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CABALETTA BIO, INC.
<div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold">Policy on the Timing of Awards of Options and Other Option-Like Instruments </div><div style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Our compensation committee has generally granted annual equity awards, including stock option grants to our named executive officers, in the first quarter of each fiscal year. In addition, new hires receive stock option grants at the time of their hiring. Eligible employees, including our named executive officers, may voluntarily enroll in our Employee Stock Purchase Plan and receive an option to purchase shares at a discount using payroll deductions accumulated during the prior six months, with purchase dates occurring in May and November. During 2025, our compensation committee did not take into account any material nonpublic information when determining the timing and terms of equity incentive awards, and we did not time the disclosure of material nonpublic information for the purpose of affecting the value of executive compensation. During 2025, we did not grant stock options to our named executive officers during any period beginning four business days before and ending one business day after the filing or furnishing of a Form <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">10-Q,</div> <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">10-K</div> or <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">8-K</div> that discloses material nonpublic information. </div>
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During 2025, we did not grant stock options to our named executive officers during any period beginning four business days before and ending one business day after the filing or furnishing of a Form <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">10-Q,</div> <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">10-K</div> or <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">8-K</div> that discloses material nonpublic information.
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<div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold">Pay Versus Performance</div><div style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As required by Section 953(a) of the Dodd-Frank Act and Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K,</div> we are providing information about the relationship between executive compensation actually paid to our PEO and the other NEOs (as calculated in accordance with Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K).</div> </div><div style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold"><div style="font-style: normal; letter-spacing: 0px; top: 0px;display:inline;"><div style="font-style:italic;display:inline;"><div style="white-space:nowrap;display:inline;">Pay-Versus-Performance</div> Table</div></div></div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:31%"></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td rowspan="2" style="vertical-align: bottom; white-space: nowrap; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: table-cell; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; line-height: normal;">Year<br/> (a)</div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" rowspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Summary<br/> Compensation<br/> Table Total<br/> for PEO($)<div style="font-size:75% !important; vertical-align:bottom;display:inline;font-size:6.6px">(1)</div><br/> (b)</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" rowspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Compensation<br/> Actually Paid<br/> to PEO($)<div style="font-size:75% !important; vertical-align:bottom;display:inline;font-size:6.6px">(2)</div><br/> (c)</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" rowspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Average<br/> Summary<br/> Compensation<br/> Table Total<br/> for <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> Named<br/> Executive<br/> Officers($)<div style="font-size:75% !important; vertical-align:bottom;display:inline;font-size:6.6px">(3)</div><br/> (d)</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" rowspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Average<br/> Compensation<br/> Actually Paid<br/> to <div style="white-space:nowrap;display:inline;">Non-PEO</div><br/> Named<br/> Executive<br/> Officers($)<div style="font-size:75% !important; vertical-align:bottom;display:inline;font-size:6.6px">(4)</div><br/> (e)</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Value of<br/> Initial Fixed<br/> $100 Investment<br/> Based On:</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" rowspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Net<br/> Income($)<div style="font-size:75% !important; vertical-align:bottom;display:inline;font-size:6.6px">(6)</div><br/> (in millions)<br/> (h)</div></div></td>
<td rowspan="2" style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Total<br/> Shareholder<br/> Return ($)<div style="font-size:75% !important; vertical-align:bottom;display:inline;font-size:6.6px">(5)</div><br/> (f)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,940,573</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,651,621</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">973,267</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">838,741</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">23.68</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">(167.86</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">8,096,947</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">(8,634,793</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">3,351,843</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">(3,023,223</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">24.54</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">(115.86</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2023</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">4,808,279</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">14,466,565</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">2,220,968</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">5,851,276</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">245.41</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">(67.68</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
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<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(1)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The dollar amounts reported in column (b) represent the amount of total compensation reported for Steven Nichtberger, M.D. (the “PEO”), for each corresponding covered fiscal year in the “Total” column of the Summary Compensation Table for each applicable fiscal year. </div></td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(2)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The Compensation Actually Paid to our PEO reflects the following adjustments required by applicable SEC rules from total compensation reported in the Summary Compensation Table: </div></td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
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<tr>
<td style="width:2%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:57%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
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<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td colspan="3" style="vertical-align: bottom; white-space: nowrap; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: table-cell; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; line-height: normal;">PEO</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2023</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2024</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2025</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Summary Compensation Table - Total Compensation</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(a)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">4,808,279</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">8,096,947</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">1,940,573</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Grant Date Fair Value of Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(b)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(3,784,529</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(7,008,417</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(1,266,978</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Fiscal Year End of Outstanding and Unvested Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(c)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">8,297,093</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">477,468</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">856,841</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value