<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Mon Apr 20 12:33:16 UTC 2026 -->
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  <xs:annotation>
    <xs:appinfo>
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      <link:linkbaseRef xlink:type="simple" xlink:href="adct-20260601_pre.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="adct-20260601_def.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef"/>
    </xs:appinfo>
  </xs:annotation>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei-sub/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
<!-- [WMV7][vi/yhxnVbXqiLd/Oxf62q2trPrXZOg+9PfpQsivv+bXaPYVhoswV1LkLj6QChVtAXvnGl9+J8pi8/y8LtsFiEWBHxh5YU5urWxvJKsRMT8iHitmGUunvroMtl+M6rCZ3zE5WmbSxCbwk3A0Q8Zccpx/U+HoJankJAQobh7K8kt7aevRYu3JG+eRJdmoG23/fbVPHkO7UbfkWavwY5jzYL1irea0yDlXUijkLar9Sqv2KSBUUJsZgZbPPzD08EUxmEbawLG4YPhneAOaxzrBWH6rMlrl2TgOXVvvil9PWkZ/CN+Lw+YWNu27e9rmTo85q/uzr/suecVu/TgQGmv8TuSHPVI7izB+4kU6HeTcoYR1LvLLK7oVsWw==] CSR-->
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</xs:schema>
