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EARNINGS PER SHARE, BASIC (in dollars per share) Earnings per common share, basic (in dollars per share) Earnings Per Share, Basic Adjustment to Compensation: Adjustment to Compensation [Axis] Named Executive Officers, Footnote Named Executive Officers, Footnote [Text Block] Accounts payable and accrued liabilities Increase (Decrease) in Accounts Payable and Accrued Liabilities Liabilities: Liabilities, Fair Value Disclosure [Abstract] Restricted cash equivalents Restricted Cash Equivalent, Noncurrent Schedule of Reportable Segment Information Schedule of Segment Reporting Information, by Segment [Table Text Block] Schedule of Reconciliation of Cash, Cash Equivalents, and Restricted Cash Equivalents Schedule of Cash and Cash Equivalents [Table Text Block] Adjustment to Compensation, Amount Adjustment to Compensation Amount Concentration risk, percentage Total Concentration Risk, Percentage Unamortized discount net of deferred offering costs Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Stock-based compensation Share-Based Payment Arrangement, Noncash Expense Employee Stock Option Share-Based Payment Arrangement, Option [Member] Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Cash and Cash Equivalents Cash and Cash Equivalents [Member] Cash paid for income taxes Income Taxes Paid Number of treatment therapies acquired Business Combination, Number Of Treatment Therapies Acquired Business Combination, Number Of Treatment Therapies Acquired Antidilutive Securities Antidilutive Securities [Axis] Impairment of assets Asset Impairment Charges Total stockholders’ equity Beginning balances Ending balances Equity, Attributable to Parent Derivative Instruments, Gain (Loss) [Line Items] Derivative Instruments, Gain (Loss) [Line Items] Insider Trading Policies and Procedures [Line Items] Total stock-based compensation expense Share-Based Payment Arrangement, Expense Schedule of Property, Plant and Equipment, Net Property, Plant and Equipment [Table Text Block] Common stock, shares authorized (in shares) Common Stock, Shares Authorized Hedging Designation Hedging Designation [Domain] Current assets: Assets, Current [Abstract] Total liabilities and stockholders’ equity Liabilities and Equity Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Concentration Risk Benchmark Concentration Risk Benchmark [Axis] Derivative Instruments, Gain (Loss) [Table] Derivative Instruments, Gain (Loss) [Table] LIABILITIES AND STOCKHOLDERS’ EQUITY Liabilities and Equity [Abstract] Cover page. Cover [Abstract] Cash, aggregate fair value Cash and Cash Equivalents, Fair Value Disclosure Maximum Maximum [Member] Bridge Loan Bridge Loan [Member] Accounting Policies [Abstract] Accounting Policies [Abstract] Net carrying value Finite-Lived Intangible Assets, Net Concentration Risk Type Concentration Risk Type [Domain] Non-PEO NEO Average Total Compensation Amount Non-PEO NEO Average Total Compensation Amount Debt Instrument [Line Items] Debt Instrument [Line Items] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Pay vs Performance Disclosure [Line Items] U.S. government agency securities US Government Agencies Debt Securities [Member] Forgone Recovery due to Disqualification of Tax Benefits, Amount Forgone Recovery due to Disqualification of Tax Benefits, Amount Non-Rule 10b5-1 Arrangement Terminated Non-Rule 10b5-1 Arrangement Terminated [Flag] INCOME BEFORE INCOME TAXES Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Entity Shell Company Entity Shell Company Other long-term liabilities Other Liabilities, Noncurrent Schedule of Long-term Debt Instruments [Table] Schedule of Long-Term Debt Instruments [Table] Proceeds from issuance of debt Proceeds from Issuance of Debt Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Company Selected Measure Amount Company Selected Measure Amount Cash Cash Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Sanofi Customers [Member] Customers. Debt issuance costs Debt Issuance Costs, Gross COMPREHENSIVE INCOME Comprehensive Income (Loss), Net of Tax, Attributable to Parent Long term marketable securities maturity period Long Term Marketable Securities Maturity Period Long-term marketable securities maturity period. 