<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019cd33b-55e2-7686-a45d-3e64ec40f088,g:5cd5bcae-d38e-4438-9e12-43823d2921f9-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://arcusbio.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="rcus-20260331.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019cd33b-5697-7292-ad07-87399312528e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019cd33b-5697-7120-a40b-eb478a171dcc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5697-7292-ad07-87399312528e" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019cd33b-5697-7120-a40b-eb478a171dcc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019cd33b-5697-7709-82a0-f39dfce86eff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5697-7292-ad07-87399312528e" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019cd33b-5697-7709-82a0-f39dfce86eff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019cd33b-5697-7328-a43f-ad403ce91760" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019cd33b-5697-7a4e-95ae-eabc7e89329d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019cd33b-5697-7328-a43f-ad403ce91760" xlink:to="loc_us-gaap_OperatingIncomeLoss_019cd33b-5697-7a4e-95ae-eabc7e89329d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019cd33b-5697-7809-9720-21f9b8472467" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019cd33b-5697-7328-a43f-ad403ce91760" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019cd33b-5697-7809-9720-21f9b8472467" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019cd33b-5697-71c1-8e0e-cb3f431a351a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019cd33b-5697-7763-b07f-d4ec73fe21a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019cd33b-5697-71c1-8e0e-cb3f431a351a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019cd33b-5697-7763-b07f-d4ec73fe21a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019cd33b-5697-7bb9-9d52-5da63fe3b146" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019cd33b-5697-71c1-8e0e-cb3f431a351a" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019cd33b-5697-7bb9-9d52-5da63fe3b146" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019cd33b-5697-702f-9d30-2d5a9b19faaf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_InterestAndOtherIncomeExpenseNonoperatingNet_019cd33b-5697-72b7-b509-47f0fdc58998" xlink:href="rcus-20260331.xsd#rcus_InterestAndOtherIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019cd33b-5697-702f-9d30-2d5a9b19faaf" xlink:to="loc_rcus_InterestAndOtherIncomeExpenseNonoperatingNet_019cd33b-5697-72b7-b509-47f0fdc58998" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019cd33b-5697-7322-8b06-9b9dbbf725c5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019cd33b-5697-702f-9d30-2d5a9b19faaf" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019cd33b-5697-7322-8b06-9b9dbbf725c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019cd33b-5697-73b4-96c7-adf608c33bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019cd33b-5697-7026-9183-f85a343546cd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019cd33b-5697-73b4-96c7-adf608c33bf8" xlink:to="loc_us-gaap_OperatingExpenses_019cd33b-5697-7026-9183-f85a343546cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019cd33b-5697-72b6-a6b8-9ea348f20ee8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019cd33b-5697-73b4-96c7-adf608c33bf8" xlink:to="loc_us-gaap_Revenues_019cd33b-5697-72b6-a6b8-9ea348f20ee8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CondensedConsolidatedStatementsofComprehensiveLoss" xlink:type="simple" xlink:href="rcus-20260331.xsd#CondensedConsolidatedStatementsofComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CondensedConsolidatedStatementsofComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019cd33b-5697-7ad5-bd0e-c3e851d3e7fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019cd33b-5697-7a31-9069-46fbc5716acc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019cd33b-5697-7ad5-bd0e-c3e851d3e7fa" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019cd33b-5697-7a31-9069-46fbc5716acc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019cd33b-5697-7d8d-b302-e0958ef2ac19" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019cd33b-5697-7ad5-bd0e-c3e851d3e7fa" xlink:to="loc_us-gaap_NetIncomeLoss_019cd33b-5697-7d8d-b302-e0958ef2ac19" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="rcus-20260331.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019cd33b-5697-7ccb-a29f-87df85b69a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019cd33b-5697-7792-bc4b-0563b42fd08e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019cd33b-5697-7ccb-a29f-87df85b69a3a" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019cd33b-5697-7792-bc4b-0563b42fd08e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019cd33b-5697-77e3-ba4d-99e0961384f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019cd33b-5697-7ccb-a29f-87df85b69a3a" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019cd33b-5697-77e3-ba4d-99e0961384f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019cd33b-5697-760a-abd0-ad500d032193" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019cd33b-5697-7ccb-a29f-87df85b69a3a" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_019cd33b-5697-760a-abd0-ad500d032193" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cd33b-5697-7656-bc58-106bf8eca5bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019cd33b-5697-7ccb-a29f-87df85b69a3a" xlink:to="loc_us-gaap_StockholdersEquity_019cd33b-5697-7656-bc58-106bf8eca5bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019cd33b-5697-7807-84ce-2a968ec82252" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019cd33b-5697-7ccb-a29f-87df85b69a3a" xlink:to="loc_us-gaap_LongTermDebt_019cd33b-5697-7807-84ce-2a968ec82252" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019cd33b-5697-780e-b531-70e67c36057f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019cd33b-5697-7ccb-a29f-87df85b69a3a" xlink:to="loc_us-gaap_LiabilitiesCurrent_019cd33b-5697-780e-b531-70e67c36057f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019cd33b-5697-7b76-897b-4a1ea4d55145" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019cd33b-5697-7f7f-b10d-dc2324f50fb7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019cd33b-5697-7b76-897b-4a1ea4d55145" xlink:to="loc_us-gaap_AssetsCurrent_019cd33b-5697-7f7f-b10d-dc2324f50fb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019cd33b-5697-713f-ac04-53d32225a19c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019cd33b-5697-7b76-897b-4a1ea4d55145" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019cd33b-5697-713f-ac04-53d32225a19c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019cd33b-5697-779a-b6d3-f193fa4d0e61" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019cd33b-5697-7b76-897b-4a1ea4d55145" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019cd33b-5697-779a-b6d3-f193fa4d0e61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019cd33b-5697-7a00-b1f9-2c05484630f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019cd33b-5697-7b76-897b-4a1ea4d55145" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019cd33b-5697-7a00-b1f9-2c05484630f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019cd33b-5697-7322-9aeb-82568da42249" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019cd33b-5697-7516-acfd-826c1a8c6d31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019cd33b-5697-7322-9aeb-82568da42249" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019cd33b-5697-7516-acfd-826c1a8c6d31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019cd33b-5697-78bf-8c87-7f0d43932243" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019cd33b-5697-7322-9aeb-82568da42249" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019cd33b-5697-78bf-8c87-7f0d43932243" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019cd33b-5697-74d5-b40f-2778277808bf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019cd33b-5697-7322-9aeb-82568da42249" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019cd33b-5697-74d5-b40f-2778277808bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019cd33b-5697-7a3f-97bc-03a7c620e77d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019cd33b-5697-7322-9aeb-82568da42249" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019cd33b-5697-7a3f-97bc-03a7c620e77d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019cd33b-5697-7cc4-b8ae-b026867a0956" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019cd33b-5697-76ba-aa91-877af08234ee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019cd33b-5697-7cc4-b8ae-b026867a0956" xlink:to="loc_us-gaap_CommonStockValue_019cd33b-5697-76ba-aa91-877af08234ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019cd33b-5697-700a-a9e5-4cedcbc58acb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019cd33b-5697-7cc4-b8ae-b026867a0956" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019cd33b-5697-700a-a9e5-4cedcbc58acb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019db20d-6e56-77e4-840f-81835b6c15d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019cd33b-5697-7cc4-b8ae-b026867a0956" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019db20d-6e56-77e4-840f-81835b6c15d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019cd33b-5697-7434-938b-a3a3442c2498" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5697-7923-884d-9e82068dda23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019cd33b-5697-7434-938b-a3a3442c2498" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5697-7923-884d-9e82068dda23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019cd33b-5697-7601-ab07-71d6c4abe6bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019cd33b-5697-7434-938b-a3a3442c2498" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019cd33b-5697-7601-ab07-71d6c4abe6bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019cd33b-5697-7f8d-9306-d10a220a9815" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019cd33b-5697-7434-938b-a3a3442c2498" xlink:to="loc_us-gaap_AccountsPayableCurrent_019cd33b-5697-7f8d-9306-d10a220a9815" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="rcus-20260331.