324-8ecd-3e15f1681c31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_019d867a-ed43-7324-8ecd-3e15f1681c31" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_019d867a-ed43-7318-8ec0-3100c9825ffd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_019d867a-ed43-7318-8ec0-3100c9825ffd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_019d867a-ed43-7aa9-a1aa-e446d87187d6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_019d8679-589d-7eae-abc4-aa3daaad7ff0" xlink:to="loc_us-gaap_EquityMethodInvestments_019d867a-ed43-7aa9-a1aa-e446d87187d6" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#LeasesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/LeasesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_019c9ac1-ae72-7cb5-a9fd-a00d78887274" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_019c9ac1-ae72-7f1a-9714-509ea48ed598" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019c9ac1-ae72-7cb5-a9fd-a00d78887274" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_019c9ac1-ae72-7f1a-9714-509ea48ed598" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019c9ac1-ae72-799f-9a71-1ed377f8ddff" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019c9ac1-ae72-7f1a-9714-509ea48ed598" xlink:to="loc_srt_RangeAxis_019c9ac1-ae72-799f-9a71-1ed377f8ddff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019c9ac1-ae72-799f-9a71-1ed377f8ddff_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019c9ac1-ae72-799f-9a71-1ed377f8ddff" xlink:to="loc_srt_RangeMember_019c9ac1-ae72-799f-9a71-1ed377f8ddff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019c9ac1-ae72-7821-bfdb-b6e874a0d7c6" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019c9ac1-ae72-799f-9a71-1ed377f8ddff" xlink:to="loc_srt_RangeMember_019c9ac1-ae72-7821-bfdb-b6e874a0d7c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_019c9ac1-ae72-7477-a219-8713f9dbae2e" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019c9ac1-ae72-7821-bfdb-b6e874a0d7c6" xlink:to="loc_srt_MinimumMember_019c9ac1-ae72-7477-a219-8713f9dbae2e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019c9ac1-ae72-722d-9af6-47e3b6ef4b29" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019c9ac1-ae72-7821-bfdb-b6e874a0d7c6" xlink:to="loc_srt_MaximumMember_019c9ac1-ae72-722d-9af6-47e3b6ef4b29" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRemainingLeaseTerm_019c9ac1-ae72-7820-ac61-87620038ae3b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseRemainingLeaseTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019c9ac1-ae72-7cb5-a9fd-a00d78887274" xlink:to="loc_us-gaap_LesseeOperatingLeaseRemainingLeaseTerm_019c9ac1-ae72-7820-ac61-87620038ae3b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019c9ac1-ae72-7661-a5c3-c6c0bf99cc25" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019c9ac1-ae72-7cb5-a9fd-a00d78887274" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019c9ac1-ae72-7661-a5c3-c6c0bf99cc25" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_IncreaseDecreaseInOperatingLeaseRightOfUseAssets_019c9ac1-ae72-73a1-a40d-8cb28d46058a" xlink:href="rxrx-20260331.xsd#rxrx_IncreaseDecreaseInOperatingLeaseRightOfUseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019c9ac1-ae72-7cb5-a9fd-a00d78887274" xlink:to="loc_rxrx_IncreaseDecreaseInOperatingLeaseRightOfUseAssets_019c9ac1-ae72-73a1-a40d-8cb28d46058a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_LesseeOperatingLeaseIncreaseDecreaseInOperatingLeaseLiabilityDueToLeaseModifications_019c9ac1-ae72-7093-8fcc-b1c0124190e1" xlink:href="rxrx-20260331.xsd#rxrx_LesseeOperatingLeaseIncreaseDecreaseInOperatingLeaseLiabilityDueToLeaseModifications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019c9ac1-ae72-7cb5-a9fd-a00d78887274" xlink:to="loc_rxrx_LesseeOperatingLeaseIncreaseDecreaseInOperatingLeaseLiabilityDueToLeaseModifications_019c9ac1-ae72-7093-8fcc-b1c0124190e1" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleassetsDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#GoodwillandIntangibleAssetsScheduleofIntangibleassetsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/GoodwillandIntangibleAssetsScheduleofIntangibleassetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_019c9ac1-ae72-77c3-b764-88bd08a3141b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_019c9ac1-ae72-77c3-b764-88bd08a3141b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019c9ac1-ae72-75be-be86-5e7d1e1e4574" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_019c9ac1-ae72-77c3-b764-88bd08a3141b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019c9ac1-ae72-75be-be86-5e7d1e1e4574" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019c9ac1-ae72-75be-be86-5e7d1e1e4574_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019c9ac1-ae72-75be-be86-5e7d1e1e4574" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019c9ac1-ae72-75be-be86-5e7d1e1e4574_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019c9ac1-ae72-771c-849d-df69772b95fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_019c9ac1-ae72-75be-be86-5e7d1e1e4574" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019c9ac1-ae72-771c-849d-df69772b95fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_019c9ac1-ae72-7e44-951f-fdf22407bd65" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019c9ac1-ae72-771c-849d-df69772b95fd" xlink:to="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_019c9ac1-ae72-7e44-951f-fdf22407bd65" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_019c9ac1-ae72-76de-9ce9-b7655b7b1aab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_019c9ac1-ae72-771c-849d-df69772b95fd" xlink:to="loc_us-gaap_LicensingAgreementsMember_019c9ac1-ae72-76de-9ce9-b7655b7b1aab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019c9ac1-ae72-7a26-8bb0-e66006b3a1a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019c9ac1-ae72-7a26-8bb0-e66006b3a1a2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019c9ac1-ae72-70d6-81da-82ab0dbb5d6f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019c9ac1-ae72-70d6-81da-82ab0dbb5d6f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c9ac1-ae72-7632-b713-be93a3b33e04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019c9ac1-ae72-7632-b713-be93a3b33e04" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019c9ac1-ae72-7d24-8753-4e522da78b74" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019c9ac1-ae72-7d24-8753-4e522da78b74" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019c9ac1-ae72-754e-acee-a6afc2396467" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019c9ac1-ae72-754e-acee-a6afc2396467" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c9ac1-ae72-7125-b0ab-f6cdcb7ed940" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_019c9ac1-ae72-7c1e-b6a2-2e097c8b8cb3" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019c9ac1-ae72-7125-b0ab-f6cdcb7ed940" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CommonStockNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-729a-a903-c7d056dcc028" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7082-be58-dcc153998c20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-729a-a903-c7d056dcc028" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7082-be58-dcc153998c20" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7d74-ac1a-67aee07f9541" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7082-be58-dcc153998c20" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7d74-ac1a-67aee07f