Payment Tranche [Axis]
Payment Tranche [Axis]
Payment Tranche
Weighted-average shares of common stock outstanding
Earnings Per Share, Diluted, Other Disclosure [Abstract]
Award Timing Predetermined
Award Timing Predetermined [Flag]
November 2025 Public Offering
November 2025 Public Offering [Member]
November 2025 Public Offering
2026 (remainder of year)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Asset Class
Asset Class [Axis]
Entity File Number
Entity File Number
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Gain from equity method investment
Gain from equity method investment
Income (Loss) from Equity Method Investments
Tabular List, Table
Tabular List [Table Text Block]
Basic net loss per share:
Earnings Per Share, Basic [Abstract]
2024 Term Loan
Two Thousand Twenty Four Loan and Security Agreement [Member]
Two thousand twenty four loan and security agreement.
Facility-related costs, laboratory equipment, and maintenance
Facility Related Costs, Laboratory Equipment, And Maintenance
Facility related costs, laboratory equipment, and maintenance.
Accounting Standards Updates
New Accounting Pronouncements, Policy [Policy Text Block]
FAIR VALUE MEASUREMENTS
Fair Value Measurement and Measurement Inputs, Recurring and Nonrecurring [Text Block]
Accounts payable
Increase (Decrease) in Accounts Payable
License
License [Member]
Trading Arrangements, by Individual
Trading Arrangements, by Individual [Table]
Warrants outstanding (in shares)
Class of Warrant or Right, Outstanding
Basic (in USD per shares)
Basic net loss per share (in USD per shares)
Earnings Per Share, Basic
Adjustment to Compensation:
Adjustment to Compensation [Axis]
Named Executive Officers, Footnote
Named Executive Officers, Footnote [Text Block]
Liabilities:
Liabilities, Fair Value Disclosure [Abstract]
Number of shares available to be issued (in shares)
Common Stock, Capital Shares Reserved for Future Issuance
Summary of Significant Research and Development and General and Administrative Expense to CODM
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Loss (gain) on changes in other fair value adjustments
Fair Value, Option, Changes in Fair Value, Gain (Loss)
ESPP
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan
Settlement of restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Issuance of common stock under employee stock purchase plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Measurement Input Type [Domain]
Measurement Input Type [Domain]
Adjustment to Compensation, Amount
Adjustment to Compensation Amount
Share-based compensation
Share-Based Payment Arrangement, Noncash Expense
Employee Stock Option
Share-Based Payment Arrangement, Option [Member]
Award Timing MNPI Disclosure
Award Timing MNPI Disclosure [Text Block]
March 2024 Public Offering
March Twenty Twenty Four Public Offering [Member]
March twenty twenty four public offering.
Grantee Status [Domain]
Grantee Status [Domain]
Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Total stockholders’ equity
Beginning balance
Ending balance
Equity, Attributable to Parent
Insider Trading Policies and Procedures [Line Items]
Share based compensation expense
Share-based compensation expense
Share-Based Payment Arrangement, Expense
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Current assets:
Assets, Current [Abstract]
Issuance of common stock to licensees
Stock Issued During Period, Value, Licenses
Stock issued during period value licenses.
Total liabilities and stockholders’ equity
Liabilities and Equity
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Outstanding Option Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Payment Tranche Two
Payment Tranche Two [Member]
Payment Tranche Two
Liabilities and Stockholders’ Equity
Liabilities and Equity [Abstract]
Other (expense) income:
Other Nonoperating Income (Expense) [Abstract]
Cover [Abstract]
Cover [Abstract]
Money market funds
Cash and Cash Equivalents, Fair Value Disclosure
2015 Plan
Two Thousand Fifteen Stock Incentive Plan [Member]
Two thousand fifteen stock incentive plan.
