75000 - Document - Document and Entity Information
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75010 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited)
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75020 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical)
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75030 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Unaudited)
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75040 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited)
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75050 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited) (Parenthetical)
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75060 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)
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75070 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) 2
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75080 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) (Parenthetical)
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995455 - Disclosure - Organization and Nature of Business
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995465 - Disclosure - Summary of Significant Accounting Policies
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995475 - Disclosure - Fair Value Measurements
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995495 - Disclosure - Collaborations
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995505 - Disclosure - Property and Equipment
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995515 - Disclosure - Leases
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995525 - Disclosure - Accrued Expenses
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995535 - Disclosure - Other Commitments and Contingencies
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995545 - Disclosure - Convertible Preferred Stock
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995555 - Disclosure - Equity-Based Compensation
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995565 - Disclosure - Related Party Transactions
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995575 - Disclosure - Income Taxes
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995585 - Disclosure - Net Loss per Share
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995595 - Disclosure - Segment Reporting
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995605 - Disclosure - Subsequent Events
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995615 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995625 - Disclosure - Fair Value Measurements (Tables)
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995645 - Disclosure - Collaborations (Tables)
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995655 - Disclosure - Property and Equipment (Tables)
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995665 - Disclosure - Leases (Tables)
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995675 - Disclosure - Accrued Expenses (Tables)
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995685 - Disclosure - Equity-Based Compensation (Tables)
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995695 - Disclosure - Net Loss per Share (Tables)
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995705 - Disclosure - Segment Reporting (Tables)
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995715 - Disclosure - Organization and Nature of Business - Additional Information (Details)
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995725 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995735 - Disclosure - Fair Value Measurements - Schedule of Assets Measured at Fair Value on Recurring Basis (Details)
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995745 - Disclosure - Fair Value Measurements - changes in warrant liability measure at fair value (Details)
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995755 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995785 - Disclosure - Collaborations - Additional Information (Details)
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995795 - Disclosure - Collaborations - Change in Accounts Receivable, Contract Asset and Liabilities (Details)
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995805 - Disclosure - Property and Equipment - Summary of Property and Equipment (Details)
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995815 - Disclosure - Property and Equipment - Additional Information (Details)
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995825 - Disclosure - Leases - Additional Information (Details)
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995835 - Disclosure - Leases - Components of Lease Costs (Details)
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995845 - Disclosure - Leases - Supplemental Cash Flow Information Relating to Leases (Details)
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995855 - Disclosure - Leases - Summary of Weighted Average Remaining Lease Terms and Discount Rates (Details)
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995865 - Disclosure - Leases - Summary of Undiscounted Future Lease Payments for Operating and Finance Leases (Details)
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995875 - Disclosure - Leases - Summary of Undiscounted Future Lease Payments for Operating and Finance Leases (Details) 2
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995885 - Disclosure - Leases - Summary of Undiscounted Future Lease Payments for Operating and Finance Leases (Details) 3
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995895 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Details)
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995905 - Disclosure - Other Commitments and Contingencies - Additional Information (Details)
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995915 - Disclosure - Convertible Preferred Stock - Additional Information (Details)
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995925 - Disclosure - Equity-Based Compensation - Additional Information (Details)
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995935 - Disclosure - Equity-Based Compensation - Summary of Stock Option Activity (Details)
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995945 - Disclosure - Equity-Based Compensation - Summary of Equity-Based Compensation Expense (Details)
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995955 - Disclosure - Equity-Based Compensation - Summary of Weighted-Average Assumptions (Details)
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995965 - Disclosure - Equity-Based Compensation - Summary of Restricted Stock Activity (Details)
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995975 - Disclosure - Related Party Transactions - Additional Information (Details)
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995985 - Disclosure - Income Taxes - Additional Information (Details)
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995995 - Disclosure - Net Loss per Share (Additional Information) (Details)
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996005 - Disclosure - Net Loss per Share - Summary of Basic and Diluted Loss Per Share (Details)
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996015 - Disclosure - Net Loss per Share - Schedule of Diluted Net Loss Per Share Attributable to Common Stockholders Anti-Diluted Effect (Details)
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996025 - Disclosure - Segment Reporting (Additional Information) (Details)
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996035 - Disclosure - Segment Reporting - Schedule of Segment Reporting Presents Reportable Segment Profit and Loss (Details)
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996045 - Disclosure - Segment Reporting - Schedule of Segment Reporting Presents Reportable Segment Profit and Loss (Parenthetical) (Details)
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996055 - Disclosure - Subsequent Events - Additional Information (Details)
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Change in fair value of warrant of liability
Change in fair value of warrant of liability
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested
2019 Lease
Two Thousand Nineteen Lease [Member]
Two Thousand Nineteen Lease [Member]
Jefferies Sales Agreement or Jefferies LLC [Member]
Jefferies Sales Agreement or Jefferies LLC [Member]
Jefferies Sales Agreement or Jefferies LLC
Other Research and Development Expense
External research and development
Finance Lease, Liability
Present value of lease liabilities
Finance Lease, Liability, Total
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Finance Lease, Liability, to be Paid, Year Four
2025
2030
Preferred Stock, Shares Issued
Statement of Financial Position Location, Balance [Domain]
Balance Sheet Location
Nello Mainolfi [Member]
Nello Mainolfi [Member]
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Plan Name [Axis]
Plan Name
Entity Current Reporting Status
Entity Current Reporting Status
Base Rent
Rental And Lease Expenses
Rental And Lease Expenses
US government agencies
US Government Agencies Debt Securities [Member]
Operating Expenses [Abstract]
Operating expenses:
Fair Value, Inputs, Level 2 [Member]
Level 2
Weighted Average Strike Price Per Option
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Commitments and Contingencies Disclosure [Text Block]
Other Commitments and Contingencies
Common Stock, Shares Authorized
Common stock, authorized
Temporary Equity, Par or Stated Value Per Share
Convertible Preferred Stock, par or stated value per share
Document Fiscal Period Focus
Document Fiscal Period Focus
Finance Lease, Liability, to be Paid
Total minimum lease payments
Entity Shell Company
Entity Shell Company
Temporary Equity, Shares Outstanding
Temporary Equity, Ending Balance, Shares
Temporary Equity, Beginning Balance, Shares
Convertible Preferred Stock, outstanding
Other Accrued Liabilities, Current
Other
Cash and Cash Equivalent
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Gilead Agreement [Member]
Gilead Agreement [Member]
Gilead Agreement
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Common Stock, Shares, Issued
Common stock, issued
Common Stock, Shares, Issued, Total
Statement [Table]
Statement [Table]
Restricted Cash, Noncurrent
Restricted cash
Fair value assets level 1 to level 3 transfers amount.