9541" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7d74-ac1a-67aee07f9541_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7d74-ac1a-67aee07f9541" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7d74-ac1a-67aee07f9541_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7adc-a1a6-de3254ed0a1f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7d74-ac1a-67aee07f9541" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7adc-a1a6-de3254ed0a1f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019c9ac1-ae72-7119-ba26-a6f1db2d4a17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7adc-a1a6-de3254ed0a1f" xlink:to="loc_us-gaap_CommonClassAMember_019c9ac1-ae72-7119-ba26-a6f1db2d4a17" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019c9ac1-ae72-7e60-9646-93052401ff22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7adc-a1a6-de3254ed0a1f" xlink:to="loc_us-gaap_CommonClassBMember_019c9ac1-ae72-7e60-9646-93052401ff22" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockVotePerShare_019c9ac1-ae72-7227-b530-0fcfeb0a0539" xlink:href="rxrx-20260331.xsd#rxrx_CommonStockVotePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-729a-a903-c7d056dcc028" xlink:to="loc_rxrx_CommonStockVotePerShare_019c9ac1-ae72-7227-b530-0fcfeb0a0539" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsStock_019c9ac1-ae72-7351-827c-23a867c9ba64" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DividendsStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-729a-a903-c7d056dcc028" xlink:to="loc_us-gaap_DividendsStock_019c9ac1-ae72-7351-827c-23a867c9ba64" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockAtTheMarketOfferingNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CommonStockAtTheMarketOfferingNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockAtTheMarketOfferingNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-777f-9676-4fa270e4385e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7962-9f25-d54dfb2d2b46" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-777f-9676-4fa270e4385e" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7962-9f25-d54dfb2d2b46" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-70e9-a120-944ae2f276dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7962-9f25-d54dfb2d2b46" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-70e9-a120-944ae2f276dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-70e9-a120-944ae2f276dc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-70e9-a120-944ae2f276dc" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-70e9-a120-944ae2f276dc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-795b-a3ff-356d01edc0e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-70e9-a120-944ae2f276dc" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-795b-a3ff-356d01edc0e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019c9ac1-ae72-790b-a012-dbfd7f32c0a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-795b-a3ff-356d01edc0e7" xlink:to="loc_us-gaap_CommonClassAMember_019c9ac1-ae72-790b-a012-dbfd7f32c0a6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019c9ac1-ae72-7e70-9dde-a4983e308d1d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7962-9f25-d54dfb2d2b46" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019c9ac1-ae72-7e70-9dde-a4983e308d1d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019c9ac1-ae72-7e70-9dde-a4983e308d1d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019c9ac1-ae72-7e70-9dde-a4983e308d1d" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019c9ac1-ae72-7e70-9dde-a4983e308d1d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019c9ac1-ae72-7d89-85f6-addcdb8f55aa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019c9ac1-ae72-7e70-9dde-a4983e308d1d" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019c9ac1-ae72-7d89-85f6-addcdb8f55aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_AtTheMarketOfferingProgramTDCowenMember_019d86b0-3b06-7d77-ba44-bfc407063294" xlink:href="rxrx-20260331.xsd#rxrx_AtTheMarketOfferingProgramTDCowenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019c9ac1-ae72-7d89-85f6-addcdb8f55aa" xlink:to="loc_rxrx_AtTheMarketOfferingProgramTDCowenMember_019d86b0-3b06-7d77-ba44-bfc407063294" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockValueAuthorized_019c9ac1-ae72-7d56-a670-6763dc70dd41" xlink:href="rxrx-20260331.xsd#rxrx_SaleOfStockValueAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-777f-9676-4fa270e4385e" xlink:to="loc_rxrx_SaleOfStockValueAuthorized_019c9ac1-ae72-7d56-a670-6763dc70dd41" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SaleOfStockValueRemainingAuthorized_019c9ac1-ae72-79d4-9d48-d6bcab7c2e8f" xlink:href="rxrx-20260331.xsd#rxrx_SaleOfStockValueRemainingAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-777f-9676-4fa270e4385e" xlink:to="loc_rxrx_SaleOfStockValueRemainingAuthorized_019c9ac1-ae72-79d4-9d48-d6bcab7c2e8f" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockValenceAcquisitionExchangeableSharesNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CommonStockValenceAcquisitionExchangeableSharesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockValenceAcquisitionExchangeableSharesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-7fcf-af74-2e672defefed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7aff-9f32-987e50af866f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-7fcf-af74-2e672defefed" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7aff-9f32-987e50af866f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae72-736f-a0c2-e87d36d337bf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7aff-9f32-987e50af866f" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae72-736f-a0c2-e87d36d337bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae72-736f-a0c2-e87d36d337bf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae72-736f-a0c2-e87d36d337bf" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae72-736f-a0c2-e87d36d337bf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae72-7fe1-86c0-3fd9c2ebc821" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae72-736f-a0c2-e87d36d337bf" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae72-7fe1-86c0-3fd9c2ebc821" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ValenceDiscoveryIncMember_019c9ac1-ae72-7619-965e-862e0def20e1" xlink:href="rxrx-20260331.xsd#rxrx_ValenceDiscoveryIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae72-7fe1-86c0-3fd9c2ebc821" xlink:to="loc_rxrx_ValenceDiscoveryIncMember_019c9ac1-ae72-7619-965e-862e0def20e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7062-b353-850c8a0f547f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae72-7aff-9f32-987e50af866f" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7062-b353-850c8a0f547f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7062-b353-850c8a0f547f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7062-b353-850c8a0f547f" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7062-b353-850c8a0f547f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7220-9d8e-cc466f750dc9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae72-7062-b353-850c8a0f547f" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7220-9d8e-cc466f750dc9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ExchangeableStockMember_019c9ac1-ae72-7485-8910-c0f903d04dac" xlink:href="rxrx-20260331.xsd#rxrx_ExchangeableStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae72-7220-9d8e-cc466f750dc9" xlink:to="loc_rxrx_ExchangeableStockMember_019c9ac1-ae72-7485-8910-c0f903d04dac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_BusinessAcquisitionContingentConsiderationEquityInterestsIssuableNumberOfShares_019c9ac1-ae73-724a-8ab0-b6e002ec5431" xlink:href="rxrx-20260331.xsd#rxrx_BusinessAcquisitionContingentConsiderationEquityInterestsIssuableNumberOfShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-7fcf-af74-2e672defefed" xlink:to="loc_rxrx_BusinessAcquisitionContingentConsiderationEquityInterestsIssuableNumberOfShares_019c9ac1-ae73-724a-8ab0-b6e002ec5431" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019c9ac1-ae73-7aa9-bed9-c9648dacd2e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae72-7fcf-af74-2e672defefed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019c9ac1-ae73-7aa9-bed9-c9648dacd2e6" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockRegistrationRightsAgreementsNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CommonStockRegistrationRightsAgreementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockRegistrationRightsAgreementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-72ca-84e8-e77d3b9da49e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae73-7113-844f-eaab78e570c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-72ca-84e8-e77d3b9da49e" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae73-7113-844f-eaab78e570c2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae73-7905-8c4f-5feb35195507" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae73-7113-844f-eaab78e570c2" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae73-7905-8c4f-5feb35195507" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae73-7905-8c4f-5feb35195507_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae73-7905-8c4f-5feb35195507" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae73-7905-8c4f-5feb35195507_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae73-79e8-8ca1-9ffd741fe434" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_019c9ac1-ae73-7905-8c4f-5feb35195507" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae73-79e8-8ca1-9ffd741fe434" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ValenceDiscoveryIncMember_019c9ac1-ae73-7620-8452-bb48cf2e2907" xlink:href="rxrx-20260331.xsd#rxrx_ValenceDiscoveryIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_019c9ac1-ae73-79e8-8ca1-9ffd741fe434" xlink:to="loc_rxrx_ValenceDiscoveryIncMember_019c9ac1-ae73-7620-8452-bb48cf2e2907" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RegistrationRightsAgreementTerm_019c9ac1-ae73-7e4a-9717-756992eacd15" xlink:href="rxrx-20260331.xsd#rxrx_RegistrationRightsAgreementTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-72ca-84e8-e77d3b9da49e" xlink:to="loc_rxrx_RegistrationRightsAgreementTerm_019c9ac1-ae73-7e4a-9717-756992eacd15" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CommonStockClassAandBCommonSharesAuthorizationNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CommonStockClassAandBCommonSharesAuthorizationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CommonStockClassAandBCommonSharesAuthorizationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-74db-8a16-2963c47a3fb2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae73-7a54-8148-25920773ad45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-74db-8a16-2963c47a3fb2" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae73-7a54-8148-25920773ad45" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae73-7447-b1c1-16db90a9559d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019c9ac1-ae73-7a54-8148-25920773ad45" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae73-7447-b1c1-16db90a9559d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae73-7447-b1c1-16db90a9559d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae73-7447-b1c1-16db90a9559d" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae73-7447-b1c1-16db90a9559d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae73-71a1-b68e-6603f2ec602d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019c9ac1-ae73-7447-b1c1-16db90a9559d" xlink:to="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae73-71a1-b68e-6603f2ec602d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019c9ac1-ae73-74ec-b91e-9d5ca2f1f604" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae73-71a1-b68e-6603f2ec602d" xlink:to="loc_us-gaap_CommonClassAMember_019c9ac1-ae73-74ec-b91e-9d5ca2f1f604" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019c9ac1-ae73-7956-9d2b-02466df2dd24" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019c9ac1-ae73-71a1-b68e-6603f2ec602d" xlink:to="loc_us-gaap_CommonClassBMember_019c9ac1-ae73-7956-9d2b-02466df2dd24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_NumberOfClassesOfCommonStockAuthorized_019c9ac1-ae73-71ed-80f9-8a34d4f1c1ba" xlink:href="rxrx-20260331.xsd#rxrx_NumberOfClassesOfCommonStockAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-74db-8a16-2963c47a3fb2" xlink:to="loc_rxrx_NumberOfClassesOfCommonStockAuthorized_019c9ac1-ae73-71ed-80f9-8a34d4f1c1ba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockVotePerShare_019c9ac1-ae73-74f7-92c7-10dbf7f62c8c" xlink:href="rxrx-20260331.xsd#rxrx_CommonStockVotePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-74db-8a16-2963c47a3fb2" xlink:to="loc_rxrx_CommonStockVotePerShare_019c9ac1-ae73-74f7-92c7-10dbf7f62c8c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_CommonStockConversionRatio_019c9ac1-ae73-7b31-a904-e0a82a2efce6" xlink:href="rxrx-20260331.xsd#rxrx_CommonStockConversionRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019c9ac1-ae73-74db-8a16-2963c47a3fb2" xlink:to="loc_rxrx_CommonStockConversionRatio_019c9ac1-ae73-7b31-a904-e0a82a2efce6" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/CollaborativeDevelopmentContractsDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#CollaborativeDevelopmentContractsDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/CollaborativeDevelopmentContractsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019c9ac1-ae73-7a77-90b2-42b8ccf62711" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019c9ac1-ae73-7a77-90b2-42b8ccf62711" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_019d86b9-8d58-7a79-ad51-7557bfd139da" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019c9ac1-ae73-7a77-90b2-42b8ccf62711" xlink:to="loc_srt_CounterpartyNameAxis_019d86b9-8d58-7a79-ad51-7557bfd139da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019d86b9-8d58-7a79-ad51-7557bfd139da_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_019d86b9-8d58-7a79-ad51-7557bfd139da" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019d86b9-8d58-7a79-ad51-7557bfd139da_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019d86b9-8d58-7049-85de-7b4163c9f006" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_019d86b9-8d58-7a79-ad51-7557bfd139da" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019d86b9-8d58-7049-85de-7b4163c9f006" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SanofiMember_019d86b9-8d58-78dd-82e4-fa44ecd5f30b" xlink:href="rxrx-20260331.xsd#rxrx_SanofiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019d86b9-8d58-7049-85de-7b4163c9f006" xlink:to="loc_rxrx_SanofiMember_019d86b9-8d58-78dd-82e4-fa44ecd5f30b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MerckKGaAMerckMember_019