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    <dei:AmendmentDescription contextRef="From2025-01-01to2025-12-31" id="Fact000046">Milestone
Scientific Inc. (the &#x201c;Company&#x201d;) is filing this Amendment No. 1 on Form 10-K/A (this &#x201c;Amendment&#x201d;) to amend its
Annual Report on Form 10-K for the fiscal year ended December 31, 2025, filed with the Securities and Exchange Commission on March 31,
2026 (the &#x201c;Original Form 10-K&#x201d;).This
Amendment is being filed solely to:

&#160;


  
    (i)
    include
    the entire Restated Certificate of Incorporation of the Company as Exhibit 3.1; and
  

    (ii)
    restore
    the Company&#x2019;s Amended and Restated By-laws as Exhibit 3.2.
  
&#160;

The
Original Form 10-K correctly described the Company&#x2019;s Restated Certificate of Incorporation; however, the exhibit link inadvertently
omitted a portion of the filed text. In addition, the Company&#x2019;s Amended and Restated By-laws, which were previously filed as Exhibit
3.2 to the Company&#x2019;s Form 10-K filed on April 1, 2025, were inadvertently omitted from the Original Form 10-K.

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