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  <xs:element name="ScheduleOfPotentiallyDilutiveSharesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ScheduleOfPotentiallyDilutiveSharesAbstract"/>     
  <xs:element name="ScheduleOfFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnARecurringBasisAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ScheduleOfFinancialAssetsAndLiabilitiesMeasuredAtFairValueOnARecurringBasisAbstract"/>     
  <xs:element name="ScheduleOfFairValueOfCryptoAssetsHeldConsolidatedBalanceSheetAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ScheduleOfFairValueOfCryptoAssetsHeldConsolidatedBalanceSheetAbstract"/>  
  <xs:element name="ScheduleOfStockOptionActivitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ScheduleOfStockOptionActivitiesAbstract"/>  
  <xs:element name="ScheduleOfWarrantActivitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ScheduleOfWarrantActivitiesAbstract"/>    
  <xs:element name="SupplementalDisclosureOfCashFlowInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SupplementalDisclosureOfCashFlowInformationAbstract"/> 
  <xs:element name="PreferredStockSharesDesignated" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="silo_PreferredStockSharesDesignated"/>    
  <xs:element name="StakingIncomeOnCryptoAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_StakingIncomeOnCryptoAssets"/>    
  <xs:element name="StockIssuedDuringPeriodValueSaleOfCommonStockAndPrefundedWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_StockIssuedDuringPeriodValueSaleOfCommonStockAndPrefundedWarrants"/>     
  <xs:element name="StockIssuedDuringPeriodShareSaleOfCommonStockAndPrefundedWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_StockIssuedDuringPeriodShareSaleOfCommonStockAndPrefundedWarrants"/>     
  <xs:element name="StockIssuedDuringPeriodValueSaleOfCommonStockAndWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_StockIssuedDuringPeriodValueSaleOfCommonStockAndWarrants"/>  
  <xs:element name="StockIssuedDuringPeriodSharesSaleOfCommonStockAndWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_StockIssuedDuringPeriodSharesSaleOfCommonStockAndWarrants"/>    
  <xs:element name="CancellationOfTreasuryStocks" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_CancellationOfTreasuryStocks"/> 
  <xs:element name="CancellationOfTreasurysStocks" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CancellationOfTreasurysStocks"/>   
  <xs:element name="ExerciseOfWarrantsNetOfOfferingCost" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ExerciseOfWarrantsNetOfOfferingCost"/>     
  <xs:element name="CommonStockIssuedForResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_CommonStockIssuedForResearchAndDevelopment"/>   
  <xs:element name="UnrealizedGainOnShorttermInvestments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_UnrealizedGainOnShorttermInvestments"/>  
  <xs:element name="CryptoAssetsAtFairValueUsedToAcquireShorttermInvestments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_CryptoAssetsAtFairValueUsedToAcquireShorttermInvestments"/>  
  <xs:element name="NoncashOrPartNoncashAcquisitionConversionCryptoAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_NoncashOrPartNoncashAcquisitionConversionCryptoAssets"/> 
  <xs:element name="IntangibleAssetsAcquiredInExchangeForAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_IntangibleAssetsAcquiredInExchangeForAccountsPayableAndAccruedExpenses"/>     
  <xs:element name="DecreaseInIntangibleAssetsAndAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_DecreaseInIntangibleAssetsAndAccountsPayableAndAccruedExpenses"/>    
  <xs:element name="CancellationOfTreasuryStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_CancellationOfTreasuryStock"/>    
  <xs:element name="LiquidityPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_LiquidityPolicyTextBlock"/>    
  <xs:element name="CryptoAssetPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CryptoAssetPolicyTextBlock"/>   
  <xs:element name="CryptoAssetsAtFairValuePolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CryptoAssetsAtFairValuePolicyTextBlock"/>  
  <xs:element name="CryptoAssetsAtCostPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CryptoAssetsAtCostPolicyTextBlock"/>  
  <xs:element name="StakingActivitiesPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_StakingActivitiesPolicyTextBlock"/>     
  <xs:element name="PrepaidExpensesPolicyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PrepaidExpensesPolicyTextBlock"/> 
  <xs:element name="ScheduleOfSummarizesActivityInTheCompanysShortTermInvestmentsAndEquityInvestmentsAtFairValueTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ScheduleOfSummarizesActivityInTheCompanysShortTermInvestmentsAndEquityInvestmentsAtFairValueTableTextBlock"/>   
  <xs:element name="ScheduleOfResearchAgreementsTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ScheduleOfResearchAgreementsTableTextBlock"/>     
  <xs:element name="FairValueofFinancialInstrumentsandFairValueMeasurementsScheduleofFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_FairValueofFinancialInstrumentsandFairValueMeasurementsScheduleofFinancialAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetailsTable"/>   
  <xs:element name="SalesAtOriginalCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SalesAtOriginalCost"/>  
  <xs:element name="CryptoAssetsHeldClassification" type="xbrli:stringItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="silo_CryptoAssetsHeldClassification"/>    
  <xs:element name="UnitsHeldFairValueCryptoAssetsHeld" type="xbrli:tokenItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_UnitsHeldFairValueCryptoAssetsHeld"/>  
  <xs:element name="CryptoAssetsCostBasis" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_CryptoAssetsCostBasis"/>  
  <xs:element name="CryptoAssetsAdjustedCarryingAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_CryptoAssetsAdjustedCarryingAmount"/> 
  <xs:element name="AdditionsFromCryptoAssetsReceivedFromPurchasesMadeWithCashAndStablecoin" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_AdditionsFromCryptoAssetsReceivedFromPurchasesMadeWithCashAndStablecoin"/>  
  <xs:element name="DepositsOfCryptoAssetsUSDCIntoTokenizedInvestmentFundT12Fund" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_DepositsOfCryptoAssetsUSDCIntoTokenizedInvestmentFundT12Fund"/>     
  <xs:element name="DepositsOfCryptoAssetsIntoLiquidStakingActivities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_DepositsOfCryptoAssetsIntoLiquidStakingActivities"/>   
  <xs:element name="ReceiptOfCryptoAssetsUponDepositsIntoLiquidStakingActivities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_ReceiptOfCryptoAssetsUponDepositsIntoLiquidStakingActivities"/>    
  <xs:element name="StockholdersEquityScheduleofStockOptionActivitiesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_StockholdersEquityScheduleofStockOptionActivitiesDetailsTable"/> 
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpiredIntrinsicValue1" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExpiredIntrinsicValue1"/> 
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueGranted" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueGranted"/>    
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePrice" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePrice"/>     
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceGranted" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceGranted"/>     
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueGranted" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueGranted"/>    
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionExercised"/> 
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceExercised" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceExercised"/>    
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExercised"/>   
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceExercisedCancelled" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceExercisedCancelled"/>  
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionAggregateIntrinsicValueCancelled" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionAggregateIntrinsicValueCancelled"/> 
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNumberOfOptionsExercisable" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNumberOfOptionsExercisable"/> 
  <xs:element name="ShareBasedCompensationArrangementBySharesBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceExercisable" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementBySharesBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageExercisePriceExercisable"/>    
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageRemainingContractualTermYearsExercisable" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsWeightedAverageRemainingContractualTermYearsExercisable"/>  
  <xs:element name="SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExercisable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExercisable"/> 
  <xs:element name="DeferredTaxAssetsUnrealizedLossOfShorttermInvestmentsAndCryptoAssets" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_DeferredTaxAssetsUnrealizedLossOfShorttermInvestmentsAndCryptoAssets"/>    
  <xs:element name="OrganizationandBusinessDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_OrganizationandBusinessDetailsTable"/>    
  <xs:element name="MinimumBidPricePerShare" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_MinimumBidPricePerShare"/> 
  <xs:element name="NumberOfBusinessDays" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_NumberOfBusinessDays"/>  
  <xs:element name="NumberOfComplianceWithMinimumBidPriceDays" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_NumberOfComplianceWithMinimumBidPriceDays"/>    
  <xs:element name="CommonStockBidPricePerShare" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CommonStockBidPricePerShare"/>    
  <xs:element name="SummaryofSignificantAccountingPoliciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_SummaryofSignificantAccountingPoliciesDetailsTable"/>    
  <xs:element name="WorkingCapital" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_WorkingCapital"/>  
  <xs:element name="StakingIncomeFromNativeStakingActivities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_StakingIncomeFromNativeStakingActivities"/>    
  <xs:element name="CryptoAssetsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_CryptoAssetsDetailsTable"/>  
  <xs:element name="IntangibleAssetsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_IntangibleAssetsDetailsTable"/>     
  <xs:element name="LicenseRevised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_LicenseRevised"/>   
  <xs:element name="StockholdersEquityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_StockholdersEquityDetailsTable"/>    
  <xs:element name="PercentageOfGrossProceedsManagementFee" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfGrossProceedsManagementFee"/>     
  <xs:element name="PercentageOfAggregateShares" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfAggregateShares"/>   
  <xs:element name="PercentageOfExercisePriceOfOfferingPricePerShare" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfExercisePriceOfOfferingPricePerShare"/>     
  <xs:element name="NonAccountableExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_NonAccountableExpenses"/>   
  <xs:element name="NetProceedFromInitialPublicOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_NetProceedFromInitialPublicOffering"/>     
  <xs:element name="WarrantPercentageNotExcess" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_WarrantPercentageNotExcess"/> 
  <xs:element name="PriorDaysOfWarrant" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PriorDaysOfWarrant"/>   
  <xs:element name="PercentageOfAggregateGrossProceeds" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfAggregateGrossProceeds"/>  
