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  <xs:element id="dtil_WarrantLiabilityNoncurrent" abstract="false" name="WarrantLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_GainLossOnChangeInFairValueOfWarrantLiability" abstract="false" name="GainLossOnChangeInFairValueOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodLicensesShares" abstract="false" name="StockIssuedDuringPeriodLicensesShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodValueLicenses" abstract="false" name="StockIssuedDuringPeriodValueLicenses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodSharesWarrantExercise" abstract="false" name="StockIssuedDuringPeriodSharesWarrantExercise" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodThroughATMFacilityNetOfIssuanceCostShares" abstract="false" name="StockIssuedDuringPeriodThroughATMFacilityNetOfIssuanceCostShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_StockIssuedDuringPeriodValueThroughATMFacilityNetOfIssuanceCost" abstract="false" name="StockIssuedDuringPeriodValueThroughATMFacilityNetOfIssuanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_AmortizationOfDiscountOnNoteReceivable" abstract="false" name="AmortizationOfDiscountOnNoteReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_IncreaseDecreaseInOtherAssetsAndOtherCurrentAssets" abstract="false" name="IncreaseDecreaseInOtherAssetsAndOtherCurrentAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_IncreaseDecreaseInAccruedOtherExpensesAndOtherCurrentLiabilities" abstract="false" name="IncreaseDecreaseInAccruedOtherExpensesAndOtherCurrentLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_PaymentsToPurchaseIntangibleAssets" abstract="false" name="PaymentsToPurchaseIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ProceedsFromEmployeeStockPurchasePlan" abstract="false" name="ProceedsFromEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ProceedsFromIssuanceOfCommonStockThroughATMFacilityNetOfIssuanceCost" abstract="false" name="ProceedsFromIssuanceOfCommonStockThroughATMFacilityNetOfIssuanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_WarrantsTextBlock" abstract="false" name="WarrantsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="dtil_InvestmentInIECUREMember" abstract="true" name="InvestmentInIECUREMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_ImugeneMember" abstract="true" name="ImugeneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TwoThousandTwentyFourLoanAndSecurityAgreementMember" abstract="true" name="TwoThousandTwentyFourLoanAndSecurityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_MarchTwentyTwentyFourPublicOfferingMember" abstract="true" name="MarchTwentyTwentyFourPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_November2025PublicOfferingMember" abstract="true" name="November2025PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_OneHalfWarrantsMember" abstract="true" name="OneHalfWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PreFundedWarrantsMember" abstract="true" name="PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TGLicenseMember" abstract="true" name="TGLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_NovartisPharmaAGMember" abstract="true" name="NovartisPharmaAGMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_IECUREMember" abstract="true" name="IECUREMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_AgricultureIndustryCollaborationPartnerMember" abstract="true" name="AgricultureIndustryCollaborationPartnerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DiscoveryAndDevelopmentMember" abstract="true" name="DiscoveryAndDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DevelopmentAndLicenseMember" abstract="true" name="DevelopmentAndLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_ResearchAndLicenseMember" abstract="true" name="ResearchAndLicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PaymentTrancheAxis" abstract="true" name="PaymentTrancheAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="dtil_PaymentTrancheDomain" abstract="true" name="PaymentTrancheDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PaymentTrancheOneMember" abstract="true" name="PaymentTrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PaymentTrancheTwoMember" abstract="true" name="PaymentTrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PercentageOfPremiumOverVolumeWeightedAveragePriceOfCompanysCommonStock" abstract="false" name="PercentageOfPremiumOverVolumeWeightedAveragePriceOfCompanysCommonStock" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_StockIssuedPricePerShareNumberOfTradingDaysPriorToAgreement" abstract="false" name="StockIssuedPricePerShareNumberOfTradingDaysPriorToAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="dtil_CollaborativeArrangementSharesAvailableForExchange" abstract="false" name="CollaborativeArrangementSharesAvailableForExchange" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_RevenueRemainingPerformanceObligationVariableConsiderationAdditionalMilestoneAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAdditionalMilestoneAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ContractWithCustomerLiabilityRevenueRecognizedUponIssuanceOfShares" abstract="false" name="ContractWithCustomerLiabilityRevenueRecognizedUponIssuanceOfShares" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ContractWithCustomerLiabilityRevenueRecognizedAsTransactionPrice" abstract="false" name="ContractWithCustomerLiabilityRevenueRecognizedAsTransactionPrice" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_TwoThousandFifteenStockIncentivePlanMember" abstract="true" name="TwoThousandFifteenStockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TwoThousandNineteenIncentiveAwardPlanMember" abstract="true" name="TwoThousandNineteenIncentiveAwardPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_AmendedPlanMember" abstract="true" name="AmendedPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_TwoThousandNineteenEmployeeStockPurchasePlanMember" abstract="true" name="TwoThousandNineteenEmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_InducementAwardPlanMember" abstract="true" name="InducementAwardPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForIssuance" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_AllowedAnnualPercentageIncreaseInSharesAuthorizedAsPercentageOfOutstandingSharesOfCommonStock" abstract="false" name="AllowedAnnualPercentageIncreaseInSharesAuthorizedAsPercentageOfOutstandingSharesOfCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAvailableForIssuance" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAvailableForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_NumberofSharesIssuedUnderEmployeeStockPurchasePlans" abstract="false" name="NumberofSharesIssuedUnderEmployeeStockPurchasePlans" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="dtil_IncomeTaxDisclosureLineItems" abstract="true" name="IncomeTaxDisclosureLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_PBGENEHepatitisBVirusMember" abstract="true" name="PBGENEHepatitisBVirusMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_PBGENEDuchenneMuscularDystrophyProgramMember" abstract="true" name="PBGENEDuchenneMuscularDystrophyProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_OperatingSegmentMember" abstract="true" name="OperatingSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_DirectResearchAndDevelopmentExpensesByProductCandidateAbstract" abstract="true" name="DirectResearchAndDevelopmentExpensesByProductCandidateAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_ExternalDevelopmentCostsCredits" abstract="false" name="ExternalDevelopmentCostsCredits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_PlatformDevelopmentAndEarlyStageResearchExpensesAbstract" abstract="true" name="PlatformDevelopmentAndEarlyStageResearchExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_EmployeeRelatedCostsResearchAndDevelopmentIncludingShare-BasedCompensation" abstract="false" name="EmployeeRelatedCostsResearchAndDevelopmentIncludingShare-BasedCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_LaboratorySuppliesAndServices" abstract="false" name="LaboratorySuppliesAndServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_CMOsAndOutsourcedResearchAndDevelopment" abstract="false" name="CMOsAndOutsourcedResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_FacilityRelatedCostsLaboratoryEquipmentAndMaintenance" abstract="false" name="FacilityRelatedCostsLaboratoryEquipmentAndMaintenance" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_LicensingFeesAndOtherResearchAndDevelopmentCosts" abstract="false" name="LicensingFeesAndOtherResearchAndDevelopmentCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_EmployeeRelatedCostsGeneralAndAdministrativeExpense" abstract="false" name="EmployeeRelatedCostsGeneralAndAdministrativeExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_ConsultingAndProfessionalServices" abstract="false" name="ConsultingAndProfessionalServices" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="dtil_March2024PublicOfferingMember" abstract="true" name="March2024PublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_WarrantsOrRightsOutstandingOwnershipOfCommonStockOutstandingPercentageConditionForCompanyRepurchase" abstract="false" name="WarrantsOrRightsOutstandingOwnershipOfCommonStockOutstandingPercentageConditionForCompanyRepurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="dtil_MeasurementInputWeightedAverageFairValuePerOptionMember" abstract="true" name="MeasurementInputWeightedAverageFairValuePerOptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="dtil_FairValueWarrantLiabilityRollForward" abstract="true" name="FairValueWarrantLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="dtil_WarrantsAndRightsIssued" abstract="false" name="WarrantsAndRightsIssued" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