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Net cash provided by (used in) investing activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member] Document Fiscal Year Focus Document Fiscal Year Focus Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] NQDC Plan assets, noncurrent Deferred Compensation Plan Assets Entity Interactive Data Current Entity Interactive Data Current Equity [Abstract] Equity [Abstract] Purchase commitment Purchase Obligation SEGMENT INFORMATION Segment Reporting Disclosure [Text Block] Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Derivatives not designated as hedging instruments: Not Designated as Hedging Instrument [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Latin America Latin America [Member] Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] ACCUMULATED OTHER COMPREHENSIVE INCOME Comprehensive Income (Loss) Note [Text Block] Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Intangible asset amortization Amortization of Intangible Assets Concentration Risk And Geographic Information [Line Items] Concentration Risk And Geographic Information [Line Items] Concentration risk and geographic information. 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February Two Thousand Thirty Four [Member] Five Point Five Percent Senior Unsecured Notes Due In February Two Thousand Thirty Four Schedule of Inventory Schedule of Inventory, Current [Table Text Block] Debt outstanding Long-term debt, gross Long-Term Debt, Gross Accrued compensation expense Employee-related Liabilities, Current 364-Day Senior Secured Bridge Facility 364-Day Senior Secured Bridge Facility [Member] 364-Day Senior Secured Bridge Facility NET INCOME Net income Net income Net Income (Loss) Attributable to Parent Subsequent Event [Table] Subsequent Event [Table] Expiration Date Trading Arrangement Expiration Date Noncurrent liabilities: Liabilities, Noncurrent [Abstract] Long-term Marketable Securities Long Term Investments [Member] Long Term Investments Schedule of Aggregate Notional Amounts for the Derivatives Outstanding Schedule of Foreign Exchange Contracts, Statement of Financial Position [Table Text Block] Other long-term liabilities Increase (Decrease) in Other Operating Liabilities VOXZOGO VOXZOGO [Member] VOXZOGO Property, plant and equipment, net Total property, plant and equipment, net Property, Plant and Equipment, Net Severance charges Restructuring Charges Adoption Date Trading Arrangement Adoption Date Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Accounts receivable, net Increase (Decrease) in Accounts Receivable Restructuring Cost [Table] Restructuring Cost [Table] Entity Current Reporting Status Entity Current Reporting Status Derivative [Line Items] Derivative [Line Items] Customer Customer [Axis] Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Revenue from External Customers by Products and Services [Table] Segment Reporting, Revenue from External Customer, Product and Service [Table] INCOME FROM OPERATIONS Operating Income (Loss) Line of Credit Line of Credit [Member] Retained earnings Retained Earnings (Accumulated Deficit) Financial Instrument [Axis] Financial Instrument [Axis] Maturity of derivatives Derivative, Remaining Maturity Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Executive Category: Executive Category [Axis] Other income (expense), net Other Operating Income (Expense), Net Total interest expense on debt Interest Expense, Operating and Nonoperating Current Fiscal Year End Date Current Fiscal Year End Date Cash Flow Hedging Gains (Losses) Reclassified into Earnings Unrealized Gains (Losses) on Cash Flow Hedges Accumulated Gain (Loss), Net, Cash Flow Hedge, Parent [Member] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member] Statement [Table] Statement [Table] Accounts payable and accrued liabilities related to intangible assets Capital Expenditures Incurred But Not Yet Paid, Intangible Assets Capital Expenditures Incurred But Not Yet Paid, Intangible Assets Effect of exchange rate changes on cash Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation Deferred income taxes Deferred Income Tax Expense (Benefit) Adjustments to reconcile net income to net cash provided by operating activities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] CASH FLOWS FROM FINANCING ACTIVITIES: Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Net Product Revenue Revenue Benchmark [Member] Proceeds from issuance of debt Proceeds from Debt, Net of Issuance Costs Total number of potentially issuable shares excluded from computation (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount All Adjustments