  <xs:element name="PurchaseAgreementPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PurchaseAgreementPeriod"/>   
  <xs:element name="AgregateGrossProceeds" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_AgregateGrossProceeds"/>  
  <xs:element name="NetCashProceeds" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_NetCashProceeds"/>    
  <xs:element name="PercentageOfGrossProceeds" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfGrossProceeds"/>    
  <xs:element name="GrossProceeds" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_GrossProceeds"/> 
  <xs:element name="PercentageOfWarrantsPurchase" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfWarrantsPurchase"/>     
  <xs:element name="PercentageOfExercisePrice" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfExercisePrice"/>    
  <xs:element name="OfferingPricePerShare" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_OfferingPricePerShare"/>  
  <xs:element name="PercentageOfLesser" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfLesser"/>     
  <xs:element name="ProvisionPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ProvisionPercentage"/>  
  <xs:element name="PurchasePricePerShare" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PurchasePricePerShare"/>  
  <xs:element name="CommonStockForCashProceeds" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_CommonStockForCashProceeds"/>  
  <xs:element name="ReserveStockSplitPerShare" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ReserveStockSplitPerShare"/>     
  <xs:element name="ConcentrationsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_ConcentrationsDetailsTable"/> 
  <xs:element name="CommitmentsandContingenciesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_CommitmentsandContingenciesDetailsTable"/>  
  <xs:element name="SublicenseIncomeReceivablePercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SublicenseIncomeReceivablePercentage"/> 
  <xs:element name="AmortizedOverTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_AmortizedOverTerm"/> 
  <xs:element name="SublicenseIncomePercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SublicenseIncomePercentage"/> 
  <xs:element name="SublicenseAgreementAmountPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SublicenseAgreementAmountPaid"/>  
  <xs:element name="InitialLicenseFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_InitialLicenseFee"/>  
  <xs:element name="PercentageOfNetSales" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfNetSales"/>    
  <xs:element name="PercentageOfLicenseFee" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfLicenseFee"/>   
  <xs:element name="NonrefundableCashPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_NonrefundableCashPayment"/>  
  <xs:element name="NetSalePercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_NetSalePercentage"/>   
  <xs:element name="RevenueTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_RevenueTerm"/>    
  <xs:element name="TradingPrice" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_TradingPrice"/>    
  <xs:element name="SecuritiesReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_SecuritiesReceived"/>    
  <xs:element name="ConsiderationFeePayablePercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ConsiderationFeePayablePercentage"/>     
  <xs:element name="UpfrontLicenseFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_UpfrontLicenseFees"/>   
  <xs:element name="FirstCommercialSale" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_FirstCommercialSale"/>     
  <xs:element name="AgreementShallExpire" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_AgreementShallExpire"/>  
  <xs:element name="PercentageOfPretaxIncomeLoss" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PercentageOfPretaxIncomeLoss"/>     
  <xs:element name="DeferredTaxAssetsValuationAllowancePercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="silo_DeferredTaxAssetsValuationAllowancePercentage"/>   
  <xs:element name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="silo_SubsequentEventsDetailsTable"/>     
  <xs:element name="ConsultantFixedFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_ConsultantFixedFee"/>     
  <xs:element name="ConsultantTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ConsultantTerm"/>     
  <xs:element name="CommitmentFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="silo_CommitmentFee"/>     
  <xs:element name="PrepaidStockbasedProfessionalFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="silo_PrepaidStockbasedProfessionalFees"/> 
  <xs:element name="AnniversaryMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_AnniversaryMember"/> 
  <xs:element name="BTCMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_BTCMember"/>     
  <xs:element name="ColumbiaLicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ColumbiaLicenseAgreementMember"/>  
  <xs:element name="CommitmentFeeSharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CommitmentFeeSharesMember"/>  
  <xs:element name="CommonWarrantSharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CommonWarrantSharesMember"/>  
  <xs:element name="CustomerPatentLicenseAgreementWithAikidoPharmaIncMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CustomerPatentLicenseAgreementWithAikidoPharmaIncMember"/>  
  <xs:element name="CustomerSublicenseAgreementWithAikidoPharmaIncMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_CustomerSublicenseAgreementWithAikidoPharmaIncMember"/> 
  <xs:element name="DanielRyweckMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_DanielRyweckMember"/>   
  <xs:element name="DrJamesKuoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_DrJamesKuoMember"/>    
  <xs:element name="ETHMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ETHMember"/>     
  <xs:element name="EricWeisblumMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_EricWeisblumMember"/>   
