<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019d02c4-9da2-7278-b858-9139be3e1e01,g:8068d171-5c43-4911-ba93-24d6105e53ff-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CoverPage" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CoverPage"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_019d6724-506a-7e06-99c2-c98615e2c085" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntitiesTable_019d6724-506a-7e06-99c2-c98615e2c085" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d6724-506a-7322-b38e-6b83c0a30da2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_019d6724-506a-7e06-99c2-c98615e2c085" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d6724-506a-7322-b38e-6b83c0a30da2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d6724-506a-7322-b38e-6b83c0a30da2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d6724-506a-7322-b38e-6b83c0a30da2" xlink:to="loc_us-gaap_ClassOfStockDomain_019d6724-506a-7322-b38e-6b83c0a30da2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d6724-506a-7e96-81f7-35b4e77294d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d6724-506a-7322-b38e-6b83c0a30da2" xlink:to="loc_us-gaap_ClassOfStockDomain_019d6724-506a-7e96-81f7-35b4e77294d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d6724-506a-7656-bc24-171aa100d40d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d6724-506a-7e96-81f7-35b4e77294d5" xlink:to="loc_us-gaap_CommonClassAMember_019d6724-506a-7656-bc24-171aa100d40d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d6724-aa12-7e8a-8c5b-5f027a10e6ee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d6724-506a-7e96-81f7-35b4e77294d5" xlink:to="loc_us-gaap_CommonClassBMember_019d6724-aa12-7e8a-8c5b-5f027a10e6ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019d02c4-9e77-7eed-8be2-630090a53a68" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_DocumentType_019d02c4-9e77-7eed-8be2-630090a53a68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_019d02c4-9e77-74b1-9468-5fe0316a55c8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_DocumentQuarterlyReport_019d02c4-9e77-74b1-9468-5fe0316a55c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019d02c4-9e77-7ece-b14f-ec125804f249" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_DocumentPeriodEndDate_019d02c4-9e77-7ece-b14f-ec125804f249" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_019d02c4-9e77-7d4d-b518-f1de7adc3beb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_DocumentTransitionReport_019d02c4-9e77-7d4d-b518-f1de7adc3beb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019d02c4-9e77-7cd2-a6db-3ee773475847" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityFileNumber_019d02c4-9e77-7cd2-a6db-3ee773475847" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019d02c4-9e77-7e3c-8fef-700ff1f5b8ec" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityRegistrantName_019d02c4-9e77-7e3c-8fef-700ff1f5b8ec" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019d02c4-9e77-77e6-9d13-0a71dfdef4a4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019d02c4-9e77-77e6-9d13-0a71dfdef4a4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019d02c4-9e77-77e0-8aef-aac0efeb4c50" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityTaxIdentificationNumber_019d02c4-9e77-77e0-8aef-aac0efeb4c50" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019d02c4-9e77-7812-a705-7159631fcbad" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityAddressAddressLine1_019d02c4-9e77-7812-a705-7159631fcbad" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019d02c4-9e77-75ba-b45a-eb1594b72b10" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityAddressCityOrTown_019d02c4-9e77-75ba-b45a-eb1594b72b10" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019d02c4-9e77-788e-ae14-a06bb36a22c4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityAddressStateOrProvince_019d02c4-9e77-788e-ae14-a06bb36a22c4" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019d02c4-9e77-75bd-b74a-9c68428a4009" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityAddressPostalZipCode_019d02c4-9e77-75bd-b74a-9c68428a4009" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019d02c4-9e77-74f6-98d3-e8e571ee88e4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_CityAreaCode_019d02c4-9e77-74f6-98d3-e8e571ee88e4" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019d02c4-9e77-7eff-8aad-db27fe1e54dd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_LocalPhoneNumber_019d02c4-9e77-7eff-8aad-db27fe1e54dd" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019d02c4-9e77-75fa-a7df-6b334f4f4d3f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_Security12bTitle_019d02c4-9e77-75fa-a7df-6b334f4f4d3f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019d02c4-9e77-7165-9e1c-b28d902692b7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_TradingSymbol_019d02c4-9e77-7165-9e1c-b28d902692b7" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019d02c4-9e77-7b4a-8ab2-f1248d29bdb6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_SecurityExchangeName_019d02c4-9e77-7b4a-8ab2-f1248d29bdb6" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_019d02c4-9e77-7d93-851d-f79084c6a5fd" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityCurrentReportingStatus_019d02c4-9e77-7d93-851d-f79084c6a5fd" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_019d02c4-9e77-773b-920c-73da16b3620a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityInteractiveDataCurrent_019d02c4-9e77-773b-920c-73da16b3620a" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_019d02c4-9e77-7558-b0d3-ffe225f934e0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityFilerCategory_019d02c4-9e77-7558-b0d3-ffe225f934e0" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_019d02c4-9e77-7952-abb8-c74719503269" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntitySmallBusiness_019d02c4-9e77-7952-abb8-c74719503269" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019d02c4-9e77-7f6f-b33b-c2911dcafbb1" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityEmergingGrowthCompany_019d02c4-9e77-7f6f-b33b-c2911dcafbb1" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_019d02c4-9e77-788e-99e5-9791c0def0fb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityExTransitionPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityExTransitionPeriod_019d02c4-9e77-788e-99e5-9791c0def0fb" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_019d02c4-9e77-7b7b-8dd6-acce0240534d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityShellCompany_019d02c4-9e77-7b7b-8dd6-acce0240534d" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_019d02c4-9e77-7858-8c6f-00f330849e9a" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_019d02c4-9e77-7858-8c6f-00f330849e9a" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019d02c4-9e77-75c9-8efe-fb3d02942d3b" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_EntityCentralIndexKey_019d02c4-9e77-75c9-8efe-fb3d02942d3b" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_019d02c4-9e77-7a5a-8ad8-2262724697fb" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_DocumentFiscalYearFocus_019d02c4-9e77-7a5a-8ad8-2262724697fb" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_019d02c4-9e77-796f-aa08-c43e5a0ebf74" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_DocumentFiscalPeriodFocus_019d02c4-9e77-796f-aa08-c43e5a0ebf74" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019d02c4-9e77-7426-b808-62b23646ea08" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_AmendmentFlag_019d02c4-9e77-7426-b808-62b23646ea08" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_019d02c4-9e77-7f06-92fa-f26e399158ac" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_019d6724-506a-7b35-8807-87a6ac550d14" xlink:to="loc_dei_CurrentFiscalYearEndDate_019d02c4-9e77-7f06-92fa-f26e399158ac" xlink:type="arc" order="29"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CONDENSEDBALANCESHEETSUnaudited" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CONDENSEDBALANCESHEETSUnaudited"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CONDENSEDBALANCESHEETSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019d02c4-9e77-7bce-bd23-b9048ca0051c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019d02c4-9e77-7f07-9028-84e7bcd4dcb6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-7bce-bd23-b9048ca0051c" xlink:to="loc_us-gaap_StatementTable_019d02c4-9e77-7f07-9028-84e7bcd4dcb6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-709d-bfd8-01fff30ad4c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d02c4-9e77-7f07-9028-84e7bcd4dcb6" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-709d-bfd8-01fff30ad4c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-709d-bfd8-01fff30ad4c6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-709d-bfd8-01fff30ad4c6" xlink:to="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-709d-bfd8-01fff30ad4c6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-71d3-a48d-c7f27b77cf74" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-709d-bfd8-01fff30ad4c6" xlink:to="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-71d3-a48d-c7f27b77cf74" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d02c4-9e77-78f1-8d90-b348147308ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-71d3-a48d-c7f27b77cf74" xlink:to="loc_us-gaap_CommonClassAMember_019d02c4-9e77-78f1-8d90-b348147308ad" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d02c4-9e77-7999-b276-e8e7b5354042" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-71d3-a48d-c7f27b77cf74" xlink:to="loc_us-gaap_CommonClassBMember_019d02c4-9e77-7999-b276-e8e7b5354042" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_019d674e-361f-777d-8524-dbca990d7617" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-7bce-bd23-b9048ca0051c" xlink:to="loc_us-gaap_AssetsAbstract_019d674e-361f-777d-8524-dbca990d7617" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_019d02c4-9e77-740a-9f70-f203d094a005" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d674e-361f-777d-8524-dbca990d7617" xlink:to="loc_us-gaap_AssetsCurrentAbstract_019d02c4-9e77-740a-9f70-f203d094a005" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d02c4-9e77-7906-8742-6441f58695b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d02c4-9e77-740a-9f70-f203d094a005" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d02c4-9e77-7906-8742-6441f58695b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_019d02c4-9e77-755a-af06-f55637a0b528" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d02c4-9e77-740a-9f70-f203d094a005" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_019d02c4-9e77-755a-af06-f55637a0b528" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019d02c4-9e77-78fd-b603-c043398bab92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d02c4-9e77-740a-9f70-f203d094a005" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019d02c4-9e77-78fd-b603-c043398bab92" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