v3.26.1
Insider Trading Arrangements
 3 Months Ended
Mar. 31, 2026
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
As disclosed in the table below, during the three months ended March 31, 2026, certain of our directors and/or executive officers adopted plans for trading arrangements intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) of the Exchange Act.
NamePositionDate of Plan Adoption
Scheduled End Date of Trading Arrangement(a)
Total Number of Securities to Be Sold Under the Plan
Michael S. Brown, M.D.
Director
2/25/202612/30/20261,929 
Joseph L. Goldstein, M.D.
Director
2/5/202611/30/20261,929 
Kathryn Guarini, Ph.D.
Director
2/13/20262/5/20271,600 
Marion McCourt
Executive Vice President, Commercial
2/17/20265/5/20276,989 
(a) The trading arrangement may expire on an earlier date if and when all transactions under the arrangement are completed
Michael S. Brown, M.D. [Member]  
Trading Arrangements, by Individual  
Name Michael S. Brown, M.D.
Title Director
Rule 10b5-1 Arrangement Adopted true
Adoption Date 2/25/2026
Expiration Date 12/30/2026
Arrangement Duration 308 days
Aggregate Available 1,929
Joseph L. Goldstein, M.D. [Member]  
Trading Arrangements, by Individual  
Name Joseph L. Goldstein, M.D.
Title Director
Rule 10b5-1 Arrangement Adopted true
Adoption Date 2/5/2026
Expiration Date 11/30/2026
Arrangement Duration 298 days
Aggregate Available 1,929
Kathryn Guarini, Ph.D. [Member]  
Trading Arrangements, by Individual  
Name Kathryn Guarini, Ph.D.
Title Director
Rule 10b5-1 Arrangement Adopted true
Adoption Date 2/13/2026
Expiration Date 2/5/2027
Arrangement Duration 357 days
Aggregate Available 1,600
Marion McCourt [Member]  
Trading Arrangements, by Individual  
Name Marion McCourt
Title Executive Vice President, Commercial
Rule 10b5-1 Arrangement Adopted true
Adoption Date 2/17/2026
Expiration Date 5/5/2027
Arrangement Duration 442 days
Aggregate Available 6,989