Fair Value Assets Level1 To Level3 Transfers Amount
Fair value assets, level 1 to level 3 transfers, amount
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average fair value of options granted
Upfront payment.
Upfront Payment
Upfront payment
Plus: [Abstract]
Plus: [Abstract]
Plus:
Statement [Line Items]
Statement [Line Items]
Entity Filer Category
Entity Filer Category
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of Units Outstanding
Liabilities and Equity
Total liabilities and stockholders’ equity
Exercisable at September 30, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Exercisable at March 31, 2025
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Finance Lease, Liability, to be Paid, Year Three
2024
2029
Prepaid Expenses and Other Current Assets [Member]
Prepaid Expenses and Other Current Assets
Private Investment in Public Equity "PIPE" [Member]
Private Investment in Public Equity "PIPE" [Member]
Private Investment in Public Equity "PIPE"
Latest Tax Year [Member]
Latest Tax Year
Cash and Cash Equivalents, Fair Value Disclosure
Cash equivalents
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Options to Purchase Common Stock
Finance Lease, Liability, to be Paid, Remainder of Fiscal Year
2024 (excluding the first quarter)
2026 (excluding the first quarter)
Deferred Revenue Gilead [Member]
Deferred Revenue Gilead [Member]
Deferred Revenue - Gilead
Debt Securities, Available-for-Sale, Noncurrent
Marketable securities, non-current (Note 4)
Fair value of available-for-sale debt securities, contractual maturity of greater than 12 months
Geographical [Domain]
Geographical
Scenario potential outcome.
Scenario Potential Outcome [Domain]
Scenario Potential Outcome
Finance lease liability payments due after year four.
Finance Lease Liability Payments Due After Year Four
Thereafter
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock
Additional paid-in capital
Additional Paid in Capital, Common Stock, Ending Balance
Increase or decrease pre-funded warrants, maximum
Increase or decrease pre-funded warrants
Increase or decrease pre-funded warrants
Development milestone payments.
Development Milestone Payments
Development milestone payments
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of Basic and Diluted Loss Per Share
Increase (Decrease) in Other Operating Assets and Liabilities, Net
Other assets and liabilities
Increase (Decrease) in Other Operating Assets and Liabilities, Net, Total
Net loss per share, basic
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share, basic and diluted
Performance Stock Options Third Clinical Milestone Vesting Percentage
Performance stock options third clinical milestone vesting percentage
Third clinical milestone vesting percentage
Collaboration Target 2
Collaboration target two.
Collaboration Target Two [Member]
Fair value assets level 3 to level 1 transfers amount.
Fair Value Assets Level3 To Level1 Transfers Amount
Fair value assets, level 3 to level 1 transfers, amount
Option Exercise Payment
Option Exercise Payment
Option Exercise Payment
Outstanding at beginning of period
Outstanding at end of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Impairment of Leasehold
Reduction of right-of-use asset and liability due to lease modification
Liabilities, Current
Total current liabilities
Available-for-sale securities, credit losses
Available For Sale Securities Credit Losses
Available for sale securities credit losses.
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Bruce Jacobs [Member]
Bruce Jacobs [Member]
Option Indexed to Issuer's Equity, Strike Price
Strike price
Accounting Standards Update [Axis]
Accounting Standards Update
Equity, Attributable to Parent [Abstract]
Stockholders’ equity:
Deferred revenue - Vertex.
Deferred Revenue Vertex [Member]
Deferred Revenue - Vertex
Entity Small Business
Entity Small Business
Increase (Decrease) in Accrued Liabilities
Accrued expenses and other current liabilities
Increase (Decrease) in Accrued Liabilities, Total
Series C SPA
Series C preferred stock purchase agreement.
Series C Preferred Stock Purchase Agreement [Member]
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Proceeds from Issuance Initial Public Offering
Public offering, net of issuance costs
Sale of Stock, Price Per Share
Common stock per share
Stock issued price per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Exercised
Intrinsic value of stock options exercised
Share-Based Payment Arrangement [Text Block]
Equity-Based Compensation
Accumulated amortization.
Accumulated Amortization
Accumulated amortization
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Significant accounting policies.
Significant Accounting Policies Policy [Text Block]
Significant Accounting Policies
Lease Contractual Term [Axis]
Leases [Abstract]
Project [Domain]
Project
Contract with Customer, Liability
Contract Liabilities, Ending balance
Contract Liabilities, Beginning balance
Contract with Customer, Liability, Total
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Amendment Flag
Amendment Flag
Loss Contingencies [Line Items]
Loss Contingencies [Line Items]
Weighted Average Common Shares Outstanding Diluted
Weighted Average Common Shares Outstanding Diluted
Weighted average common shares outstanding, diluted
Issuance of Common Stock Under A T M Net of Issuance Costs Shares
Issuance of Common Stock Under A T M Net of Issuance Costs Shares
Issuance of common stock under ATM, net of issuance costs Shares
Issuance of common stock through at-the market sales agreement, net of issuance costs of $1.2 million, Shares
Proceeds from Sale, Maturity and Collection of Investments
Maturities of investments
Proceeds from Sale, Maturity and Collection of Investments, Total
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of Common Stock Purchased in Place of Pre funded Warrants
Finance Lease, Interest Expense
Interest expense for finance lease liabilities
Liabilities and Equity [Abstract]
Liabilities and Stockholders’ Equity
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Increase decrease in operating lease liabilities.
Increase Decrease In Operating Lease Liabilities
Operating lease liabilities
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Common Stock [Member]
Common Stock
Common Stock [Member]
Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Lessee, Operating Lease, Liability, to be Paid, Year Three
2024
2029
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Performance award Percentage
Share Based Compensation Arrangement By Share Based Payment Award Performance Award Percentage
Share Based Compensation Arrangement By Share Based Payment Award Performance Award Percentage
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
Entity Address, Address Line One
Entity Address, Address Line One
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in accounting principle, accounting standards update, immaterial effect
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Weighted-Average Assumptions
Marketable Securities [Table]
Marketable Securities [Table]
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Earnings Per Share [Abstract]
Loss Contingency Accrual
Liabilities accrued
Loss Contingency Accrual, Beginning Balance
Loss Contingency Accrual, Ending Balance
Supplemental Cash Flow Information [Abstract]
Supplemental disclosure of cash flow activities
Statement of Financial Position Location, Balance [Axis]
Balance Sheet Location
Investment Type [Axis]
Investment Type
Operating Lease, Right-of-Use Asset
Right-of-use assets, operating leases
Finance Lease, Liability, Undiscounted Excess Amount
Less amounts representing interest or imputed interest
Share based compensation arrangement by share based payment award options granted in period intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Intrinsic Value
Granted
Class of Warrant or Right [Axis]
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Debt Securities, Available-for-Sale [Table Text Block]
Summary of Available-for-Sale Debt Securities
Income tax disclosure.
Income Tax Disclosure [Line Items]
Income Tax Disclosure [Line Items]
Pre Funded Warrants [Member]
Pre Funded Warrants [Member]
Pre-funded warrants
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net decrease in cash, cash equivalents and restricted cash
Subsequent Event Type [Domain]
Subsequent Event Type
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive stock
Impairment of Long-Lived Assets to be Disposed of
Impairment of long-lived assets
Common Stock, Par or Stated Value Per Share
Common stock, par value
Common Stock Per Share Exercise Price
Accounting Standards Update [Domain]
Accounting Standards Update
Security Deposit
Security deposit
Pre-funded warrants to purchase
Proceeds from Issuance of Warrants
Pre-funded common stock purchase warrants
common stock purchase warrants
common stock purchase warrants
Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Debt Securities, Available-for-Sale
Fair Value
Marketable securities
Debt Securities, Available-for-sale, Total
Indemnification Agreement [Member]
Indemnified Parties
Lab and office equipment.
Lab And Office Equipment [Member]
Lab and Office Equipment Under Finance Right of Use Asset
Lab And Office Equipment
2021 Lease
Two Thousand Twenty One Lease [Member]
Two Thousand Twenty One Lease [Member]
Lesser of potential outcome one.
Lesser of Potential Outcome 1
Lesser Of Potential Outcome One [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercise of stock options, Shares
Exercised
Fair Value, Ending
Fair value , Beginning
Fair Value
Fair Value
Accrued Liabilities, Current
Accrued expenses (Note 8)
Accrued expenses
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Current Fiscal Year End Date
Current Fiscal Year End Date
Document Quarterly Report
Document Quarterly Report
Issuance Of Classified Warrants
Issuance Of Classified Warrants
Commission on gross proceeds, percent
Commission on Gross Proceeds, Percent
Commission on Gross Proceeds, Percent
Fair Value, by Balance Sheet Grouping [Table]
Fair Value By Balance Sheet Grouping [Table]
Entity Address, State or Province
Entity Address, State or Province
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Unvested at end of period
Unvested at beginning of period
Property plant and equipment not in service.
Property Plant And Equipment Not in Service
Prior notice period, minimum
Prior notice period
Prior notice period
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Total comprehensive loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Unrealized Gains
Class of Warrant or Right [Domain]
Geographical [Axis]
Geographical
Contract with Customer, Liability, Revenue Recognized
Revenue recognized recorded in deferred revenue
Conversion of Stock, Shares Converted
Number of preferred Stock converted to common stock
Marketable securities, current
Marketable Securities, Current
Marketable Securities, Current, Total
Increase decrease in operating lease right-of-use assets.
Increase Decrease In Operating Lease Right Of Use Assets
Operating lease right-of-use assets
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Equity-Based Compensation Expense
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Accrued Expenses
Collaborative Arrangement Disclosure [Text Block]
Collaborations
Performance Stock
Performance Shares [Member]
Subsequent Event [Member]
Subsequent Events
Property, Plant and Equipment [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Number of additional shares authorized
Other Assets, Noncurrent
Other non-current assets
Other Assets, Noncurrent, Total
Debt Securities, Available-for-Sale, Current
Marketable securities (Note 4)
Debt Securities, Available-for-sale, Current, Total
Proceeds from Issuance of Convertible Preferred Stock
Proceeds from the issuance of Convertible Preferred Stock, net of issuance costs
Proceeds from issuance of convertible preferred stock
Antidilutive Securities [Axis]
Antidilutive Securities
Watertown, Massachusetts.