019d02c4-9e77-74bb-9607-5396c7f5b5fb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsCurrentAbstract_019d02c4-9e77-740a-9f70-f203d094a005" xlink:to="loc_us-gaap_AssetsCurrent_019d02c4-9e77-74bb-9607-5396c7f5b5fb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019d02c4-9e77-73c9-bf00-bf8fcb2e311b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d674e-361f-777d-8524-dbca990d7617" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019d02c4-9e77-73c9-bf00-bf8fcb2e311b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019d02c4-9e77-7060-b7dc-b0326f00c7b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d674e-361f-777d-8524-dbca990d7617" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019d02c4-9e77-7060-b7dc-b0326f00c7b9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d02c4-9e77-7946-be15-a3ab8ead5629" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d674e-361f-777d-8524-dbca990d7617" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d02c4-9e77-7946-be15-a3ab8ead5629" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019d02c4-9e77-708e-97c2-ee02e516d6b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract_019d674e-361f-777d-8524-dbca990d7617" xlink:to="loc_us-gaap_Assets_019d02c4-9e77-708e-97c2-ee02e516d6b7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-7bce-bd23-b9048ca0051c" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_019d02c4-9e77-79c7-acbd-266147019c17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_019d02c4-9e77-79c7-acbd-266147019c17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019d02c4-9e77-7bcf-9ea7-7e4dd434daf0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d02c4-9e77-79c7-acbd-266147019c17" xlink:to="loc_us-gaap_AccountsPayableCurrent_019d02c4-9e77-7bcf-9ea7-7e4dd434daf0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019d02c4-9e77-7d02-9f7b-c209b3ae0b37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d02c4-9e77-79c7-acbd-266147019c17" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019d02c4-9e77-7d02-9f7b-c209b3ae0b37" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d02c4-9e77-71be-8913-83d753f1ee32" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d02c4-9e77-79c7-acbd-266147019c17" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d02c4-9e77-71be-8913-83d753f1ee32" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019d02c4-9e77-7c71-9f25-dc3addf6ed83" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_019d02c4-9e77-79c7-acbd-266147019c17" xlink:to="loc_us-gaap_LiabilitiesCurrent_019d02c4-9e77-7c71-9f25-dc3addf6ed83" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d02c4-9e77-7658-9363-4a7e87053d60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d02c4-9e77-7658-9363-4a7e87053d60" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019d02c4-9e77-70d7-96e0-70500a4bbe2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:to="loc_us-gaap_Liabilities_019d02c4-9e77-70d7-96e0-70500a4bbe2d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019d02c4-9e77-768c-ac47-ed8d1328f836" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019d02c4-9e77-768c-ac47-ed8d1328f836" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:to="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019d02c4-9e77-7729-8f2e-eb0aed1a42b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:to="loc_us-gaap_CommonStockValue_019d02c4-9e77-7729-8f2e-eb0aed1a42b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019d02c4-9e77-7022-8b44-7a79a833a4ac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:to="loc_us-gaap_PreferredStockValue_019d02c4-9e77-7022-8b44-7a79a833a4ac" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019d02c4-9e77-756d-b832-79af78d2f5f5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019d02c4-9e77-756d-b832-79af78d2f5f5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d02c4-9e77-7799-8e01-c80d81a8a2cc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d02c4-9e77-7799-8e01-c80d81a8a2cc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019d02c4-9e77-71ae-8013-397875564261" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019d02c4-9e77-71ae-8013-397875564261" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019d02c4-9e77-7b22-aa5f-e9d836cdd548" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StockholdersEquityAbstract_019d02c4-9e77-781a-871a-b52ceae06742" xlink:to="loc_us-gaap_StockholdersEquity_019d02c4-9e77-7b22-aa5f-e9d836cdd548" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019d02c4-9e77-781a-879a-c9df5fdb4f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_019d6753-c885-7d27-8388-d3d992fd8d26" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_019d02c4-9e77-781a-879a-c9df5fdb4f5d" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CONDENSEDBALANCESHEETSUnauditedParenthetical" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CONDENSEDBALANCESHEETSUnauditedParenthetical"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CONDENSEDBALANCESHEETSUnauditedParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019d02c4-9e77-7b98-8035-1b81aa4cdb43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_StatementTable_019d02c4-9e77-7b98-8035-1b81aa4cdb43" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7fac-b8c4-986c6c78c2e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d02c4-9e77-7b98-8035-1b81aa4cdb43" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7fac-b8c4-986c6c78c2e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7fac-b8c4-986c6c78c2e5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7fac-b8c4-986c6c78c2e5" xlink:to="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7fac-b8c4-986c6c78c2e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7888-9d1b-bb3139f171a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7fac-b8c4-986c6c78c2e5" xlink:to="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7888-9d1b-bb3139f171a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d02c4-9e77-7e1e-a7e3-9a42f76a44a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7888-9d1b-bb3139f171a2" xlink:to="loc_us-gaap_CommonClassAMember_019d02c4-9e77-7e1e-a7e3-9a42f76a44a1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d02c4-9e77-7df6-a933-67f13e76944e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7888-9d1b-bb3139f171a2" xlink:to="loc_us-gaap_CommonClassBMember_019d02c4-9e77-7df6-a933-67f13e76944e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d02c4-9e77-764b-bd3c-09dad0462c68" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d02c4-9e77-764b-bd3c-09dad0462c68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_019d02c4-9e77-7acf-b21f-a99f0dd255c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_019d02c4-9e77-7acf-b21f-a99f0dd255c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_019d02c4-9e77-7f4e-b2aa-795da3be4750" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_CommonStockSharesIssued_019d02c4-9e77-7f4e-b2aa-795da3be4750" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_019d02c4-9e77-7c7c-9425-df56e0879085" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_019d02c4-9e77-7c7c-9425-df56e0879085" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019d02c4-9e77-710d-a91d-3ec1b3205058" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_019d02c4-9e77-710d-a91d-3ec1b3205058" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_019d02c4-9e77-7290-a733-be7ce5d78030" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_019d02c4-9e77-7290-a733-be7ce5d78030" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_019d02c4-9e77-7267-b196-1fa23de81e1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_PreferredStockSharesIssued_019d02c4-9e77-7267-b196-1fa23de81e1e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_019d02c4-9e77-7fa8-ab6f-f36d04ce772e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d02c4-9e77-74f3-aad8-53d36ea08c31" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_019d02c4-9e77-7fa8-ab6f-f36d04ce772e" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CONDENSEDSTATEMENTSOFSTOCKHOLDERSEQUITYUnaudited" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CONDENSEDSTATEMENTSOFSTOCKHOLDERSEQUITYUnaudited"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CONDENSEDSTATEMENTSOFSTOCKHOLDERSEQUITYUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_019d67b7-09bf-778e-b67a-5817a8c60691" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_019d67b7-09bf-71ce-8e4e-ed58b55f9301" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_019d67b7-09bf-778e-b67a-5817a8c60691" xlink:to="loc_us-gaap_StatementTable_019d67b7-09bf-71ce-8e4e-ed58b55f9301" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_019d67b7-09bf-7e1a-9aaa-b39f05810005" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_019d67b7-09bf-71ce-8e4e-ed58b55f9301" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_019d67b7-09bf-7e1a-9aaa-b39f05810005" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7e1a-9aaa-b39f05810005_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d67b7-09bf-7e1a-9aaa-b39f05810005" xlink:to="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7e1a-9aaa-b39f05810005_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7268-8012-9d6c0e614ab3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_019d67b7-09bf-7e1a-9aaa-b39f05810005" xlink:to="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7268-8012-9d6c0e614ab3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_019d67b7-09bf-78d7-8df5-3816d554a976" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7268-8012-9d6c0e614ab3" xlink:to="loc_us-gaap_CommonStockMember_019d67b7-09bf-78d7-8df5-3816d554a976" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_019d67b7-09bf-7057-8f5f-1fe78b67f860" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7268-8012-9d6c0e614ab3" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_019d67b7-09bf-7057-8f5f-1fe78b67f860" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019d67b7-09bf-7b9b-97b4-cbc0e6500e17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7268-8012-9d6c0e614ab3" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_019d67b7-09bf-7b9b-97b4-cbc0e6500e17" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_019d67b7-09bf-7328-8f42-d373196fbb4a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_019d67b7-09bf-7268-8012-9d6c0e614ab3" xlink:to="loc_us-gaap_RetainedEarningsMember_019d67b7-09bf-7328-8f42-d373196fbb4a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_019d67b7-09bf-778e-b67a-5817a8c60691" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_019d67b7-09bf-7674-bf30-43da142f7c93" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:to="loc_us-gaap_SharesOutstanding_019d67b7-09bf-7674-bf30-43da142f7c93" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019d67b7-09bf-76af-9ab1-fed48134c713" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:to="loc_us-gaap_StockholdersEquity_019d67b7-09bf-76af-9ab1-fed48134c713" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019d