<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Mon Apr 27 20:39:35 UTC 2026 -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:xbrldt="http://xbrl.org/2005/xbrldt">
  <roleRef xlink:type="simple" xlink:href="bgne-20251231.xsd#bgne_r_AdditionalDimensions" roleURI="http://www.beonemedicines.com/role/AdditionalDimensions"/>
  <roleRef xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#PvpAdjustmentsOnly" roleURI="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>
  <definitionLink xlink:role="http://www.beonemedicines.com/role/AdditionalDimensions" xlink:type="extended"/>
  <definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ecd_AllAdjToCompMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_AllAdjToCompMember"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityShareAwardsValueInCompensationTableForTheApplicableYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityShareAwardsValueInCompensationTableForTheApplicableYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="bgne_EquityShareAwardsValueInCompensationTableForTheApplicableYearMember" order="5" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityOptionAwardsValueInCompensationTableForTheApplicableYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityOptionAwardsValueInCompensationTableForTheApplicableYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="bgne_EquityOptionAwardsValueInCompensationTableForTheApplicableYearMember" order="7" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:href="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd#ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAwardsAdjustmentsYearEndFairValueOfShareAwardsGrantedInCurrentYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityAwardsAdjustmentsYearEndFairValueOfShareAwardsGrantedInCurrentYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAwardsAdjustmentsYearEndFairValueOfShareAwardsGrantedInCurrentYearMember" order="1" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedShareAwardsGrantedInPriorYearsMember" xlink:href="bgne-20251231.xsd#bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedShareAwardsGrantedInPriorYearsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedShareAwardsGrantedInPriorYearsMember" order="2" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearShareAwardsVestedDuringCurrentYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearShareAwardsVestedDuringCurrentYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearShareAwardsVestedDuringCurrentYearMember" order="3" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAdjustmentsAwardsIncreaseDecreaseInFairValueOfShareAwardsForfeitedDuringCurrentYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityAdjustmentsAwardsIncreaseDecreaseInFairValueOfShareAwardsForfeitedDuringCurrentYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAdjustmentsAwardsIncreaseDecreaseInFairValueOfShareAwardsForfeitedDuringCurrentYearMember" order="4" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAwardsAdjustmentsYearEndFairValueOfOptionAwardsGrantedInCurrentYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityAwardsAdjustmentsYearEndFairValueOfOptionAwardsGrantedInCurrentYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAwardsAdjustmentsYearEndFairValueOfOptionAwardsGrantedInCurrentYearMember" order="5" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedOptionAwardsGrantedInPriorYearsMember" xlink:href="bgne-20251231.xsd#bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedOptionAwardsGrantedInPriorYearsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfYearEndOfOutstandingAndUnvestedOptionAwardsGrantedInPriorYearsMember" order="6" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearOptionAwardsVestedDuringCurrentYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearOptionAwardsVestedDuringCurrentYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAwardsAdjustmentsChangeInFairValueAsOfVestingDateOfPriorYearOptionAwardsVestedDuringCurrentYearMember" order="7" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="bgne_EquityAdjustmentsAwardsIncreaseDecreaseInFairValueOfOptionAwardsForfeitedDuringCurrentYearMember" xlink:href="bgne-20251231.xsd#bgne_EquityAdjustmentsAwardsIncreaseDecreaseInFairValueOfOptionAwardsForfeitedDuringCurrentYearMember"/>
<!-- [WMV7][XE+mjrljfjGDii/mUK1EUBgOrUlAlBVIzuaTIk7UFe+Qnixl67RvOhow81mbi/yT6V4ssNi2Fd7ThEA2r9/HmdLLDRTcgsvz5u7+RR1SH95zu1INKKp24glRXhhgfMmLlEMtwVr8RFwf4XnxyqAwjItYMgDJoxcljlv9m1gbikt75vq8OF7n/4X1xk2ApDPAO83o8IosAwhI/35SWRADQhnPl3p5OK3PKsS75RNVSAf4oTVlqQ475XC/QvGVxXW9/XOV40mtUZ13MFZpcEVxyohACc9/QClI/NfYwFpOD1ZQUWAOoSzw2/FqgBedWpZ3JnA0uw==] CSR-->
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember" xlink:to="bgne_EquityAdjustmentsAwardsIncreaseDecreaseInFairValueOfOptionAwardsForfeitedDuringCurrentYearMember" order="8" xbrldt:closed="true"/>
  </definitionLink>
</linkbase>