General and administrative
General and Administrative Expense [Member]
Schedule of Future Lease Payments under Non-Cancelable Leases
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Total Compensation Amount
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Treasury Stock
Treasury Stock, Common [Member]
Adjustment to Non-PEO NEO Compensation Footnote
Adjustment to Non-PEO NEO Compensation Footnote [Text Block]
Pay vs Performance Disclosure [Line Items]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Axis]
Total operating lease liabilities
Operating Lease, Liability
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Non-Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Final payment fee
Financial Liabilities Fair Value Disclosure
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction
Entity Shell Company
Entity Shell Company
Other noncurrent liabilities
Other Liabilities, Noncurrent
Debt Instrument [Table]
Schedule of Long-Term Debt Instruments [Table]
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Company Selected Measure Amount
Company Selected Measure Amount
2029
Lessee, Operating Lease, Liability, to be Paid, Year Three
Award Timing MNPI Considered
Award Timing MNPI Considered [Flag]
Measurement Input Type [Axis]
Measurement Input Type [Axis]
Name
Measure Name
Schedule of Share-Based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Lease liabilities
Operating Lease, Liability, Current
Novartis Pharma AG
Novartis Pharma A G [Member]
Novartis Pharma A.G.
Document Fiscal Period Focus
Document Fiscal Period Focus
Award Timing Method
Award Timing Method [Text Block]
Award Type
Award Type [Axis]
Loss on change in fair value of warrant liability
Loss on change in fair value of warrant liability
Gain (Loss) on Change in Fair Value of Warrant Liability
Gain (loss) on change in fair value of warrant liability.
Issuance of common stock through ATM facility, net of issuance cost
Stock Issued During Period, Value Through A T M Facility, Net Of Issuance Cost
Stock issued during period value through atm facility, net of issuance cost.
Total assets
Assets
Collaboration and License Agreements [Line items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Trading Symbol
Trading Symbol
Vested (in USD per shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Entity Address, City or Town
Entity Address, City or Town
Agriculture Industry Collaboration Partner
Agriculture Industry Collaboration Partner [Member]
Agriculture Industry Collaboration Partner
Cash flows used in operating activities:
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
DESCRIPTION OF BUSINESS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block]
Non-PEO NEO Average Compensation Actually Paid Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Income Statement Location
Statement of Income Location, Balance [Domain]
Restricted Stock Units
Restricted Stock Units (RSUs) [Member]
Compensation Actually Paid vs. Other Measure
Compensation Actually Paid vs. Other Measure [Text Block]
Assets:
Assets, Fair Value Disclosure [Abstract]
Entity Emerging Growth Company
Entity Emerging Growth Company
Warrant
Warrant [Member]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Lease Cost
Lease, Cost [Abstract]
Number of shares available for issuance (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Issuance
Share based compensation arrangement by share based payment award number of shares available for issuance.
Options outstanding (in shares)
Outstanding option shares, beginning balance (in shares)
Outstanding option shares, ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year
Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member]
Level 2
Fair Value, Inputs, Level 2 [Member]
Restricted cash
Restricted Cash and Cash Equivalent
Insider Trading Policies and Procedures Not Adopted
Insider Trading Policies and Procedures Not Adopted [Text Block]
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance (in shares)
Common Stock, Shares, Outstanding
Change in fair value of warrant liability
Fair Value Adjustment of Warrants
One-Half Warrants
One-Half Warrants [Member]
One-Half Warrants
Plan Name
Plan Name [Axis]
PEO
PEO [Member]
Investment in iECURE
Investment In iECURE [Member]
Investment in iECURE member.
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year
Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member]
Weighted-average expected stock price volatility
Measurement Input, Share Price [Member]
Accumulated Deficit
Retained Earnings [Member]
RSU Awards
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Effective interest rate (as a percent)
Debt Instrument, Interest Rate, Effective Percentage
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Restatement Determination Date
Restatement Determination Date
Share-Based Payment Arrangement [Abstract]
Share-Based Payment Arrangement [Abstract]
Cash, cash equivalents, and restricted cash — beginning of period
Cash, cash equivalents, and restricted cash — end of period
Total of cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Income Statement [Abstract]
Income Statement [Abstract]
Weighted-average fair value per option
Measurement Input, Weighted-Average Fair Value Per Option [Member]
Measurement input, weighted-average fair value per option.
Basis point added to the prime rate (as percent)
Debt Instrument, Basis Spread on Variable Rate
Sale of Stock
Sale of Stock [Domain]
Beginning balance
Ending balance
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Value
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
Intangible assets—net
Intangible Assets, Net (Excluding Goodwill)
Pension Adjustments Service Cost
Pension Adjustments Service Cost [Member]
Estimated dividend yield
Measurement Input, Expected Dividend Rate [Member]
Product and Service [Domain]
Product and Service [Domain]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Restatement does not require Recovery
Restatement Does Not Require Recovery [Text Block]
Liabilities
Liabilities, Fair Value Disclosure
Subsidiary or Equity Method Investee, Sale of Stock [Table]
Subsidiary or Equity Method Investee, Sale of Stock [Table]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Other Information
Cash Flow, Operating Activities, Lessee [Abstract]
Development and License
Development and License [Member]
Development and License
Amortization of right-of-use assets
Operating Lease, Right-of-Use Asset, Periodic Reduction
Compensation Actually Paid vs. Company Selected Measure
Compensation Actually Paid vs. Company Selected Measure [Text Block]
City Area Code
City Area Code
Award Timing, How MNPI Considered
Award Timing, How MNPI Considered [Text Block]
All Trading Arrangements
All Trading Arrangements [Member]
Equity Awards Adjustments, Footnote
Equity Awards Adjustments, Footnote [Text Block]
Total Shareholder Return Vs Peer Group
Total Shareholder Return Vs Peer Group [Text Block]
Number of additional shares available for issuance (in shares)
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Available For Issuance
Share based compensation arrangement by share based payment award number of additional shares available for issuance.
Unvested, beginning balance (in shares)
Unvested, ending balance (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Class of Warrant or Right [Line Items]
Class of Warrant or Right [Line Items]
Issuance of common stock through ATM facility, net of issuance cost (in shares)
Stock Issued During Period Through ATM Facility, Net Of Issuance Cost, Shares
Stock issued during period through atm facility, net of issuance cost shares.
Cash flows used in investing activities:
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
General and administrative
Total general and administrative expenses
General and Administrative Expense
Pay vs Performance Disclosure
Pay vs Performance Disclosure [Table]
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Warrants expire year
Debt Instrument, Term
Income Tax Disclosure [Table]
Effective Income Tax Rate Reconciliation [Table]
Preferred stock, par value (in USD per shares)
Preferred Stock, Par or Stated Value Per Share
Total Lease Cost
Lease, Cost
Investments and marketable securities
Equity Securities, FV-NI
Equity Valuation Assumption Difference, Footnote
Equity Valuation Assumption Difference, Footnote [Text Block]
Schedule of Components of Lease Expense
Lease, Cost [Table Text Block]
PEO Total Compensation Amount
PEO Total Compensation Amount
Long-Term Debt, Type [Axis]
Long-Term Debt, Type [Axis]
Equity Component [Axis]
Equity Components [Axis]
Sublease income
Sublease Income
Purchases of intangible assets
Payments To Purchase Intangible Assets
Payments To Purchase Intangible Assets
iECURE
I E C U R E [Member]
iECURE member.
Non-Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Warrant liability
Warrant Liability Noncurrent
Warrant liability noncurrent.
Number of reportable segments
Number of Reportable Segments
Loan payable
Loans Payable
Other Performance Measure, Amount
Other Performance Measure, Amount
Weighted-Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Total current liabilities
Liabilities, Current
(Loss) gain on changes in other fair value adjustments
Decrease in fair value of equity
Equity Securities, FV-NI, Gain (Loss)
Individual:
Individual [Axis]
Restricted cash
Restricted Cash
Imugene Marketable Securities
Imugene [Member]
Imugene.
Amended Plan
Amended Plan [Member]
Amended Plan member.
Other current assets
Other Assets, Current
Research and development
Research and Development Expense [Member]
Additional paid-in capital
Additional Paid in Capital, Common Stock
Net cash used in investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Issuance of common stock to licensees (in shares)
Stock Issued During Period, Licenses, Shares
Stock issued during period licenses shares.
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table
Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member]
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activity
Proceeds from issuance of common stock to collaboration partners and licensees
Proceeds from Noncontrolling Interests
Document Fiscal Year Focus
Document Fiscal Year Focus
Right-of-use assets—net
Operating Lease, Right-of-Use Asset
Forgone Recovery, Explanation of Impracticability
Forgone Recovery, Explanation of Impracticability [Text Block]
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Entity Interactive Data Current
Entity Interactive Data Current
Percentage of premium over the volume-weighted-average-price of the company’s common stock (as a percent)
Percentage Of Premium Over Volume Weighted Average Price Of Company's Common Stock
Percentage of premium over the volume-weighted-average-price of the company’s common stock.