67b7-09bf-7367-97df-bd35fa7347b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019d67b7-09bf-7367-97df-bd35fa7347b6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_019d67b7-09bf-7c5f-a55e-d4735c29a557" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_019d67b7-09bf-7c5f-a55e-d4735c29a557" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019d67b7-09bf-7854-9d42-9007045bf3a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_019d67b7-09bf-7854-9d42-9007045bf3a3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019d67b7-09bf-7c32-b5a9-4330e8757746" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:to="loc_us-gaap_NetIncomeLoss_019d67b7-09bf-7c32-b5a9-4330e8757746" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019d67b7-09bf-7676-b8fb-073a08d4ea79" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d67b7-09bf-7bd9-9239-6e09d6655b13" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019d67b7-09bf-7676-b8fb-073a08d4ea79" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_019d67b7-09bf-781d-878e-08412646d0e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019d67b7-09bf-7553-b059-47cee5ee14b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/OrganizationandBasisofPresentationDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#OrganizationandBasisofPresentationDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/OrganizationandBasisofPresentationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019d02c4-9e77-7351-bce4-583faa940a83" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019d02c4-9e77-7351-bce4-583faa940a83" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019d02c4-9e77-729d-9bf8-a6a68496c7f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019d02c4-9e77-7351-bce4-583faa940a83" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019d02c4-9e77-729d-9bf8-a6a68496c7f1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d02c4-9e77-729d-9bf8-a6a68496c7f1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019d02c4-9e77-729d-9bf8-a6a68496c7f1" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d02c4-9e77-729d-9bf8-a6a68496c7f1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d02c4-9e77-7947-8ce9-e8d87142f204" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019d02c4-9e77-729d-9bf8-a6a68496c7f1" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d02c4-9e77-7947-8ce9-e8d87142f204" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_AtTheMarketOfferingMember_019d02c4-9e77-78de-88ec-7202e70d192d" xlink:href="ctnm-20260331.xsd#ctnm_AtTheMarketOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d02c4-9e77-7947-8ce9-e8d87142f204" xlink:to="loc_ctnm_AtTheMarketOfferingMember_019d02c4-9e77-78de-88ec-7202e70d192d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_FollowOnOfferingMember_019d90a8-4732-7496-af73-b38377c40eed" xlink:href="ctnm-20260331.xsd#ctnm_FollowOnOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d02c4-9e77-7947-8ce9-e8d87142f204" xlink:to="loc_ctnm_FollowOnOfferingMember_019d90a8-4732-7496-af73-b38377c40eed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7983-b752-5dc05fe3a6e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019d02c4-9e77-7351-bce4-583faa940a83" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7983-b752-5dc05fe3a6e3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7983-b752-5dc05fe3a6e3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7983-b752-5dc05fe3a6e3" xlink:to="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7983-b752-5dc05fe3a6e3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7ade-b5d1-170115d7e0e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d02c4-9e77-7983-b752-5dc05fe3a6e3" xlink:to="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7ade-b5d1-170115d7e0e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d02c4-9e77-72fc-bbb8-a5e9f7ea1eed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d02c4-9e77-7ade-b5d1-170115d7e0e2" xlink:to="loc_us-gaap_CommonClassAMember_019d02c4-9e77-72fc-bbb8-a5e9f7ea1eed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019d02c4-9e77-70fe-a336-c596502d9c5c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_NetIncomeLoss_019d02c4-9e77-70fe-a336-c596502d9c5c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d02c4-9e77-725c-ab78-5a7854b28c4b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d02c4-9e77-725c-ab78-5a7854b28c4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_SaleOfStockSharesAuthorizedToIssuanceAmount_019d02c4-9e77-7eeb-a881-b9fa8b148120" xlink:href="ctnm-20260331.xsd#ctnm_SaleOfStockSharesAuthorizedToIssuanceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_ctnm_SaleOfStockSharesAuthorizedToIssuanceAmount_019d02c4-9e77-7eeb-a881-b9fa8b148120" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d02c4-9e77-7d83-b679-9cf329420dd6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d02c4-9e77-7d83-b679-9cf329420dd6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019daaae-d370-79bf-a85f-caf1ce49d5c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019daaae-d370-79bf-a85f-caf1ce49d5c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019d67da-5b4d-72fe-ba4a-c8353f943b05" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019d67da-5b4d-72fe-ba4a-c8353f943b05" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019d90a8-4732-7673-b511-314cd82448ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019d90a8-4732-7673-b511-314cd82448ce" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_019d90a8-4732-7b1c-81ea-43c55b1f3a92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_019d90a8-4732-7b1c-81ea-43c55b1f3a92" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_019d02c4-9e77-7efe-b9e7-b0286ca0b8cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d02c4-9e77-7f37-837d-3e5aa68956d4" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_019d02c4-9e77-7efe-b9e7-b0286ca0b8cb" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CashEquivalentsandMarketableSecuritiesScheduleofAmortizedCostandFairValueoftheCompanysCashEquivalentsandMarketableSecuritiesbyMajorInvestmentCategoryDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CashEquivalentsandMarketableSecuritiesScheduleofAmortizedCostandFairValueoftheCompanysCashEquivalentsandMarketableSecuritiesbyMajorInvestmentCategoryDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CashEquivalentsandMarketableSecuritiesScheduleofAmortizedCostandFairValueoftheCompanysCashEquivalentsandMarketableSecuritiesbyMajorInvestmentCategoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-7f02-a2b5-5d6fdd8565a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-7f02-a2b5-5d6fdd8565a4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-7504-8de0-44c93db46c64" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-7f02-a2b5-5d6fdd8565a4" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-7504-8de0-44c93db46c64" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7504-8de0-44c93db46c64_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-7504-8de0-44c93db46c64" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7504-8de0-44c93db46c64_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-7504-8de0-44c93db46c64" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_019d02c4-9e77-7144-ae65-8990ffeb8ed7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_019d02c4-9e77-7144-ae65-8990ffeb8ed7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_019d02c4-9e77-7975-9ac2-554689820fda" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:to="loc_us-gaap_CertificatesOfDepositMember_019d02c4-9e77-7975-9ac2-554689820fda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_019d02c4-9e77-7ed3-9a7e-a6b5059ec572" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_019d02c4-9e77-7ed3-9a7e-a6b5059ec572" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_019d02c4-9e77-7764-ac4e-c98fedd7dc72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:to="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_019d02c4-9e77-7764-ac4e-c98fedd7dc72" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_019d02c4-9e77-7762-8a05-a0ddfae6cf8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:to="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_019d02c4-9e77-7762-8a05-a0ddfae6cf8f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_019d02c4-9e77-7cc5-8e98-0bcbd5fee9cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-76da-b240-17a65a5eddee" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_019d02c4-9e77-7cc5-8e98-0bcbd5fee9cb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_019daf29-f1fa-73bd-8547-7a233b25cc7f" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-7f02-a2b5-5d6fdd8565a4" xlink:to="loc_srt_RangeAxis_019daf29-f1fa-73bd-8547-7a233b25cc7f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019daf29-f1fa-73bd-8547-7a233b25cc7f_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_019daf29-f1fa-73bd-8547-7a233b25cc7f" xlink:to="loc_srt_RangeMember_019daf29-f1fa-73bd-8547-7a233b25cc7f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_019daf29-f1fa-74be-a58f-041b6c45571e" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_019daf29-f1fa-73bd-8547-7a233b25cc7f" xlink:to="loc_srt_RangeMember_019daf29-f1fa-74be-a58f-041b6c45571e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_019daf29-f1fa-763f-9139-f0ef9586cb50" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_019daf29-f1fa-74be-a58f-041b6c45571e" xlink:to="loc_srt_MaximumMember_019daf29-f1fa-763f-9139-f0ef9586cb50" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019de3f8-46a8-7e0e-9ef0-a720144c7ade" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-7f02-a2b5-5d6fdd8565a4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019de3f8-46a8-7e0e-9ef0-a720144c7ade" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019de3f8-46a8-7e0e-9ef0-a720144c7ade_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019de3f8-46a8-7e0e-9ef0-a720144c7ade" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019de3f8-46a8-7e0e-9ef0-a720144c7ade_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019de3f8-46a8-780f-a92c-8c23c8f09c33" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019de3f8-46a8-7e0e-9ef0-a720144c7ade" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019de3f8-46a8-780f-a92c-8c23c8f09c33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsMember_019de3f8-885a-748d-a10f-70d32ce00ab2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019de3f8-46a8-780f-a92c-8c23c8f09c33" xlink:to="loc_us-gaap_CashEquivalentsMember_019de3f8-885a-748d-a10f-70d32ce00ab2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashAndCashEquivalentsTerm_019ddd2c-0e87-7e25-a534-2f2018ea80b3" xlink:href="ctnm-20260331.xsd#ctnm_CashAndCashEquivalentsTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_ctnm_CashAndCashEquivalentsTerm_019ddd2c-0e87-7e25-a534-2f2018ea80b3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_019dc489-044a-73b7-9167-0116b5a34821" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