The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
SPROTT FDS TR URANIUM MINERS E 85208P303 208,521 3,302 SH SOLE 3,302 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 8,856,781 5,467,149 SH SOLE 5,467,149 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 9,040,468 3,299,441 SH SOLE 3,299,441 0 0
AMBEV SA SPONSORED ADR 02319V103 2,769,789 948,558 SH SOLE 948,558 0 0
FATE THERAPEUTICS INC COM 31189P102 497,173 414,311 SH SOLE 414,311 0 0
UNIQURE NV SHS N90064101 7,954,602 486,520 SH SOLE 486,520 0 0
ENGENE HOLDINGS INC COM 29286M105 2,397,712 352,087 SH SOLE 352,087 0 0
AUTOLUS THERAPEUTICS LTD SPON ADS 05280R100 501,533 363,430 SH SOLE 363,430 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 7,562,100 320,972 SH SOLE 320,972 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 23,006,887 366,936 SH SOLE 366,936 0 0
DENALI THERAPEUTICS INC COM 24823R105 4,893,254 254,857 SH SOLE 254,857 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 7,642,602 364,802 SH SOLE 364,802 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 866,883 242,146 SH SOLE 242,146 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,747,323 241,010 SH SOLE 241,010 0 0
UROGEN PHARMA LTD COM M96088105 4,281,434 238,122 SH SOLE 238,122 0 0
IONIS PHARMACEUTICALS INC COM 462222100 21,777,902 290,024 SH SOLE 290,024 0 0
MEIRAGTX HLDGS PLC COM G59665102 1,836,890 212,112 SH SOLE 212,112 0 0
SHOPIFY INC CL A SUB VTG SHS 82509L107 48,278,340 407,000 SH SOLE 407,000 0 0
LEXEO THERAPEUTICS INC COM 52886X107 1,176,700 205,000 SH SOLE 205,000 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 813,093 181,900 SH SOLE 181,900 0 0
LEMONADE INC COM 52567D107 15,999,634 255,259 SH SOLE 255,259 0 0
IREN LIMITED ORDINARY SHARES Q4982L109 10,974,742 320,150 SH SOLE 320,150 0 0
CARTESIAN THERAPEUTICS INC COM NEW 816212302 1,101,551 179,114 SH SOLE 179,114 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 3,393,973 173,516 SH SOLE 173,516 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100 1,585,083 170,256 SH SOLE 170,256 0 0
ZAI LAB LTD ADR 98887Q104 2,486,475 132,189 SH SOLE 132,189 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 463,200 120,000 SH SOLE 120,000 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108 29,256,000 200,000 SH SOLE 200,000 0 0
TESLA INC COM 88160R101 82,528,500 222,000 SH SOLE 222,000 0 0
TRANSOCEAN LTD REGISTERED SHS H8817H100 706,785 106,604 SH SOLE 106,604 0 0
B2GOLD CORP COM 11777Q209 437,041 96,477 SH SOLE 96,477 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 5,214,309 92,305 SH SOLE 92,305 0 0
AST SPACEMOBILE INC COM CL A 00217D100 12,016,150 145,000 SH SOLE 145,000 0 0
SEA LTD SPONSORD ADS 81141R100 11,427,780 138,000 SH SOLE 138,000 0 0
AMAZON COM INC COM 023135106 26,033,750 125,000 SH SOLE 125,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 1,524,691 63,982 SH SOLE 63,982 0 0
AXSOME THERAPEUTICS INC. COM 05464T104 9,926,376 58,729 SH SOLE 58,729 0 0
NVIDIA CORPORATION COM 67066G104 14,126,400 81,000 SH SOLE 81,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 1,628,000 50,000 SH SOLE 50,000 0 0
COINBASE GLOBAL INC COM CL A 19260Q107 13,794,190 79,000 SH SOLE 79,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,000,960 46,000 SH SOLE 46,000 0 0
PFIZER INC COM 717081103 1,479,226 52,679 SH SOLE 52,679 0 0
BIOGEN INC COM 09062X103 8,029,854 43,800 SH SOLE 43,800 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,039,516 42,874 SH SOLE 42,874 0 0
NOV INC COM 62955J103 790,509 42,026 SH SOLE 42,026 0 0
ADVANCED MICRO DEVICES INC COM 007903107 12,612,660 62,000 SH SOLE 62,000 0 0
HIMS & HERS HEALTH INC COM CL A 433000106 830,400 40,000 SH SOLE 40,000 0 0
SANDRIDGE ENERGY INC COM NEW 80007P869 632,698 38,792 SH SOLE 38,792 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 32,488,970 67,000 SH SOLE 67,000 0 0
MODERNA INC COM 60770K107 1,523,695 29,994 SH SOLE 29,994 0 0
BIONTECH SE SPONSORED ADS 09075V102 2,399,760 27,000 SH SOLE 27,000 0 0
SEABRIDGE GOLD INC COM 811916105 703,626 24,828 SH SOLE 24,828 0 0
SLB LIMITED COM STK 806857108 948,197 18,451 SH SOLE 18,451 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,043,893 12,222 SH SOLE 12,222 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 5,070,462 11,355 SH SOLE 11,355 0 0
KRYSTAL BIOTECH INC COM 501147102 2,885,434 11,170 SH SOLE 11,170 0 0
MOLINA HEALTHCARE INC COM 60855R100 1,085,062 8,140 SH SOLE 8,140 0 0
NOBLE CORP PLC ORD SHS A G65431127 336,080 6,849 SH SOLE 6,849 0 0
TIDEWATER INC NEW COM 88642R109 458,105 5,483 SH SOLE 5,483 0 0
PAN AMERN SILVER CORP COM 697900108 213,057 3,900 SH SOLE 3,900 0 0