Operating lease cost
Operating Lease, Cost
Plan Name
Plan Name [Domain]
Fair Value Warrant Liability
Fair Value Warrant Liability [Roll Forward]
Fair Value Warrant Liability
Weighted-average period for recognition of compensation cost
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Exercised (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Warrants
Derivatives, Policy [Policy Text Block]
SEGMENT REPORTING
Segment Reporting Disclosure [Text Block]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Class of Warrant or Right [Table]
Class of Warrant or Right [Table]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Proceeds from employee stock purchase plan
Proceeds From Employee Stock Purchase Plan
Proceeds from employee stock purchase plan
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Total Shareholder Return [Text Block]
Amortization of discount on note receivable
Amortization Of Discount On Note Receivable
Amortization of discount on note receivable.
Contract liabilities
Business Combination, Contingent Consideration, Liability
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Laboratory supplies and services
Laboratory Supplies And Services
Laboratory supplies and services.
Purchases of property, equipment and software
Payments to Acquire Productive Assets
Number of trading days prior to agreement to determine price per share
Stock Issued, Price Per Share, Number Of Trading Days Prior To Agreement
Stock Issued, Price Per Share, Number Of Trading Days Prior To Agreement
Other assets
Other Assets, Noncurrent
Entity Central Index Key
Entity Central Index Key
PEO Name
PEO Name
Net proceeds from sale of stock
Sale of Stock, Consideration Received on Transaction
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year
Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member]
Outstanding Aggregate Erroneous Compensation Amount
Outstanding Aggregate Erroneous Compensation Amount
Revolving Credit Facility
Revolving Credit Facility [Member]
Arrangement Duration
Trading Arrangement Duration
Schedule of Segment Reporting Information, by Segment [Table]
Schedule of Segment Reporting Information, by Segment [Table]
Contract with customer, liability, revenue recognized as transaction price
Contract With Customer, Liability, Revenue Recognized As Transaction Price
Contract With Customer, Liability, Revenue Recognized As Transaction Price
Platform development and early-stage research expenses:
Platform Development And Early-Stage Research Expenses [Abstract]
Platform development and early-stage research expenses.
Segments [Axis]
Segments [Axis]
Exercise price per share (in USD per shares)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Unaudited Interim Financial Information
Comparability of Prior Year Financial Data, Policy [Policy Text Block]
Operating Leases
Lessee, Operating Lease, Description [Abstract]
Exercise Price
Award Exercise Price
Entity Filer Category
Entity Filer Category
Local Phone Number
Local Phone Number
Additional 402(v) Disclosure
Additional 402(v) Disclosure [Text Block]
SHARE-BASED COMPENSATION
Share-Based Payment Arrangement [Text Block]
Assets
Assets [Abstract]
Credit Facility
Credit Facility [Axis]
Underlying Security Market Price Change
Underlying Security Market Price Change, Percent
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
Debt Instrument
Debt Instrument [Axis]
Forfeited (in USD per shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Contract with customer, liability, revenue recognized upon issuance of shares
Contract With Customer, Liability, Revenue Recognized Upon Issuance of Shares
Contract with Customer, Liability, Revenue Recognized Upon Issuance of Shares
Credit Facility
Credit Facility [Domain]
Stockholders’ equity:
Equity, Attributable to Parent [Abstract]
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year
Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member]
Research and development
Research and Development [Abstract]
Entity Address, Address Line One
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Two
Research and development
Total research and development expenses
Research and Development Expense
Interest rate during period (as a percent)
Debt Instrument, Interest Rate, Stated Percentage
Lease liabilities
Operating Lease, Liability, Noncurrent
Warrants exercised (in shares)
Stock Issued During Period, Shares, Conversion of Convertible Securities
Fair Value as of Grant Date
Award Grant Date Fair Value
Entity Registrant Name
Entity Registrant Name
Stock Price or TSR Estimation Method
Stock Price or TSR Estimation Method [Text Block]
PBGENE-DMD external development costs
PBGENE - Duchenne Muscular Dystrophy Program [Member]
PBGENE-Duchenne Muscular Dystrophy Program.
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Unrecognized compensation cost
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Document Quarterly Report
Document Quarterly Report
Assets
Assets, Fair Value Disclosure
Schedule of Estimated Fair Value of Warrants
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Changed Peer Group, Footnote
Changed Peer Group, Footnote [Text Block]
Income Tax Disclosure [Line Items]
Income Tax Disclosure [Line Items]
Income tax disclosure.