_019dc489-044a-73b7-9167-0116b5a34821" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax_019dc48c-9b34-7986-92bc-f67f8a096f82" xlink:href="ctnm-20260331.xsd#ctnm_CashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_ctnm_CashEquivalentsAccumulatedGrossUnrealizedGainBeforeTax_019dc48c-9b34-7986-92bc-f67f8a096f82" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax_019dc48a-17d3-768e-9ed9-c3243edff1d7" xlink:href="ctnm-20260331.xsd#ctnm_CashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_ctnm_CashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax_019dc48a-17d3-768e-9ed9-c3243edff1d7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019dc48b-948f-76d4-9517-3b304521e31a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019dc48b-948f-76d4-9517-3b304521e31a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTerm_019daf18-3990-718a-9edc-1e7c9c5cf814" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTerm_019daf18-3990-718a-9edc-1e7c9c5cf814" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019d02c4-9e77-74b4-9fbf-e0aed6573349" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019d02c4-9e77-74b4-9fbf-e0aed6573349" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019d02c4-9e77-7bb3-affb-0b63a6876944" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019d02c4-9e77-7bb3-affb-0b63a6876944" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019d02c4-9e77-7c12-b8d2-82787e86510c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019d02c4-9e77-7c12-b8d2-82787e86510c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019d02c4-9e77-7627-aee2-7020a31862ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019d02c4-9e77-7627-aee2-7020a31862ca" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCost_019df587-9a7a-7ea6-98bd-83fca8b6afca" xlink:href="ctnm-20260331.xsd#ctnm_CashCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_ctnm_CashCashEquivalentsAndAvailableForSaleDebtSecuritiesAmortizedCost_019df587-9a7a-7ea6-98bd-83fca8b6afca" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTax_019df588-00b5-7e1a-8aaa-ef8206f26140" xlink:href="ctnm-20260331.xsd#ctnm_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_ctnm_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTax_019df588-00b5-7e1a-8aaa-ef8206f26140" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTax_019df588-4704-7d12-bf9b-2d9bec6228de" xlink:href="ctnm-20260331.xsd#ctnm_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_ctnm_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTax_019df588-4704-7d12-bf9b-2d9bec6228de" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashCashEquivalentsAndAvailableForSaleDebtSecurities_019df588-92e0-7011-b00d-51148beae999" xlink:href="ctnm-20260331.xsd#ctnm_CashCashEquivalentsAndAvailableForSaleDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9e77-7711-9356-344590f2571d" xlink:to="loc_ctnm_CashCashEquivalentsAndAvailableForSaleDebtSecurities_019df588-92e0-7011-b00d-51148beae999" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CashEquivalentsandMarketableSecuritiesScheduleofCashEquivalentsandDebtSecuritiesAvailableforSaleUnrealizedLossPositionFairValueDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CashEquivalentsandMarketableSecuritiesScheduleofCashEquivalentsandDebtSecuritiesAvailableforSaleUnrealizedLossPositionFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CashEquivalentsandMarketableSecuritiesScheduleofCashEquivalentsandDebtSecuritiesAvailableforSaleUnrealizedLossPositionFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-750d-8e82-733d6e03cb93" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-750d-8e82-733d6e03cb93" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-700e-aa29-e23c86d2da71" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_019d02c4-9e77-750d-8e82-733d6e03cb93" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-700e-aa29-e23c86d2da71" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-700e-aa29-e23c86d2da71_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-700e-aa29-e23c86d2da71" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-700e-aa29-e23c86d2da71_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7314-965a-ce791acd7ee0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9e77-700e-aa29-e23c86d2da71" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7314-965a-ce791acd7ee0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_019d02c4-9e77-725d-a52d-7656192563b0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7314-965a-ce791acd7ee0" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_019d02c4-9e77-725d-a52d-7656192563b0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_019d02c4-9e77-7d0d-a744-987de9aaf2ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7314-965a-ce791acd7ee0" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_019d02c4-9e77-7d0d-a744-987de9aaf2ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_019d02c4-9f45-74bd-80ba-e8fd55761862" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7314-965a-ce791acd7ee0" xlink:to="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_019d02c4-9f45-74bd-80ba-e8fd55761862" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_YankeeDebtMember_019d90ac-4f27-728d-8e98-2a533430ffac" xlink:href="ctnm-20260331.xsd#ctnm_YankeeDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7314-965a-ce791acd7ee0" xlink:to="loc_ctnm_YankeeDebtMember_019d90ac-4f27-728d-8e98-2a533430ffac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_019d90ab-f47e-74bb-8347-e365cb004ee8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9e77-7314-965a-ce791acd7ee0" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_019d90ab-f47e-74bb-8347-e365cb004ee8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashEquivalentUnrealizedLossPosition_019dc4a5-1690-7877-80dd-2745b2dae9ff" xlink:href="ctnm-20260331.xsd#ctnm_CashEquivalentUnrealizedLossPosition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:to="loc_ctnm_CashEquivalentUnrealizedLossPosition_019dc4a5-1690-7877-80dd-2745b2dae9ff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CashEquivalentUnrealizedLossPositionAccumulatedLoss_019dc4a5-966f-7c98-915b-02690c56e1b9" xlink:href="ctnm-20260331.xsd#ctnm_CashEquivalentUnrealizedLossPositionAccumulatedLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:to="loc_ctnm_CashEquivalentUnrealizedLossPositionAccumulatedLoss_019dc4a5-966f-7c98-915b-02690c56e1b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019d02c4-9f45-785a-b7df-7d0eaafc8c30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_019d02c4-9f45-785a-b7df-7d0eaafc8c30" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019d02c4-9f45-7881-bc63-64c19d06049f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_019d02c4-9f45-7881-bc63-64c19d06049f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_DebtSecuritiesAvailableForSaleAndCashEquivalentsUnrealizedLossPosition_019de3f6-552a-796a-b1fd-be831f4efd88" xlink:href="ctnm-20260331.xsd#ctnm_DebtSecuritiesAvailableForSaleAndCashEquivalentsUnrealizedLossPosition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:to="loc_ctnm_DebtSecuritiesAvailableForSaleAndCashEquivalentsUnrealizedLossPosition_019de3f6-552a-796a-b1fd-be831f4efd88" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_DebtSecuritiesAvailableForSaleAndCashEquivalentsUnrealizedLossPositionAccumulatedLoss_019de3f6-c42d-7a7e-aa67-9373f04693f1" xlink:href="ctnm-20260331.xsd#ctnm_DebtSecuritiesAvailableForSaleAndCashEquivalentsUnrealizedLossPositionAccumulatedLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_019d02c4-9f45-7e7f-82cf-f1aebad97700" xlink:to="loc_ctnm_DebtSecuritiesAvailableForSaleAndCashEquivalentsUnrealizedLossPositionAccumulatedLoss_019de3f6-c42d-7a7e-aa67-9373f04693f1" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/FairValueMeasurementsScheduleofFairValueAssetsandLiabilitiesMeasuredonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-796c-ad96-6fa6bd7d9b26" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-7cde-83df-008aa3ac2f8f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-796c-ad96-6fa6bd7d9b26" xlink:to="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-7cde-83df-008aa3ac2f8f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d02c4-9f45-7287-a4fd-34a215cf5628" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-7cde-83df-008aa3ac2f8f" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d02c4-9f45-7287-a4fd-34a215cf5628" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d02c4-9f45-7287-a4fd-34a215cf5628_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d02c4-9f45-7287-a4fd-34a215cf5628" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d02c4-9f45-7287-a4fd-34a215cf5628_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d02c4-9f45-71b4-baeb-d664f231fe79" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_019d02c4-9f45-7287-a4fd-34a215cf5628" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d02c4-9f45-71b4-baeb-d664f231fe79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_019d02c4-9f45-75f4-b989-5d5bba8c8876" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d02c4-9f45-71b4-baeb-d664f231fe79" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_019d02c4-9f45-75f4-b989-5d5bba8c8876" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_019d02c4-9f45-78e7-8e00-b8323636a07a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d02c4-9f45-71b4-baeb-d664f231fe79" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_019d02c4-9f45-78e7-8e00-b8323636a07a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_019d02c4-9f45-7e86-a2ea-072a464c3a29" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_019d02c4-9f45-71b4-baeb-d664f231fe79" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_019d02c4-9f45-7e86-a2ea-072a464c3a29" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9f45-7378-b09e-6f256d0df3fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-7cde-83df-008aa3ac2f8f" xlink:to="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9f45-7378-b09e-6f256d0df3fc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7378-b09e-6f256d0df3fc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9f45-7378-b09e-6f256d0df3fc" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7378-b09e-6f256d0df3fc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_019d02c4-9f45-7378-b09e-6f256d0df3fc" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_019d02c4-9f45-7155-988f-623a9292a9eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_019d02c4-9f45-7155-988f-623a9292a9eb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_019d02c4-9f45-7b24-891c-02869fde26ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:to="loc_us-gaap_CertificatesOfDepositMember_019d02c4-9f45-7b24-891c-02869fde26ca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_019d02c4-9f45-7faf-9339-5cb93116bed0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_019d02c4-9f45-7faf-9339-5cb93116bed0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