0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Condensed Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Condensed Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Condensed Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Condensed Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Condensed Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Condensed Consolidated Statements of Cash Flows (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Nature of Business link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Cash Equivalents link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Property and Equipment, net link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Stock-based Compensation link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Net Loss per Share link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Restructuring and Impairment Charges link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Segments link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Cash Equivalents (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Property and Equipment, net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Collaboration Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Stock-based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Net Loss per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Restructuring and Impairment Charges (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Segments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Nature of Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Cash Equivalents - Schedule of Cash Equivalents and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Cash Equivalents - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Property and Equipment, net (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Collaboration Agreements - Schedule of Accounts Receivable and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Collaboration Agreements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Stock-based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Stock-based Compensation - Restricted Stock Unit Awards Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Stock-based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Stock-based Compensation - Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Debt - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Debt - Schedule of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Restructuring and Impairment Charges - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Restructuring and Impairment Charges - Schedule of Restructuring and Related Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Restructuring and Impairment Charges - Schedule of Employee Termination Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Restructuring and Impairment Charges - Schedule of Contract Termination Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Segments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Segments - Schedule of Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink