0001645469 2025-01-01 2025-12-31 0001645469 2026-03-17 0001645469 2025-06-30 shares iso4217:USD FY 2025 --12-31 true 0001645469 10-K/A Amendment No. 1 true 2025-12-31 false 001-39070 MONOPAR THERAPEUTICS INC. DE 32-0463781 1000 Skokie Blvd., Suite 350 Wilmette IL 60091 847 388-0349 Common stock, $0.001 par value MNPR NASDAQ No No Yes Yes Non-accelerated Filer true false false false false 155527932 6692140