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VIA EDGAR

May 5, 2026

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re:          Morgan Stanley Variable Insurance Fund, Inc.

File Nos. 333-03013; 811-07607

Ladies and Gentlemen:

On behalf of Morgan Stanley Variable Insurance Fund, Inc. (“Registrant”) and pursuant to Rule 497(j) under the Securities Act of 1933, as amended (the “Securities Act”), I hereby certify that (i) the forms of prospectuses and statement of additional information contained in Post-Effective Amendment No. 78 to Registrant’s Registration Statement on Form N-1A, filed on April 16, 2026, constituting the most recent amendment to this Registration Statement (the “Amendment”), that would have been filed pursuant to Rule 497(c) under the Securities Act would not have differed from those contained in the Amendment, and (ii) the text of the Amendment was filed electronically with the Securities and Exchange Commission on April 16, 2026, accession number 0001133228-26-005514.

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