v3.26.1
Company information - Company to present the results of LEGEND Phase (Details)
Nov. 18, 2024
Mar. 18, 2024
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Jun. 13, 2023
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Phase II clinical trial evaluating lanifibranor in patients with T2D and nonalcoholic fatty liver disease      
Collaborative Arrangements      
Demonstrated reduction of hepatic fat measured by proton magnetic resonance spectroscopy     44.00%
Duration of clinical trial     168 days
Percentage of liver triglyceride reduction achieved in a higher proportion of patients     30.00%
Daily dose of lanifibranor in trial   0.80 800,000
Percentage of patients hemoglobin levels 50.00%    
Specific percentage of hemoglobin level 6.50%    
Percentage of patients On lanifibranor alone 58.00%    
Percentage of reduction of placebo group 0.00%    
LEGEND Phase IIa combination trial with lanifibranor and empagliflozin in patients with MASH/NASH and T2D      
Collaborative Arrangements      
Number of patients in main cohort | item   63  
Daily dose of lanifibranor in trial   0.80  
Daily dose of empagliflozin in trial   0.01  
Treatment period under study   168 days  
Minimum | Phase II clinical trial evaluating lanifibranor in patients with T2D and nonalcoholic fatty liver disease      
Collaborative Arrangements      
Percentage reduction in results on treatments 1.00%    
Minimum | LEGEND Phase IIa combination trial with lanifibranor and empagliflozin in patients with MASH/NASH and T2D      
Collaborative Arrangements      
Demonstrated reduction of hepatic fat measured by proton magnetic resonance spectroscopy   30.00%  
Patients treated with lanifibranor | LEGEND Phase IIa combination trial with lanifibranor and empagliflozin in patients with MASH/NASH and T2D      
Collaborative Arrangements      
Percentage reduction in results on treatments   1.14%  
Reduction in hepatic steatosis (in percent)   (47.00%)  
Percentage of patients showing significant reduction in hepatic fat   83.00%  
Significant relative reduction in VAT/SAT ratio (in percent)   (5.00%)  
Patients treated with lanifibranor in combination with empagliflozin | Phase II clinical trial evaluating lanifibranor in patients with T2D and nonalcoholic fatty liver disease      
Collaborative Arrangements      
Percentage of patients On combination therapy 80.00%    
Patients treated with lanifibranor in combination with empagliflozin | LEGEND Phase IIa combination trial with lanifibranor and empagliflozin in patients with MASH/NASH and T2D      
Collaborative Arrangements      
Percentage reduction in results on treatments   1.59%  
Reduction in hepatic steatosis (in percent)   (38.00%)  
Percentage of patients showing significant reduction in hepatic fat   67.00%  
Significant relative reduction in VAT/SAT ratio (in percent)   (17.00%)  
Patients treated with placebo | LEGEND Phase IIa combination trial with lanifibranor and empagliflozin in patients with MASH/NASH and T2D      
Collaborative Arrangements      
Demonstrated reduction of hepatic fat measured by proton magnetic resonance spectroscopy   0.00%  
Percentage of increase observed in the placebo arm   0.26%  
Reduction in hepatic steatosis (in percent)   0.00%  
Significant relative reduction in VAT/SAT ratio (in percent)   11.00%