to Compensation All Adjustments to Compensation [Member] Accounts payable and accrued liabilities Total accounts payable and accrued liabilities Accounts Payable and Accrued Liabilities, Current Amendment Flag Amendment Flag Change in Common stock held by the Nonqualified Deferred Compensation plan (NQDC) Adjustments To Additional Paid In Capital, Shares Held By Nonqualified Deferred Compensation Plan Adjustments To Additional Paid In Capital, Shares Held By Nonqualified Deferred Compensation Plan Termination Date Trading Arrangement Termination Date Net cash provided by (used in) financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Measure: Measure [Axis] Raw materials Inventory, Raw Materials, Net of Reserves Long-term investments Debt Securities, Available-for-Sale, Noncurrent Weighted average common shares outstanding, basic (in shares) Weighted-average common shares outstanding, basic (in shares) Weighted Average Number of Shares Outstanding, Basic Schedule of Computation of Basic and Diluted Earnings Per Common Share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] NQDC Plan liability, current Deferred Compensation Liability, Current Subsequent Events [Abstract] Subsequent Events [Abstract] Segment Reporting [Abstract] Cost of sales Cost of Revenue Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Debt Disclosure [Abstract] Debt Disclosure [Abstract] Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Amortization of debt issuance costs Amortization of Debt Issuance Costs Entity Tax Identification Number Entity Tax Identification Number OPERATING EXPENSES: Costs and Expenses [Abstract] Less: gain (loss) reclassified from AOCI Reclassification from AOCI, Current Period, before Tax, Attributable to Parent Schedule of Cash, Cash Equivalents, Restricted Cash Equivalents and Available-for-Sale Securities by Significant Investment Category Schedule Of Cash Cash Equivalents, Restricted Cash Equivalents And Available For Sale Securities [Table Text Block] Schedule of cash, cash equivalents and available-for-sale securities. Restructuring and Related Activities [Abstract] Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Sell Short [Member] Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Common stock, shares issued (in shares) Common Stock, Shares, Issued Effect of dilutive securities: Dilutive Securities, Effect on Basic Earnings Per Share [Abstract] Use of Estimates Use of Estimates, Policy [Policy Text Block] Tax effect Other Comprehensive Income (Loss), Tax, Portion Attributable to Parent Interest expense Interest Expense, Nonoperating Trading Arrangement: Trading Arrangement [Axis] Total Shareholder Return Amount Total Shareholder Return Amount SUBSEQUENT EVENTS Subsequent Events [Text Block] Insider Trading Arrangements [Line Items] Short term marketable securities maturity period Short Term Marketable Securities Maturity Period Short-term marketable securities maturity period. Security Exchange Name Security Exchange Name NQDC Plan assets, current Deferred Compensation Plan Assets, Current Deferred Compensation Plan Assets, Current Total liabilities Liabilities Antidilutive Securities, Name Antidilutive Securities, Name [Domain] Maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Schedule Of Cash Cash Equivalents And Available For Sale Securities [Table] Schedule Of Cash Cash Equivalents And Available For Sale Securities [Table] Schedule of cash, cash equivalents and available-for-sale securities. Pension Adjustments Prior Service Cost Pension Adjustments Prior Service Cost [Member] Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Statement [Line Items] Statement [Line Items] Asset-backed securities Asset-Backed Securities [Member] Schedule of Restructuring Reserve Activity Schedule of Restructuring Reserve by Type of Cost [Table Text Block] Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Cash and cash equivalents Cash and Cash Equivalent Subsequent Event [Line Items] Subsequent Event [Line Items] Common stock: Common Stock [Member] Aggregate Fair Value Debt Securities, Available-for-Sale ALDURAZYME ALDURAZYME [Member] ALDURAZYME Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Non-NEOs Non-NEOs [Member] Corporate debt securities Corporate Debt Securities [Member] Customer C Customer Three [Member] Customer 3 NET INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH EQUIVALENTS Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation