
		As of March 31, 2026			As of December 31, 2025
	Estimated Useful Lives	Gross Carrying Amount	Accumulated Amortization	Net Carrying Amount	Gross Carrying Amount	Accumulated Amortization	Net Carrying Amount
		(in millions, except useful lives)
In-process research and development	Indefinite	$224.6	$—	$224.6	$224.6	$—	$224.6
Finite-lived intangible assets - marketed products	10 to 12 years	238.0	(47.1)	190.9	238.0	(42.1)	195.9
Finite-lived intangible assets - assembled workforce	3 years	7.7	(4.7)	3.0	7.7	(4.0)	3.7
Total other intangible assets, net		$470.3	$(51.8)	$418.5	$470.3	$(46.1)	$424.2

In March 2025, based on results from a Phase 1/2 clinical trial evaluating our VX-264 clinical program in patients with

type 1 diabetes (“T1D”), we concluded that VX-264 will not be advancing further in clinical development. Based on this

event, we performed an interim impairment test on the fair value of our VX-264 indefinite-lived in-process research and

development asset that we acquired from Semma Therapeutics, Inc. in 2019. As a result, using the multi period earnings

method of the income approach, we recorded a full intangible asset impairment charge of $379.0 million in the first quarter of

2025. As of March 31, 2026, our remaining indefinite-lived in-process research and development assets were associated with