Counterparty Name
Counterparty Name [Domain]
WARRANTS
Warrants [Text Block]
Warrants.
Number of operating segments
Number of Operating Segments
2028
Lessee, Operating Lease, Liability, to be Paid, Year Two
Accrued research and development expenses
Accrued Research And Development Expenses
Accrued research and development expenses.
Adjustment To PEO Compensation, Footnote
Adjustment To PEO Compensation, Footnote [Text Block]
Granted (in USD per shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Title
Trading Arrangement, Individual Title
Peer Group Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Restatement Determination Date:
Restatement Determination Date [Axis]
Non-PEO NEO
Non-PEO NEO [Member]
Issuance of common stock under employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Shares outstanding percentage (as percent)
Warrants or Rights Outstanding, Ownership Of Common Stock Outstanding, Percentage, Condition For Company Repurchase
Warrants or Rights Outstanding, Ownership Of Common Stock Outstanding, Percentage, Condition For Company Repurchase
Interest income
Interest Income, Other
Sale of Stock
Sale of Stock [Axis]
Warrants and Rights Note Disclosure [Abstract]
Warrants and Rights Note Disclosure [Abstract]
Proceeds from issuance of common stock through ATM facility, net of issuance cost
Proceeds from Issuance of Common Stock through ATM Facility, Net of Issuance Cost
Proceeds from issuance of common stock through ATM facility, net of issuance cost
Name
Trading Arrangement, Individual Name
All Award Types
Award Type [Domain]
2027
Lessee, Operating Lease, Liability, to be Paid, Year One
Equity Awards Adjustments
Equity Awards Adjustments [Member]
Licensing fees and other research and development costs
Licensing Fees And Other Research And Development, Costs
Licensing fees and other research and development costs.
Pension Benefits Adjustments, Footnote
Pension Benefits Adjustments, Footnote [Text Block]
Warrants assumptions
Warrants and Rights Outstanding, Measurement Input
Compensation Amount
Outstanding Recovery Compensation Amount
Debt Instrument, Name
Debt Instrument, Name [Domain]
March 2024 Public Offering
March 2024 Public Offering [Member]
March 2024 Public Offering
Recovery of Erroneously Awarded Compensation Disclosure [Line Items]
Revenue recognized
Contract with Customer, Liability, Revenue Recognized
MNPI Disclosure Timed for Compensation Value
MNPI Disclosure Timed for Compensation Value [Flag]
Name
Awards Close in Time to MNPI Disclosures, Individual Name
Unvested, beginning balance (in USD per shares)
Unvested, ending balance (in USD per shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Escrow account cash balance
Escrow Deposit
Aggregate Erroneous Compensation Not Yet Determined
Aggregate Erroneous Compensation Not Yet Determined [Text Block]
Employee Stock
Employee Stock [Member]
Share-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Treasury stock
Treasury Stock, Value
Issuance of common stock from pre-funded warrants (in shares)
Stock Issued During Period, Shares, Warrant Exercise
Stock Issued During Period, Shares, Warrant Exercise
Financial Instruments [Domain]
Financial Instruments [Domain]
Segments [Domain]
Segments [Domain]
Income Statement Location
Statement of Income Location, Balance [Axis]
Aggregate Pension Adjustments Service Cost
Aggregate Pension Adjustments Service Cost [Member]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Class of warrant or right, number of securities called by warrants or rights (in shares)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Company Selected Measure Name
Company Selected Measure Name
General and administrative expense
General and Administrative Expense [Abstract]
Research and License
Research and License [Member]
Research and License
DEBT
Debt Disclosure [Text Block]
Preferred stock: $0.0001 par value— 10,000,000 shares authorized as of March 31, 2026 and December 31, 2025; no shares issued and outstanding as of March 31, 2026 and December 31, 2025
Preferred Stock, Value, Issued
Aggregate Available
Trading Arrangement, Securities Aggregate Available Amount
Accounts payable
Accounts Payable, Current
Operating cash flows used for operating leases
Operating Lease, Payments
Stock Appreciation Rights (SARs)
Stock Appreciation Rights (SARs) [Member]
External development costs (credits)
External Development Costs (Credits)
External development costs.