of Outstanding and Unvested Stock Awards and Option Awards Granted in Prior Fiscal Years</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(d)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">4,320,037</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(7,049,758</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">144,556</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Vesting of Stock Awards and Option Awards Granted in Fiscal Year That Vested During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(e)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value as of Vesting Date of Stock Awards and Option Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(f)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">825,685</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(3,151,033</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(23,370</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value as of Prior Fiscal Year End of Stock Awards and Option Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(g)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">=</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Compensation Actually Paid</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">14,466,565</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(8,634,793</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">1,651,621</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr></table><div style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">For purposes of the adjustments to determine “Compensation Actually Paid”, we computed the fair value of equity awards in accordance with ASC 718. The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(3)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The dollar amounts reported in column (d) represent the average of the amounts of total compensation reported for our named executive officers (collectively, our NEOs) as a group (excluding our PEOs) for </div></td></tr></table> <div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:center"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%"> </td>
<td style="vertical-align:top;text-align:left">each covered fiscal year in the “Total” column of the Summary Compensation Table for each applicable fiscal year. The (excluding our PEO) for fiscal years 2025, 2024 and 2023 were Gwendolyn Binder, Ph.D. and David J. Chang, M.D., M.P.H.. </td></tr></table><div style="font-size:6pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(4)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The Compensation Actually Paid to our NEOs (excluding PEOs) on average reflects the following adjustments required by applicable SEC rules from total compensation reported in the Summary Compensation Table: </div></td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:2%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:59%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td colspan="3" style="vertical-align: bottom; white-space: nowrap; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: table-cell; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; line-height: normal;">NEO Average</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2023</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2024</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2025</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Summary Compensation Table - Total Compensation</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(a)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">2,220,968</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">3,351,843</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">973,267</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Grant Date Fair Value of Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(b)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(1,498,733</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(2,581,003</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(456,567</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Fiscal Year End of Outstanding and Unvested Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(c)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">3,285,778</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">178,838</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">276,093</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value of Outstanding and Unvested Stock Awards and Option Awards Granted in Prior Fiscal Years</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(d)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">1,565,975</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(2,758,684</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">54,484</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Vesting of Stock Awards and Option Awards Granted in Fiscal Year That Vested During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(e)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value as of Vesting Date of Stock Awards and Option Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(f)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">277,288</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(1,211,216</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(8,536</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value as of Prior Fiscal Year End of Stock Awards and Option Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(g)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">=</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Compensation Actually Paid</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">5,851,276</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(3,023,223</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">838,741</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr></table><div style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">For purposes of the adjustments to determine “Compensation Actually Paid”, we computed the fair value of equity awards in accordance with ASC 718. The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(5)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">Total shareholder return is calculated by assuming that a $100 investment was made on the close of trading on December 31, 2022. Our company did not pay any dividends during fiscal years 2023, 2024 and 2025. </div></td></tr></table><div style="font-size:6pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(6)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The dollar amounts reported represent the amount of net income reflected in the Company’s audited financial statements for the applicable fiscal year. </div></td></tr></table>
1940573
1651621
973267
838741
23.68
-167860000
8096947
-8634793
3351843
-3023223
24.54
-115860000
4808279
14466565
2220968
5851276
245.41
-67680000
Steven Nichtberger
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(2)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The Compensation Actually Paid to our PEO reflects the following adjustments required by applicable SEC rules from total compensation reported in the Summary Compensation Table: </div></td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:2%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:57%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td colspan="3" style="vertical-align: bottom; white-space: nowrap; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: table-cell; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; line-height: normal;">PEO</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2023</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2024</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2025</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Summary Compensation Table - Total Compensation</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(a)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">4,808,279</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">8,096,947</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">1,940,573</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Grant Date Fair Value of Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(b)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(3,784,529</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(7,008,417</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(1,266,978</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Fiscal Year End of Outstanding and Unvested Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(c)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">8,297,093</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">477,468</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">856,841</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value of Outstanding and Unvested Stock Awards and Option Awards Granted in Prior Fiscal Years</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(d)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">4,320,037</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(7,049,758</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">144,556</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Vesting of Stock Awards and Option Awards Granted in Fiscal Year That Vested During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(e)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value as of Vesting Date of Stock Awards and Option Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(f)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">825,685</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(3,151,033</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(23,370</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value as of Prior Fiscal Year End of Stock Awards and Option Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(g)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">=</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Compensation Actually Paid</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">14,466,565</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(8,634,793</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">1,651,621</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr></table>
4808279
8096947
1940573
-3784529
-7008417
-1266978
8297093
477468
856841
4320037
-7049758
144556
0
0
0
825685
-3151033
-23370
0
0
0
14466565
-8634793
1651621
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(3)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The dollar amounts reported in column (d) represent the average of the amounts of total compensation reported for our named executive officers (collectively, our NEOs) as a group (excluding our PEOs) for </div></td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%"> </td>
<td style="vertical-align:top;text-align:left">each covered fiscal year in the “Total” column of the Summary Compensation Table for each applicable fiscal year. The (excluding our PEO) for fiscal years 2025, 2024 and 2023 were Gwendolyn Binder, Ph.D. and David J. Chang, M.D., M.P.H.. </td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(4)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The Compensation Actually Paid to our NEOs (excluding PEOs) on average reflects the following adjustments required by applicable SEC rules from total compensation reported in the Summary Compensation Table: </div></td></tr></table><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:2%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:59%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:2%"></td>
<td></td>
<td></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td colspan="3" style="vertical-align: bottom; white-space: nowrap; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: table-cell; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; line-height: normal;">NEO Average</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2023</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2024</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">2025</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Summary Compensation Table - Total Compensation</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(a)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">2,220,968</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">3,351,843</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">973,267</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Grant Date Fair Value of Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(b)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(1,498,733</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(2,581,003</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(456,567</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Fiscal Year End of Outstanding and Unvested Stock Awards and Option Awards Granted in Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(c)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">3,285,778</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">178,838</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">276,093</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value of Outstanding and Unvested Stock Awards and Option Awards Granted in Prior Fiscal Years</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(d)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">1,565,975</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(2,758,684</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">54,484</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value at Vesting of Stock Awards and Option Awards Granted in Fiscal Year That Vested During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(e)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">+</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Change in Fair Value as of Vesting Date of Stock Awards and Option Awards Granted in Prior Fiscal Years For Which Applicable Vesting Conditions Were Satisfied During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(f)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">277,288</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(1,211,216</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(8,536</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">-</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Fair Value as of Prior Fiscal Year End of Stock Awards and Option Awards Granted in Prior Fiscal Years That Failed to Meet Applicable Vesting Conditions During Fiscal Year</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;text-align:center">(g)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">0</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">=</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">Compensation Actually Paid</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">5,851,276</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">(3,023,223</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom">$</td>
<td style="vertical-align:bottom;text-align:right">838,741</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td></tr></table>
2220968
3351843
973267
-1498733
-2581003
-456567
3285778
178838
276093
1565975
-2758684
54484
0
0
0
277288
-1211216
-8536
0
0
0
5851276
-3023223
838741
<div style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold"><div style="font-style: normal; letter-spacing: 0px; top: 0px;display:inline;"><div style="font-style:italic;display:inline;">Compensation Actually Paid and Company Total Shareholder Return </div></div></div><div style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following graph reflects the relationship between the PEO and average <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-PEO</div> NEO “compensation actually paid” (“CAP”) and our cumulative Total Shareholder Return (“TSR”), assuming an initial fixed investment on December 31, 2022 of $100, for the fiscal years ended December 31, 2025, 2024 and 2023. </div><div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div><div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:center"> </div><div style="font-size:0pt;margin-top:0pt;margin-bottom:0pt"> </div><div style="margin-top:0pt;margin-bottom:0pt;text-align:center">
<img alt="LOGO" src="g922609g49k02.jpg" style="width:6.32639in;height:2.52797in"/> </div>
<div style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><div style="font-style: normal; letter-spacing: 0px; top: 0px;display:inline;"><div style="font-style:italic;display:inline;">Compensation Actually Paid and Net Income</div></div></div><div style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following graph reflects the relationship between the PEO and average <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-PEO</div> NEO CAP, and our net income (loss) for the fiscal years ended December 31, 2025, 2024 and 2023. Because we are not a commercial-stage company, we did not have any revenue during the years ending 2025, 2024 and 2023. Consequently, our company has not historically looked to net income (loss) as a performance measure for our executive compensation program. </div><div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div><div style="font-size:0pt;margin-top:0pt;margin-bottom:0pt"> </div><div style="margin-top:0pt;margin-bottom:0pt;text-align:center"></div><div style="margin-top:0pt;margin-bottom:0pt;text-align:center">
<img alt="LOGO" src="g922609g49k01.jpg" style="width:6.32639in;height:2.52797in"/> </div><div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div>