d86bc-1554-7bdd-9421-ec768252dd1d" xlink:href="rxrx-20260331.xsd#rxrx_MerckKGaAMerckMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019d86b9-8d58-7049-85de-7b4163c9f006" xlink:to="loc_rxrx_MerckKGaAMerckMember_019d86bc-1554-7bdd-9421-ec768252dd1d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RocheAndGenentechMember_019d86be-7eb6-77e0-b34d-759d850ac6d5" xlink:href="rxrx-20260331.xsd#rxrx_RocheAndGenentechMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_019d86b9-8d58-7049-85de-7b4163c9f006" xlink:to="loc_rxrx_RocheAndGenentechMember_019d86be-7eb6-77e0-b34d-759d850ac6d5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019d86b9-8d58-75c0-bccf-aec46758ccaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019c9ac1-ae73-7a77-90b2-42b8ccf62711" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019d86b9-8d58-75c0-bccf-aec46758ccaf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d86b9-8d58-75c0-bccf-aec46758ccaf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019d86b9-8d58-75c0-bccf-aec46758ccaf" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d86b9-8d58-75c0-bccf-aec46758ccaf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d86b9-8d58-75fd-8392-affed4e2bca2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019d86b9-8d58-75c0-bccf-aec46758ccaf" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d86b9-8d58-75fd-8392-affed4e2bca2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_019d86b9-8d58-7704-bb65-99fa86c61be2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d86b9-8d58-75fd-8392-affed4e2bca2" xlink:to="loc_us-gaap_CollaborativeArrangementMember_019d86b9-8d58-7704-bb65-99fa86c61be2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MilestoneTypeAxis_019d86ba-800f-7552-b720-3b705312c12f" xlink:href="rxrx-20260331.xsd#rxrx_MilestoneTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019c9ac1-ae73-7a77-90b2-42b8ccf62711" xlink:to="loc_rxrx_MilestoneTypeAxis_019d86ba-800f-7552-b720-3b705312c12f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MilestoneTypeDomain_019d86ba-800f-7552-b720-3b705312c12f_default" xlink:href="rxrx-20260331.xsd#rxrx_MilestoneTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_rxrx_MilestoneTypeAxis_019d86ba-800f-7552-b720-3b705312c12f" xlink:to="loc_rxrx_MilestoneTypeDomain_019d86ba-800f-7552-b720-3b705312c12f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_MilestoneTypeDomain_019d86ba-800f-76b1-8518-356b58476737" xlink:href="rxrx-20260331.xsd#rxrx_MilestoneTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_rxrx_MilestoneTypeAxis_019d86ba-800f-7552-b720-3b705312c12f" xlink:to="loc_rxrx_MilestoneTypeDomain_019d86ba-800f-76b1-8518-356b58476737" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ResearchMilestonesMember_019d86ba-800f-7ec6-9446-d5d68f3efdf0" xlink:href="rxrx-20260331.xsd#rxrx_ResearchMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_MilestoneTypeDomain_019d86ba-800f-76b1-8518-356b58476737" xlink:to="loc_rxrx_ResearchMilestonesMember_019d86ba-800f-7ec6-9446-d5d68f3efdf0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DevelopmentAndRegulatoryMilestonesMember_019d86ba-800f-7b72-be16-eef7b74737fa" xlink:href="rxrx-20260331.xsd#rxrx_DevelopmentAndRegulatoryMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_MilestoneTypeDomain_019d86ba-800f-76b1-8518-356b58476737" xlink:to="loc_rxrx_DevelopmentAndRegulatoryMilestonesMember_019d86ba-800f-7b72-be16-eef7b74737fa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DiscoveryDevelopmentAndSalesMilestonesMember_019d86bc-1554-78fe-b6e9-89ef35276d35" xlink:href="rxrx-20260331.xsd#rxrx_DiscoveryDevelopmentAndSalesMilestonesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_MilestoneTypeDomain_019d86ba-800f-76b1-8518-356b58476737" xlink:to="loc_rxrx_DiscoveryDevelopmentAndSalesMilestonesMember_019d86bc-1554-78fe-b6e9-89ef35276d35" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019d86c2-74a2-7e02-8992-92a3035370f3" xlink:href="rxrx-20260331.xsd#rxrx_RevenueRemainingPerformanceObligationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019c9ac1-ae73-7a77-90b2-42b8ccf62711" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019d86c2-74a2-7e02-8992-92a3035370f3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7e02-8992-92a3035370f3_default" xlink:href="rxrx-20260331.xsd#rxrx_RevenueRemainingPerformanceObligationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019d86c2-74a2-7e02-8992-92a3035370f3" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7e02-8992-92a3035370f3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7411-b611-ed16c7d1838d" xlink:href="rxrx-20260331.xsd#rxrx_RevenueRemainingPerformanceObligationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationAxis_019d86c2-74a2-7e02-8992-92a3035370f3" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7411-b611-ed16c7d1838d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PhenomapsCreationMember_019d86c2-74a2-7f11-86dd-841767719e95" xlink:href="rxrx-20260331.xsd#rxrx_PhenomapsCreationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7411-b611-ed16c7d1838d" xlink:to="loc_rxrx_PhenomapsCreationMember_019d86c2-74a2-7f11-86dd-841767719e95" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PhenomapsRawImagesMember_019d86c2-74a2-7154-b0cc-e01c47cc2def" xlink:href="rxrx-20260331.xsd#rxrx_PhenomapsRawImagesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7411-b611-ed16c7d1838d" xlink:to="loc_rxrx_PhenomapsRawImagesMember_019d86c2-74a2-7154-b0cc-e01c47cc2def" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DevelopedAndCommercializedProgramsMember_019d86c2-74a2-75af-b7dc-8608b2ed44ea" xlink:href="rxrx-20260331.xsd#rxrx_DevelopedAndCommercializedProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7411-b611-ed16c7d1838d" xlink:to="loc_rxrx_DevelopedAndCommercializedProgramsMember_019d86c2-74a2-75af-b7dc-8608b2ed44ea" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_GastrointestinalCancerMember_019d86c3-5664-7793-b3b6-01bc6a41bfda" xlink:href="rxrx-20260331.xsd#rxrx_GastrointestinalCancerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7411-b611-ed16c7d1838d" xlink:to="loc_rxrx_GastrointestinalCancerMember_019d86c3-5664-7793-b3b6-01bc6a41bfda" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_NeuroscienceMember_019d86c3-5664-759e-842d-b20d617cf885" xlink:href="rxrx-20260331.xsd#rxrx_NeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_RevenueRemainingPerformanceObligationDomain_019d86c2-74a2-7411-b611-ed16c7d1838d" xlink:to="loc_rxrx_NeuroscienceMember_019d86c3-5664-759e-842d-b20d617cf885" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ContractWithCustomerNumberOfNovelSmallMoleculeCandidates_019d86b9-8d58-70a1-859d-08d37b51970a" xlink:href="rxrx-20260331.xsd#rxrx_ContractWithCustomerNumberOfNovelSmallMoleculeCandidates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_rxrx_ContractWithCustomerNumberOfNovelSmallMoleculeCandidates_019d86b9-8d58-70a1-859d-08d37b51970a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_019d86ba-800f-7879-899d-3ee51d7a8d69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_us-gaap_ContractWithCustomerLiability_019d86ba-800f-7879-899d-3ee51d7a8d69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019d86ba-800f-7bba-954a-3113deead32c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_019d86ba-800f-7bba-954a-3113deead32c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenuePerformanceObligationNumberOfObligations_019d86ba-ddbc-7d68-9fcf-c8f486ddb9b9" xlink:href="rxrx-20260331.xsd#rxrx_RevenuePerformanceObligationNumberOfObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_rxrx_RevenuePerformanceObligationNumberOfObligations_019d86ba-ddbc-7d68-9fcf-c8f486ddb9b9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_019d86bb-4d90-776b-a0a2-7923049b796c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_019d86bb-4d90-776b-a0a2-7923049b796c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_019d86c2-74a2-710d-89fd-9d9cc5ef66bf" xlink:href="rxrx-20260331.xsd#rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationVariableConsiderationAmount_019d86c2-74a2-710d-89fd-9d9cc5ef66bf" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ContractWithCustomerMaximumAcceptedProduct_019d86c2-74a2-726c-9fd6-32558fa1b9f3" xlink:href="rxrx-20260331.xsd#rxrx_ContractWithCustomerMaximumAcceptedProduct"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_rxrx_ContractWithCustomerMaximumAcceptedProduct_019d86c2-74a2-726c-9fd6-32558fa1b9f3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_019d86c2-74a2-7a21-9e79-6686f80d823f" xlink:href="rxrx-20260331.xsd#rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_rxrx_RevenueRemainingPerformanceObligationNumberOfProjectsThatMayBeInitiated_019d86c2-74a2-7a21-9e79-6686f80d823f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019d86c5-65c0-7042-856d-e1503fa14ebf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d86b9-8d58-79dd-822a-33762a86a1da" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019d86c5-65c0-7042-856d-e1503fa14ebf" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9203-4db8-74fc-9809-04d30bffc129" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019c9ac1-ae73-78c3-ac04-c3f8072437bf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9203-4db8-74fc-9809-04d30bffc129" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019c9ac1-ae73-78c3-ac04-c3f8072437bf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019d9203-4db8-7f05-9918-e7c485e34ac2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019c9ac1-ae73-78c3-ac04-c3f8072437bf" xlink:to="loc_us-gaap_PlanNameAxis_019d9203-4db8-7f05-9918-e7c485e34ac2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019d9203-4db8-7f05-9918-e7c485e34ac2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019d9203-4db8-7f05-9918-e7c485e34ac2" xlink:to="loc_us-gaap_PlanNameDomain_019d9203-4db8-7f05-9918-e7c485e34ac2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019d9203-4db8-70bc-8214-ab5dff30d985" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019d9203-4db8-7f05-9918-e7c485e34ac2" xlink:to="loc_us-gaap_PlanNameDomain_019d9203-4db8-70bc-8214-ab5dff30d985" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2021EquityIncentivePlanMember_019d9203-4db8-731f-933e-6d5662b6b6d5" xlink:href="rxrx-20260331.xsd#rxrx_A2021EquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019d9203-4db8-70bc-8214-ab5dff30d985" xlink:to="loc_rxrx_A2021EquityIncentivePlanMember_019d9203-4db8-731f-933e-6d5662b6b6d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_A2024InducementEquityIncentivePlanMember_019d9203-4db8-7587-b6ac-91cdce3ba2c7" xlink:href="rxrx-20260331.xsd#rxrx_A2024InducementEquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019d9203-4db8-70bc-8214-ab5dff30d985" xlink:to="loc_rxrx_A2024InducementEquityIncentivePlanMember_019d9203-4db8-7587-b6ac-91cdce3ba2c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019d9203-6c8c-74ca-9e08-aea2f33ded99" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019c9ac1-ae73-78c3-ac04-c3f8072437bf" xlink:to="loc_us-gaap_AwardTypeAxis_019d9203-6c8c-74ca-9e08-aea2f33ded99" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9203-6c8c-74ca-9e08-aea2f33ded99_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019d9203-6c8c-74ca-9e08-aea2f33ded99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9203-6c8c-74ca-9e08-aea2f33ded99_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9203-6c8c-7e81-929d-8804931a862a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019d9203-6c8c-74ca-9e08-aea2f33ded99" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9203-6c8c-7e81-929d-8804931a862a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019d9203-6c8c-7887-84a8-d3b9c91fcc28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d9203-6c8c-7e81-929d-8804931a862a" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019d9203-6c8c-7887-84a8-d3b9c91fcc28" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019d9203-4db8-7446-9d0d-05dc3a74df81" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9203-4db8-74fc-9809-04d30bffc129" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_019d9203-4db8-7446-9d0d-05dc3a74df81" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019d9203-6c8c-746b-b297-44526604f728" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9203-4db8-74fc-9809-04d30bffc129" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_019d9203-6c8c-746b-b297-44526604f728" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_019d9203-908d-75b3-9f10-185be72a65d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9203-4db8-74fc-9809-04d30bffc129" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_019d9203-908d-75b3-9f10-185be72a65d3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_019d9203-908d-7f58-981f-3694e96120b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9203-4db8-74fc-9809-04d30bffc129" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_019d9203-908d-7f58-981f-3694e96120b5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019d9203-908d-780b-b03f-fd738da9cc95" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d9203-4db8-74fc-9809-04d30bffc129" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019d9203-908d-780b-b03f-fd738da9cc95" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019c9ac1-ae73-7ac2-8b7d-4c31908e68da" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019c9ac1-ae73-7af8-b735-670a1d75c0d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019c9ac1-ae73-7ac2-8b7d-4c31908e68da" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019c9ac1-ae73-7af8-b735-670a1d75c0d3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019c9ac1-ae73-7f03-ad66-8441efbaa0c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_019c9ac1-ae73-7af8-b735-670a1d75c0d3" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019c9ac1-ae73-7f03-ad66-8441efbaa0c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019c9ac1-ae73-7f03-ad66-8441efbaa0c2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019c9ac1-ae73-7f03-ad66-8441efbaa0c2" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019c9ac1-ae73-7f03-ad66-8441efbaa0c2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019c9ac1-ae73-7d58-a2ac-3178136e8c02" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019c9ac1-ae73-7f03-ad66-8441efbaa0c2" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019c9ac1-ae73-7d58-a2ac-3178136e8c02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_019c9ac1-ae73-752e-8e52-c1b78027200b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019c9ac1-ae73-7d58-a2ac-3178136e8c02" xlink:to="loc_us-gaap_CostOfSalesMember_019c9ac1-ae73-752e-8e52-c1b78027200b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019c9ac1-ae73-78df-9f95-7daaeede72d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019c9ac1-ae73-7d58-a2ac-3178136e8c02" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019c9ac1-ae73-78df-9f95-7daaeede72d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019c9ac1-ae73-7b03-967b-79f62b052025" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019c9ac1-ae73-7d58-a2ac-3178136e8c02" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019c9ac1-ae73-7b03-967b-79f62b052025" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019c9ac1-ae73-7e6e-aa8f-e27d300de15f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_019c9ac1-ae73-7ac2-8b7d-4c31908e68da" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019c9ac1-ae73-7e6e-aa8f-e27d300de15f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#StockBasedCompensationScheduleofRSUActivityDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/StockBasedCompensationScheduleofRSUActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019c9ac1-ae73-74db-b1f5-62691cd054dd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019c9ac1-ae73-73b6-bf16-22fa2b65562a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019c9ac1-ae73-74db-b1f5-62691cd054dd" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019c9ac1-ae73-73b6-bf16-22fa2b65562a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019c9ac1-ae73-753c-a94f-0dc7c17b553a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019c9ac1-ae73-73b6-bf16-22fa2b65562a" xlink:to="loc_us-gaap_AwardTypeAxis_019c9ac1-ae73-753c-a94f-0dc7c17b553a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019c9ac1-ae73-753c-a94f-0dc7c17b553a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019c9ac1-ae73-753c-a94f-0dc7c17b553a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019c9ac1-ae73-753c-a94f-0dc7c17b553a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019c9ac1-ae73-7789-a8a1-a8011e4574f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019c9ac1-ae73-753c-a94f-0dc7c17b553a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019c9ac1-ae73-7789-a8a1-a8011e4574f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_019c9ac1-ae73-7359-a9c1-69b7e986d25c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019c9ac1-ae73-7789-a8a1-a8011e4574f6" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_019c9ac1-ae73-7359-a9c1-69b7e986d25c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019c9ac1-ae73-7d18-99ce-68c8be2df4fb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019c9ac1-ae73-74db-b1f5-62691cd054dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019c9ac1-ae73-7d18-99ce-68c8be2df4fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019c9ac1-ae73-769a-8ad6-dee1add873ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019c9ac1-ae73-7d18-99ce-68c8be2df4fb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019c9ac1-ae73-769a-8ad6-dee1add873ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019c9ac1-ae73-7bb3-97b0-f0f2998b4018" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019c9ac1-ae73-7d18-99ce-68c8be2df4fb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_019c9ac1-ae73-7bb3-97b0-f0f2998b4018" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019c9ac1-ae73-70c0-a644-5d1f27d65849" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019c9ac1-ae73-7d18-99ce-68c8be2df4fb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_019c9ac1-ae73-70c0-a644-5d1f27d65849" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019c9ac1-ae73-7e30-a979-3ab5d30ea430" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingRollForward_019c9ac1-ae73-7d18-99ce-68c8be2df4fb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_019c9ac1-ae73-7e30-a979-3ab5d30ea430" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_019c9ac1-ae73-7889-b1df-6eba03f885e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019c9ac1-ae73-7ee2-a911-cf1844ca7354" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019c9ac1-ae73-74db-b1f5-62691cd054dd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019c9ac1-ae73-7ee2-a911-cf1844ca7354" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019c9ac1-ae73-7330-9202-777a6c515f2c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019c9ac1-ae73-7ee2-a911-cf1844ca7354" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019c9ac1-ae73-7330-9202-777a6c515f2c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019c9ac1-ae73-7413-9fef-64fafd30432b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019c9ac1-ae73-7ee2-a911-cf1844ca7354" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019c9ac1-ae73-7413-9fef-64fafd30432b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_019c9ac1-ae73-7e3b-a914-c486ab2b3795" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019c9ac1-ae73-7ee2-a911-cf1844ca7354" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_019c9ac1-ae73-7e3b-a914-c486ab2b3795" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_019c9ac1-ae73-7efc-a440-32e0071484d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_019c9ac1-ae73-7ee2-a911-cf1844ca7354" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_019c9ac1-ae73-7efc-a440-32e0071484d9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_019c9ac1-ae73-7628-be2a-23dfb7c7785e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/NetLossPerShareScheduleofAntidilutiveSecuritiesExcludedfromComputationofNetLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019c9ac1-ae73-7cf2-b5a1-962c2c12ca8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019c9ac1-ae73-74d0-974b-d000defc3833" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019c9ac1-ae73-7cf2-b5a1-962c2c12ca8b" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019c9ac1-ae73-74d0-974b-d000defc3833" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019c9ac1-ae73-7a73-bb46-9b767fc3a717" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019c9ac1-ae73-74d0-974b-d000defc3833" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019c9ac1-ae73-7a73-bb46-9b767fc3a717" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019c9ac1-ae73-7a73-bb46-9b767fc3a717_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019c9ac1-ae73-7a73-bb46-9b767fc3a717" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019c9ac1-ae73-7a73-bb46-9b767fc3a717_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019c9ac1-ae73-79d2-b2e7-bd989cd2ff76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019c9ac1-ae73-7a73-bb46-9b767fc3a717" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019c9ac1-ae73-79d2-b2e7-bd989cd2ff76" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockCompensationPlanMember_019c9ac1-ae73-77c1-ae4e-65812e0930bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockCompensationPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019c9ac1-ae73-79d2-b2e7-bd989cd2ff76" xlink:to="loc_us-gaap_StockCompensationPlanMember_019c9ac1-ae73-77c1-ae4e-65812e0930bb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_TempusAgreementMember_019c9ac1-ae73-782e-ab10-0259c2315720" xlink:href="rxrx-20260331.xsd#rxrx_TempusAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019c9ac1-ae73-79d2-b2e7-bd989cd2ff76" xlink:to="loc_rxrx_TempusAgreementMember_019c9ac1-ae73-782e-ab10-0259c2315720" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019c9ac1-ae73-766c-b050-481f37a2a43d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019c9ac1-ae73-7cf2-b5a1-962c2c12ca8b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019c9ac1-ae73-766c-b050-481f37a2a43d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsScheduleofAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019c9ac1-ae73-795e-beb2-b4df2f31fe7f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019c9ac1-ae73-76a7-99f9-33e750f60a9a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019c9ac1-ae73-795e-beb2-b4df2f31fe7f" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019c9ac1-ae73-76a7-99f9-33e750f60a9a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019c9ac1-ae73-7f70-a559-9938946be5b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019c9ac1-ae73-76a7-99f9-33e750f60a9a" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019c9ac1-ae73-7f70-a559-9938946be5b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019c9ac1-ae73-7f70-a559-9938946be5b7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019c9ac1-ae73-7f70-a559-9938946be5b7" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019c9ac1-ae73-7f70-a559-9938946be5b7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019c9ac1-ae73-78d4-81bd-b47e0fad43b4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019c9ac1-ae73-7f70-a559-9938946be5b7" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019c9ac1-ae73-78d4-81bd-b47e0fad43b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019c9ac1-ae73-7b4f-b831-b04b9f856ebe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019c9ac1-ae73-78d4-81bd-b47e0fad43b4" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019c9ac1-ae73-7b4f-b831-b04b9f856ebe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019c9ac1-ae73-727c-8909-f3e03667ce5b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019c9ac1-ae73-78d4-81bd-b47e0fad43b4" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019c9ac1-ae73-727c-8909-f3e03667ce5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019c9ac1-ae73-732f-962e-42606715a6e1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019c9ac1-ae73-78d4-81bd-b47e0fad43b4" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019c9ac1-ae73-732f-962e-42606715a6e1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019c9ac1-ae73-7bd7-86c9-c3f53c49d0fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_019c9ac1-ae73-76a7-99f9-33e750f60a9a" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019c9ac1-ae73-7bd7-86c9-c3f53c49d0fc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c9ac1-ae73-7bd7-86c9-c3f53c49d0fc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019c9ac1-ae73-7bd7-86c9-c3f53c49d0fc" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c9ac1-ae73-7bd7-86c9-c3f53c49d0fc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c9ac1-ae73-775a-b06f-00a2ccbe0930" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019c9ac1-ae73-7bd7-86c9-c3f53c49d0fc" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c9ac1-ae73-775a-b06f-00a2ccbe0930" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashMember_019c9ac1-ae73-7a90-b692-2af8bb992c98" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c9ac1-ae73-775a-b06f-00a2ccbe0930" xlink:to="loc_us-gaap_CashMember_019c9ac1-ae73-7a90-b692-2af8bb992c98" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_019c9ac1-ae73-7fa1-869a-c7dfcd8de70c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019c9ac1-ae73-775a-b06f-00a2ccbe0930" xlink:to="loc_us-gaap_MoneyMarketFundsMember_019c9ac1-ae73-7fa1-869a-c7dfcd8de70c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019c9ac1-ae73-7986-aa8f-5ac3f9d3f63f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019c9ac1-ae73-795e-beb2-b4df2f31fe7f" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019c9ac1-ae73-7986-aa8f-5ac3f9d3f63f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_019c9ac1-ae73-7507-bf96-85f5c742793c" xlink:href="rxrx-20260331.xsd#rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019c9ac1-ae73-795e-beb2-b4df2f31fe7f" xlink:to="loc_rxrx_RestrictedCashAndCashEquivalentsFairValueDisclosure_019c9ac1-ae73-7507-bf96-85f5c742793c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019c9ac1-ae73-7b27-9332-f0937c75adcb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_019c9ac1-ae73-795e-beb2-b4df2f31fe7f" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_019c9ac1-ae73-7b27-9332-f0937c75adcb" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/FairValueMeasurementsScheduleofFinancialInstrumentsNotMeasuredatFairValueDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#FairValueMeasurementsScheduleofFinancialInstrumentsNotMeasuredatFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/FairValueMeasurementsScheduleofFinancialInstrumentsNotMeasuredatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_019c9ac1-ae73-7e6c-be9d-deff3aaf65bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_019c9ac1-ae73-75fe-a714-9bb0b50d86fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_019c9ac1-ae73-7e6c-be9d-deff3aaf65bc" xlink:to="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_019c9ac1-ae73-75fe-a714-9bb0b50d86fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_019c9ac1-ae73-7366-aba5-e731b293cc90" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_019c9ac1-ae73-75fe-a714-9bb0b50d86fe" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_019c9ac1-ae73-7366-aba5-e731b293cc90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019c9ac1-ae73-7366-aba5-e731b293cc90_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019c9ac1-ae73-7366-aba5-e731b293cc90" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019c9ac1-ae73-7366-aba5-e731b293cc90_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019c9ac1-ae73-7e56-b408-55de29728556" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_019c9ac1-ae73-7366-aba5-e731b293cc90" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019c9ac1-ae73-7e56-b408-55de29728556" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019c9ac1-ae73-7cba-8919-c89afd6faedd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_019c9ac1-ae73-7e56-b408-55de29728556" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019c9ac1-ae73-7cba-8919-c89afd6faedd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_019c9ac1-ae73-7d07-a3e6-44074b8438a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019c9ac1-ae73-7cba-8919-c89afd6faedd" xlink:to="loc_us-gaap_PortionAtOtherThanFairValueFairValueDisclosureMember_019c9ac1-ae73-7d07-a3e6-44074b8438a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019c9ac1-ae73-715d-a73b-c9e7a625dd17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_019c9ac1-ae73-7cba-8919-c89afd6faedd" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_019c9ac1-ae73-715d-a73b-c9e7a625dd17" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_019c9ac1-ae73-7e7d-a01f-c58b9c59d12f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueDisclosureOfAssetAndLiabilityNotMeasuredAtFairValueTable_019c9ac1-ae73-75fe-a714-9bb0b50d86fe" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_019c9ac1-ae73-7e7d-a01f-c58b9c59d12f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019c9ac1-ae73-7e7d-a01f-c58b9c59d12f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019c9ac1-ae73-7e7d-a01f-c58b9c59d12f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019c9ac1-ae73-7e7d-a01f-c58b9c59d12f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_019c9ac1-ae73-7693-98e2-c6117dc6f704" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_019c9ac1-ae73-7e7d-a01f-c58b9c59d12f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_019c9ac1-ae73-7693-98e2-c6117dc6f704" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableOtherPayablesMember_019c9ac1-ae73-7a40-8912-98ef2101ceea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NotesPayableOtherPayablesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_019c9ac1-ae73-7693-98e2-c6117dc6f704" xlink:to="loc_us-gaap_NotesPayableOtherPayablesMember_019c9ac1-ae73-7a40-8912-98ef2101ceea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_019c9ac1-ae73-737e-a765-aa53ec96224a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_019c9ac1-ae73-7e6c-be9d-deff3aaf65bc" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_019c9ac1-ae73-737e-a765-aa53ec96224a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019c9ac1-ae73-7466-9358-dfd5d7c1f0f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_019c9ac1-ae73-7e6c-be9d-deff3aaf65bc" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_019c9ac1-ae73-7466-9358-dfd5d7c1f0f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_019c9ac1-ae73-77c6-8a59-2f7ab3b25a4a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureAssetAndLiabilityNotMeasuredAtFairValueLineItems_019c9ac1-ae73-7e6c-be9d-deff3aaf65bc" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_019c9ac1-ae73-77c6-8a59-2f7ab3b25a4a" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.recursion.com/role/SegmentInformationScheduleofSegmentNetLossandReconciliationsofSegmentOperatingLosstoLossBeforeIncomeTaxBenefitDetails" xlink:type="simple" xlink:href="rxrx-20260331.xsd#SegmentInformationScheduleofSegmentNetLossandReconciliationsofSegmentOperatingLosstoLossBeforeIncomeTaxBenefitDetails"/>
  <link:definitionLink xlink:role="http://www.recursion.com/role/SegmentInformationScheduleofSegmentNetLossandReconciliationsofSegmentOperatingLosstoLossBeforeIncomeTaxBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019c9ac1-ae73-7fa0-bedb-3225aa04049d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019c9ac1-ae73-7faf-b3d1-0c9c35d691b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019c9ac1-ae73-7fa0-bedb-3225aa04049d" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019c9ac1-ae73-7faf-b3d1-0c9c35d691b9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019c9ac1-ae73-78f1-a5cb-c93e953fc0d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019c9ac1-ae73-7faf-b3d1-0c9c35d691b9" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019c9ac1-ae73-78f1-a5cb-c93e953fc0d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019c9ac1-ae73-78f1-a5cb-c93e953fc0d5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019c9ac1-ae73-78f1-a5cb-c93e953fc0d5" xlink:to="loc_us-gaap_SegmentDomain_019c9ac1-ae73-78f1-a5cb-c93e953fc0d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019c9ac1-ae73-781f-934c-7e6561c5885c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019c9ac1-ae73-78f1-a5cb-c93e953fc0d5" xlink:to="loc_us-gaap_SegmentDomain_019c9ac1-ae73-781f-934c-7e6561c5885c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ReportableSegmentMember_019c9ac1-ae73-7fe5-add9-463b159eae76" xlink:href="rxrx-20260331.xsd#rxrx_ReportableSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019c9ac1-ae73-781f-934c-7e6561c5885c" xlink:to="loc_rxrx_ReportableSegmentMember_019c9ac1-ae73-7fe5-add9-463b159eae76" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c9ac1-ae73-770f-b861-061f984a58ac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019c9ac1-ae73-7fa0-bedb-3225aa04049d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019c9ac1-ae73-770f-b861-061f984a58ac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:href="rxrx-20260331.xsd#rxrx_SignificantSegmentExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019c9ac1-ae73-7fa0-bedb-3225aa04049d" xlink:to="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019c9ac1-ae73-7afa-90fa-0b81e7fd19c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019c9ac1-ae73-7afa-90fa-0b81e7fd19c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ConsumableExpense_019c9ac1-ae73-744c-83aa-96f88c63709b" xlink:href="rxrx-20260331.xsd#rxrx_ConsumableExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_rxrx_ConsumableExpense_019c9ac1-ae73-744c-83aa-96f88c63709b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_PlatformFeeExpense_019c9ac1-ae73-7479-aa93-e97e5dc52a18" xlink:href="rxrx-20260331.xsd#rxrx_PlatformFeeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_rxrx_PlatformFeeExpense_019c9ac1-ae73-7479-aa93-e97e5dc52a18" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_DiscoveryExpense_019c9ac1-ae73-73ff-a3c8-1f54fffb04fb" xlink:href="rxrx-20260331.xsd#rxrx_DiscoveryExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_rxrx_DiscoveryExpense_019c9ac1-ae73-73ff-a3c8-1f54fffb04fb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_ClinicalDevelopmentExpense_019c9ac1-ae73-73fd-a47f-3cfd2b66fec5" xlink:href="rxrx-20260331.xsd#rxrx_ClinicalDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_rxrx_ClinicalDevelopmentExpense_019c9ac1-ae73-73fd-a47f-3cfd2b66fec5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization_019c9ac1-ae73-70df-9f74-776385d45b7f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciationAndAmortization_019c9ac1-ae73-70df-9f74-776385d45b7f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019c9ac1-ae73-70b9-a477-7e02e0f5ad96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019c9ac1-ae73-70b9-a477-7e02e0f5ad96" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019c9ac1-ae73-7e66-9fc8-8410bcd1acb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_us-gaap_OperatingIncomeLoss_019c9ac1-ae73-7e66-9fc8-8410bcd1acb9" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019c9ac1-ae73-7fb0-9995-bf4aec15ea4d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019c9ac1-ae73-7fb0-9995-bf4aec15ea4d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019c9ac1-ae73-7fc8-b300-6dcced5fb7e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019c9ac1-ae73-7fc8-b300-6dcced5fb7e5" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019c9ac1-ae73-72fd-b15d-c3f8489ce118" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SignificantSegmentExpensesAbstract_019c9ac1-ae73-7183-8e15-8ddf886b45af" xlink:to="loc_us-gaap_NetIncomeLoss_019c9ac1-ae73-72fd-b15d-c3f8489ce118" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_SupplementalAssetInformationAbstract_019c9ac1-ae73-7888-9a4f-26a2e1f5ae9a" xlink:href="rxrx-20260331.xsd#rxrx_SupplementalAssetInformationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019c9ac1-ae73-7fa0-bedb-3225aa04049d" xlink:to="loc_rxrx_SupplementalAssetInformationAbstract_019c9ac1-ae73-7888-9a4f-26a2e1f5ae9a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_019c9ac1-ae73-73c9-b7f8-6ca3e6b62eba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentExpenditureAdditionToLongLivedAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_rxrx_SupplementalAssetInformationAbstract_019c9ac1-ae73-7888-9a4f-26a2e1f5ae9a" xlink:to="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_019c9ac1-ae73-73c9-b7f8-6ca3e6b62eba" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#IndividualsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_AllIndividualsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_rxrx_NamandjeBumpusMember_019d8754-5c47-794b-abdb-f5c363ccdae7" xlink:href="rxrx-20260331.xsd#rxrx_NamandjeBumpusMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_rxrx_NamandjeBumpusMember_019d8754-5c47-794b-abdb-f5c363ccdae7" xlink:type="arc" order="2"/>
  </link:definitionLink>
</link:linkbase>