  <xs:element name="HCWainwrightCoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_HCWainwrightCoMember"/>  
  <xs:element name="July2024CommonWarrantSharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_July2024CommonWarrantSharesMember"/>   
  <xs:element name="July2024OfferingAndConcurrentPrivatePlacementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_July2024OfferingAndConcurrentPrivatePlacementMember"/>    
  <xs:element name="June2024CommonWarrantSharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_June2024CommonWarrantSharesMember"/>   
  <xs:element name="June2024InvestorsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_June2024InvestorsMember"/>   
  <xs:element name="June2024OfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_June2024OfferingMember"/> 
  <xs:element name="June2024PlacementAgentWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_June2024PlacementAgentWarrantsMember"/>    
  <xs:element name="June2024PurchaseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_June2024PurchaseAgreementMember"/>    
  <xs:element name="LicenseFeeRevenuesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_LicenseFeeRevenuesMember"/>     
  <xs:element name="LsETHAndMSOLMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_LsETHAndMSOLMember"/>   
  <xs:element name="LsETHMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_LsETHMember"/>    
  <xs:element name="MasterLincenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_MasterLincenseAgreementMember"/>     
  <xs:element name="May2025CommonWarrantSharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_May2025CommonWarrantSharesMember"/> 
  <xs:element name="May2025PlacementAgentWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_May2025PlacementAgentWarrantsMember"/>  
  <xs:element name="May2025PrefundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_May2025PrefundedWarrantsMember"/>  
  <xs:element name="May2025PublicOfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_May2025PublicOfferingMember"/> 
  <xs:element name="May2025PurchaseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_May2025PurchaseAgreementMember"/>  
  <xs:element name="MayTwoThousandTwentyTwoSeriesATwoWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_MayTwoThousandTwentyTwoSeriesATwoWarrantsMember"/> 
  <xs:element name="MrRyweckMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_MrRyweckMember"/>     
  <xs:element name="MrWeisblumMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_MrWeisblumMember"/>    
  <xs:element name="October2025OfferingMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_October2025OfferingMember"/>  
  <xs:element name="October2025RegisteredDirectOfferingWithConcurrentPrivatePlacementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_October2025RegisteredDirectOfferingWithConcurrentPrivatePlacementMember"/>    
  <xs:element name="OneLicenseeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_OneLicenseeMember"/> 
  <xs:element name="OneLicensorMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_OneLicensorMember"/> 
  <xs:element name="PatentProductsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PatentProductsMember"/>  
  <xs:element name="PlacementAgentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PlacementAgentMember"/>  
  <xs:element name="PlanAmendmentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PlanAmendmentMember"/>     
  <xs:element name="PreFundedWarrantSharesMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PreFundedWarrantSharesMember"/>   
  <xs:element name="PreFundedWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_PreFundedWarrantsMember"/>   
  <xs:element name="RSCMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_RSCMember"/>     
  <xs:element name="SOLMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SOLMember"/>     
  <xs:element name="SeriesA1WarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SeriesA1WarrantsMember"/> 
  <xs:element name="SeriesA2CommonWarrantMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SeriesA2CommonWarrantMember"/> 
  <xs:element name="SeriesA2WarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SeriesA2WarrantsMember"/> 
  <xs:element name="SeriesMConvertiblePreferredMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SeriesMConvertiblePreferredMember"/>   
  <xs:element name="SeriesMConvertiblePreferredStockMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SeriesMConvertiblePreferredStockMember"/>   
  <xs:element name="StockRepurchasePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_StockRepurchasePlanMember"/>  
  <xs:element name="StockWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_StockWarrantsMember"/>     
  <xs:element name="SublicenseAgreementMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_SublicenseAgreementMember"/>  
  <xs:element name="ThirdPaymentMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_ThirdPaymentMember"/>   
  <xs:element name="TwoThousandTwentyOmnibusEquityIncentivePlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_TwoThousandTwentyOmnibusEquityIncentivePlanMember"/>     
  <xs:element name="TwoThousandTwentyPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_TwoThousandTwentyPlanMember"/> 
  <xs:element name="USDCMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_USDCMember"/>  
  <xs:element name="UniversityOfMarylandBaltimoreMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_UniversityOfMarylandBaltimoreMember"/>  
  <xs:element name="WainwrightCoLLCMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_WainwrightCoLLCMember"/>    
  <xs:element name="XRPMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_XRPMember"/>     
  <xs:element name="mSOLMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_mSOLMember"/>  
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  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="silo_DocumentAndEntityInformationAbstract"/> 
</xs:schema>