Watertown Massachusetts [Member]
Watertown, Massachusetts
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income/(Loss)
Customer [Domain]
Lease termination date.
Lease Termination Date
Lease termination date
Land, Buildings and Improvements [Member]
Operating cash flows used in operating leases
Operating lease payments (proceeds).
Operating Lease Payments Proceeds
Preferred Stock, Value, Issued
Preferred stock, $0.0001 par value; 10,000,000 shares authorized as of March 31, 2026 and December 31, 2025; 0 shares issued and outstanding as of March 31, 2026 and December 31, 2025
Milestone payment
Revenue Recognition, Milestone Method, Revenue Recognized
Research and development compensation and related personnel expense
Research And Development Compensation And Related Personnel Expenses
Research And Development Compensation And Related Personnel Expenses
Minimum [Member]
Minimum
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Financial Instrument [Axis]
Financial Instrument
Assets, Current [Abstract]
Current assets:
Interest Expense, Other
Interest and other expense
Fair Value, Inputs, Level 3 [Member]
Level 3
Segment Reporting [Abstract]
Tax Period [Domain]
Tax Period
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of Assets Measured at Fair Value on Recurring Basis
Liabilities, Current [Abstract]
Current liabilities:
Related Party Transactions [Abstract]
Rule10b51Arr Modified Flag
Rule10b51Arr Modified Flag
Pre-funded warrants, exercised
Payments for Repurchase of Warrants
Shares, Outstanding
Shares, Outstanding, Ending Balance
Shares, Outstanding, Beginning Balance
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Proceeds from Stock Plans
Proceeds from stock option exercises
Milestone Two [Member]
Milestone Two [Member]
Milestone Two [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Unvested at end of period
Unvested at beginning of period
General and Administrative Expense [Member]
General and Administrative
Operating Lease, Liability
Present value of lease liabilities
Operating Lease, Liability, Total
Collaboration agreement transaction price.
Collaboration Agreement Transaction Price
Collaboration agreement transaction price
Lab equipment.
Lab Equipment [Member]
Lab Equipment
Weighted Average Common Shares Outstanding Basic
Weighted Average Common Shares Outstanding Basic
Weighted average common shares outstanding, basic
Marketable securities, non-current
Marketable Securities, Noncurrent
Marketable Securities, Noncurrent, Total
Revenue from Contract with Customer, Product and Service [Extensible Enumeration]
Series B-1 Preferred Stock
Series B1 preferred stock.
Series B1 Preferred Stock [Member]
Finance Lease, Liability, Current
Finance lease liabilities
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Finance Lease, Weighted Average Discount Rate, Percent
Finance lease, discount rate
2018 stock option and grant plan.
Two Thousand Eighteen Stock Option And Grant Plan [Member]
2018 Plan
Liabilities, Noncurrent [Abstract]
Non-current liabilities
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Lease Contractual Term [Domain]
Loss Contingencies [Table]
Loss Contingencies [Table]
Weighted average common shares outstanding, basic
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares outstanding, basic and diluted
Less:
Less: [Abstract]
Less: [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Exercisable at September 30, 2021
Exercisable at March 31, 2025
Tenant incentive allowance receivable.
Tenant Incentive Allowance Receivable
Tenant incentive allowance receivable
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Private placement, net of issuance costs
Proceeds from Issuance of Private Placement
Aggregate proceeds from issuance of private placement
Subsequent Events [Text Block]
Subsequent Events
Debt securities, available-for-sale, contractual maturity of 12 months or longer, number of securities.
Debt Securities Available For Sale Contractual Maturity Of12 Months Or Longer Number Of Securities
Number of available-for-sale debt securities, contractual maturity of greater than 12 months
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Performance stock options range
Performance Stock Options Range
Performance Stock Options Range
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Property And Equipment Improvements
Property And Equipment Improvements
Adjustments to additional paid in capital related to temporary equity deemed dividend.
Adjustments To Additional Paid In Capital Related To Temporary Equity Deemed Dividend
Reduction of additional paid-in-capital related to temporary equity deemed dividend
Beginning Balance
Equity, Attributable to Parent
Ending Balance
Total stockholders’ equity
Payments to Acquire Investments
Purchases of investments
Payments to Acquire Investments, Total
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Statement of Stockholders' Equity [Abstract]
Over-Allotment Option [Member]
Underwriters
Leasehold Improvements [Member]
Leasehold Improvements
Entity Address, Address Line Two
Entity Address, Address Line Two
Fair Value Disclosures [Text Block]
Fair Value Measurements
Two Thosuand Twenty Four Follow On Public Offering [Member]
Two Thousand Twenty Four Follow On Public Offering [Member]
2024 Follow-on Public Offerings
Earliest Tax Year [Member]
Earliest Tax Year
Stock issued during period shares restricted stock vested.
Stock Issued During Period Shares Restricted Stock Vested
Vesting restricted stock, Shares
Lessee operating and finance leases.
Lessee Operating And Finance Leases [Text Block]
Leases
Pre-funded warrants per share
Accelerated Share Repurchases, Initial Price Paid Per Share
Issuance of Common Stock Under A T M Net of Issuance Costs Amount
Issuance of Common Stock Under A T M Net of Issuance Costs Amount
Issuance of common stock under ATM, net of issuance costs value
Issuance of common stock through at-the market sales agreement, net of issuance costs of $1.2 million
Project [Axis]
Project
Offering expenses
General Partners' Offering Costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Liabilities
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of noncash investing and financing activities
Plan Name [Domain]
Plan Name
Credit Facility [Axis]
Credit Facility
2020 stock option and incentive plan.