All Executive Categories
All Executive Categories [Member]
Stockholders' Equity Note [Abstract]
Stockholders' Equity Note [Abstract]
Common stock: $0.000005 par value— 200,000,000 shares authorized as of March 31, 2026 and December 31, 2025; 25,832,913 shares issued and 25,805,898 shares outstanding as of March 31, 2026; 24,115,346 shares issued and 24,088,425 shares outstanding as of December 31, 2025
Common Stock, Value, Issued
Employee
Share-Based Payment Arrangement, Employee [Member]
COMMITMENTS AND CONTINGENCIES
Commitments and Contingencies Disclosure [Text Block]
Diluted (in shares)
Diluted weighted-average common shares (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Segment Reporting
Segment Reporting, Policy [Policy Text Block]
Non-GAAP Measure Description
Non-GAAP Measure Description [Text Block]
Entity Small Business
Entity Small Business
Total number of shares issued under 2019 ESPP (in shares)
Numberof Shares Issued Under Employee Stock Purchase Plans
Number of shares issued under employee stock purchase plans.
Offering expenses
Payments of Stock Issuance Costs
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Other operating expenses and all other costs
Other Cost and Expense, Operating
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
Document Transition Report
Document Transition Report
Operating Segment
Operating Segment [Member]
Operating Segment
Underlying Securities
Award Underlying Securities Amount
Equity Component [Domain]
Equity Component [Domain]
Document Period End Date
Document Period End Date
PEO Actually Paid Compensation Amount
PEO Actually Paid Compensation Amount
Forfeited/canceled (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period
INCOME TAXES
Income Tax Disclosure [Text Block]
Diluted net loss per share:
Earnings Per Share, Diluted [Abstract]
Awards Close in Time to MNPI Disclosures, Table
Awards Close in Time to MNPI Disclosures [Table Text Block]
Short-term lease cost
Short-Term Lease, Cost
Scenario
Scenario [Axis]
Lease liabilities
Increase (Decrease) in Operating Lease Liability
Non-cash interest expense
Amortization of Debt Discount (Premium)
Document Type
Document Type
RSU outstanding (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number
Level 3
Fair Value, Inputs, Level 3 [Member]
EARNINGS PER SHARE
Earnings Per Share [Text Block]
Name
Outstanding Recovery, Individual Name
Product and Service [Axis]
Product and Service [Axis]
Variable lease cost
Variable Lease, Cost
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
All Individuals
All Individuals [Member]
Long-Term Debt, Type [Domain]
Long-Term Debt, Type [Domain]
Fair Value Disclosures [Abstract]
Name
Forgone Recovery, Individual Name
Total current assets
Assets, Current
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested
Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member]
Forfeited/canceled (in USD per shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Contract liabilities
Loss Contingency Accrual
Reconciliation of cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Amount
Purchase of common stock through payroll deductions expressed in percentage of fair market value (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Peer Group Issuers, Footnote
Peer Group Issuers, Footnote [Text Block]
Marketable securities
Marketable Securities, Current
Issuance of warrants
Warrants and Rights Issued
Warrants and Rights Issued
Erroneous Compensation Analysis
Erroneous Compensation Analysis [Text Block]
Current liabilities:
Liabilities, Current [Abstract]
Total operating expenses
Operating Expenses
Rule 10b5-1 Arrangement Terminated
Rule 10b5-1 Arrangement Terminated [Flag]
Allowed annual percentage increase in shares authorized as percentage of outstanding shares of common stock (as a percent)
Allowed Annual Percentage Increase In Shares Authorized As Percentage Of Outstanding Shares Of Common Stock
Allowed annual percentage increase in shares authorized as percentage of outstanding shares of common stock.
Borrowings
Long-Term Line of Credit
Level 1
Fair Value, Inputs, Level 1 [Member]
Gain (loss) on disposal of assets
Gain (Loss) on Disposition of Assets
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Other liabilities and other current liabilities
Increase Decrease In Accrued Other Expenses And Other Current Liabilities
Increase decrease in accrued other expenses and other current liabilities.