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019cd33b-5741-77ec-947f-92d269a26167" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5741-7e50-afad-9a6ffe760c40" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019cd33b-5741-77ec-947f-92d269a26167" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5741-7e50-afad-9a6ffe760c40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019cd33b-5741-7563-bd56-c780ba6ba29e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019cd33b-5741-77ec-947f-92d269a26167" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019cd33b-5741-7563-bd56-c780ba6ba29e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019cd33b-5741-79b1-b44e-55f8b0c3735d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019cd33b-5741-77ec-947f-92d269a26167" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019cd33b-5741-79b1-b44e-55f8b0c3735d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019cd33b-5697-7919-9843-a82cd03dec12" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_ProceedsFromMaturityOfMarketableSecurities_019cd33b-5697-7086-a1b6-886eccafce26" xlink:href="rcus-20260331.xsd#rcus_ProceedsFromMaturityOfMarketableSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019cd33b-5697-7919-9843-a82cd03dec12" xlink:to="loc_rcus_ProceedsFromMaturityOfMarketableSecurities_019cd33b-5697-7086-a1b6-886eccafce26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019cd33b-5697-7d12-9985-7927dbac6a88" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019cd33b-5697-7919-9843-a82cd03dec12" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019cd33b-5697-7d12-9985-7927dbac6a88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_ProceedsFromSaleOfMarketableSecurities_019cd33b-5697-743b-bb10-764001ff24b0" xlink:href="rcus-20260331.xsd#rcus_ProceedsFromSaleOfMarketableSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019cd33b-5697-7919-9843-a82cd03dec12" xlink:to="loc_rcus_ProceedsFromSaleOfMarketableSecurities_019cd33b-5697-743b-bb10-764001ff24b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019cd33b-5697-76d2-8d61-9fdb0177ad3c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019cd33b-5697-7919-9843-a82cd03dec12" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019cd33b-5697-76d2-8d61-9fdb0177ad3c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019cd33b-5697-76c9-9768-6f5d5b3f3337" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019cd33b-5697-76c9-9768-6f5d5b3f3337" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_019cd33b-5697-7988-b149-18bfe295218a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_DepreciationAndAmortization_019cd33b-5697-7988-b149-18bfe295218a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_019cd33b-5741-7c0e-ac29-7e7a596b82b8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_ProfitLoss_019cd33b-5741-7c0e-ac29-7e7a596b82b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019cd33b-5741-7bd6-b238-34b380760b15" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_ShareBasedCompensation_019cd33b-5741-7bd6-b238-34b380760b15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019cd33b-5741-7c12-a02b-736dc309c637" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_019cd33b-5741-7c12-a02b-736dc309c637" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019cd33b-5741-7c32-bcba-10ad38c0f21b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019cd33b-5741-7c32-bcba-10ad38c0f21b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019cd33b-5741-76b6-82e7-2d6078e644e3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019cd33b-5741-76b6-82e7-2d6078e644e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019cd33b-5741-78d1-a449-102b46f68758" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_019cd33b-5741-78d1-a449-102b46f68758" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_019cd33b-5741-7542-83eb-872f9437fcb7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerAsset"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_019cd33b-5741-7542-83eb-872f9437fcb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019cd33b-5741-7d96-a211-a1d2345db00e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019cd33b-5741-7d96-a211-a1d2345db00e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_019cd33b-5741-77e4-8e35-c4422fc61c04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019cd33b-5697-757c-8ee4-343dfdd0ad23" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_019cd33b-5741-77e4-8e35-c4422fc61c04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019cd33b-5741-7485-a61f-2442ff56fa51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019cd33b-5742-7086-8369-0ff3b05e3ea1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019cd33b-5741-7485-a61f-2442ff56fa51" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019cd33b-5742-7086-8369-0ff3b05e3ea1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019cd33b-5742-7664-9c61-91559bd9fdcb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019cd33b-5741-7485-a61f-2442ff56fa51" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019cd33b-5742-7664-9c61-91559bd9fdcb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/RevenuesSummaryofRevenuesbyCollaborationCategoryofRevenueandMethodofRecognitionDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#RevenuesSummaryofRevenuesbyCollaborationCategoryofRevenueandMethodofRecognitionDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/RevenuesSummaryofRevenuesbyCollaborationCategoryofRevenueandMethodofRecognitionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019cd33b-5742-7a35-acd5-4b698c0d2160" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cd33b-5742-7dc4-b2e5-7e397cc82cd1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_019cd33b-5742-7a35-acd5-4b698c0d2160" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019cd33b-5742-7dc4-b2e5-7e397cc82cd1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer_019cd33b-5742-76c9-a061-90c2c72318cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_019cd33b-5742-7a35-acd5-4