144/A 0001958244-26-000251 0001805812 XXXXXXXX LIVE 0001579428 Axsome Therapeutics, Inc. 001-37635 One World Trade Center 29th Floor New York NY 10007 1-212-332-3241 Mark Jacobson Officer Class A Common Goldman Sachs & Co. LLC 200 West Street New York NY 10282 4517 1010452.9 51439952 05/04/2026 NASD Class A Common 05/04/2026 Acquired as compensation -- Stock Options Issuer N 4517 05/04/2026 Compensation -- Cashless exercise / same-day sale N Mark Jacobson One World Trade Center 29th Floor New York NY 10007 Class A Common 02/26/2026 15378 2505062.36 Mark Jacobson One World Trade Center 29th Floor New York NY 10007 Class A Common 02/26/2026 20000 3221848 Amendment to the Form 144 filed on May 4, 2026, which inadvertently omitted the Date of Plan Adoption. 05/05/2026 11/10/2025 Goldman Sachs & Co. LLC on behalf of Mark Jacobson