Pre Funded Warrants
Pre Funded Warrants [Member]
Pre Funded Warrants
Diluted (in USD per shares)
Diluted net loss per share (in USD per shares)
Earnings Per Share, Diluted
Forecast
Forecast [Member]
Erroneously Awarded Compensation Recovery
Erroneously Awarded Compensation Recovery [Table]
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Title of 12(b) Security
Title of 12(b) Security
Supplemental disclosures of cash flow information:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
2019 ESPP
Two Thousand Nineteen Employee Stock Purchase Plan [Member]
Two thousand nineteen employee stock purchase plan.
Sale of stock, number of shares issued in transaction (in shares)
Sale of Stock, Number of Shares Issued in Transaction
Proceeds from sale of equipment
Proceeds from Sale of Machinery and Equipment
Net loss per share
Earnings Per Share [Abstract]
Prepaid expenses
Increase (Decrease) in Prepaid Expense
Consulting and professional services
Consulting And Professional Services
Consulting and professional services.
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Investment in equity securities
Equity Securities, FV-NI, Noncurrent
Marketable securities
Increase (Decrease) in Marketable Securities, Restricted
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Exercised (in USD per shares)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Investor
Investor [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Award Timing Disclosures [Line Items]
2019 Plan
Two Thousand Nineteen Incentive Award Plan [Member]
Two thousand nineteen incentive award plan.
Granted (in USD per shares)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Accrued compensation
Employee-related Liabilities, Current
Total lease payments
Lessee, Operating Lease, Liability, to be Paid
STOCKHOLDERS' EQUITY
Equity [Text Block]
TG License
TG License [Member]
TG license.
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Employee-related costs (including share-based compensation)
Employee Related Costs Research And Development Including Share-Based Compensation
Employee related costs research and development including share-based compensation.
Subsidiary or Equity Method Investee [Line Items]
Subsidiary or Equity Method Investee [Line Items]
Expiration Date
Trading Arrangement Expiration Date
Additional milestone
Revenue, Remaining Performance Obligation, Variable Consideration, Additional Milestone, Amount
Revenue, Remaining Performance Obligation, Variable Consideration, Additional Milestone, Amount
Property, equipment, and software—net
Property, Plant and Equipment, Net
Segment Reporting Information [Line Items]
Segment Reporting Information [Line Items]
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Adoption Date
Trading Arrangement Adoption Date
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Net Income [Text Block]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Entity Current Reporting Status
Entity Current Reporting Status
Expected term (in years)
Measurement Input, Expected Term [Member]
Awards Close in Time to MNPI Disclosures
Awards Close in Time to MNPI Disclosures [Table]
Operating loss
Operating loss
Operating Income (Loss)
Line of Credit
Line of Credit [Member]
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Schedule of Share-Based Compensation Expense by Line Item
Share-Based Payment Arrangement, Cost by Plan [Table Text Block]
Financial Instrument [Axis]
Financial Instrument [Axis]
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested
Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member]
Executive Category:
Executive Category [Axis]
Property, equipment and software additions included in accounts payable and accrued expenses and other current liabilities
Noncash or Part Noncash Acquisition, Fixed Assets Acquired
Current Fiscal Year End Date
Current Fiscal Year End Date
Inducement Award Plan
Inducement Award Plan [Member]
Inducement award plan member.
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table
Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member]
Weighted-Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Remaining shares available to be granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Statement [Table]
Statement [Table]
Total other (expense) income
Other Nonoperating Income (Expense)
Intangible asset additions included in accounts payable and accrued expenses and other current liabilities
Noncash or Part Noncash Acquisition, Intangible Assets Acquired
Warrant Liability
Derivative Liability
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
COLLABORATION AND LICENSE AGREEMENTS
Collaborative Arrangement Disclosure [Text Block]
Cash flows provided by financing activities:
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Equity Awards Adjustments, Excluding Value Reported in Compensation Table
Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member]
PBGENE-HBV external development costs
PBGENE - Hepatitis B Virus [Member]
Potential treatment of chronic hepatitis B virus.
Weighted-average risk-free interest rate
Measurement Input, Risk Free Interest Rate [Member]
Collaborative arrangement, upfront payments and liabilities
Contract with Customer, Liability
Schedule of Assets and Liabilities Measured on a Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Unrecognized tax benefits
Unrecognized Tax Benefits
(Gain) loss on disposal of assets
Gain (Loss) on Disposition of Assets for Financial Service Operations
Antidilutive common share equivalents (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Summary of Financial Assets Measured at Fair Value on Recurring Basis Using Significant Unobservable Inputs
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
All Adjustments to Compensation
All Adjustments to Compensation [Member]
Amendment Flag
Amendment Flag
Sale of stock, price per share (in USD per shares)
Sale of Stock, Price Per Share
Maximum shares allowed to be issued under ESPP (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
CMOs and outsourced research and development
CMOs And Outsourced Research And Development
CMOs and outsourced research and development.