_019d02c4-9f45-7d59-977f-38a6313fec1a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:to="loc_us-gaap_CommercialPaperNotIncludedWithCashAndCashEquivalentsMember_019d02c4-9f45-7d59-977f-38a6313fec1a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_019d02c4-9f45-7f41-8ae5-52353da6e9b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:to="loc_us-gaap_ForeignGovernmentDebtSecuritiesMember_019d02c4-9f45-7f41-8ae5-52353da6e9b2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_019d02c4-9f45-7ea4-a7d3-02244d614d9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_019d02c4-9f45-7ebc-a96a-f13208d18eba" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_019d02c4-9f45-7ea4-a7d3-02244d614d9e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019ddd2a-07d3-7bc8-9817-5ef5f816cb6e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-7cde-83df-008aa3ac2f8f" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019ddd2a-07d3-7bc8-9817-5ef5f816cb6e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ddd2a-07d3-7bc8-9817-5ef5f816cb6e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019ddd2a-07d3-7bc8-9817-5ef5f816cb6e" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ddd2a-07d3-7bc8-9817-5ef5f816cb6e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ddd2a-07d3-781f-85a1-ec2dd0012f61" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019ddd2a-07d3-7bc8-9817-5ef5f816cb6e" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ddd2a-07d3-781f-85a1-ec2dd0012f61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_019dc4db-0b2d-7719-8957-25da9f735f31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ddd2a-07d3-781f-85a1-ec2dd0012f61" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_019dc4db-0b2d-7719-8957-25da9f735f31" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_OtherCashEquivalentsMember_019dc4db-0b2d-781b-9604-0ca4b3bd03c9" xlink:href="ctnm-20260331.xsd#ctnm_OtherCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019ddd2a-07d3-781f-85a1-ec2dd0012f61" xlink:to="loc_ctnm_OtherCashEquivalentsMember_019dc4db-0b2d-781b-9604-0ca4b3bd03c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019d6817-d653-782b-9af6-740dbbcede6a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-796c-ad96-6fa6bd7d9b26" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019d6817-d653-782b-9af6-740dbbcede6a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019d02c4-9f45-7ea0-b9c8-d509c27f7ac6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-796c-ad96-6fa6bd7d9b26" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019d02c4-9f45-7ea0-b9c8-d509c27f7ac6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019d02c4-9f45-7340-bb13-86b0053da301" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-796c-ad96-6fa6bd7d9b26" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_019d02c4-9f45-7340-bb13-86b0053da301" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#FairValueMeasurementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-77ac-9fd2-0c338fe61464" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-777e-907a-2bf01617724b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-77ac-9fd2-0c338fe61464" xlink:to="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-777e-907a-2bf01617724b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_019d02c4-9f45-7fa9-b579-f7dc7ae491e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationTable_019d02c4-9f45-777e-907a-2bf01617724b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_019d02c4-9f45-7fa9-b579-f7dc7ae491e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019d02c4-9f45-7fa9-b579-f7dc7ae491e5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019d02c4-9f45-7fa9-b579-f7dc7ae491e5" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019d02c4-9f45-7fa9-b579-f7dc7ae491e5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019d02c4-9f45-7b8f-aeb2-16cf9bd4320a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_019d02c4-9f45-7fa9-b579-f7dc7ae491e5" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019d02c4-9f45-7b8f-aeb2-16cf9bd4320a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_019d02c4-9f45-7b5a-9ce6-1fc8d0d36d18" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_019d02c4-9f45-7b8f-aeb2-16cf9bd4320a" xlink:to="loc_us-gaap_MoneyMarketFundsMember_019d02c4-9f45-7b5a-9ce6-1fc8d0d36d18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d02c4-9f45-78c5-850c-7dfb8f132476" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_019d02c4-9f45-77ac-9fd2-0c338fe61464" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d02c4-9f45-78c5-850c-7dfb8f132476" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#StockholdersEquityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7fe0-9949-84135f0f8305" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7fe0-9949-84135f0f8305" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-7832-bd7b-a360610721ea" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7fe0-9949-84135f0f8305" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-7832-bd7b-a360610721ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-7832-bd7b-a360610721ea_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-7832-bd7b-a360610721ea" xlink:to="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-7832-bd7b-a360610721ea_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-76e8-85e2-211398f5d3e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-7832-bd7b-a360610721ea" xlink:to="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-76e8-85e2-211398f5d3e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d68d0-74e3-787b-b2af-e1342abba72d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-76e8-85e2-211398f5d3e9" xlink:to="loc_us-gaap_CommonClassAMember_019d68d0-74e3-787b-b2af-e1342abba72d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019daac5-f7b5-7f41-ae44-841bd3da66a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-76e8-85e2-211398f5d3e9" xlink:to="loc_us-gaap_CommonClassBMember_019daac5-f7b5-7f41-ae44-841bd3da66a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_019d68d0-74e3-74a1-b7db-2e5d9cc37c44" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7fe0-9949-84135f0f8305" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_019d68d0-74e3-74a1-b7db-2e5d9cc37c44" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d68d0-74e3-74a1-b7db-2e5d9cc37c44_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019d68d0-74e3-74a1-b7db-2e5d9cc37c44" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d68d0-74e3-74a1-b7db-2e5d9cc37c44_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d68d0-74e3-7c5f-8993-43a291e58610" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_019d68d0-74e3-74a1-b7db-2e5d9cc37c44" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d68d0-74e3-7c5f-8993-43a291e58610" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_FollowOnOfferingMember_019d90d0-0957-7878-900b-c0dabe03ba33" xlink:href="ctnm-20260331.xsd#ctnm_FollowOnOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d68d0-74e3-7c5f-8993-43a291e58610" xlink:to="loc_ctnm_FollowOnOfferingMember_019d90d0-0957-7878-900b-c0dabe03ba33" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_AtTheMarketOfferingMember_019d68d0-74e3-75ea-a966-1c00119d3a10" xlink:href="ctnm-20260331.xsd#ctnm_AtTheMarketOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_019d68d0-74e3-7c5f-8993-43a291e58610" xlink:to="loc_ctnm_AtTheMarketOfferingMember_019d68d0-74e3-75ea-a966-1c00119d3a10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7882-b988-b68ca2ee3b2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7fe0-9949-84135f0f8305" xlink:to="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7882-b988-b68ca2ee3b2d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7882-b988-b68ca2ee3b2d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7882-b988-b68ca2ee3b2d" xlink:to="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7882-b988-b68ca2ee3b2d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019d68d0-74e3-78de-9a2f-59d096086249" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7882-b988-b68ca2ee3b2d" xlink:to="loc_us-gaap_PlanNameDomain_019d68d0-74e3-78de-9a2f-59d096086249" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_The2024EquityIncentivePlanMember_019d68d0-74e3-74fe-b7db-b12c29864064" xlink:href="ctnm-20260331.xsd#ctnm_The2024EquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019d68d0-74e3-78de-9a2f-59d096086249" xlink:to="loc_ctnm_The2024EquityIncentivePlanMember_019d68d0-74e3-74fe-b7db-b12c29864064" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_A2026InducementPlanMember_019d90d1-86ab-7c6d-81f2-64baf87aca68" xlink:href="ctnm-20260331.xsd#ctnm_A2026InducementPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019d68d0-74e3-78de-9a2f-59d096086249" xlink:to="loc_ctnm_A2026InducementPlanMember_019d90d1-86ab-7c6d-81f2-64baf87aca68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_019d68d0-74e3-7f98-84a0-51626404685d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7fe0-9949-84135f0f8305" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_019d68d0-74e3-7f98-84a0-51626404685d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_019d68d0-74e3-7f98-84a0-51626404685d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_019d68d0-74e3-7f98-84a0-51626404685d" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_019d68d0-74e3-7f98-84a0-51626404685d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_019d68d0-74e3-76b9-918e-fe41516a5a46" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_019d68d0-74e3-7f98-84a0-51626404685d" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_019d68d0-74e3-76b9-918e-fe41516a5a46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_A2024EmployeeStockPurchasePlanThe2024ESPPMember_019d68d6-5fd2-74e8-9a6f-2d9445fe3fc3" xlink:href="ctnm-20260331.xsd#ctnm_A2024EmployeeStockPurchasePlanThe2024ESPPMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_019d68d0-74e3-76b9-918e-fe41516a5a46" xlink:to="loc_ctnm_A2024EmployeeStockPurchasePlanThe2024ESPPMember_019d68d6-5fd2-74e8-9a6f-2d9445fe3fc3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CommonStockNumberOfVotes_019d68d0-74e3-7cee-a54c-f2bdcc1e098a" xlink:href="ctnm-20260331.xsd#ctnm_CommonStockNumberOfVotes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_ctnm_CommonStockNumberOfVotes_019d68d0-74e3-7cee-a54c-f2bdcc1e098a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019d68d5-67bb-7e9a-897d-0d6f7e364ece" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019d68d5-67bb-7e9a-897d-0d6f7e364ece" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019d90d5-8ab1-7f77-8f76-98b9360987eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_019d90d5-8ab1-7f77-8f76-98b9360987eb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_019d90d5-8ab1-7ceb-b2c3-99df91352115" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_019d90d5-8ab1-7ceb-b2c3-99df91352115" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