Two Thousand Twenty Stock Option And Incentive Plan [Member]
2020 Plan
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment, Long-Lived Asset, Held-for-Use
Impairment of long-lived assets
Business Description and Basis of Presentation [Text Block]
Organization and Nature of Business
Finance Lease, Liability, to be Paid, Year One
2022
2027
August Two Thousand Twenty Four [Member]
August Two Thousand Twenty Four [Member]
August 2024 [Member]
Pre-funded warrants outstanding
Class of Warrant or Right, Outstanding
Tax Period [Axis]
Tax Period
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Operating Leases
Organization and nature of business.
Organization And Nature Of Business [Table]
Organization And Nature Of Business [Table]
Related and Nonrelated Parties [Axis]
Related Party
Class of Warrant or Right [Table]
Area of Real Estate Property
Area of office space
Entity Address, City or Town
Entity Address, City or Town
Collaboration generated income
Collaboration Income
Collaboration Income
Number of Reportable Segments
Number of reportable segment
Property And Equipment Purchases Included In Accounts Payable And Accrued Expenses
Property and equipment purchases included in accounts payable and accrued expenses.
Property and equipment purchases included in accounts payable and accrued expenses
Security Exchange Name
Security Exchange Name
Credit Facility [Domain]
Credit Facility
Property, Plant and Equipment, Gross
Total property and equipment
Property and equipment right of use assets under finance leases with cost basis
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Fair value of available-for-sale debt securities contractual maturity of less than twelve months.
Fair Value Of Available For Sale Debt Securities Contractual Maturity Of Less Than Twelve Months
Fair value of available-for-sale debt securities, contractual maturity of less than 12 months
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Temporary Equity, Dividends, Adjustment
Deemed dividend from exchange of convertible preferred stock
Deemed dividend from exchange of convertible preferred stock
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement [Domain]
Statistical Measurement
Pre-funded warrant purchase price
Class of Warrant or Right, Exercise Price of Warrants or Rights
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Equity-based compensation expense
Recognized stock-based compensation expense
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Document Period End Date
Document Period End Date
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Commercial milestone payments.
Commercial Milestone Payments
Commercial Milestone Payments
Exercisable at September 30, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Exercisable at March 31, 2025
Subsequent event description
Subsequent Event, Description
Accrued Salaries, Current
Payroll and payroll-related
Statement of Financial Position [Abstract]
Loss Contingency Nature [Axis]
Loss Contingency Nature
Loss Contingency, Nature [Domain]
Loss Contingency, Nature
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss:
Class of Stock [Axis]
Class of Stock
Organization and nature of business.
Organization And Nature Of Business [Line Items]
Organization and Nature of Business [Line Items]
Finance Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Finance Leases
Liabilities
Total liabilities
At-the-Market Offerings
At The Market Offerings [Member]
At The Market Offerings Member
Summary of weighted average remaining lease terms and discount rates.
Summary Of Weighted Average Remaining Lease Terms And Discount Rates Table [Text Block]
Summary of Weighted Average Remaining Lease Terms and Discount Rates
Financial Instruments [Domain]
Financial Instruments
Share-Based Compensation Arrangement by Share-Based Payment Award, Description
Share-based compensation, description
Restricted cash fair value.
Restricted Cash Fair Value
Restricted cash
Series C convertible preferred stock.
Series C Convertible Preferred Stock [Member]
Series C Convertible Preferred Stock
Series C Preferred Stock
Lessee, Operating Lease, Liability, to be Paid, Year Two
2023
2028
Restricted Cash
Restricted cash
Restricted Cash, Total
Series A convertible preferred stock.
Series A Convertible Preferred Stock [Member]
Series A Convertible Preferred Stock
Restricted Stock [Member]
Restricted Stock
Unvested Restricted Stock
Finance Lease, Right-of-Use Asset, Amortization
Amortization of right-to-use assets, finance leases
Amortization expense related to right-of-use assets
Weighted average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted average common shares outstanding, basic and diluted
Securities Act File Number
Entity File Number
Unrealized loss on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Share based compensation arrangement by share based payment award aggregate intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Aggregate Intrinsic Value [Abstract]
Aggregate Intrinsic Value
Cover [Abstract]
Contract with customer liability deductions.
Contract With Customer Liability Deductions
Contract Liabilities, Deductions
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited
Forfeited
Premiums and discounts on available for sale marketable securities.
Premiums And Discounts On Available For Sale Marketable Securities
Premiums and discounts on available-for-sale marketable securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum
Maximum number of shares to be issued, percentage
Investments [Domain]
Investments
Minimum pre-funded warrants, exercise
Minimum pre-funded warrants, exercise
Minimum pre-funded warrants, exercise
US Treasury Securities [Member]
US Treasuries
US treasury securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of shares authorized for issuance under plan
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Sale of Stock
Segment Reporting
Segment Reporting Disclosure [Text Block]
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Subsequent Event [Table]
Subsequent Event [Table]
Vertex Agreement.
Vertex Agreement [Member]
Vertex Agreement
Sanofi collaboration arrangement.
Sanofi Collaboration Arrangement [Member]
Sanofi Agreement
Marketable Securities [Abstract]
Weighted Average Remaining Contractual Term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Issued Accounting Pronouncements
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Contract with Customer, Liability, Current
Deferred revenue
STAT6 Programs [Member]
STAT6 Programs [Member]
STAT6 [Member]
Billed receivables - Sanofi.
Billed Receivables Sanofi [Member]
Billed Receivables - Sanofi
Vertex Pharmaceuticals Incorporated.
Vertex Pharmaceuticals Incorporated [Member]
Vertex Pharmaceuticals Incorporated
Depreciation
Depreciation expense
Depreciation, Total
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Common Stock, Shares, Outstanding
Common Stock, outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Segment Net Loss
Segment Net Loss
Segment net loss
Segment net loss
Operating Lease, Liability, Current
Operating lease liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Document Transition Report
Document Transition Report
Operating Expenses
Total operating expenses
Accrued Liabilities, Current [Abstract]
Research and Development Expense
Research and development
Research and Development Expense, Total
Asset Impairment Charges, Total
Asset Impairment Charges
Lease Impairment Charge
Cost of Revenue
Cost of Revenue, Total
Revenue
Convertible Preferred Stock [Member]
Convertible Preferred Stock
landlord [Member]
landlord [Member]
Statement of Cash Flows [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Grant Date Fair Value per Share
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Earnings Per Share [Text Block]
Net Loss per Share
Contract asset
Contract asset
Increase (decrease) in contract with customer asset related parties.
Increase Decrease In Contract With Customer Asset Related Parties
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Two Thousand Twenty Five Follow On Public Offering [Member]
Two Thousand Twenty Five Follow On Public Offering [Member]
2025 Follow-on Public Offerings
Computer Equipment [Member]
Computer Equipment
Net loss
Net loss
Outstanding at beginning of period
Outstanding at end of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Revenue recognized milestone Payment
Revenue Recognized Milestone Payment
Revenue Recognized Milestone Payment
IRAK4.
I R A K4 [Member]
IRAK4 Program
Interest and other Income
Other Nonoperating Income
Operating Lease, Cost
Operating lease costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Dividend yield
Operating Lease, Payments
Assets [Abstract]
Assets
Fair value assets level 3 to level 2 transfers amount.
Fair Value Assets Level3 To Level2 Transfers Amount
Fair value assets, level 3 to level 2 transfers, amount
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Document Fiscal Year Focus
Document Fiscal Year Focus
Debt securities available for sale decline in market value for unrealized loss position number of securities.
Debt Securities Available For Sale Decline In Market Value For Unrealized Loss Position Number Of Securities
Number of securities decline in market value for in an unrealized loss position
Proceeds From Issuance Of Common Stock Under A T M
Proceeds From Issuance Of Common Stock Under A T M
Issuance of common stock under ATM
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Investing activities
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Research and Development Expense [Member]
Research and Development Expense
Research and Development
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Marketable Securities
Accounting Standards Update 2019-12 [Member]
ASU 2019-12
Lease additional term.
Lease Additional Term
Lease additional term
Pre funded common stock exercised price per share
common stock exercised price per share
common stock exercised price per share
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Change in Accounts Receivable, Contract Asset and Liabilities
Deferred Revenue
Deferred Revenue
Deferred Revenue, Total
Increase in accumulated deficit related to temporary equity deemed dividend.
Increase In Accumulated Deficit Related To Temporary Equity Deemed Dividend
Increase in accumulated deficit related to temporary equity deemed dividend
Two thousand and twenty plan.
Two Thousand And Twenty Plan [Member]
2020 Plan
Schedule of Unvested Restricted Stock Units Roll Forward [Table Text Block]
Summary of Restricted Stock Activity
Temporary Equity Disclosure [Abstract]
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Year One
2025
2027
Net Income (Loss) Available to Common Stockholders, Basic
Net loss
Debt Securities Available For Sale Continuous Unrealized Loss Position Greater Than 12 Months
Debt Securities Available For Sale Continuous Unrealized Loss Position Greater Than 12 Months
Aggregate fair value of available-for-sale debt securities, continuous unrealized loss position for greater than 12 months
Contract assets
Contract with Customer, Asset, after Allowance for Credit Loss, Current
Contract assets—due from related parties
Contract with Customer, Asset, after Allowance for Credit Loss, Current, Total
Equity-Based Compensation
Share-Based Payment Arrangement [Abstract]
Assets, Fair Value Disclosure
Total
Fair Value Measurements [Abstract]
Fair Value Measurements [Abstract]
Sale of Stock [Axis]
Sale of Stock
Lesser of potential outcome two.
Lesser Of Potential Outcome Two [Member]
Lesser of Potential Outcome 2
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by (used in) investing activities
Private Placement [Member]
Private Placement
Private Placement
Finance Lease, Weighted Average Remaining Lease Term
Finance lease, remaining lease term
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited
Income tax disclosure.
Income Tax Disclosure [Table]
Income Tax Disclosure [Table]
Money Market Funds [Member]
Money Market Fund
Lease term.
Lease Term
Lease term
Related and Nonrelated Parties [Domain]
Related Party
Income Tax Disclosure [Text Block]
Income Taxes
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Temporary Equity, Shares Issued
Convertible Preferred Stock, issued
Lessee operating and financing lease liability maturity.
Lessee Operating And Financing Lease Liability Maturity Table [Text Block]
Summary of Undiscounted Future Lease Payments for Operating and Finance Leases
Class of Warrant or Right [Line Items]
Proceeds from issuance initial public offering gross.
Proceeds From Issuance Initial Public Offering Gross
Gross proceeds from issuance initial public offering
2023 (fourth quarter)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
2023 (excluding the first quarter)
2026 (excluding the first quarter)
Milestone One [Member]
Milestone One [Member]
Milestone One [Member]
Consolidated Entities [Axis]
Consolidated Entities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Property, Plant and Equipment [Table Text Block]
Summary of Property and Equipment
Outstanding at end of period
Outstanding at beginning of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Preferred Stock [Text Block]
Convertible Preferred Stock
Income Tax Disclosure [Abstract]
Additional Paid-in Capital [Member]
Additional Paid In Capital
Maximum pre-funded warrants, exercise
Maximum pre-funded warrants, exercise
Series B convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock
Series B Preferred Stock
Measurement Frequency [Domain]
Measurement Frequency
Statement of Income Location, Balance [Axis]
Income Statement Location
Unbilled receivables - Sanofi.
