​

​

​

​

​

​

Percentage of legal

​

​

​

​

Date of

​

Place of

​

ownership

​

​

Entity

  ​ ​ ​

incorporation

  ​ ​ ​

incorporation

  ​ ​ ​

by the Company

  ​ ​ ​

Principal activities

Adagene (Hong Kong) Limited

​

December 12, 2011

Hong Kong

100

%

Investment holding, and research and development of innovative medicines

Adagene Incorporated

​

September 20, 2017

The United States of America

100

%

Research and development of innovative medicines

Adagene (Suzhou) Limited

​

February 28, 2012

The People’s Republic of China (“PRC” or “China”)

100

%

Research and development of innovative medicines

Adagene Australia PTY Ltd.

​

May 30, 2018

​

Australia

​

100

%

Research and development of innovative medicines

Adagene PTE. Ltd.

​

March 27, 2020

​

Singapore

​

100

%

Research and development of innovative medicines

Adagene AG

​

August 31, 2020

Switzerland

100

%

Research and development of innovative medicines

Adagene Project C1 PTE. Ltd.

​

March 25, 2022

Singapore

100

%

Research and development of innovative medicines