_SaleOfStockSharesAuthorizedToIssuanceAmount_019d90d5-e695-7744-9672-965f956282b3" xlink:href="ctnm-20260331.xsd#ctnm_SaleOfStockSharesAuthorizedToIssuanceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_ctnm_SaleOfStockSharesAuthorizedToIssuanceAmount_019d90d5-e695-7744-9672-965f956282b3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d90d5-e695-74d6-938e-d8f7274f8a96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_019d90d5-e695-74d6-938e-d8f7274f8a96" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019d90d5-e695-740a-8749-43adfcd11157" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_019d90d5-e695-740a-8749-43adfcd11157" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019d90d5-8ab1-70b6-aa0c-b01645dc4fe8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_019d90d5-8ab1-70b6-aa0c-b01645dc4fe8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_019d90d6-c10a-797f-8bf8-a33ea51128fb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_019d90d6-c10a-797f-8bf8-a33ea51128fb" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019d90d6-dc66-72e1-8546-4873bc6c455b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_019d90d6-dc66-72e1-8546-4873bc6c455b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_019d90d6-fb55-73ec-aa72-2940880a5ff1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_019d90d6-fb55-73ec-aa72-2940880a5ff1" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019d90d6-fb55-747a-a4c3-433ada7ec7b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_019d90d6-fb55-747a-a4c3-433ada7ec7b7" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPSharesContributedToESOP_019d90d7-2fec-7433-b74e-4320a46899e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOwnershipPlanESOPSharesContributedToESOP"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7c7d-bb07-296244660a63" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPSharesContributedToESOP_019d90d7-2fec-7433-b74e-4320a46899e5" xlink:type="arc" order="12"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/StockholdersEquityScheduleofCommonStockOutstandingRollForwardDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#StockholdersEquityScheduleofCommonStockOutstandingRollForwardDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/StockholdersEquityScheduleofCommonStockOutstandingRollForwardDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7eec-8777-faa1c7303281" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7033-a0a2-893934fa580f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7eec-8777-faa1c7303281" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7033-a0a2-893934fa580f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-71f1-884a-6d5c4053ab74" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7033-a0a2-893934fa580f" xlink:to="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-71f1-884a-6d5c4053ab74" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-71f1-884a-6d5c4053ab74_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-71f1-884a-6d5c4053ab74" xlink:to="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-71f1-884a-6d5c4053ab74_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-79aa-b453-41dacec22ea1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_019d68d0-74e3-71f1-884a-6d5c4053ab74" xlink:to="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-79aa-b453-41dacec22ea1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_019d68d0-74e3-7387-ac5b-dff59cb8ffcd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-79aa-b453-41dacec22ea1" xlink:to="loc_us-gaap_CommonClassAMember_019d68d0-74e3-7387-ac5b-dff59cb8ffcd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_019d68d0-74e3-78b1-8de6-bfaa91ff699b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonClassBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_019d68d0-74e3-79aa-b453-41dacec22ea1" xlink:to="loc_us-gaap_CommonClassBMember_019d68d0-74e3-78b1-8de6-bfaa91ff699b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d68d0-74e3-7f8b-99dc-d20a1b489399" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-7eec-8777-faa1c7303281" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d68d0-74e3-7f8b-99dc-d20a1b489399" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_019d68d0-74e3-7d25-8af9-0fd2692f7441" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d68d0-74e3-7f8b-99dc-d20a1b489399" xlink:to="loc_us-gaap_SharesOutstanding_019d68d0-74e3-7d25-8af9-0fd2692f7441" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019d68d0-74e3-70ff-80a7-d7dd94169a37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d68d0-74e3-7f8b-99dc-d20a1b489399" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_019d68d0-74e3-70ff-80a7-d7dd94169a37" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019d68d0-74e3-7beb-8cdc-0e62d43af31d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_019d68d0-74e3-7f8b-99dc-d20a1b489399" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_019d68d0-74e3-7beb-8cdc-0e62d43af31d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_019d68d0-74e3-7723-9ecf-146b0f0325d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharesOutstanding"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/StockholdersEquityScheduleofCommonStockReservedforFutureIssuanceDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#StockholdersEquityScheduleofCommonStockReservedforFutureIssuanceDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/StockholdersEquityScheduleofCommonStockReservedforFutureIssuanceDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_019d68d0-74e3-7f22-8f1e-4e666b634276" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_019d68d0-74e3-7c1c-8c2a-e79c1d4c6ebb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d68d0-74e3-7f22-8f1e-4e666b634276" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_019d68d0-74e3-7c1c-8c2a-e79c1d4c6ebb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-71ed-8fd3-0a7a20ca36b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019d68d0-74e3-7c1c-8c2a-e79c1d4c6ebb" xlink:to="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-71ed-8fd3-0a7a20ca36b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-71ed-8fd3-0a7a20ca36b9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-71ed-8fd3-0a7a20ca36b9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-71ed-8fd3-0a7a20ca36b9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-7412-ae20-a6f23059624b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-71ed-8fd3-0a7a20ca36b9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-7412-ae20-a6f23059624b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019d68d0-74e3-7450-880e-f27c991b14de" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-7412-ae20-a6f23059624b" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019d68d0-74e3-7450-880e-f27c991b14de" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7b06-bc7b-89ae326bdc50" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019d68d0-74e3-7c1c-8c2a-e79c1d4c6ebb" xlink:to="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7b06-bc7b-89ae326bdc50" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7b06-bc7b-89ae326bdc50_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7b06-bc7b-89ae326bdc50" xlink:to="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7b06-bc7b-89ae326bdc50_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7ceb-b532-177c4451f316" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_019d68d0-74e3-7b06-bc7b-89ae326bdc50" xlink:to="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7ceb-b532-177c4451f316" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_The2024EquityIncentivePlanMember_019d68d0-74e3-78b4-93cb-c2222b0492e9" xlink:href="ctnm-20260331.xsd#ctnm_The2024EquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7ceb-b532-177c4451f316" xlink:to="loc_ctnm_The2024EquityIncentivePlanMember_019d68d0-74e3-78b4-93cb-c2222b0492e9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_A2024EmployeeStockPurchasePlanThe2024ESPPMember_019d68d2-e8dc-7b94-b91e-be4e32eb4636" xlink:href="ctnm-20260331.xsd#ctnm_A2024EmployeeStockPurchasePlanThe2024ESPPMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7ceb-b532-177c4451f316" xlink:to="loc_ctnm_A2024EmployeeStockPurchasePlanThe2024ESPPMember_019d68d2-e8dc-7b94-b91e-be4e32eb4636" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_A2026InducementPlanMember_019d90cf-6f7b-78a4-b1fb-47775b7d1dd7" xlink:href="ctnm-20260331.xsd#ctnm_A2026InducementPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_019d68d0-74e3-7ceb-b532-177c4451f316" xlink:to="loc_ctnm_A2026InducementPlanMember_019d90cf-6f7b-78a4-b1fb-47775b7d1dd7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_019d68d0-74e3-7325-b5c2-be4ea3dd2252" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_019d68d0-74e3-7c1c-8c2a-e79c1d4c6ebb" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_019d68d0-74e3-7325-b5c2-be4ea3dd2252" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019d68d0-74e3-7325-b5c2-be4ea3dd2252_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019d68d0-74e3-7325-b5c2-be4ea3dd2252" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019d68d0-74e3-7325-b5c2-be4ea3dd2252_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_019d68d0-74e3-7706-9274-9fe5fa6a0ac1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_019d68d0-74e3-7325-b5c2-be4ea3dd2252" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_019d68d0-74e3-7706-9274-9fe5fa6a0ac1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CommonStockWarrantMember_019d68d0-74e3-7e2a-ad9f-b613e793cc04" xlink:href="ctnm-20260331.xsd#ctnm_CommonStockWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_019d68d0-74e3-7706-9274-9fe5fa6a0ac1" xlink:to="loc_ctnm_CommonStockWarrantMember_019d68d0-74e3-7e2a-ad9f-b613e793cc04" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019d68d0-74e3-7ff6-9bcf-089edba6fa22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_019d68d0-74e3-7f22-8f1e-4e666b634276" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_019d68d0-74e3-7ff6-9bcf-089edba6fa22" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/StockholdersEquityScheduleofFairValueofStockOptionswasEstimatedusingWeightedaverageAssumptionsDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#StockholdersEquityScheduleofFairValueofStockOptionswasEstimatedusingWeightedaverageAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/StockholdersEquityScheduleofFairValueofStockOptionswasEstimatedusingWeightedaverageAssumptionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-79e2-a45a-d109b0885e94" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-72f3-a60a-0e9c9451c2bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-79e2-a45a-d109b0885e94" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-72f3-a60a-0e9c9451c2bd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-708b-9d43-17bac9111a48" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-72f3-a60a-0e9c9451c2bd" xlink:to="