Unbilled Receivables Sanofi [Member]
Unbilled Receivables - Sanofi
Trading Symbol
Trading Symbol
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment
Related Party Transaction [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Noncancelable facility lease agreement.
Noncancelable Facility Lease Agreement [Member]
Noncancelable Facility Lease Agreement
Subsequent Event Type [Axis]
Subsequent Event Type
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Financing activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Fair Value, Recurring [Member]
Fair Value, Recurring
Entity Ex Transition Period
Entity Ex Transition Period
Lessee, Operating Lease, Liability, to be Paid
Total minimum lease payments
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less amounts representing interest or imputed interest
Equity Components [Axis]
Equity Components
Equity Component [Domain]
Equity Component
Series seed convertible preferred stock.
Series Seed Convertible Preferred Stock [Member]
Series Seed Convertible Preferred Stock
Initial Public Offering
IPO [Member]
Customer [Axis]
Contract with customer liability additions.
Contract With Customer Liability Additions
Contract Liabilities, Additions
Assets not yet in service.
Assets Not Yet In Service [Member]
Assets Not Yet in Service
Issuance of Common Stock at Private Placement, net of issuance cost, shares
Issuance of Common Stock at Private Placement, net of issuance cost, shares
Issuance of common stock and accompanying pre-funded warrants from public offering, net of issuance costs of $14.9 million, Shares
Maximum [Member]
Maximum
Statistical Measurement [Axis]
Statistical Measurement
Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Contract with Customer, Liability, Noncurrent
Deferred revenue, net of current portion
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common stock, $0.0001 par value; 150,000,000 shares authorized as of June 30, 2022 and December 31, 2021, 51,856,668 and 51,573,924 shares issued at June 30, 2022 and December 31, 2021, respectively; 51,847,049 and 51,536,181 shares outstanding at June 30, 2022 and December 31, 2021, respectively
Common stock, $0.0001 par value; 150,000,000 shares authorized at March 31, 2026 and December 31, 2025, 82,182,101 and 81,323,532 shares issued and outstanding at March 31, 2026 and December 31, 2025, respectively
Finance Lease, Principal Payments
Financing cash flows used in finance leases
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Research And Development Overheads And Administrative Costs
Research And Development Overheads And Administrative Costs
Research and development overhead and administrative costs
Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total
Unrealized (loss) gain on marketable securities
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Cambridge, Massachusetts.
Cambridge Massachusetts [Member]
Cambridge, Massachusetts
January Two Thousand Twenty Four [Member]
January Two Thousand Twenty Four [Member]
January 2024 [Member]
Other Nonoperating Income (Expense) [Abstract]
Other income (expense):
Warrants exercised
Warrants Exercised
Warrants Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Tenant Improvement Allowance
Tenant Improvement Allowance
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Entity Registrant Name
Entity Registrant Name
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Losses
Schedule of changes in warrant liability measure at fair value [Table]
changes in warrant liability measure at fair value Table Text Block
changes in warrant liability measure at fair value Table Text Block
Other Nonoperating Income (Expense)
Total other income:
Conversion of Stock, Shares Issued
Conversion of stock, shares issued and outstanding
Subsequent Events [Abstract]
Share based compensation arrangement by share based payment award options forfeited in period intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Intrinsic Value
Forfeited
Consolidated Entities [Domain]
Consolidated Entities
Income Tax Expense (Benefit)
Income tax expense (benefit)
Income Tax Expense (Benefit), Total
Measurement Frequency [Axis]
Measurement Frequency
Scenario potential outcome.
Scenario Potential Outcome [Axis]
Scenario Potential Outcome
Lease commencement date
Lease commencement date.
Lease Commencement Date
Proceeds from Issuance of Common Stock
Net proceeds from sale of common stock in public offering
Aggregate gross proceeds
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Performance Stock Options Second Clinical Milestone Vesting Percentage
Performance stock options second clinical milestone vesting percentage
Second clinical milestone vesting percentage
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Payments to Acquire Property, Plant, and Equipment
Purchase of property and equipment, net
Payments to Acquire Property, Plant, and Equipment, Total
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Temporary Equity, by Class of Stock [Table]
Temporary Equity By Class Of Stock [Table]
Assets
Total assets
Facility sublease agreement.
Facility Sublease Agreement [Member]
Facility Sublease Agreement
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Exercisable at September 30, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Exercisable at March 31, 2025
Income Statement [Abstract]
Finance Lease, Interest Payment on Liability
Operating cash flows used in finance leases
Performance Stock Options Vesting Percentage
Performance stock options vesting percentage
Performance stock options vesting
Series B-1 convertible preferred stock.
Series B1 Convertible Preferred Stock [Member]
Series B-1 Convertible Preferred Stock
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Net operating loss carryforwards period CARES Act.
Net Operating Loss Carryforwards Period C A R E S Act
Net operating loss carryforwards period CARES Act
Series A Preferred Units.
Series A Preferred Units [Member]
Series A Preferred Units
Collaboration target one.
Collaboration Target One [Member]
Collaboration Target 1
Unconstrained Consideration
Unconstrained Consideration
Unconstrained Consideration
Common stock shares issued
Stock Issued During Period, Shares, New Issues
Stock Issued During Period, Shares, New Issues
Temporary Equity, Shares Authorized
Convertible Preferred Stock, authorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested
Net loss per share, diluted
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share, basic and diluted
Schedule of Segment Reporting Presents Reportable Segment Profit and Loss
Schedule of Segment Reporting Information, by Segment [Table Text Block]
City Area Code
City Area Code
Rent paid
Payments for Rent
Follow-on offering.
Follow On Offering [Member]
Follow-on Offering
Finance Lease, Liability, Noncurrent
Finance lease liabilities, net of current portion
Debt securities, available-for-sale, contractual maturity of less than 12 months, number of securities.
Debt Securities Available For Sale Contractual Maturity Of Less Than12 Months Number Of Securities
Number of available-for-sale debt securities, contractual maturity of less than 12 months
Restricted cash.
Restricted Cash [Member]
Restricted Cash
Significant accounting policies.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Debt Securities, Available-for-Sale, Sold at Par Value
Sales of marketable securities
Variable Lease, Cost
Variable lease costs
Operating Lease, Weighted Average Remaining Lease Term
Operating lease, remaining lease term
2020 Employee stock purchase plan.
Two Thousand Twenty Employee Stock Purchase Plan [Member]
2020 ESPP
Investor [Member]
Investor
Lease Expiration Date
Lease expiration date
Lease, Cost
Total lease costs
Award Date [Axis]
Letter of Credit [Member]
Letter of Credit
Property, Plant and Equipment, Net
Property and equipment, net (Note 6)
Property and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Deferred revenue - Sanofi.
Deferred Revenue Sanofi [Member]
Deferred Revenue - Sanofi
Total cash, cash equivalents, and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash, cash equivalents and restricted cash at end of period
Cash, cash equivalents and restricted cash at beginning of period
Corporate Bond Securities [Member]
Corporate Bonds
Operating Income (Loss)
Loss from operations
Award Date [Domain]
Retained Earnings [Member]
Accumulated Deficit
Accrued research and development expenses current.
Accrued Research And Development Expenses Current
Research and development expenses
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense, Total
Payments of Stock Issuance Costs
Underwriting discounts, offering costs and issuance costs
Stock issuance costs
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Aggregate fair value of available-for-sale debt securities, continuous unrealized loss position for less than 12 months
Interest and other expense
Other Nonoperating Expense
Other Nonoperating Expense, Total
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease, discount rate
Operating Lease, Liability, Noncurrent
Operating lease liabilities, net of current portion
Fair Value, Inputs, Level 1 [Member]
Level 1
Class of Stock [Line Items]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Components of Lease Costs
Lease, Cost [Table Text Block]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in accounting principle, accounting standards update, adopted
US Government Corporations and Agencies Securities [Member]
US Government Corporations and Agencies Securities [Member]
US government agencies
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Diluted Net Loss Per Share Attributable to Common Stockholders Anti-Diluted Effect
Issuance of Common Stock at Private Placement, net of issuance cost
Issuance of Common Stock at Private Placement, net of issuance cost
Issuance of common stock and accompanying pre-funded warrants from public offering, net of issuance costs of $14.9 million
Issuance of common stock and accompanying pre-funded warrants from public offering, net of issuance costs of $14.9 million
Issuance of common stock and accompanying pre-funded warrants from January 2024 public offering, net of issuance costs of $14.9 million
Corporate Debt Securities [Member]
Corporate securities
Entity Interactive Data Current
Entity Interactive Data Current
Compound Collaboration Agreement [Member]
Compound Collaboration Agreement.
Compound Collaboration
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Statement of Income Location, Balance [Domain]
Income Statement Location
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Operating activities
Furniture & Fixtures
Furniture and Fixtures [Member]
Convertible Preferred Stock, Shares Issued upon Conversion
Shares issued upon exchange of Series A convertible preferred stock
Performance Stock Options Outstanding
Performance stock options outstanding
Performance stock options outstanding
Entity Tax Identification Number
Entity Tax Identification Number
Lessee operating lease liability payments due after year four.
Lessee Operating Lease Liability Payments Due After Year Four
Thereafter
Fair value assets, level 2 to level 3 transfers, amount
Fair value assets level 2 to Level 3 transfers amount.
Fair Value Assets Level2 To Level3 Transfers Amount
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Number of Positions
Number of available-for-sale debt securities, continuous unrealized loss position for less than 12 months
Interest Income, Other
Interest income
Proceeds from Issuance or Sale of Equity, Total
Proceeds from Issuance or Sale of Equity
Aggregate Gross Proceeds
Local Phone Number
Local Phone Number
Other Liabilities, Current
Other current liabilities
Other Liabilities, Current, Total
Unrecognized stock-based compensation expense
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Supplemental cash flow information relating to leases.
Supplemental Cash Flow Information Relating To Leases Table [Text Block]
Supplemental Cash Flow Information Relating to Leases
NonRule10b51Arr Modified Flag
NonRule10b51Arr Modified Flag
Annual increase percentage of rent
Base Rent Annual Increase Over The Lease Term
Base rent annual increase over the lease term.
Finance Lease, Liability, to be Paid, Year Two
2023
2028
Payments of Financing Costs
Payments on finance leases
Payments of Financing Costs, Total
Accounting Policies [Abstract]
Investments and Cash
Cash, cash equivalents and marketable securities
Investments and Cash, Total
Collaboration Revenues
Revenue from Contract with Customer, Excluding Assessed Tax
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue
Collaboration revenue recognised
Collaboration revenue recognised
Collaboration revenue recognised
Lessee, Operating Lease, Liability, to be Paid, Year Four
2025
2030
Class of Stock [Domain]
Class of Stock
Undiscounted Future Lease Payments
Undiscounted Future Lease Payments
Commercial Paper
Commercial Paper [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares remaining available for future grants
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized compensation cost, recognition period
Accrued Professional Fees, Current
Professional fees
Impairment Charge on Reclassified Assets
impairment charge
Stock, Class of Stock [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company