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  <xs:element id="iart_DebtCovenantPeriodDomain" abstract="true" name="DebtCovenantPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod1Member" abstract="true" name="DebtCovenantPeriod1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod2Member" abstract="true" name="DebtCovenantPeriod2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod3Member" abstract="true" name="DebtCovenantPeriod3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtCovenantPeriod4Member" abstract="true" name="DebtCovenantPeriod4Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_SeniorCreditFacilityMember" abstract="true" name="SeniorCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtInstrumentCovenantMaximumLeverageRatio" abstract="false" name="DebtInstrumentCovenantMaximumLeverageRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="iart_TermLoanFacilityMember" abstract="true" name="TermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_TwoThousandTwentyFiveSeniorConvertibleNotesMember" abstract="true" name="TwoThousandTwentyFiveSeniorConvertibleNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_SecuritizationFacilityMember" abstract="true" name="SecuritizationFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CovenantReliefPeriodMember" abstract="true" name="CovenantReliefPeriodMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_ThereafterCovenantReliefPeriodMember" abstract="true" name="ThereafterCovenantReliefPeriodMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_SwinglineLoansMember" abstract="true" name="SwinglineLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtCovenantRangeAxis" abstract="true" name="DebtCovenantRangeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="iart_DebtCovenantRangeDomain" abstract="true" name="DebtCovenantRangeDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtCovenantConsolidatedTotalLeverageRatioRangeOneMember" abstract="true" name="DebtCovenantConsolidatedTotalLeverageRatioRangeOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtCovenantConsolidatedTotalLeverageRatioRangeFiveMember" abstract="true" name="DebtCovenantConsolidatedTotalLeverageRatioRangeFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DebtInstrumentBasisSpreadAdjustmentOnVariableRate" abstract="false" name="DebtInstrumentBasisSpreadAdjustmentOnVariableRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iart_DebtInstrumentGrossFairValueDisclosure" abstract="false" name="DebtInstrumentGrossFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestPaymentsReminderOfFiscalYear" abstract="false" name="InterestPaymentsReminderOfFiscalYear" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestPaymentsYearOne" abstract="false" name="InterestPaymentsYearOne" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_InterestPaymentsYearTwo" abstract="false" name="InterestPaymentsYearTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_PaymentsForOptionIndexToIssuersEquity" abstract="false" name="PaymentsForOptionIndexToIssuersEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit" abstract="false" name="TransferorsInterestsInTransferredFinancialAssetsMaximumInvestmentLimit" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_DebtWeightedAverageInterestRateFromSecuritization" abstract="false" name="DebtWeightedAverageInterestRateFromSecuritization" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember182018Tranche1Member" abstract="true" name="InterestRateSwapDesignatedDecember182018Tranche1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember182018Tranche2Member" abstract="true" name="InterestRateSwapDesignatedDecember182018Tranche2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember152020Tranche1Member" abstract="true" name="InterestRateSwapDesignatedDecember152020Tranche1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedDecember152020Tranche2Member" abstract="true" name="InterestRateSwapDesignatedDecember152020Tranche2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_InterestRateSwapDesignatedMarch312023Member" abstract="true" name="InterestRateSwapDesignatedMarch312023Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractOneMember" abstract="true" name="CrossCurrencyInterestRateContractOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractTwoMember" abstract="true" name="CrossCurrencyInterestRateContractTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CNHExchangeForwardMember" abstract="true" name="CNHExchangeForwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CHFExchangeForwardMember" abstract="true" name="CHFExchangeForwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_EURExchangeForwardMember" abstract="true" name="EURExchangeForwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_IntercompanyLoanQuarterlyPayment" abstract="false" name="IntercompanyLoanQuarterlyPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_NumberOfIntercompanyLoans" abstract="false" name="NumberOfIntercompanyLoans" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_IntercompanyLoanFaceAmount" abstract="false" name="IntercompanyLoanFaceAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_IntercompanyLoanAnnualPayment" abstract="false" name="IntercompanyLoanAnnualPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractThreeMember" abstract="true" name="CrossCurrencyInterestRateContractThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractFourMember" abstract="true" name="CrossCurrencyInterestRateContractFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CrossCurrencyInterestRateContractFiveMember" abstract="true" name="CrossCurrencyInterestRateContractFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_AccruedExpensesAndOtherCurrentLiabilitiesMember" abstract="true" name="AccruedExpensesAndOtherCurrentLiabilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_EmployeeMember" abstract="true" name="EmployeeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DirectorsandCertainExecutiveOfficersMember" abstract="true" name="DirectorsandCertainExecutiveOfficersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DefinedBenefitPlanDeferPaymentAndTaxationBaseSalaryPercentage" abstract="false" name="DefinedBenefitPlanDeferPaymentAndTaxationBaseSalaryPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iart_DefinedBenefitPlanDeferPaymentAndTaxationBonusAndOtherCompensationPercentage" abstract="false" name="DefinedBenefitPlanDeferPaymentAndTaxationBonusAndOtherCompensationPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iart_FiveYearOptionLeasePeriodOneMember" abstract="true" name="FiveYearOptionLeasePeriodOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_FiveYearOptionLeasePeriodTwoMember" abstract="true" name="FiveYearOptionLeasePeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_LesseeOperatingLeaseNumberOfRenewalOptions" abstract="false" name="LesseeOperatingLeaseNumberOfRenewalOptions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector" abstract="false" name="PercentOfManufacturingFacilityOwnedByCorporationWhoseShareholdersAreTrustsWhoseBeneficiariesIncludeFamilyMembersOfCompanysFormerDirector" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="iart_AnnualRateOfLeaseAgreement" abstract="false" name="AnnualRateOfLeaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="iart_OptionToExtendLeaseYears" abstract="false" name="OptionToExtendLeaseYears" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="iart_CashFlowLesseeAbstract" abstract="true" name="CashFlowLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iart_RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" abstract="true" name="RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="iart_RelatedPartiesMember" abstract="true" name="RelatedPartiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_ThirdPartiesMember" abstract="true" name="ThirdPartiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_A2023ShareRepurchaseProgramMember" abstract="true" name="A2023ShareRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CodmanSpecialtySurgicalMember" abstract="true" name="CodmanSpecialtySurgicalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_SegmentReportingInformationNumberOfProductsOffered" abstract="false" name="SegmentReportingInformationNumberOfProductsOffered" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_RestOfTheWorldMember" abstract="true" name="RestOfTheWorldMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_ArkisBioSciencesInc.Member" abstract="true" name="ArkisBioSciencesInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DermaSciencesMember" abstract="true" name="DermaSciencesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_ACellMember" abstract="true" name="ACellMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_SurgicalInnovationAssociatesIncMember" abstract="true" name="SurgicalInnovationAssociatesIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_ContingentConsiderationLiabilityMember" abstract="true" name="ContingentConsiderationLiabilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_DevelopmentMilestonesMember" abstract="true" name="DevelopmentMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_CommercialSalesMilestonesMember" abstract="true" name="CommercialSalesMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" abstract="true" name="BioDEarnoutPaymentsandMedihoneyEarnoutPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_RevenueBasedPerformanceMilestonesMember" abstract="true" name="RevenueBasedPerformanceMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_FDAApprovalOfPremarketApprovalMember" abstract="true" name="FDAApprovalOfPremarketApprovalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="iart_BusinessCombinationContingentConsiderationNumberOfLiabilities" abstract="false" name="BusinessCombinationContingentConsiderationNumberOfLiabilities" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_BusinessAcquisitionNumberOfContingentLiabilities" abstract="false" name="BusinessAcquisitionNumberOfContingentLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="iart_ShortTermInvestmentsFairValueDisclosure" abstract="false" name="ShortTermInvestmentsFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