b698c0d2160" xlink:to="loc_us-gaap_RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer_019cd33b-5742-76c9-a061-90c2c72318cf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CashCashEquivalentsandMarketableSecuritiesSummaryofAmortizedCostGrossUnrealizedGainsandLossesandFairValueofOurCashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#CashCashEquivalentsandMarketableSecuritiesSummaryofAmortizedCostGrossUnrealizedGainsandLossesandFairValueofOurCashCashEquivalentsandMarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CashCashEquivalentsandMarketableSecuritiesSummaryofAmortizedCostGrossUnrealizedGainsandLossesandFairValueofOurCashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019cd33b-5742-7945-899a-9da7d33950fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019cd33b-5742-76ab-8129-cef102abf3fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019cd33b-5742-7945-899a-9da7d33950fa" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_019cd33b-5742-76ab-8129-cef102abf3fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019cd33b-5742-7233-9b11-9796fae31a96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019cd33b-5742-7945-899a-9da7d33950fa" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019cd33b-5742-7233-9b11-9796fae31a96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019cd33b-5742-72cc-add7-8bc131ac87ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019cd33b-5742-7945-899a-9da7d33950fa" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019cd33b-5742-72cc-add7-8bc131ac87ab" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CashCashEquivalentsandMarketableSecuritiesSummaryofFairValuesofOurCashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#CashCashEquivalentsandMarketableSecuritiesSummaryofFairValuesofOurCashCashEquivalentsandMarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CashCashEquivalentsandMarketableSecuritiesSummaryofFairValuesofOurCashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_rcus_CashCashEquivalentsAndAvailableForSaleInvestments_019cd33b-5742-743b-aea1-06beb848116d" xlink:href="rcus-20260331.xsd#rcus_CashCashEquivalentsAndAvailableForSaleInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019cd33b-5742-7627-b04f-c4a8626214d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_rcus_CashCashEquivalentsAndAvailableForSaleInvestments_019cd33b-5742-743b-aea1-06beb848116d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019cd33b-5742-7627-b04f-c4a8626214d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019cd33b-5742-788e-af2e-0f5a767d4210" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_rcus_CashCashEquivalentsAndAvailableForSaleInvestments_019cd33b-5742-743b-aea1-06beb848116d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019cd33b-5742-788e-af2e-0f5a767d4210" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019cd33b-5742-7454-a740-6d84bcd1501a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_rcus_CashCashEquivalentsAndAvailableForSaleInvestments_019cd33b-5742-743b-aea1-06beb848116d" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019cd33b-5742-7454-a740-6d84bcd1501a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CashCashEquivalentsandMarketableSecuritiesSummaryofCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#CashCashEquivalentsandMarketableSecuritiesSummaryofCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CashCashEquivalentsandMarketableSecuritiesSummaryofCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019cd33b-5742-79d3-9693-800a3fbced33" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019cd33b-5742-739f-9ac7-4db4130f58ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019cd33b-5742-79d3-9693-800a3fbced33" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019cd33b-5742-739f-9ac7-4db4130f58ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_019cd33b-5742-73f8-abb4-6363bf626119" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_019cd33b-5742-79d3-9693-800a3fbced33" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_019cd33b-5742-73f8-abb4-6363bf626119" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CondensedConsolidatedBalanceSheetComponentsSummaryofPrepaidandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#CondensedConsolidatedBalanceSheetComponentsSummaryofPrepaidandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CondensedConsolidatedBalanceSheetComponentsSummaryofPrepaidandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019cd33b-5742-740e-b3cd-22eece40dce0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivableCurrent_019cd33b-5742-7e4a-a496-aa28137b1a6e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestReceivableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019cd33b-5742-740e-b3cd-22eece40dce0" xlink:to="loc_us-gaap_InterestReceivableCurrent_019cd33b-5742-7e4a-a496-aa28137b1a6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_PrepaidExpensesAndOtherCurrentAssets_019cd33b-5742-7c0c-97f2-c48153f9f171" xlink:href="rcus-20260331.xsd#rcus_PrepaidExpensesAndOtherCurrentAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019cd33b-5742-740e-b3cd-22eece40dce0" xlink:to="loc_rcus_PrepaidExpensesAndOtherCurrentAssets_019cd33b-5742-7c0c-97f2-c48153f9f171" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/CondensedConsolidatedBalanceSheetComponentsSummaryofOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#CondensedConsolidatedBalanceSheetComponentsSummaryofOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/CondensedConsolidatedBalanceSheetComponentsSummaryofOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5742-7154-ac41-d044c77ed4ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesCurrent_019cd33b-5742-7ab3-b3d8-1162aad1128a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherSundryLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5742-7154-ac41-d044c77ed4ab" xlink:to="loc_us-gaap_OtherSundryLiabilitiesCurrent_019cd33b-5742-7ab3-b3d8-1162aad1128a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019cd33b-5742-7fdc-84d1-7f3d6d7747d7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5742-7154-ac41-d044c77ed4ab" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019cd33b-5742-7fdc-84d1-7f3d6d7747d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_AccruedResearchAndDevelopmentExpensesCurrent_019cd33b-5742-7d62-b472-435f461da197" xlink:href="rcus-20260331.xsd#rcus_AccruedResearchAndDevelopmentExpensesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5742-7154-ac41-d044c77ed4ab" xlink:to="loc_rcus_AccruedResearchAndDevelopmentExpensesCurrent_019cd33b-5742-7d62-b472-435f461da197" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019cd33b-5742-76dd-b8f0-c88d7bc8c0c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5742-7154-ac41-d044c77ed4ab" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019cd33b-5742-76dd-b8f0-c88d7bc8c0c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_019cfa6b-47a6-7d44-a936-d7d5499779e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019cd33b-5742-7154-ac41-d044c77ed4ab" xlink:to="loc_us-gaap_TaxesPayableCurrent_019cfa6b-47a6-7d44-a936-d7d5499779e7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/LongTermDebtSummaryofLongTermDebtInstrumentsDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#LongTermDebtSummaryofLongTermDebtInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/LongTermDebtSummaryofLongTermDebtInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019cd33b-5742-7a01-a446-eff0747c87b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019cd33b-5742-722a-b8ed-6235c3d94ef4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019cd33b-5742-7a01-a446-eff0747c87b5" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_019cd33b-5742-722a-b8ed-6235c3d94ef4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019cd33b-5742-74f0-a03e-fccaf2eb3c34" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019cd33b-5742-7a01-a446-eff0747c87b5" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019cd33b-5742-74f0-a03e-fccaf2eb3c34" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#FairValueMeasurementsDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019cd33b-5742-708e-9095-c6a4a7dc876c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_019cd33b-5742-7de6-8d07-08ad044784e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019cd33b-5742-708e-9095-c6a4a7dc876c" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_019cd33b-5742-7de6-8d07-08ad044784e0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://arcusbio.com/role/BusinessSegmentSummaryofSegmentReportingInformationDetails" xlink:type="simple" xlink:href="rcus-20260331.xsd#BusinessSegmentSummaryofSegmentReportingInformationDetails"/>
  <link:calculationLink xlink:role="http://arcusbio.com/role/BusinessSegmentSummaryofSegmentReportingInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019cd33b-5742-7b3a-8f82-61814b8aab7f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_us-gaap_Revenues_019cd33b-5742-7b3a-8f82-61814b8aab7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_LateStageDevelopmentPrograms_019cd33b-5742-787f-a3c2-5627169711d8" xlink:href="rcus-20260331.xsd#rcus_LateStageDevelopmentPrograms"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_rcus_LateStageDevelopmentPrograms_019cd33b-5742-787f-a3c2-5627169711d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_EarlyStageDevelopmentAndPreclinicalPrograms_019cd33b-5742-7489-8bbe-7b44dce78d77" xlink:href="rcus-20260331.xsd#rcus_EarlyStageDevelopmentAndPreclinicalPrograms"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_rcus_EarlyStageDevelopmentAndPreclinicalPrograms_019cd33b-5742-7489-8bbe-7b44dce78d77" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019cd33b-5742-75ac-9bec-b86de4608125" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019cd33b-5742-75ac-9bec-b86de4608125" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019cd33b-5742-7cd2-b79e-da0516e7cf90" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019cd33b-5742-7cd2-b79e-da0516e7cf90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019cd33b-5742-7997-88b0-aa0c3e27cf58" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019cd33b-5742-7997-88b0-aa0c3e27cf58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019cd33b-5742-7510-9c76-eed655e2201c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019cd33b-5742-7510-9c76-eed655e2201c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rcus_PartnershipReimbursements_019cfa9c-e56d-7011-bbf2-cbb0820c3130" xlink:href="rcus-20260331.xsd#rcus_PartnershipReimbursements"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019cd33b-5742-736f-844f-cc3ad6466a05" xlink:to="loc_rcus_PartnershipReimbursements_019cfa9c-e56d-7011-bbf2-cbb0820c3130" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
