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  <xs:element id="sdgr_AjaxTherapeuticsIncMember" abstract="true" name="AjaxTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sdgr_StructureTherapeuticsMember" abstract="true" name="StructureTherapeuticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sdgr_NumberOfPreferredSharesPurchased" abstract="false" name="NumberOfPreferredSharesPurchased" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="sdgr_NumberOfSharesPurchased" abstract="false" name="NumberOfSharesPurchased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="sdgr_AmericanDepositorySharesPurchasedPricePerShare" abstract="false" name="AmericanDepositorySharesPurchasedPricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="sdgr_GatesVenturesLLCMember" abstract="true" name="GatesVenturesLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sdgr_ColumbiaUniversityAndRichardFriesnerMember" abstract="true" name="ColumbiaUniversityAndRichardFriesnerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sdgr_PercentageOfVotingSecurities" abstract="false" name="PercentageOfVotingSecurities" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="sdgr_SoftwareSegmentMember" abstract="true" name="SoftwareSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sdgr_DrugDiscoverySegmentMember" abstract="true" name="DrugDiscoverySegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="sdgr_UnallocatedAbstract" abstract="true" name="UnallocatedAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="sdgr_APACMember" abstract="true" name="APACMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