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-708b-9d43-17bac9111a48" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-708b-9d43-17bac9111a48_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-708b-9d43-17bac9111a48" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-708b-9d43-17bac9111a48_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-7c5e-9a16-80ce203b9a90" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_019d68d0-74e3-708b-9d43-17bac9111a48" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-7c5e-9a16-80ce203b9a90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019d68d0-74e3-7e59-8817-6159802f673c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_019d68d0-74e3-7c5e-9a16-80ce203b9a90" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019d68d0-74e3-7e59-8817-6159802f673c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019d68d0-74e3-7421-863c-1215908b7c01" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-79e2-a45a-d109b0885e94" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_019d68d0-74e3-7421-863c-1215908b7c01" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_019d68d0-74e3-7132-bc1e-e98a1280a5a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-79e2-a45a-d109b0885e94" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_019d68d0-74e3-7132-bc1e-e98a1280a5a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_019d68d0-74e3-70b3-b276-87d8ff919f57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-79e2-a45a-d109b0885e94" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_019d68d0-74e3-70b3-b276-87d8ff919f57" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_019d68d0-74e3-79bd-b29e-94b2d45f4e30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-79e2-a45a-d109b0885e94" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_019d68d0-74e3-79bd-b29e-94b2d45f4e30" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/StockholdersEquityScheduleofShareBasedPaymentArrangementExpensedandCapitalizedAmountDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#StockholdersEquityScheduleofShareBasedPaymentArrangementExpensedandCapitalizedAmountDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/StockholdersEquityScheduleofShareBasedPaymentArrangementExpensedandCapitalizedAmountDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-755a-9878-9db8a8bbee42" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7dd8-a378-be00347ac41a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-755a-9878-9db8a8bbee42" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7dd8-a378-be00347ac41a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_019d68d0-74e3-7289-9eda-e804988c98aa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_019d68d0-74e3-7dd8-a378-be00347ac41a" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_019d68d0-74e3-7289-9eda-e804988c98aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019d68d0-74e3-7289-9eda-e804988c98aa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019d68d0-74e3-7289-9eda-e804988c98aa" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019d68d0-74e3-7289-9eda-e804988c98aa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_019d68d0-74e3-73b6-bf47-965ec3a77cac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_019d68d0-74e3-7289-9eda-e804988c98aa" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_019d68d0-74e3-73b6-bf47-965ec3a77cac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019d68d0-74e3-79fa-b851-0d965829d021" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019d68d0-74e3-73b6-bf47-965ec3a77cac" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_019d68d0-74e3-79fa-b851-0d965829d021" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019d68d0-74e3-77e5-a606-287175c9ceb5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_019d68d0-74e3-73b6-bf47-965ec3a77cac" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_019d68d0-74e3-77e5-a606-287175c9ceb5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019d68d0-74e3-79ee-8efc-60a10e9a4be8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_019d68d0-74e3-755a-9878-9db8a8bbee42" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019d68d0-74e3-79ee-8efc-60a10e9a4be8" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/LicenseAgreementDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#LicenseAgreementDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/LicenseAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d684b-efa2-7978-bd9a-accebd204cc2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019d684b-efa2-7395-b1d4-9d2b3ad3d388" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d684b-efa2-7978-bd9a-accebd204cc2" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019d684b-efa2-7395-b1d4-9d2b3ad3d388" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019d684b-efa2-711a-818b-9cb9d09e9aa6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_019d684b-efa2-7395-b1d4-9d2b3ad3d388" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019d684b-efa2-711a-818b-9cb9d09e9aa6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d684b-efa2-711a-818b-9cb9d09e9aa6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019d684b-efa2-711a-818b-9cb9d09e9aa6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d684b-efa2-711a-818b-9cb9d09e9aa6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d684b-efa2-77b8-a64e-4db3b4a1bb62" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019d684b-efa2-711a-818b-9cb9d09e9aa6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d684b-efa2-77b8-a64e-4db3b4a1bb62" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_JJLicenseAgreementMember_019d684b-efa2-7890-8e69-4c8869fe9de3" xlink:href="ctnm-20260331.xsd#ctnm_JJLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019d684b-efa2-77b8-a64e-4db3b4a1bb62" xlink:to="loc_ctnm_JJLicenseAgreementMember_019d684b-efa2-7890-8e69-4c8869fe9de3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_UpfrontPaymentReceived_019d684b-efa2-7d41-8041-fae45848c95c" xlink:href="ctnm-20260331.xsd#ctnm_UpfrontPaymentReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d684b-efa2-7978-bd9a-accebd204cc2" xlink:to="loc_ctnm_UpfrontPaymentReceived_019d684b-efa2-7d41-8041-fae45848c95c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNet_019d684b-efa2-779b-bcb5-a0ffe5c9736e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerAssetNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_019d684b-efa2-7978-bd9a-accebd204cc2" xlink:to="loc_us-gaap_ContractWithCustomerAssetNet_019d684b-efa2-779b-bcb5-a0ffe5c9736e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_019d6853-6f2f-7993-9bda-33b7b5dfc3c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_019d6853-6f2f-7e14-8c41-13076255fbfc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_019d6853-6f2f-7993-9bda-33b7b5dfc3c8" xlink:to="loc_us-gaap_LossContingenciesTable_019d6853-6f2f-7e14-8c41-13076255fbfc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-78de-af58-869491a95c9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_019d6853-6f2f-7e14-8c41-13076255fbfc" xlink:to="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-78de-af58-869491a95c9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-78de-af58-869491a95c9d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-78de-af58-869491a95c9d" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-78de-af58-869491a95c9d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-78be-9e98-45c975370d88" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-78de-af58-869491a95c9d" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-78be-9e98-45c975370d88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_GeneralAtomicsCourtLeaseMember_019d6853-6f2f-7214-ab50-1b6490388740" xlink:href="ctnm-20260331.xsd#ctnm_GeneralAtomicsCourtLeaseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-78be-9e98-45c975370d88" xlink:to="loc_ctnm_GeneralAtomicsCourtLeaseMember_019d6853-6f2f-7214-ab50-1b6490388740" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_019d6853-6f2f-7604-b28b-684d1270a2aa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019d6853-6f2f-7993-9bda-33b7b5dfc3c8" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_019d6853-6f2f-7604-b28b-684d1270a2aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019d6853-6f2f-7ffe-8da4-bd5fb0c4a2d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019d6853-6f2f-7993-9bda-33b7b5dfc3c8" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_019d6853-6f2f-7ffe-8da4-bd5fb0c4a2d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d6859-7197-7ace-aaf6-ac36ac730787" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019d6853-6f2f-7993-9bda-33b7b5dfc3c8" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d6859-7197-7ace-aaf6-ac36ac730787" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019d6859-7197-78da-b1f6-9ce15aabff2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019d6853-6f2f-7993-9bda-33b7b5dfc3c8" xlink:to="loc_us-gaap_OperatingLeaseLiability_019d6859-7197-78da-b1f6-9ce15aabff2a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_019d6853-6f2f-78b9-9f2b-e9f4bf196559" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_019d6853-6f2f-7993-9bda-33b7b5dfc3c8" xlink:to="loc_us-gaap_OperatingLeaseExpense_019d6853-6f2f-78b9-9f2b-e9f4bf196559" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/CommitmentsandContingenciesScheduleofLesseeOperatingLeaseLiabilityFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#CommitmentsandContingenciesScheduleofLesseeOperatingLeaseLiabilityFutureMinimumLeasePaymentsDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/CommitmentsandContingenciesScheduleofLesseeOperatingLeaseLiabilityFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_019d6853-6f2f-7936-a662-61af6399d488" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_019d6853-6f2f-7936-a662-61af6399d488" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-745a-8635-bacdcf28ab2e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_019d6853-6f2f-7936-a662-61af6399d488" xlink:to="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-745a-8635-bacdcf28ab2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-745a-8635-bacdcf28ab2e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-745a-8635-bacdcf28ab2e" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-745a-8635-bacdcf28ab2e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-7882-b00d-aa6e6cad87a2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LeaseContractualTermAxis_019d6853-6f2f-745a-8635-bacdcf28ab2e" xlink:to="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-7882-b00d-aa6e6cad87a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_NewLeaseAgreementMember_019d6853-6f2f-7b33-8332-0f2db606cc82" xlink:href="ctnm-20260331.xsd#ctnm_NewLeaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeaseContractualTermDomain_019d6853-6f2f-7882-b00d-aa6e6cad87a2" xlink:to="loc_ctnm_NewLeaseAgreementMember_019d6853-6f2f-7b33-8332-0f2db606cc82" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019d6855-1154-765e-b537-4d8b45661f54" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019d6855-1154-765e-b537-4d8b45661f54" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019d6853-6f2f-7640-81dc-a3ec84e3fcf5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019d6853-6f2f-7640-81dc-a3ec84e3fcf5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019d6853-6f2f-722a-9469-1dc21946bff5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019d6853-6f2f-722a-9469-1dc21946bff5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019d6853-6f2f-7c49-aaba-d0bfad7c9ff8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019d6853-6f2f-7c49-aaba-d0bfad7c9ff8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d6853-6f2f-7cb0-9bf0-2d6da07723e6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d6853-6f2f-7cb0-9bf0-2d6da07723e6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019d6853-6f2f-7d2e-9f1d-0961ee2e0c8a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019d6853-6f2f-7d2e-9f1d-0961ee2e0c8a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019d6853-6f2f-7856-8fca-715b7db86b17" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_OperatingLeaseLiability_019d6853-6f2f-7856-8fca-715b7db86b17" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d6853-6f2f-7246-b1ad-c5c0062cee3d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d6853-6f2f-7246-b1ad-c5c0062cee3d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d6853-6f2f-7a60-86d6-b25354d0d52e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_019d6853-6f2f-77bb-96cb-a12bd8f0c98c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d6853-6f2f-7a60-86d6-b25354d0d52e" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/NetLossPerShareDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#NetLossPerShareDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/NetLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019d02c4-9f45-7269-9521-8808ce7a3488" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019d02c4-9f45-7673-9a66-4d00de6a27fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019d02c4-9f45-7269-9521-8808ce7a3488" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019d02c4-9f45-7673-9a66-4d00de6a27fd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019d02c4-9f45-7e7b-a835-a20d4e2c8a7b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_019d02c4-9f45-7673-9a66-4d00de6a27fd" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019d02c4-9f45-7e7b-a835-a20d4e2c8a7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019d02c4-9f45-7e7b-a835-a20d4e2c8a7b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019d02c4-9f45-7e7b-a835-a20d4e2c8a7b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019d02c4-9f45-7e7b-a835-a20d4e2c8a7b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019d02c4-9f45-788e-8200-3a8d5977122b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_019d02c4-9f45-7e7b-a835-a20d4e2c8a7b" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019d02c4-9f45-788e-8200-3a8d5977122b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_019d02c4-9f45-7d7b-92d1-2544ac17ed30" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019d02c4-9f45-788e-8200-3a8d5977122b" xlink:to="loc_us-gaap_EmployeeStockOptionMember_019d02c4-9f45-7d7b-92d1-2544ac17ed30" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CommonStockWarrantMember_019d02c4-9f45-7ec6-ae95-81b7da80240b" xlink:href="ctnm-20260331.xsd#ctnm_CommonStockWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_019d02c4-9f45-788e-8200-3a8d5977122b" xlink:to="loc_ctnm_CommonStockWarrantMember_019d02c4-9f45-7ec6-ae95-81b7da80240b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019d02c4-9f45-7207-8cb0-bd93e8abf93a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_019d02c4-9f45-7269-9521-8808ce7a3488" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_019d02c4-9f45-7207-8cb0-bd93e8abf93a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.contineum-tx.com/role/SegmentReportingScheduleofSegmentReportingInformationbySegmentDetails" xlink:type="simple" xlink:href="ctnm-20260331.xsd#SegmentReportingScheduleofSegmentReportingInformationbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.contineum-tx.com/role/SegmentReportingScheduleofSegmentReportingInformationbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_019d6871-6069-73a7-a59a-6d7735e2fe4f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d6871-6069-765b-a497-8998e6336a15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d6871-6069-73a7-a59a-6d7735e2fe4f" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d6871-6069-765b-a497-8998e6336a15" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_019d6871-6069-75c7-9156-620d603755b0" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d6871-6069-765b-a497-8998e6336a15" xlink:to="loc_srt_ProductOrServiceAxis_019d6871-6069-75c7-9156-620d603755b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019d6871-6069-75c7-9156-620d603755b0_default" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_019d6871-6069-75c7-9156-620d603755b0" xlink:to="loc_srt_ProductsAndServicesDomain_019d6871-6069-75c7-9156-620d603755b0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_019d6871-6069-76aa-bea8-911b515f56d6" xlink:href="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_019d6871-6069-75c7-9156-620d603755b0" xlink:to="loc_srt_ProductsAndServicesDomain_019d6871-6069-76aa-bea8-911b515f56d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_PIPE791Member_019d6871-6069-70f2-be7b-4051fd1c1a7f" xlink:href="ctnm-20260331.xsd#ctnm_PIPE791Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019d6871-6069-76aa-bea8-911b515f56d6" xlink:to="loc_ctnm_PIPE791Member_019d6871-6069-70f2-be7b-4051fd1c1a7f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_PIPE307Member_019d6871-6069-73f4-a0e5-f6e780dd09b0" xlink:href="ctnm-20260331.xsd#ctnm_PIPE307Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019d6871-6069-76aa-bea8-911b515f56d6" xlink:to="loc_ctnm_PIPE307Member_019d6871-6069-73f4-a0e5-f6e780dd09b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_CTX343Member_019d6871-6069-7611-aa2a-4d87f322965a" xlink:href="ctnm-20260331.xsd#ctnm_CTX343Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_019d6871-6069-76aa-bea8-911b515f56d6" xlink:to="loc_ctnm_CTX343Member_019d6871-6069-7611-aa2a-4d87f322965a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NatureOfExpenseAxis_019d6871-6069-75f9-b726-15956f48e4fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NatureOfExpenseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d6871-6069-765b-a497-8998e6336a15" xlink:to="loc_us-gaap_NatureOfExpenseAxis_019d6871-6069-75f9-b726-15956f48e4fe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019d6871-6069-75f9-b726-15956f48e4fe_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterimPeriodCostsNotAllocableDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_NatureOfExpenseAxis_019d6871-6069-75f9-b726-15956f48e4fe" xlink:to="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019d6871-6069-75f9-b726-15956f48e4fe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019d6871-6069-7780-a951-7d698f1ac7d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterimPeriodCostsNotAllocableDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_NatureOfExpenseAxis_019d6871-6069-75f9-b726-15956f48e4fe" xlink:to="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019d6871-6069-7780-a951-7d698f1ac7d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_DiscoveryProgramsMember_019d6871-6069-71db-b5df-4be93c4cb88f" xlink:href="ctnm-20260331.xsd#ctnm_DiscoveryProgramsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019d6871-6069-7780-a951-7d698f1ac7d0" xlink:to="loc_ctnm_DiscoveryProgramsMember_019d6871-6069-71db-b5df-4be93c4cb88f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_UnallocatedInternalCostsMember_019d6871-6069-75cb-a3df-7a6bb7bdae91" xlink:href="ctnm-20260331.xsd#ctnm_UnallocatedInternalCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InterimPeriodCostsNotAllocableDomain_019d6871-6069-7780-a951-7d698f1ac7d0" xlink:to="loc_ctnm_UnallocatedInternalCostsMember_019d6871-6069-75cb-a3df-7a6bb7bdae91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_019d6871-6069-772f-9c13-d093524ca057" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_019d6871-6069-765b-a497-8998e6336a15" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_019d6871-6069-772f-9c13-d093524ca057" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019d6871-6069-772f-9c13-d093524ca057_default" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019d6871-6069-772f-9c13-d093524ca057" xlink:to="loc_us-gaap_SegmentDomain_019d6871-6069-772f-9c13-d093524ca057_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_019d6871-6069-7342-8064-9d405dcb80c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_019d6871-6069-772f-9c13-d093524ca057" xlink:to="loc_us-gaap_SegmentDomain_019d6871-6069-7342-8064-9d405dcb80c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ctnm_ReportableSegmentMember_019d6871-6069-74a8-9045-d7e8d14eab97" xlink:href="ctnm-20260331.xsd#ctnm_ReportableSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_019d6871-6069-7342-8064-9d405dcb80c5" xlink:to="loc_ctnm_ReportableSegmentMember_019d6871-6069-74a8-9045-d7e8d14eab97" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_019d6871-6069-73a7-a59a-6d7735e2fe4f" xlink:to="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019d6871-6069-7686-905e-c1e61ba2bfaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019d6871-6069-7686-905e-c1e61ba2bfaf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019d6871-6069-7f23-91d9-e3071a279744" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019d6871-6069-7f23-91d9-e3071a279744" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019d90e0-3c73-716c-bf8e-fb61c4bea491" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:to="loc_us-gaap_OperatingExpenses_019d90e0-3c73-716c-bf8e-fb61c4bea491" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019d90e0-3c73-7430-aa70-636363b4d310" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:to="loc_us-gaap_OperatingIncomeLoss_019d90e0-3c73-7430-aa70-636363b4d310" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019d68f0-4277-73ee-a1ff-c65b32aa9b9a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019d68f0-4277-73ee-a1ff-c65b32aa9b9a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019d6871-6069-7810-a643-8858913b0815" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019d6871-6069-7810-a643-8858913b0815" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019d6871-6069-7690-87f0-b7223d228c34" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReconciliationFromSegmentTotalsToConsolidatedAbstract_019d6871-6069-7fc5-8ebe-28899bf05969" xlink:to="loc_us-gaap_NetIncomeLoss_019d6871-6069-7690-87f0-b7223d228c34" xlink:type="arc" order="7"/>
  </link:definitionLink>
</link:linkbase>
