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  <xsd:element name="EffectiveIncomeTaxRateReconciliationShareBasedCompensationDeferredTaxAssetWriteOffAmount" id="vyne_EffectiveIncomeTaxRateReconciliationShareBasedCompensationDeferredTaxAssetWriteOffAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesPercent" id="vyne_EffectiveIncomeTaxRateReconciliationPermanentDifferencesPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowanceExcludingIncomeFromDiscontinuedOperationsPercent" id="vyne_EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowanceExcludingIncomeFromDiscontinuedOperationsPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationFederalNolCarryforwardDeferredTaxAssetWriteOffPercent" id="vyne_EffectiveIncomeTaxRateReconciliationFederalNolCarryforwardDeferredTaxAssetWriteOffPercent" type="xbrli:pureItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationRDTaxCreditCarryforwardDeferredTaxWriteOffPercent" id="vyne_EffectiveIncomeTaxRateReconciliationRDTaxCreditCarryforwardDeferredTaxWriteOffPercent" type="xbrli:pureItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationShareBasedCompensationDeferredTaxAssetWriteOffPercent" id="vyne_EffectiveIncomeTaxRateReconciliationShareBasedCompensationDeferredTaxAssetWriteOffPercent" type="xbrli:pureItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IncomeTaxTable" id="vyne_IncomeTaxTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IncomeTaxLineItems" id="vyne_IncomeTaxLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FederalNetOperatingLossExpectedToExpireUnutilized" id="vyne_FederalNetOperatingLossExpectedToExpireUnutilized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="ResearchAndDevelopmentTaxCreditsExpectedToExpireUnutilized" id="vyne_ResearchAndDevelopmentTaxCreditsExpectedToExpireUnutilized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="UnrecognizedTaxBenefitsReductionsRelatedToWriteOffOfRDTaxCreditFromDeferredTaxAsset" id="vyne_UnrecognizedTaxBenefitsReductionsRelatedToWriteOffOfRDTaxCreditFromDeferredTaxAsset" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="ReportableSegmentMember" id="vyne_ReportableSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="RepibresibVYN201Member" id="vyne_RepibresibVYN201Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ResearchAndDevelopmentOfVYN202Member" id="vyne_ResearchAndDevelopmentOfVYN202Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
</xsd:schema>