Termination Date
Trading Arrangement Termination Date
Net cash provided by financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Contract asset
Increase (Decrease) in Contract with Customer, Asset
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Adopted [Flag]
Measure:
Measure [Axis]
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Summary of Activity of Option Plans
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Warrant Liability
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Basic (in shares)
Basic weighted-average common shares (in shares)
Weighted Average Number of Shares Outstanding, Basic
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Beginning balance
Ending balance
Warrants and Rights Outstanding
Schedule of Basic and Diluted Net (Loss) Income Per Share Attributable to Common Stockholders
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Payment Tranche [Domain]
Payment Tranche [Domain]
Payment Tranche [Domain]
Direct research and development expenses by product candidate:
Direct Research And Development Expenses By Product Candidate [Abstract]
Direct Research And Development Expenses By Product Candidate
Discovery and Development
Discovery and Development [Member]
Discovery and Development
Subsequent Events [Abstract]
Subsequent Events [Abstract]
Segment Reporting [Abstract]
Segment Reporting [Abstract]
Pay vs Performance Disclosure, Table
Pay vs Performance [Table Text Block]
Debt Disclosure [Abstract]
Debt Disclosure [Abstract]
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Shares available for exchange (in shares)
Collaborative Arrangement, Shares Available For Exchange
Collaborative Arrangement, Shares Available For Exchange
Entity Tax Identification Number
Entity Tax Identification Number
Scenario
Scenario [Domain]
Nonemployee
Share-Based Payment Arrangement, Nonemployee [Member]
Grantee Status [Axis]
Grantee Status [Axis]
Other assets and other current assets
Increase Decrease In Other Assets And Other Current Assets
Increase decrease in other assets and other current assets.
Unamortized revolving line debt discount balance
Debt Instrument, Unamortized Discount
Weighted-average exercise price outstanding at beginning balance (in USD per shares)
Weighted-average exercise price outstanding at ending balance (in USD per shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Expense of Enforcement, Amount
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Common stock, par value (in USD per shares)
Common Stock, Par or Stated Value Per Share
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Employee-related costs (including share-based compensation)
Employee Related Costs, General And Administrative Expense
Employee Related Costs, General And Administrative Expense
Weighted-average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Interest expense
Interest Expense, Nonoperating
Trading Arrangement:
Trading Arrangement [Axis]
Total Shareholder Return Amount
Total Shareholder Return Amount
SUBSEQUENT EVENTS
Subsequent Events [Text Block]
Insider Trading Arrangements [Line Items]
Security Exchange Name
Security Exchange Name
Investment in iECURE
Equity Securities [Member]
Total liabilities
Liabilities
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Principal amount
Line of Credit Facility, Maximum Borrowing Capacity
Pension Adjustments Prior Service Cost
Pension Adjustments Prior Service Cost [Member]
Operating expenses
Operating Expenses [Abstract]
Prepaid expenses
Prepaid Expense, Current
Material Terms of Trading Arrangement
Material Terms of Trading Arrangement [Text Block]
Other current liabilities
Other Liabilities, Current
Asset Class
Asset Class [Domain]
(Loss) gain from changes in fair value included in earnings
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Gain (Loss) Included in Earnings
Statement [Line Items]
Statement [Line Items]
Rule 10b5-1 Arrangement Adopted
Rule 10b5-1 Arrangement Adopted [Flag]
Cash and cash equivalents
Cash and Cash Equivalent
Payment Tranche One
Payment Tranche One [Member]
Payment Tranche One
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Counterparty Name
Counterparty Name [Axis]
Summary of Restricted Stock Unit Activity
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Common Stock
Common Stock [Member]
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Non-NEOs
Non-NEOs [Member]
Net decrease in cash and cash equivalents
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Dilutive impact of share-based awards (in shares)
Weighted Average Number of Shares Outstanding, Diluted, Adjustment